Reticuloendothelial system blockade does not enhance siRNA-LNP circulation or tumor accumulation in mice

Authors: Escudé Martinez de Castilla, Pol ^a, Estapé Senti, Mariona ^a, Erkens, Sigrun ^b, van Weerden, Wytske M. ^b, Kooijmans, Sander A.A. ^a, Fens, Marcel H. ^c, Vader, Pieter ^{a, d}, Schiffelers, Raymond M. ^{a, ⁎}

Source: In International Journal of Pharmaceutics: X June 2025 9

Prostate cancer androgen biosynthesis relies solely on CYP17A1 downstream metabolites

Authors: Snaterse, Gido, Taylor, Angela E., Moll, J. Matthijs, O’Neil, Donna M., Teubel, Wilma J., van Weerden, Wytske M., Arlt, Wiebke, Hofland, Johannes

Source: In Journal of Steroid Biochemistry and Molecular Biology February 2024 236

Toll-Like Receptor 3 Overexpression Induces Invasion of Prostate Cancer Cells, whereas Its Activation Triggers Apoptosis

Authors: Muresan, Ximena M., Slabáková, Eva, Procházková, Jiřina, Drápela, Stanislav, Fedr, Radek, Pícková, Markéta, Vacek, Ondřej, Víchová, Ráchel, Suchánková, Tereza, Bouchal, Jan, Kürfürstová, Daniela, Král, Milan, Hulínová, Tereza, Sýkora, Radek P., Študent, Vladimír, Hejret, Václav, van Weerden, Wytske M., Puhr, Martin, Pustka, Václav, Potěšil, David, Zdráhal, Zbyněk, Culig, Zoran, Souček, Karel

Source: American journal of pathology. 192(9):1321-1335

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100169229343.0x000001&indx=1&recIds=ETOCvdc_100169229343.0x000001

Pre-existing cell subpopulations in primary prostate cancer tumors display surface fingerprints of docetaxel-resistant cells.

Authors: Drápela, Stanislav, Kvokačková, Barbora, Slabáková, Eva, Kotrbová, Anna, Gömöryová, Kristína, Fedr, Radek, Kurfürstová, Daniela, Eliáš, Martin, Študent jr, Vladimír, Lenčéšová, Frederika, Ranjani, Ganji Sri, Pospíchalová, Vendula, Bryja, Vítězslav, van Weerden, Wytske M., Puhr, Martin, Culig, Zoran, Bouchal, Jan, Souček, Karel

Source: Cellular Oncology (2211-3428); Feb2025, Vol. 48 Issue 1, p205-218, 14p

Subject Terms: MEDICAL sciences, CELL surface antigens, EPITHELIAL-mesenchymal transition, EXTRACELLULAR vesicles, DOCETAXEL

Continued androgen signalling inhibition improves cabazitaxel efficacy in prostate cancer

Authors: Mout, Lisanne, van Royen, Martin E., de Ridder, Corrina, Stuurman, Debra, van de Geer, Wesley S., Marques, Rute, Buck, Stefan A.J., French, Pim J., van de Werken, Harmen J.G., Mathijssen, Ron H.J., de Wit, Ronald, Lolkema, Martijn P., van Weerden, Wytske M.

Source: In EBioMedicine November 2021 73

Generating human prostate cancer organoids from leukapheresis enriched circulating tumour cells

Authors: Mout, Lisanne, van Dessel, Lisanne F., Kraan, Jaco, de Jong, Anouk C., Neves, Rui P.L., Erkens-Schulze, Sigrun, Beaufort, Corine M., Sieuwerts, Anieta M., van Riet, Job, Woo, Thomas L.C., de Wit, Ronald, Sleijfer, Stefan, Hamberg, Paul, Sandberg, Yorick, te Boekhorst, Peter A.W., van de Werken, Harmen J.G., Martens, John W.M., Stoecklein, Nikolas H., van Weerden, Wytske M., Lolkema, Martijn P.

