A Chemical Biological Approach to Study G Protein-Coupled Receptors: Labeling the Adenosine A~1 Receptor Using an Electrophilic Covalent Probe

Authors: Beerkens, Bert L. H., Koç, Çağla, Liu, Rongfang, Florea, Bogdan I., Le Dévédec, Sylvia E., Heitman, Laura H., IJzerman, Adriaan P., van der Es, Daan

Source: ACS chemical biology. 17(11):3131-3139

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Development of subtype-selective covalent ligands for the adenosine A2B receptor by tuning the reactive groupElectronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d2md00132b

Authors: Beerkens, Bert L. H., Wang, Xuesong, Avgeropoulou, Maria, Adistia, Lisa N., van Veldhoven, Jacobus P. D., Jespers, Willem, Liu, Rongfang, Heitman, Laura H., IJzerman, Adriaan P., van der Es, Daan

Source: RSC medicinal chemistry. 13(7):850-856

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Generation of glucosylated sn-1-glycerolphosphate teichoic acids: glycerol stereochemistry affects synthesis and antibody interactionElectronic supplementary information (ESI) available: Experimental procedures and analytical data (PDF). See DOI: 10.1039/d0cb00206b

Authors: Berni, Francesca, Wang, Liming, Kalfopoulou, Ermioni, Nguyen, D. Linh, van der Es, Daan, Huebner, Johannes, Overkleeft, Herman S., Hokke, Cornelis H., van der Marel, Gijsbert A., van Diepen, Angela, Codée, Jeroen D. C.

Source: RSC chemical biology. 2(1):187-191

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100128495956.0x000001&indx=1&recIds=ETOCvdc_100128495956.0x000001

Stereochemical optimization of N,2-substituted cycloalkylamines as norepinephrine reuptake inhibitors.

Authors: Dilweg, Majlen A., Mocking, Tamara A. M., Maragkoudakis, Pantelis, van Westen, Gerard J. P., Heitman, Laura H., IJzerman, Adriaan P., Jespers, Willem, van der Es, Daan

Source: RSC Medicinal Chemistry; Dec2024, Vol. 15 Issue 12, p4068-4079, 12p

Design and pharmacological profile of a novel covalent partial agonist for the adenosine A1 receptor

Authors: Yang, Xue, Dilweg, Majlen A., Osemwengie, Dion, Burggraaff, Lindsey, van der Es, Daan, Heitman, Laura H., IJzerman, Adriaan P.

Source: In Biochemical Pharmacology October 2020 180

LC–MS/MS analysis of the central energy and carbon metabolites in biological samples following derivatization by dimethylaminophenacyl bromide

Authors: Willacey, Cornelius C.W. ^*, Naaktgeboren, Martijn, Lucumi Moreno, Edinson, Wegrzyn, Agnieszka B., van der Es, Daan, Karu, Naama, Fleming, Ronan M.T., Harms, Amy C., Hankemeier, Thomas ^*

Source: In Journal of Chromatography A 20 December 2019 1608

Labeling of CC Chemokine Receptor 2 with a Versatile Intracellular Allosteric Probe.

Authors: den Hollander, Lisa S., Beerkens, Bert L.H., Dekkers, Sebastian, van Veldhoven, Jacobus P.D., Ortiz Zacarías, Natalia V., van der Horst, Cas, Sieders, Elisabeth G., de Valk, Bert, Wang, Jianhui, IJzerman, Adriaan P., van der Es, Daan, Heitman, Laura H.

Source: ACS Chemical Biology; 9/20/2024, Vol. 19 Issue 9, p2070-2080, 11p

Inducing Receptor Degradation as a Novel Approach to Target CC Chemokine Receptor 2 (CCR2).

Authors: Ortiz Zacarías, Natalia V., Röth, Sascha, Broekhuis, Jeremy D., van der Es, Daan, Moreau, Kevin, Heitman, Laura H.

Source: International Journal of Molecular Sciences; Aug2024, Vol. 25 Issue 16, p8984, 22p

Subject Terms: CHIMERIC proteins, CHEMOKINE receptors, PROTEOLYSIS, DRUG target, CELL physiology

Kinetics of human cannabinoid 1 (CB1) receptor antagonists: Structure-kinetics relationships (SKR) and implications for insurmountable antagonism

Authors: Xia, Lizi, de Vries, Henk, Yang, Xue, Lenselink, Eelke B., Kyrizaki, Athina, Barth, Francis, Louvel, Julien, Dreyer, Matthias K., van der Es, Daan, IJzerman, Adriaan P., Heitman, Laura H.

Source: In Biochemical Pharmacology May 2018 151:166-179

N‑Acyl‑N‑Alkyl Sulfonamide Probes for Ligand-Directed Covalent Labeling of GPCRs: The Adenosine A2B Receptor as Case Study.

Authors: Beerkens, Bert L. H., Andrianopoulou, Vasiliki, Wang, Xuesong, Liu, Rongfang, van Westen, Gerard J. P., Jespers, Willem, IJzerman, Adriaan P., Heitman, Laura H., van der Es, Daan

Source: ACS Chemical Biology; 7/19/2024, Vol. 19 Issue 7, p1554-1562, 9p

Synthesis of E. faecium wall teichoic acid fragments

Authors: van der Es, Daan, Groenia, Nadia A., Laverde, Diana, Overkleeft, Herman S., Huebner, Johannes, van der Marel, Gijsbert A., Codée, Jeroen D.C.

