Altered IL-6 signalling and risk of tuberculosis: a multi-ancestry mendelian randomisation study

Authors: Akhtar, Shaheen, Anwar, Mohammad, Asgar, Omar, Ashraf, Samina, Bidi, Saeed, Breen, Gerome, Broster, James, Chung, Raymond, Collier, David, Curtis, Charles J, Chaudhary, Shabana, Colligan, Grainne, Deloukas, Panos, Durham, Ceri, Durrani, Faiza, Eto, Fabiola, Finer, Sarah, Gafton, Joseph, Angel, Ana, Griffiths, Chris, Harvey, Joanne, Heng, Teng, Hodgson, Sam, Huang, Qin Qin, Hurles, Matt, Hunt, Karen A, Hussain, Shapna, Islam, Kamrul, Iyer, Vivek, Jacobs, Benjamin M, Kalantzis, Georgios, Khan, Ahsan, Langenberg, Claudia, Lavery, Cath, Lee, Sang Hyuck, MacArthur, Daniel, Malik, Sidra, Malawsky, Daniel, Martin, Hilary, Mason, Dan, Mathur, Rohini, Mazid, Mohammed Bodrul, McDermott, John, Morton, Caroline, Newman, Bill, Owor, Elizabeth, Qureshi, Asma, Ramachandrappa, Shwetha, Raza, Mehru, Russell, Jessry, Safa, Nishat, Samuel, Miriam, Siddiqui, Moneeza, Simpson, Michael, Solly, John, Spreckley, Marie, Stow, Daniel, Taylor, Michael, Trembath, Richard C, Tricker, Karen, van Heel, David A, Walter, Klaudia, Winckley, Caroline, Wood, Suzanne, Wright, John, Zengeya, Ishevanhu, Zöllner, Julia, Schurz, Haiko ¹, Naranbhai, Vivek ^{2, 3, 4, 5, 6}, Yates, Tom A ⁷, Gilchrist, James J ^{2, 8}, Parks, Tom ^{2, 9}, Dodd, Peter J ¹⁰, Möller, Marlo ¹, Hoal, Eileen G ¹, Morris, Andrew P ¹¹, Hill, Adrian V S ^{2, 12}, van Crevel, Reinout ^{13, 14}, van Laarhoven, Arjan ¹³, Ottenhoff, Tom H M ¹⁵, Metspalu, Andres ¹⁶, Magi, Reedik ¹⁶, Meyer, Christian G ¹⁷, Ellis, Magda ¹⁸, Thye, Thorsten ¹⁹, Mahasirimongkol, Surakameth ²⁰, Pasomsub, Ekawat ²¹, Tokunaga, Katsushi ²², Omae, Yosuke ²², Yanai, Hideki ²³, Mushiroda, Taisei ²⁴, Kubo, Michiaki ²⁴, Takahashi, Atsushi ^{25, 26}, Kamatani, Yoichiro ²⁵, Alisjahbana, Bachti ²⁷, Liu, Wei ^{28, 29}, Sheng, A-dong ^{30, 31, 32, 33}, Yang, Yurong ³⁴, Hamilton, Fergus ^{a, ∗}, Ghazal, Peter ^{l, ‡}, Timpson, Nicholas J ^a, Pollara, Gabriele ^{c, ∗∗}

Source: In The Lancet Microbe January 2025 6(1)

Clinical exome sequencing data from patients with inborn errors of immunity: Cohort level diagnostic yield and the benefit of systematic reanalysis