Source: In European Journal of Cancer June 2021 150:179-189

GRPr Antagonist ^6^8Ga-SB3 PET/CT Imaging of Primary Prostate Cancer in Therapy-Naïve Patients

Authors: Bakker, Ingrid L., Fröberg, Alida C., Busstra, Martijn B., Verzijlbergen, J. Fred, Konijnenberg, Mark, van Leenders, Geert J. L. H., Schoots, Ivo G., de Blois, Erik, van Weerden, Wytske M., Dalm, Simone U.

Source: Journal of nuclear medicine. 62(11):1517-1523

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN627823549&indx=1&recIds=ETOCRN627823549

Novel patient-derived 3D culture models to guide clinical decision-making in prostate cancer

Authors: Van Hemelryk, Annelies, van Weerden, Wytske M.

Source: In Current Opinion in Endocrine and Metabolic Research February 2020 10:7-15

Hybrid Tracers Based on Cyanine Backbones Targeting Prostate-Specific Membrane Antigen: Tuning Pharmacokinetic Properties and Exploring Dye—Protein Interaction

Authors: Hensbergen, Albertus W., Buckle, Tessa, van Willigen, Danny M., Schottelius, Margret, Welling, Mick M., van der Wijk, Felicia A., Maurer, Tobias, van der Poel, Henk G., van der Pluijm, Gabri, van Weerden, Wytske M.

Source: Journal of nuclear medicine. 61(2):234-241

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN623006278&indx=1&recIds=ETOCRN623006278

Darolutamide does not interfere with OATP‐mediated uptake of docetaxel.

Authors: Buck, Stefan A. J., Talebi, Zahra, Drabison, Thomas, Jin, Yan, Gibson, Alice A., Hu, Peng, de Bruijn, Peter, de Ridder, Corrina M. A., Stuurman, Debra, Hu, Shuiying, van Weerden, Wytske M., Koolen, Stijn L. W., de Wit, Ronald, Sparreboom, Alex, Mathijssen, Ron H. J., Eisenmann, Eric D.

Source: International Journal of Cancer; Jul2024, Vol. 155 Issue 2, p314-323, 10p

Subject Terms: DOCETAXEL, ANDROGEN receptors, PROSTATE cancer patients, DRUG interactions

Construction of a chimeric antigen receptor bearing a nanobody against prostate a specific membrane antigen in prostate cancer

Authors: Hassani, Mahmoud, Hajari Taheri, Fatemeh, Sharifzadeh, Zahra, Arashkia, Arash, Hadjati, Jamshid, van Weerden, Wytske M., Modarressi, Mohammad Hossein, Abolhassani, Mohsen

Source: Journal of cellular biochemistry. 120(6):10787-10795

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100125734056.0x000001&indx=1&recIds=ETOCvdc_100125734056.0x000001

Capivasertib combines with docetaxel to enhance anti-tumour activity through inhibition of AKT-mediated survival mechanisms in prostate cancer.

Authors: Eberlein, Cath, Williamson, Stuart C., Hopcroft, Lorna, Ros, Susana, Moss, Jennifer I., Kerr, James, van Weerden, Wytske M., de Bruin, Elza C., Dunn, Shanade, Willis, Brandon, Ross, Sarah J., Rooney, Claire, Barry, Simon T.

Source: British Journal of Cancer; May2024, Vol. 130 Issue 8, p1377-1387, 11p

Targeting the Androgen Receptor Confers In Vivo Cross-resistance Between Enzalutamide and Docetaxel, But Not Cabazitaxel, in Castration-resistant Prostate Cancer

Authors: van Soest, Robert J., de Morrée, Ellen S., Kweldam, Charlotte F., de Ridder, Corrina M.A., Wiemer, Erik A.C., Mathijssen, Ron H.J., de Wit, Ronald, van Weerden, Wytske M.

