Neuregulin-1 enhances cell-cycle activity, delays cardiac fibrosis, and improves cardiac performance in rat pups with right ventricular pressure load

Authors: Bossers, Guido P.L., Günthel, Marie, van der Feen, Diederik E., Hagdorn, Quint A.J., Koop, Anne-Marie C., van Duijvenboden, Karel, Barnett, Phil, Borgdorff, Marinus A.J., Christoffels, Vincent M., Silljé, Herman H.W., Berger, Rolf M.F., Bartelds, Beatrijs

Source: In The Journal of Thoracic and Cardiovascular Surgery December 2022 164(6):e493-e510

3D-cardiomics: A spatial transcriptional atlas of the mammalian heart

Authors: Mohenska, Monika, Tan, Nathalia M., Tokolyi, Alex, Furtado, Milena B., Costa, Mauro W., Perry, Andrew J., Hatwell-Humble, Jessica, van Duijvenboden, Karel, Nim, Hieu T., Ji, Yuan M.M., Charitakis, Natalie, Bienroth, Denis, Bolk, Francesca, Vivien, Celine, Knaupp, Anja S., Powell, David R., Elliott, David A., Porrello, Enzo R., Nilsson, Susan K., del Monte-Nieto, Gonzalo, Rosenthal, Nadia A., Rossello, Fernando J., Polo, Jose M., Ramialison, Mirana

Source: In Journal of Molecular and Cellular Cardiology February 2022 163:20-32

Patient-Specific TBX5-G125R Variant Induces Profound Transcriptional Deregulation and Atrial Dysfunction

Authors: van Ouwerkerk, Antoinette F., Bosada, Fernanda M., van Duijvenboden, Karel, Houweling, Arjan C., Scholman, Koen T., Wakker, Vincent, Allaart, Cornelis P., Uhm, Jae-Sun, Mathijssen, Inge B., Baartscheer, Ton, Postma, Alex V., Barnett, Phil, Verkerk, Arie O., Boukens, Bastiaan J., Christoffels, Vincent M.

Source: Circulation. 145(8):606-619

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100169102468.0x000001&indx=1&recIds=ETOCvdc_100169102468.0x000001

Common Genetic Variants Contribute to Risk of Transposition of the Great Arteries

Authors: Škorić-Milosavljević, Doris, Tadros, Rafik, Bosada, Fernanda M., Tessadori, Federico, van Weerd, Jan Hendrik, Woudstra, Odilia I., Tjong, Fleur V.Y., Lahrouchi, Najim, Bajolle, Fanny, Cordell, Heather J., Agopian, A.J., Blue, Gillian M., Barge-Schaapveld, Daniela Q.C.M., Gewillig, Marc, Preuss, Christoph, Lodder, Elisabeth M., Barnett, Phil, Ilgun, Aho, Beekman, Leander, van Duijvenboden, Karel, Bokenkamp, Regina, Müller-Nurasyid, Martina, Vliegen, Hubert W., Konings, Thelma C., van Melle, Joost P., van Dijk, Arie P.J., van Kimmenade, Roland R.J., Roos-Hesselink, Jolien W., Sieswerda, Gertjan T., Meijboom, Folkert, Abdul-Khaliq, Hashim, Berger, Felix, Dittrich, Sven, Hitz, Marc-Phillip, Moosmann, Julia, Riede, Frank-Thomas, Schubert, Stephan, Galan, Pilar, Lathrop, Mark, Munter, Hans M., Al-Chalabi, Ammar, Shaw, Christopher E., Shaw, Pamela J., Morrison, Karen E., Veldink, Jan H., van den Berg, Leonard H., Evans, Sylvia, Nobrega, Marcelo A., Aneas, Ivy, Radivojkov-Blagojević, Milena, Meitinger, Thomas, Oechslin, Erwin, Mondal, Tapas, Bergin, Lynn, Smythe, John F., Altamirano-Diaz, Luis, Lougheed, Jane, Bouma, Berto J., Chaix, Marie-A., Kline, Jennie, Bassett, Anne S., Andelfinger, Gregor, van der Palen, Roel L.F., Bouvagnet, Patrice, Clur, Sally-Ann B., Breckpot, Jeroen, Kerstjens-Frederikse, Wilhelmina S., Winlaw, David S., Bauer, Ulrike M.M., Mital, Seema, Goldmuntz, Elizabeth, Keavney, Bernard, Bonnet, Damien, Mulder, Barbara J., Tanck, Michael W.T., Bakkers, Jeroen, Christoffels, Vincent M., Boogerd, Cornelis J., Postma, Alex V., Bezzina, Connie R.