Source: In Bioorganic & Medicinal Chemistry 1 September 2016 24(17):3893-3907

N-Acyl-N-Alkyl Sulfonamide Probes for Ligand-Directed Covalent Labeling of GPCRs: The Adenosine A2BReceptor as Case Study

Authors: Beerkens, Bert L. H., Andrianopoulou, Vasiliki, Wang, Xuesong, Liu, Rongfang, van Westen, Gerard J. P., Jespers, Willem, IJzerman, Adriaan P., Heitman, Laura H., van der Es, Daan

Source: ACS Chemical Biology; July 2024, Vol. 19 Issue: 7 p1554-1562, 9p

A stabilized glycomimetic conjugate vaccine inducing protective antibodies against Neisseria meningitidis serogroup A

Authors: Enotarpi, Jacopo, Tontini, Marta, Balocchi, Cristiana, van der Es, Daan, Auberger, Ludovic, Balducci, Evita, Carboni, Filippo, Proietti, Daniela, Casini, Daniele, Filippov, Dmitri V., Overkleeft, Hermen S., van der Marel, Gijsbert A., Colombo, Cinzia, Romano, Maria Rosaria, Berti, Francesco, Costantino, Paolo, Codeé, Jeroen D. C., Lay, Luigi, Adamo, Roberto

Source: Nature communications. 11(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190738317.0x000001&indx=1&recIds=ETOCvdc_100190738317.0x000001

Publisher Correction: A stabilized glycomimetic conjugate vaccine inducing protective antibodies against Neisseria meningitidis serogroup A

Authors: Enotarpi, Jacopo, Tontini, Marta, Balocchi, Cristiana, van der Es, Daan, Auberger, Ludovic, Balducci, Evita, Carboni, Filippo, Proietti, Daniela, Casini, Daniele, Filippov, Dmitri V., Overkleeft, Hermen S., van der Marel, Gijsbert A., Colombo, Cinzia, Romano, Maria Rosaria, Berti, Francesco, Costantino, Paolo, Codeé, Jeroen D. C., Lay, Luigi, Adamo, Roberto

Source: Nature communications. 11(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190738063.0x000001&indx=1&recIds=ETOCvdc_100190738063.0x000001

Development of an Affinity-Based Probe to Profile Endogenous Human Adenosine A3 Receptor Expression.

Authors: Beerkens, Bert L. H., Snijders, Inge M., Snoeck, Joep, Liu, Rongfang, Tool, Anton T. J., Le Dévédec, Sylvia E., Jespers, Willem, Kuijpers, Taco W., van Westen, Gerard J.P., Heitman, Laura H., IJzerman, Adriaan P., van der Es, Daan

Source: Journal of Medicinal Chemistry; 8/24/2023, Vol. 66 Issue 16, p11399-11413, 15p

Stereochemical optimization of N,2-substituted cycloalkylamines as norepinephrine reuptake inhibitorsElectronic supplementary information (ESI) available: Supplementary figures and experimental, 1H NMR, 13C NMR, 2D NMR spectra and HPLC traces of the in-house synthesized compounds. See DOI: https://doi.org/10.1039/d4md00521j

Authors: Dilweg, Majlen A., Mocking, Tamara A. M., Maragkoudakis, Pantelis, van Westen, Gerard J. P., Heitman, Laura H., IJzerman, Adriaan P., Jespers, Willem, van der Es, Daan

Source: MedChemComm; 2024, Vol. 15 Issue: 12 p4068-4079, 12p

Development of an Affinity-Based Probe to Profile Endogenous Human Adenosine A3Receptor Expression

Authors: Beerkens, Bert L. H., Snijders, Inge M., Snoeck, Joep, Liu, Rongfang, Tool, Anton T. J., Le Dévédec, Sylvia E., Jespers, Willem, Kuijpers, Taco W., van Westen, Gerard J.P., Heitman, Laura H., IJzerman, Adriaan P., van der Es, Daan

Source: Journal of Medicinal Chemistry; August 2023, Vol. 66 Issue: 16 p11399-11413, 15p

A Chemical Biological Approach to Study G Protein-Coupled Receptors: Labeling the Adenosine A1 Receptor Using an Electrophilic Covalent Probe.

Authors: Beerkens, Bert L. H., Koç, Çağla, Liu, Rongfang, Florea, Bogdan I., Le Dévédec, Sylvia E., Heitman, Laura H., IJzerman, Adriaan P., van der Es, Daan

Source: ACS Chemical Biology; 11/18/2022, Vol. 17 Issue 11, p3131-3139, 9p

Profiling acidic metabolites by capillary electrophoresis‐mass spectrometry in low numbers of mammalian cells using a novel chemical derivatization approach.

Authors: van Mever, Marlien¹, Willacey, Cornelius C. W.¹, Zhang, Wei¹, Drouin, Nicolas¹, Christina, Alphert E.², Lindenburg, Peter W.^1,2, van Veldhoven, Jaco P. D.¹, van der Es, Daan¹, Harms, Amy C.¹, Hankemeier, Thomas¹, Ramautar, Rawi¹, r.ramautar@lacdr.leidenuniv.nl

Source: Analytical Science Advances; Feb2022, Vol. 3 Issue 1/2, p3-13, 11p

Development of subtype-selective covalent ligands for the adenosine A2Breceptor by tuning the reactive groupElectronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d2md00132b

Authors: Beerkens, Bert L. H., Wang, Xuesong, Avgeropoulou, Maria, Adistia, Lisa N., van Veldhoven, Jacobus P. D., Jespers, Willem, Liu, Rongfang, Heitman, Laura H., IJzerman, Adriaan P., van der Es, Daan

Source: MedChemComm; 2022, Vol. 13 Issue: 7 p850-856, 7p