Authors: Arts, Rob J.W., Bijker, Else M., Bruno, Mariolina, Hobo, Willemijn, Hoppenreijs, Esther, de Jonge, Marien I., van Laarhoven, Arjan, van der Molen, Renate, Oud, Manon, Schatorje, Ellen J.H., Smeets, Ruben, Sprenkeler, Evelien G.G., Stol, Kim, Verhagen, Lilly M., Zonneveld-Huijssoon, Evelien, Vorsteveld, Emil E., Van der Made, Caspar I., Smeekens, Sanne P., Schuurs-Hoeijmakers, Janneke H., Astuti, Galuh, Diepstra, Heleen, Gilissen, Christian, Hoenselaar, Evelien, Janssen, Alice, van Roozendaal, Kees, Engelen, Jettie Sikkema-van, Steyaert, Wouter, Weiss, Marjan M., Yntema, Helger G., Mantere, Tuomo, AlZahrani, Mofareh S., van Aerde, Koen, Derfalvi, Beata, Faqeih, Eissa Ali, Henriet, Stefanie S.V., van Hoof, Elise, Idressi, Eman, Issekutz, Thomas B., Jongmans, Marjolijn C.J., Keski-Filppula, Riikka, Krapels, Ingrid, te Loo, Maroeska, Mulders-Manders, Catharina M., ten Oever, Jaap, Potjewijd, Judith, Sarhan, Nora Tarig, Slot, Marjan C., Terhal, Paulien A., Thijs, Herman, Vandersteen, Anthony, Vanhoutte, Els K., van de Veerdonk, Frank, van Well, Gijs, Netea, Mihai G., Simons, Annet, Hoischen, Alexander

Source: In Clinical Immunology November 2024 268

Elderly patients with tuberculosis in a low-incidence country – Clinical characteristics, inflammation and outcome

Authors: van Arkel, Cynthia, Storms, Iris, Kurver, Lisa, Smeenk, Frank, Wielders, Pascal, Hoefsloot, Wouter, Carpaij, Neeltje, Boeree, Martin J., van Crevel, Reinout, van Laarhoven, Arjan, Magis-Escurra, Cécile

Source: In Journal of Infection August 2024 89(2)

Sequencing whole genomes of the West Javanese population in Indonesia reveals novel variants and improves imputation accuracy.

Authors: Ardiansyah, Edwin, Riza, Anca-Lelia, Dian, Sofiati, Ganiem, Ahmad Rizal, Alisjahbana, Bachti, Setiabudiawan, Todia P., van Laarhoven, Arjan, van Crevel, Reinout, Kumar, Vinod

Source: Frontiers in Genetics; 2025, p1-9, 9p

Subject Terms: EAST Asians, SINGLE nucleotide polymorphisms, WHOLE genome sequencing, INDONESIANS, GENOME-wide association studies

Improving host-directed therapy for tuberculous meningitis by linking clinical and multi-omics data

Authors: Avila-Pacheco, Julian, Thuong, Nguyen T.T., Ganiem, A. Rizal, Imran, Darma, Hamers, Raph L., Alisjahbana, Bachti, Dian, Sofiati, Estiasari, Riwanti, Tram, Trinh T.B., Vinh, Dao N., Hai, Hoang T., Donovan, Joseph, Ardiansyah, Edwin, Koeken, Valerie, Kumar, Vinod, Netea, Mihai G., van Laarhoven, Arjan, Clish, Clary, Thwaites, Guy, van Crevel, Reinout

Source: In Tuberculosis May 2021 128

Central nervous system tuberculosis

Authors: Dian, Sofiati, Ganiem, Ahmad Rizal, van Laarhoven, Arjan

Source: Current opinion in neurology. 34(3):396-402

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100121686884.0x000001&indx=1&recIds=ETOCvdc_100121686884.0x000001

The effect of BCG vaccination on alveolar macrophages obtained from induced sputum from healthy volunteers

Authors: Koeken, Valerie A.C.M., van der Pasch, Eva S., Leijte, Guus P., Mourits, Vera P., de Bree, L. Charlotte J., Moorlag, Simone J.C.F.M., Budnick, Isadore, Idh, Nina, Lerm, Maria, Kox, Matthijs, van Laarhoven, Arjan, Netea, Mihai G., van Crevel, Reinout

Source: In Cytokine September 2020 133

Metabolite transport across central nervous system barriers.