Source: Circulation research. 130(2):166-180

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100156327406.0x000001&indx=1&recIds=ETOCvdc_100156327406.0x000001

T-box transcription factor 3 governs a transcriptional program for the function of the mouse atrioventricular conduction system

Authors: Mohan, Rajiv A., Bosada, Fernanda M., van Weerd, Jan H., van Duijvenboden, Karel, Wang, Jianan, Mommersteeg, Mathilda T. M., Hooijkaas, Ingeborg B., Wakker, Vincent, de Gier-de Vries, Corrie, Coronel, Ruben, Boink, Gerard J. J., Bakkers, Jeroen, Barnett, Phil, Boukens, Bas J., Christoffels, Vincent M.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2020 Aug 01. 117(31), 18617-18626.

Access URL: https://www.jstor.org/stable/26935614

A Rare Noncoding Enhancer Variant in SCN5A Contributes to the High Prevalence of Brugada Syndrome in Thailand.

Authors: Walsh, Roddy, Mauleekoonphairoj, John, Mengarelli, Isabella, Bosada, Fernanda M., Verkerk, Arie O., van Duijvenboden, Karel, Poovorawan, Yong, Wongcharoen, Wanwarang, Sutjaporn, Boosamas, Wandee, Pharawee, Chimparlee, Nitinan, Chokesuwattanaskul, Ronpichai, Vongpaisarnsin, Kornkiat, Dangkao, Piyawan, Wu, Cheng-I, Tadros, Rafik, Amin, Ahmad S., Lieve, Krystien V.V., Postema, Pieter G., Kooyman, Maarten

Source: Circulation; 1/7/2025, Vol. 151 Issue 1, p31-44, 14p

A Variant Noncoding Region Regulates Prrx1 and Predisposes to Atrial Arrhythmias

Authors: Bosada, Fernanda M., Rivaud, Mathilde R., Uhm, Jae-Sun, Verheule, Sander, van Duijvenboden, Karel, Verkerk, Arie O., Christoffels, Vincent M., Boukens, Bastiaan J.

Source: Circulation research. 129(3):420-434

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190156191.0x000001&indx=1&recIds=ETOCvdc_100190156191.0x000001

Genetic Dissection of a Super Enhancer Controlling the Nppa-Nppb Cluster in the Heart

Authors: Man, Joyce C.K., van Duijvenboden, Karel, Krijger, Peter H.L., Hooijkaas, Ingeborg B., van der Made, Ingeborg, de Gier-de Vries, Corrie, Wakker, Vincent, Creemers, Esther E., de Laat, Wouter, Boukens, Bastiaan J., Christoffels, Vincent M.

Source: Circulation research. 128(1):115-129

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190151011.0x000001&indx=1&recIds=ETOCvdc_100190151011.0x000001

Variant Intronic Enhancer Controls SCN10A-short Expression and Heart Conduction

Authors: Man, Joyce C.K., Bosada, Fernanda M., Scholman, Koen T., Offerhaus, Joost A., Walsh, Roddy, van Duijvenboden, Karel, van Eif, Vincent W.W., Bezzina, Connie R., Verkerk, Arie O., Boukens, Bastiaan J., Barnett, Phil, Christoffels, Vincent M.

Source: Circulation. 144(3):229-242

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100189137487.0x000001&indx=1&recIds=ETOCvdc_100189137487.0x000001

A Rare Noncoding Enhancer Variant in SCN5AContributes to the High Prevalence of Brugada Syndrome in Thailand

Authors: Walsh, Roddy, Mauleekoonphairoj, John, Mengarelli, Isabella, Bosada, Fernanda M., Verkerk, Arie O., van Duijvenboden, Karel, Poovorawan, Yong, Wongcharoen, Wanwarang, Sutjaporn, Boosamas, Wandee, Pharawee, Chimparlee, Nitinan, Chokesuwattanaskul, Ronpichai, Vongpaisarnsin, Kornkiat, Dangkao, Piyawan, Wu, Cheng-I, Tadros, Rafik, Amin, Ahmad S., Lieve, Krystien V.V., Postema, Pieter G., Kooyman, Maarten, Beekman, Leander, Sahasatas, Dujdao, Amnueypol, Montawatt, Krittayaphong, Rungroj, Prechawat, Somchai, Anannab, Alisara, Makarawate, Pattarapong, Ngarmukos, Tachapong, Phusanti, Keerapa, Veerakul, Gumpanart, Kingsbury, Zoya, Newington, Taksina, Maheswari, Uma, Ross, Mark T., Grace, Andrew, Lambiase, Pier D., Behr, Elijah R., Schott, Jean-Jacques, Redon, Richard, Barc, Julien, Christoffels, Vincent M., Wilde, Arthur A.M., Nademanee, Koonlawee, Bezzina, Connie R., Khongphatthanayothin, Apichai

Source: Circulation (Ovid); January 2025, Vol. 151 Issue: 1 p31-44, 14p

Identification of Functional Variant Enhancers Associated With Atrial Fibrillation

Authors: van Ouwerkerk, Antoinette F., Bosada, Fernanda M., Liu, Jia, Zhang, Juan, van Duijvenboden, Karel, Chaffin, Mark, Tucker, Nathan R., Pijnappels, Daniel, Ellinor, Patrick T., Barnett, Phil, de Vries, Antoine A.F., Christoffels, Vincent M.

