Loss of p53 impairs death receptor expression and confers resistance to CD19 CAR T-cell therapy in BCP-ALL

Authors: Cox, Willem P. J. ¹, Dautzenberg, Noël M. M. ^{1, 2}, Dekker, Linde ¹, Klenovsek, Tesa ¹, Cornel, Annelisa M. ^{1, 2}, van Hoesel, Marliek ¹, van Ingen Schenau, Dorette S. ¹, Bladergroen, Reno S. ¹, Kuiper, Roland P. ^{1, 3}, van der Meer, Laurens T. ¹, Calkoen, Friso G. ¹, Nierkens, Stefan ^{1, 2, ∗}, van Leeuwen, Frank N. ¹

Source: In Blood Neoplasia February 2025 2(1)

Btg1 and Btg2 regulate neonatal cardiomyocyte cell cycle arrest

Authors: Velayutham, Nivedhitha, Calderon, Maria Uscategui, Alfieri, Christina M., Padula, Stephanie L., van Leeuwen, Frank N., Scheijen, Blanca, Yutzey, Katherine E.

Source: Journal of molecular and cellular cardiology. 179:30-41

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100195196903.0x000001&indx=1&recIds=ETOCvdc_100195196903.0x000001

Genetic Cancer Susceptibility in Adolescents and Adults 25 Years or Younger With Colorectal Cancer

Authors: Mensenkamp, Arjen R., van Kessel, Ad Geurts, Spruijt, Liesbeth, Kets, C. Marleen, van Zelst-Stam, Wendy A.G., Schouten, Meyke I., Wevers, Marijke R., Olderode-Berends, Maran J.W., Oosterwijk, Jan C., Hitzert, Marrit M., Letteboer, Tom G.W., Stanković, Snežana, Kamping, Eveline J., Yuniati, Laurensia, van Leeuwen, Frank N., Weitz, Jürgen, van der Post, Rachel S., Teixeira, Manuel R., Liu, Huanliang, Wang, Jianping, Jongmans, Marjolijn C.J., Zhang, Junxiao, Kuiper, Roland P., Hoogerbrugge, Nicoline, Ligtenberg, Marjolijn J.L., De Voer, Richarda M.

Source: In Gastroenterology March 2022 162(3):969-974

BTK inhibition sensitizes acute lymphoblastic leukemia to asparaginase by suppressing the amino acid response pathway

Authors: Butler, Miriam, van Ingen Schenau, Dorette S. ^*, Yu, Jiangyan ^*, Jenni, Silvia, Dobay, Maria P., Hagelaar, Rico, Vervoort, Britt M.T., Tee, Trisha M., Hoff, Fieke W., Meijerink, Jules P., Kornblau, Steven M., Bornhauser, Beat, Bourquin, Jean-Pierre, Kuiper, Roland P., van der Meer, Laurens T., van Leeuwen, Frank N. ^*

Source: In Blood 9 December 2021 138(23):2383-2395

Amino Acid Depletion Therapies: Starving Cancer Cells to Death

Authors: Butler, Miriam, van der Meer, Laurens T., van Leeuwen, Frank N.

Source: In Trends in Endocrinology & Metabolism June 2021 32(6):367-381

IKZF1 in acute lymphoblastic leukemia: the rise before the fall?

Authors: Østergaard, Anna, Boer, Judith M., van Leeuwen, Frank N., Pieters, Rob, Den Boer, Monique L.

Source: Leukemia & Lymphoma; Dec2024, Vol. 65 Issue 14, p2077-2087, 11p

Subject Terms: LYMPHOBLASTIC leukemia, TRANSCRIPTION factors, ACUTE leukemia, SUBSTANCE abuse relapse, CELL communication

The transcriptional repressor SNAI2 impairs neuroblastoma differentiation and inhibits response to retinoic acid therapy

Authors: Vrenken, Kirsten S., Vervoort, Britt M.T., van Ingen Schenau, Dorette S., Derks, Yvonne H.W., van Emst, Liesbeth, Grytsenko, Pavlo G., Middelbeek, Jeroen A.J., van Leeuwen, Frank N.

Source: In BBA - Molecular Basis of Disease 1 March 2020 1866(3)

Mutational mechanisms in multiply relapsed pediatric acute lymphoblastic leukemia

Authors: van der Ham, Cédric G., Suurenbroek, Lianne C., Kleisman, Michelle M., Antić, Željko, Lelieveld, Stefan H., Yeong, Marley, Westera, Liset, Sonneveld, Edwin, Hoogerbrugge, Peter M., van der Velden, Vincent H. J., van Leeuwen, Frank N., Kuiper, Roland P.

Source: Leukemia; November 2024, Vol. 38 Issue: 11 p2366-2375, 10p

TRPM7 controls mesenchymal features of breast cancer cells by tensional regulation of SOX4

Authors: Kuipers, Arthur J., Middelbeek, Jeroen, Vrenken, Kirsten, Pérez-González, Carlos, Poelmans, Geert, Klarenbeek, Jeffrey, Jalink, Kees, Trepat, Xavier, van Leeuwen, Frank N.