Authors: Carstens, Gesa, Verbeek, Marcel M, Rohlwink, Ursula K, Figaji, Anthony A, te Brake, Lindsey, van Laarhoven, Arjan

Source: Journal of Cerebral Blood Flow & Metabolism; Jul2024, Vol. 44 Issue 7, p1063-1077, 15p

Predicting Mortality of Tuberculous Meningitis

Authors: Dian, Sofiati, Rahmadi, Ridho, van Laarhoven, Arjan, Ganiem, Ahmad Rizal, van Crevel, Reinout

Source: Clinical Infectious Diseases, 2018 Dec . 67(12), 1954-1955.

Access URL: https://www.jstor.org/stable/26573834

Neuromarker Levels Also Predict Mortality in Adult Tuberculous Meningitis

Authors: van Laarhoven, Arjan, Koeken, Valerie A. C. M., Dian, Sofiati, Ganiem, Ahmad Rizal, van Crevel, Reinout

Source: Clinical Infectious Diseases, 2018 Aug . 67(4), 642-643.

Access URL: https://www.jstor.org/stable/26524997

Cerebral tryptophan metabolism and outcome of tuberculous meningitis: an observational cohort study

Authors: van Laarhoven, Arjan, Dian, Sofiati, Aguirre-Gamboa, Raúl, Avila-Pacheco, Julian, Ricaño-Ponce, Isis, Ruesen, Carolien, Annisa, Jessi, Koeken, Valerie A C M, Chaidir, Lidya, Li, Yang, Achmad, Tri Hanggono, Joosten, Leo A B, Notebaart, Richard A, Ruslami, Rovina, Netea, Mihai G, Verbeek, Marcel M, Alisjahbana, Bachti, Kumar, Vinod, Clish, Clary B, Ganiem, A Rizal, van Crevel, Reinout

Source: In The Lancet Infectious Diseases May 2018 18(5):526-535

Reply to Neeradi et al and Dhawan and Sankhyan

Authors: van Laarhoven, Arjan, Dian, Sofiati, Ganiem, Ahmad Rizal, van Crevel, Reinout

Source: The Journal of Infectious Diseases, 2017 Aug 01. 216(3), 395-396.

Access URL: https://www.jstor.org/stable/26364964

Clinical Parameters, Routine Inflammatory Markers, and LTA4H Genotype as Predictors of Mortality Among 608 Patients With Tuberculous Meningitis in Indonesia

Authors: van Laarhoven, Arjan, Dian, Sofiati, Ruesen, Carolien, Hayati, Ela, Damen, Michelle S. M. A., Annisa, Jessi, Chaidir, Lidya, Ruslami, Rovina, Achmad, Tri Hanggono, Netea, Mihai G., Alisjahbana, Bachti, Ganiem, Ahmad Rizal, van Crevel, Reinout

Source: The Journal of Infectious Diseases, 2017 Apr 01. 215(7), 1029-1039.

Access URL: http://www.jstor.org/stable/26166967

Clinical presentation, management, and outcome of suspected central nervous system infections in Indonesia: a prospective cohort study.

Authors: Maharani, Kartika, Dian, Sofiati, Ganiem, Ahmad Rizal, Imran, Darma, Estiasari, Riwanti, Ardiansyah, Edwin, Andini, Putri Widya, Kristina, Fransisca, Pangeran, David, Chaidir, Lidya, Alisjahbana, Bachti, Rukmana, Andriansjah, Kusumaningrum, Ardiana, Adawiyah, Robiatul, Subekti, Decy, Yunihastuti, Evy, Yunus, Reyhan Eddy, Waslia, Lia, van Ingen, Jakko, van Laarhoven, Arjan

Source: Infection; Apr2024, Vol. 52 Issue 2, p583-595, 13p

Subject Terms: HIV infection epidemiology, RESEARCH funding, CEREBRAL toxoplasmosis, NEUROSYPHILIS, MENINGITIS, EVALUATION of medical care, CRYPTOCOCCUS neoformans, CENTRAL nervous system infections, LONGITUDINAL method