Source: European urology. 67(6):981-985

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100069996605.0x000001&indx=1&recIds=ETOCvdc_100069996605.0x000001

High Efficacy of Combination Therapy Using PI3K/AKT Inhibitors with Androgen Deprivation in Prostate Cancer Preclinical Models

Authors: Marques, Rute B., Aghai, Ashraf, de Ridder, Corrina M.A., Stuurman, Debra, Hoeben, Sander, Boer, Agnes, Ellston, Rebecca P., Barry, Simon T., Davies, Barry R., Trapman, Jan, van Weerden, Wytske M.

Source: European urology. 67(6):1177-1185

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100069996537.0x000001&indx=1&recIds=ETOCvdc_100069996537.0x000001

A Novel ^1^1^1In-Labeled Anti-Prostate-Specific Membrane Antigen Nanobody for Targeted SPECT/CT Imaging of Prostate Cancer

Authors: Chatalic, Kristell L. S., Veldhoven-Zweistra, Joke, Bolkestein, Michiel, Hoeben, Sander, Koning, Gerben A., Boerman, Otto C., de Jong, Marion, van Weerden, Wytske M.

Source: Journal of nuclear medicine. 56(7):1094-1099

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN601880567&indx=1&recIds=ETOCRN601880567

Awe and anxiety for cancer cells: connecting scientists and patients in a holistic approach of metastasis research.

Authors: Bronkhorst, Hildert, van Weerden, Wytske M., Bunnik, Eline M., Zwart, Hub

Source: Research Involvement & Engagement; 9/26/2023, Vol. 9 Issue 1, p1-13, 13p

Subject Terms: CANCER cells, PATIENT experience, RESEARCH personnel, LABORATORY personnel, METASTASIS

GRPR versus PSMA: expression profiles during prostate cancer progression demonstrate the added value of GRPR-targeting theranostic approaches.

Authors: Verhoeven, Marjolein, Ruigrok, Eline A. M., van Leenders, Geert J. L. H., van den Brink, Lilian, Balcioglu, Hayri E., van Weerden, Wytske M., Dalm, Simone U.

Source: Frontiers in Oncology; 2023, p1-10, 10p

Subject Terms: PROSTATE cancer, GENE expression, CANCER invasiveness, BENIGN prostatic hyperplasia, RADIONUCLIDE imaging, PEPTIDE receptors

ERG immunohistochemistry is not predictive for PSA recurrence, local recurrence or overall survival after radical prostatectomy for prostate cancer

Authors: Hoogland, A Marije, Jenster, Guido, van Weerden, Wytske M, Trapman, Jan, van der Kwast, Theo, Roobol, Monique J, Schröder, Fritz H, Wildhagen, Mark F, van Leenders, Geert JLH

Source: In Modern Pathology March 2012 25(3):471-479

Viability Analysis and High-Content Live-Cell Imaging for Drug Testing in Prostate Cancer Xenograft-Derived Organoids.

Authors: Van Hemelryk, Annelies, Erkens-Schulze, Sigrun, Lim, Lifani, de Ridder, Corrina M. A., Stuurman, Debra C., Jenster, Guido W., van Royen, Martin E., van Weerden, Wytske M.

Source: Cells (2073-4409); May2023, Vol. 12 Issue 10, p1377, 16p

Subject Terms: DRUG use testing, PROSTATE cancer, ORGANOIDS, ENDORECTAL ultrasonography, CELL nuclei, PROPIDIUM iodide

Changes in the Penile Arteries of the Rat after Fractionated Irradiation of the Prostate: A Pilot Study

Authors: Van Der Wielen, Gerard J. ^*, Vermeij, Marcel, De Jong, Bas W.D., Schuit, Maarten, Marijnissen, Johannes, Kok, Dik J., Van Weerden, Wytske M., Incrocci, Luca ^{*, *}

Source: In The Journal of Sexual Medicine July 2009 6(7):1908-1913