Source: Circulation research. 127(2):229-243

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190134632.0x000001&indx=1&recIds=ETOCvdc_100190134632.0x000001

Genome-Wide Analysis Identifies an Essential Human TBX3 Pacemaker Enhancer

Authors: van Eif, Vincent W.W., Protze, Stephanie I., Bosada, Fernanda M., Yuan, Xuefei, Sinha, Tanvi, van Duijvenboden, Karel, Ernault, Auriane C., Mohan, Rajiv A., Wakker, Vincent, de Gier-de Vries, Corrie, Hooijkaas, Ingeborg B., Wilson, Michael D., Verkerk, Arie O., Bakkers, Jeroen, Boukens, Bastiaan J., Black, Brian L., Scott, Ian C., Christoffels, Vincent M.

Source: Circulation research. 127(12):1522-1535

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190150154.0x000001&indx=1&recIds=ETOCvdc_100190150154.0x000001

Conserved NPPB+ Border Zone Switches From MEF2- to AP-1–Driven Gene Program

Authors: van Duijvenboden, Karel, de Bakker, Dennis E.M., Man, Joyce C.K., Janssen, Rob, Günthel, Marie, Hill, Matthew C., Hooijkaas, Ingeborg B., van der Made, Ingeborg, van der Kraak, Petra H., Vink, Aryan, Creemers, Esther E., Martin, James F., Barnett, Phil, Bakkers, Jeroen, Christoffels, Vincent M.

Source: Circulation. 140(10):864-879

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100087512807.0x000001&indx=1&recIds=ETOCvdc_100087512807.0x000001

Identification of atrial fibrillation associated genes and functional non-coding variants

Authors: van Ouwerkerk, Antoinette F., Bosada, Fernanda M., van Duijvenboden, Karel, Hill, Matthew C., Montefiori, Lindsey E., Scholman, Koen T., Liu, Jia, de Vries, Antoine A. F., Boukens, Bastiaan J., Ellinor, Patrick T., Goumans, Marie José T. H., Efimov, Igor R., Nobrega, Marcelo A., Barnett, Phil, Martin, James F., Christoffels, Vincent M.

Source: Nature communications. 10(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100130621639.0x000001&indx=1&recIds=ETOCvdc_100130621639.0x000001

An atrial fibrillation-associated regulatory region modulates cardiac Tbx5 levels and arrhythmia susceptibility.

Authors: Bosada, Fernanda M.^1,2, van Duijvenboden, Karel¹, Giovou, Alexandra E.¹, Rivaud, Mathilde R.^1,2, Jae-Sun Uhm^1,3, Verkerk, Arie O.^1,2, Boukens, Bastiaan J.^1,4, Christoffels, Vincent M.¹ v.m.christoffels@amsterdamumc.nl

Source: eLife. 2/14/2023, p1-25. 25p.

Subject Terms: *ATRIAL fibrillation, *GENE regulatory networks, *ATRIAL arrhythmias, *ARRHYTHMIA, *GENE expression, *ION transport (Biology), *ACTION potentials, *HEART development

OccuPeak: ChIP-Seq Peak Calling Based on Internal Background Modelling.

Authors: de Boer, Bouke A.¹, van Duijvenboden, Karel¹, van den Boogaard, Malou¹, Christoffels, Vincent M.¹, Barnett, Phil¹ p.barnett@amc.uva.nl, Ruijter, Jan M.¹ j.m.ruijter@amc.uva.nl

Source: PLoS ONE. Jun2014, Vol. 9 Issue 6, p1-15. 15p.

Subject Terms: *CHROMATIN, *IMMUNOPRECIPITATION, *COMPUTATIONAL biology, *EPIGENOMICS, *GENE regulatory networks, *TRANSCRIPTION factors

Variant Intronic Enhancer Controls Expression and Heart Conduction.

Authors: Man, Joyce C. K., Bosada, Fernanda M., Scholman, Koen T., Offerhaus, Joost A., Walsh, Roddy, van Duijvenboden, Karel, van Eif, Vincent W. W., Bezzina, Connie R., Verkerk, Arie O., Boukens, Bastiaan J., Barnett, Phil, Christoffels, Vincent M.

Source: Circulation; 7/20/2021, Vol. 144 Issue 3, p229-242, 14p

Gene regulatory elements of the cardiac conduction system.

Authors: van Duijvenboden, Karel, Ruijter, Jan M., Christoffels, Vincent M.

Source: Briefings in Functional Genomics. Jan2014, Vol. 13 Issue 1, p28-38. 11p.

Subject Terms: *GENETIC regulation, *HEART conduction system, *CHROMOSOME abnormalities, *CARDIAC arrest, *ARRHYTHMIA, *HUMAN genetic variation, *GENETICS

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