Assortative mating and parental genetic relatedness contribute to the pathogenicity of variably expressive variants

Authors: Smolen, Corrine, Jensen, Matthew, Dyer, Lisa, Pizzo, Lucilla, Tyryshkina, Anastasia, Banerjee, Deepro, Rohan, Laura, Huber, Emily, El Khattabi, Laila, Prontera, Paolo, Caberg, Jean-Hubert, Van Dijck, Anke, Schwartz, Charles, Faivre, Laurence, Callier, Patrick, Mosca-Boidron, Anne-Laure, Lefebvre, Mathilde, Pope, Kate, Snell, Penny, Lockhart, Paul J., Castiglia, Lucia, Galesi, Ornella, Avola, Emanuela, Mattina, Teresa, Fichera, Marco, Luana Mandarà, Giuseppa Maria, Bruccheri, Maria Grazia, Pichon, Olivier, Le Caignec, Cedric, Stoeva, Radka, Cuinat, Silvestre, Mercier, Sandra, Bénéteau, Claire, Blesson, Sophie, Nordsletten, Ashley, Martin-Coignard, Dominique, Sistermans, Erik, Kooy, R. Frank, Amor, David J., Romano, Corrado, Isidor, Bertrand, Juusola, Jane, Girirajan, Santhosh

Source: In The American Journal of Human Genetics 7 December 2023 110(12):2015-2028

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ADNP dysregulates methylation and mitochondrial gene expression in the cerebellum of a Helsmoortel–Van der Aa syndrome autopsy case.

Authors: D'Incal, Claudio^1,2 (AUTHOR), Van Dijck, Anke^1,3 (AUTHOR), Ibrahim, Joe¹ (AUTHOR), De Man, Kevin^1,2 (AUTHOR), Bastini, Lina² (AUTHOR), Konings, Anthony² (AUTHOR), Elinck, Ellen¹ (AUTHOR), Theys, Claudia² (AUTHOR), Gozes, Illana⁴ (AUTHOR), Marusic, Zlatko⁵ (AUTHOR), Anicic, Mirna⁶ (AUTHOR), Vukovic, Jurica⁶ (AUTHOR), Van der Aa, Nathalie¹ (AUTHOR), Mateiu, Ligia¹ (AUTHOR), Vanden Berghe, Wim² (AUTHOR) wim.vandenberghe@uantwerpen.be, Kooy, R. Frank¹ (AUTHOR) frank.kooy@uantwerpen.be

Source: Acta Neuropathologica Communications. 10/24/2024, Vol. 12 Issue 1, p1-32. 32p.

Subject Terms: *TRANSCRIPTION factors, *GENE expression, *CARRIER proteins, *MULTIPLE organ failure, *MITOCHONDRIAL proteins

Aberrant Function of the C-Terminal Tail of HIST1H1E Accelerates Cellular Senescence and Causes Premature Aging

Authors: Flex, Elisabetta, Martinelli, Simone, Van Dijck, Anke, Ciolfi, Andrea, Cecchetti, Serena, Coluzzi, Elisa, Pannone, Luca, Andreoli, Cristina, Radio, Francesca Clementina, Pizzi, Simone, Carpentieri, Giovanna, Bruselles, Alessandro, Catanzaro, Giuseppina, Pedace, Lucia, Miele, Evelina, Carcarino, Elena, Ge, Xiaoyan, Chijiwa, Chieko, Lewis, M.E. Suzanne, Meuwissen, Marije, Kenis, Sandra, Van der Aa, Nathalie, Larson, Austin, Brown, Kathleen, Wasserstein, Melissa P., Skotko, Brian G., Begtrup, Amber, Person, Richard, Karayiorgou, Maria, Roos, J. Louw, Van Gassen, Koen L., Koopmans, Marije, Bijlsma, Emilia K., Santen, Gijs W.E., Barge-Schaapveld, Daniela Q.C.M., Ruivenkamp, Claudia A.L., Hoffer, Mariette J.V., Lalani, Seema R., Streff, Haley, Craigen, William J., Graham, Brett H., van den Elzen, Annette P.M., Kamphuis, Daan J., Õunap, Katrin, Reinson, Karit, Pajusalu, Sander, Wojcik, Monica H., Viberti, Clara, Di Gaetano, Cornelia, Bertini, Enrico, Petrucci, Simona, De Luca, Alessandro, Rota, Rossella, Ferretti, Elisabetta, Matullo, Giuseppe, Dallapiccola, Bruno, Sgura, Antonella, Walkiewicz, Magdalena, Kooy, R. Frank, Tartaglia, Marco

Source: In The American Journal of Human Genetics 5 September 2019 105(3):493-508