Source: In BBA - Molecular Basis of Disease July 2018 1864(7):2409-2419

Tumor suppressor BTG1 limits activation of BCL6 expression downstream of ETV6-RUNX1

Authors: Tijchon, Esther, van Emst, Liesbeth, Yuniati, Laurensia, van Ingen Schenau, Dorette, Gerritsen, Mylène, van der Meer, Laurens T., Williams, Owen, Hoogerbrugge, Peter M., Scheijen, Blanca, van Leeuwen, Frank N. ^*

Source: In Experimental Hematology April 2018 60:57-62

Microdomains of the C-Type Lectin DC-SIGN Are Portals for Virus Entry into Dendritic Cells

Authors: Cambi, Alessandra, de Lange, Frank, van Maarseveen, Noortje M., Nijhuis, Monique, Joosten, Ben, de Bakker, Bärbel I., van Leeuwen, Frank N., Van Hulst, Niek F., Figdor, Carl G.

Source: The Journal of Cell Biology, 2004 Jan 01. 164(1), 145-155.

Access URL: https://www.jstor.org/stable/1622046

Surviving Stress: Modulation of ATF4-Mediated Stress Responses in Normal and Malignant Cells

Authors: Wortel, Inge M.N., van der Meer, Laurens T., Kilberg, Michael S., van Leeuwen, Frank N.

Source: In Trends in Endocrinology & Metabolism November 2017 28(11):794-806

The Guanine Nucleotide Exchange Factor Tiam1 Affects Neuronal Morphology; Opposing Roles for the Small GTPases Rac and Rho

Authors: van Leeuwen, Frank N., van der Kammen, Rob A., Michiels, Frits, Kranenburg, Onno W., Collard, John G.

Source: The Journal of Cell Biology, 1997 Nov 01. 139(3), 797-807.

Access URL: https://www.jstor.org/stable/1618345

The TRPM7 interactome defines a cytoskeletal complex linked to neuroblastoma progression

Authors: Middelbeek, Jeroen, Vrenken, Kirsten, Visser, Daan, Lasonder, Edwin, Koster, Jan, Jalink, Kees, Clark, Kristopher, van Leeuwen, Frank N.

Source: In European Journal of Cell Biology November 2016 95(11):465-474

Beyond ion-conduction: Channel-dependent and -independent roles of TRP channels during development and tissue homeostasis

Authors: Vrenken, Kirsten S., Jalink, Kees, van Leeuwen, Frank N., Middelbeek, Jeroen

Source: In BBA - Molecular Cell Research June 2016 1863(6) Part B:1436-1446

Rapid Remodeling of Invadosomes by Gi-coupled Receptors: DISSECTING THE ROLE OF Rho GTPases

Authors: Kedziora, Katarzyna M., Leyton-Puig, Daniela, Argenzio, Elisabetta, Boumeester, Anja J., van Butselaar, Bram, Yin, Taofei, Wu, Yi I., van Leeuwen, Frank N., Innocenti, Metello, Jalink, Kees, Moolenaar, Wouter H.

Source: In Journal of Biological Chemistry 26 February 2016 291(9):4323-4333

The Prognostic Effect of IKZF1 Deletions in ETV6::RUNX1 and High Hyperdiploid Childhood Acute Lymphoblastic Leukemia

Authors: Østergaard, Anna, Enshaei, Amir, Pieters, Rob, Vora, Ajay, Horstmann, Martin A., Escherich, Gabriele, Johansson, Bertil, Heyman, Mats, Schmiegelow, Kjeld, Hoogerbrugge, Peter M., den Boer, Monique L., Kuiper, Roland P., Moorman, Anthony V., Boer, Judith M., van Leeuwen, Frank N.

Source: HemaSphere. 7(5):e875-e875

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190877400.0x000001&indx=1&recIds=ETOCvdc_100190877400.0x000001

TRPM7 triggers Ca2+ sparks and invadosome formation in neuroblastoma cells

Authors: Visser, Daan, Langeslag, Michiel, Kedziora, Katarzyna M., Klarenbeek, Jeffrey, Kamermans, Alwin, Horgen, F. David, Fleig, Andrea, van Leeuwen, Frank N., Jalink, Kees

Source: In Cell Calcium December 2013 54(6):404-415

The Prognostic Effect of IKZF1 Deletions in ETV6::RUNX1 and High Hyperdiploid Childhood Acute Lymphoblastic Leukemia

Authors: Østergaard, Anna ^*, Enshaei, Amir ^*, Pieters, Rob, Vora, Ajay, Horstmann, Martin A., Escherich, Gabriele ^*, Johansson, Bertil, Heyman, Mats, Schmiegelow, Kjeld, Hoogerbrugge, Peter M., den Boer, Monique L., Kuiper, Roland P., Moorman, Anthony V., Boer, Judith M., van Leeuwen, Frank N

Source: In Blood 15 November 2022 140 Supplement 1:3483-3485

Mechanoregulation of cytoskeletal dynamics by TRP channels

Authors: Kuipers, Arthur J., Middelbeek, Jeroen, van Leeuwen, Frank N.

Source: In European Journal of Cell Biology November-December 2012 91(11-12):834-846