Geographic Terms: INDONESIA

Large-scale genomic analysis shows association between homoplastic genetic variation in Mycobacterium tuberculosis genes and meningeal or pulmonary tuberculosis

Authors: Ruesen, Carolien, Chaidir, Lidya, van Laarhoven, Arjan, Dian, Sofiati, Ganiem, Ahmad, Nebenzahl-Guimaraes, Hanna, Huynen, Martijn, Alisjahbana, Bachti, Dutilh, Bas, van Crevel, Reinout

Source: BMC genomics. 19(1):1-11

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100161420544.0x000001&indx=1&recIds=ETOCvdc_100161420544.0x000001

Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity

Authors: Arts, Rob J.W., Novakovic, Boris, ter Horst, Rob, Carvalho, Agostinho, Bekkering, Siroon, Lachmandas, Ekta, Rodrigues, Fernando, Silvestre, Ricardo, Cheng, Shih-Chin, Wang, Shuang-Yin, Habibi, Ehsan, Gonçalves, Luís G., Mesquita, Inês, Cunha, Cristina, van Laarhoven, Arjan, van de Veerdonk, Frank L., Williams, David L., van der Meer, Jos W.M., Logie, Colin, O'Neill, Luke A., Dinarello, Charles A., Riksen, Niels P., van Crevel, Reinout, Clish, Clary, Notebaart, Richard A., Joosten, Leo A.B., Stunnenberg, Hendrik G., Xavier, Ramnik J., Netea, Mihai G.

Source: In Cell Metabolism 13 December 2016 24(6):807-819

Cerebrospinal fluid IL-1β is elevated in tuberculous meningitis patients but not associated with mortality

Authors: Koeken, Valerie A.C.M., Ganiem, Ahmad R., Dian, Sofiati, Ruslami, Rovina, Chaidir, Lidya, Netea, Mihai G., Kumar, Vinod, Alisjahbana, Bachti, van Crevel, Reinout, van Laarhoven, Arjan

Source: Tuberculosis. 126

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100135835451.0x000001&indx=1&recIds=ETOCvdc_100135835451.0x000001

Transmissible Mycobacterium tuberculosis Strains Share Genetic Markers and Immune Phenotypes

Authors: Nebenzahl-Guimaraes, Hanna, van Laarhoven, Arjan, Farhat, Maha R., Koeken, Valerie A. C. M., Mandemakers, Jornt J., Zomer, Aldert, van Hijum, Sacha A. F. T., Netea, Mihai G., Murray, Megan, van Crevel, Reinout

Source: American journal of respiratory and critical care medicine. 195(11):1519-1527

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN611578670&indx=1&recIds=ETOCRN611578670

Plasma metabolome predicts trained immunity responses after antituberculosis BCG vaccination.

Authors: Koeken, Valerie A. C. M.^1,2,3, Qi, Cancan^2,3, Mourits, Vera P.¹, de Bree, L. Charlotte J.¹, Moorlag, Simone J. C. F. M.¹, Sonawane, Vidhisha¹, Lemmers, Heidi¹, Dijkstra, Helga¹, Joosten, Leo A. B.^1,4, van Laarhoven, Arjan¹, Xu, Cheng-Jian^1,2,3, van Crevel, Reinout¹, Netea, Mihai G.^1,4,5, Li, Yang^1,2,3, Yang.Li@helmholtz-hzi.de

Source: PLoS Biology; 9/12/2022, Vol. 20 Issue 9, p1-19, 19p, 1 Diagram, 4 Graphs

Current Insights into Diagnosing and Treating Neurotuberculosis in Adults.

Authors: Dian, Sofiati, Ganiem, Ahmad Rizal, te Brake, Lindsey HM, van Laarhoven, Arjan

Source: CNS Drugs; Nov2023, Vol. 37 Issue 11, p957-972, 16p

Subject Terms: TUBERCULOSIS, EXTRAPULMONARY tuberculosis, TUBERCULOMA, ANTITUBERCULAR agents, TUBERCULOUS meningitis, DIAGNOSIS