A mouse model for intellectual disability caused by mutations in the X-linked 2′‑O‑methyltransferase Ftsj1 gene

Authors: Jensen, Lars R., Garrett, Lillian, Hölter, Sabine M., Rathkolb, Birgit, Rácz, Ildikó, Adler, Thure, Prehn, Cornelia, Hans, Wolfgang, Rozman, Jan, Becker, Lore, Aguilar-Pimentel, Juan Antonio, Puk, Oliver, Moreth, Kristin, Dopatka, Monika, Walther, Diego J., von Bohlen und Halbach, Viola, Rath, Matthias, Delatycki, Martin, Bert, Bettina, Fink, Heidrun, Blümlein, Katharina, Ralser, Markus, Van Dijck, Anke, Kooy, Frank, Stark, Zornitza, Müller, Sabine, Scherthan, Harry, Gecz, Jozef, Wurst, Wolfgang, Wolf, Eckhard, Zimmer, Andreas, Klingenspor, Martin, Graw, Jochen, Klopstock, Thomas, Busch, Dirk, Adamski, Jerzy, Fuchs, Helmut, Gailus-Durner, Valérie, de Angelis, Martin Hrabě, von Bohlen und Halbach, Oliver, Ropers, Hans-Hilger, Kuss, Andreas W.

Source: In BBA - Molecular Basis of Disease 1 September 2019 1865(9):2083-2093

Rare variants in the genetic background modulate cognitive and developmental phenotypes in individuals carrying disease-associated variants

Authors: Pizzo, Lucilla, Jensen, Matthew, Polyak, Andrew, Rosenfeld, Jill A., Mannik, Katrin, Krishnan, Arjun, McCready, Elizabeth, Pichon, Olivier, Le Caignec, Cedric, Van Dijck, Anke, Pope, Kate, Voorhoeve, Els, Yoon, Jieun, Stankiewicz, Paweł, Cheung, Sau Wai, Pazuchanics, Damian, Huber, Emily, Kumar, Vijay, Kember, Rachel L., Mari, Francesca, Curró, Aurora, Castiglia, Lucia, Galesi, Ornella, Avola, Emanuela, Mattina, Teresa, Fichera, Marco, Mandarà, Luana, Vincent, Marie, Nizon, Mathilde, Mercier, Sandra, Bénéteau, Claire, Blesson, Sophie, Martin-Coignard, Dominique, Mosca-Boidron, Anne-Laure, Caberg, Jean-Hubert, Bucan, Maja, Zeesman, Susan, Nowaczyk, Małgorzata J.M., Lefebvre, Mathilde, Faivre, Laurence, Callier, Patrick, Skinner, Cindy, Keren, Boris, Perrine, Charles, Prontera, Paolo, Marle, Nathalie, Renieri, Alessandra, Reymond, Alexandre, Kooy, R. Frank, Isidor, Bertrand, Schwartz, Charles, Romano, Corrado, Sistermans, Erik, Amor, David J., Andrieux, Joris, Girirajan, Santhosh

Source: In Genetics in Medicine April 2019 21(4):816-825

The translational regulator FMRP controls lipid and glucose metabolism in mice and humans

Authors: Leboucher, Antoine, Pisani, Didier F., Martinez-Gili, Laura, Chilloux, Julien, Bermudez-Martin, Patricia, Van Dijck, Anke, Ganief, Tariq, Macek, Boris, Becker, Jérôme A.J., Le Merrer, Julie, Kooy, R. Frank, Amri, Ez-Zoubir, Khandjian, Edouard W., Dumas, Marc-Emmanuel, Davidovic, Laetitia

Source: In Molecular Metabolism March 2019 21:22-35

Clinical Presentation of a Complex Neurodevelopmental Disorder Caused by Mutations in ADNP

Authors: Bakshi, Madhura, Wilson, Meredith, Berman, Yemina, Dickson, Rebecca, Fransen, Erik, Helsmoortel, Céline, Van den Ende, Jenneke, Van der Aa, Nathalie, van de Wijdeven, Marina J., Rosenblum, Jessica, Monteiro, Fabíola, Kok, Fernando, Quercia, Nada, Bowdin, Sarah, Dyment, David, Chitayat, David, Alkhunaizi, Ebba, Boonen, Susanne E., Keren, Boris, Jacquette, Aurelia, Faivre, Laurence, Bezieau, Stephane, Isidor, Bertrand, Rieß, Angelika, Moog, Ute, Lynch, Sally Ann, McVeigh, Terri, Elpeleg, Orly, Smeland, Marie Falkenberg, Fannemel, Madeleine, van Haeringen, Arie, Maas, Saskia M., Veenstra-Knol, H.E., Schouten, Meyke, Willemsen, Marjolein H., Marcelis, Carlo L., Ockeloen, Charlotte, van der Burgt, Ineke, Feenstra, Ilse, van der Smagt, Jasper, Jezela-Stanek, Aleksandra, Krajewska-Walasek, Malgorzata, González-Lamuño, Domingo, Anderlid, Britt-Marie, Malmgren, Helena, Nordenskjöld, Magnus, Clement, Emma, Hurst, Jane, Metcalfe, Kay, Mansour, Sahar, Lachlan, Katherine, Clayton-Smith, Jill, Hendon, Laura G., Abdulrahman, Omar A., Morrow, Eric, McMillan, Clare, Gerdts, Jennifer, Peeden, Joseph, Schrier Vergano, Samantha A., Valentino, Caitlin, Chung, Wendy K., Ozmore, Jillian R., Bedrosian-Sermone, Sandra, Dennis, Anna, Treat, Kayla, Hughes, Susan Starling, Safina, Nicole, Le Pichon, Jean-Baptiste, McGuire, Marianne, Infante, Elena, Madan-Khetarpal, Suneeta, Desai, Sonal, Benke, Paul, Krokosky, Alyson, Cristian, Ingrid, Baker, Laura, Gripp, Karen, Stessman, Holly A., Eichenberger, Jacob, Jayakar, Parul, Pizzino, Amy, Manning, Melanie Ann, Slattery, Leah, Van Dijck, Anke, Vulto-van Silfhout, Anneke T., Cappuyns, Elisa, van der Werf, Ilse M., Mancini, Grazia M., Tzschach, Andreas, Bernier, Raphael, Gozes, Illana, Eichler, Evan E., Romano, Corrado, Lindstrand, Anna, Nordgren, Ann, Kvarnung, Malin, Kleefstra, Tjitske, de Vries, Bert B.A., Küry, Sébastien, Rosenfeld, Jill A., Meuwissen, Marije E., Vandeweyer, Geert, Kooy, R. Frank

Source: In Biological Psychiatry 15 February 2019 85(4):287-297

Clinical Presentation of a Complex Neurodevelopmental Disorder Caused by Mutations in ADNP

Authors: Van Dijck, Anke, Vulto-van Silfhout, Anneke T., Cappuyns, Elisa, van der Werf, Ilse M., Mancini, Grazia M., Tzschach, Andreas, Bernier, Raphael, Gozes, Illana, Eichler, Evan E., Romano, Corrado, Lindstrand, Anna, Nordgren, Ann, Kvarnung, Malin, Kleefstra, Tjitske, de Vries, Bert B.A., Küry, Sébastien, Rosenfeld, Jill A., Meuwissen, Marije E., Vandeweyer, Geert, Kooy, R. Frank

Source: Biological psychiatry. 85(4):287-297

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100097537197.0x000001&indx=1&recIds=ETOCvdc_100097537197.0x000001

Tracing the invisible mutant ADNP protein in Helsmoortel-Van der Aa syndrome patients.

Authors: D'Incal, Claudio Peter, Cappuyns, Elisa, Choukri, Kaoutar, De Man, Kevin, Szrama, Kristy, Konings, Anthony, Bastini, Lina, Van Meel, Kim, Buys, Amber, Gabriele, Michele, Rizzuti, Ludovico, Vitriolo, Alessandro, Testa, Giuseppe, Mohn, Fabio, Bühler, Marc, Van der Aa, Nathalie, Van Dijck, Anke, Kooy, R. Frank, Berghe, Wim Vanden

Source: Scientific Reports; 6/26/2024, Vol. 14 Issue 1, p1-23, 23p

Subject Terms: MUTANT proteins, LYMPHOBLASTOID cell lines, PEPTIDES, ESCHERICHIA coli, BINDING site assay, ENDONUCLEASES, IMMUNOGLOBULINS

Truncating Variants in NAA15 Are Associated with Variable Levels of Intellectual Disability, Autism Spectrum Disorder, and Congenital Anomalies

Authors: Cheng, Hanyin, Dharmadhikari, Avinash V., Varland, Sylvia, Ma, Ning, Domingo, Deepti, Kleyner, Robert, Rope, Alan F., Yoon, Margaret, Stray-Pedersen, Asbjørg, Posey, Jennifer E., Crews, Sarah R., Eldomery, Mohammad K., Akdemir, Zeynep Coban, Lewis, Andrea M., Sutton, Vernon R., Rosenfeld, Jill A., Conboy, Erin, Agre, Katherine, Xia, Fan, Walkiewicz, Magdalena, Longoni, Mauro, High, Frances A., van Slegtenhorst, Marjon A., Mancini, Grazia M.S., Finnila, Candice R., van Haeringen, Arie, den Hollander, Nicolette, Ruivenkamp, Claudia, Naidu, Sakkubai, Mahida, Sonal, Palmer, Elizabeth E., Murray, Lucinda, Lim, Derek, Jayakar, Parul, Parker, Michael J., Giusto, Stefania, Stracuzzi, Emanuela, Romano, Corrado, Beighley, Jennifer S., Bernier, Raphael A., Küry, Sébastien, Nizon, Mathilde, Corbett, Mark A., Shaw, Marie, Gardner, Alison, Barnett, Christopher, Armstrong, Ruth, Kassahn, Karin S., Van Dijck, Anke, Vandeweyer, Geert, Kleefstra, Tjitske, Schieving, Jolanda, Jongmans, Marjolijn J., de Vries, Bert B.A., Pfundt, Rolph, Kerr, Bronwyn, Rojas, Samantha K., Boycott, Kym M., Person, Richard, Willaert, Rebecca, Eichler, Evan E., Kooy, R. Frank, Yang, Yaping, Wu, Joseph C., Lupski, James R., Arnesen, Thomas, Cooper, Gregory M., Chung, Wendy K., Gecz, Jozef, Stessman, Holly A.F., Meng, Linyan, Lyon, Gholson J.

Source: American journal of human genetics. 102(5):985-994

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100140301030.0x000001&indx=1&recIds=ETOCvdc_100140301030.0x000001

Five patients with a chromosome 1q21.1 triplication show macrocephaly, increased weight and facial similarities

Authors: Van Dijck, Anke, van der Werf, Ilse M., Reyniers, Edwin, Scheers, Stefaan, Azage, Meron, Siefkas, Kiana, Van der Aa, Nathalie, Lacroix, Amy, Rosenfeld, Jill, Argiropoulos, Bob, Davis, Kellie, Innes, A.Micheil, Mefford, Heather C., Mortier, Geert, Meuwissen, Marije, Kooy, R.Frank

Source: In European Journal of Medical Genetics October 2015 58(10):503-508

A randomized double-blind, placebo-controlled trial of ganaxolone in children and adolescents with fragile X syndrome

Authors: Ligsay, Andrew, Van Dijck, Anke, Nguyen, Danh, Lozano, Reymundo, Chen, Yanjun, Bickel, Erika, Hessl, David, Schneider, Andrea, Angkustsiri, Kathleen, Tassone, Flora, Ceulemans, Berten, Kooy, R., Hagerman, Randi

Source: Journal of neurodevelopmental disorders. 9(1):1-13

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100139994493.0x000001&indx=1&recIds=ETOCvdc_100139994493.0x000001

Mutations in two large pedigrees highlight the role of ZNF711 in X-linked intellectual disability

Authors: van der Werf, Ilse M., Van Dijck, Anke, Reyniers, Edwin, Helsmoortel, Céline, Kumar, Ajay Anand, Kalscheuer, Vera M., de Brouwer, Arjan PM, Kleefstra, Tjitske, van Bokhoven, Hans, Mortier, Geert, Janssens, Sandra, Vandeweyer, Geert, Kooy, R. Frank

Source: Gene. 605:92-98

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100047524135.0x000001&indx=1&recIds=ETOCvdc_100047524135.0x000001

Reduced serum levels of pro-inflammatory chemokines in fragile X syndrome.

Authors: Van Dijck, Anke¹ (AUTHOR), Barbosa, Susana² (AUTHOR), Bermudez-Martin, Patricia² (AUTHOR), Khalfallah, Olfa² (AUTHOR), Gilet, Cyprien³ (AUTHOR), Martinuzzi, Emanuela² (AUTHOR), Elinck, Ellen¹ (AUTHOR), Kooy, R. Frank¹ (AUTHOR), Glaichenhaus, Nicolas² (AUTHOR), Davidovic, Laetitia² (AUTHOR) davidovic@ipmc.cnrs.fr

Source: BMC Neurology. 4/15/2020, Vol. 20 Issue 1, p1-12. 12p. 3 Charts, 2 Graphs, 1 Map.

Subject Terms: *FRAGILE X syndrome, *CHEMOKINES, *CENTRAL nervous system, *SERUM, *INTELLECTUAL disabilities, *CYTOKINES, *CASE-control method, *PROGNOSIS, *RESEARCH funding

Author Correction: Large-scale targeted sequencing identifies risk genes for neurodevelopmental disorders

Authors: Wang, Tianyun, Hoekzema, Kendra, Vecchio, Davide, Wu, Huidan, Sulovari, Arvis, Coe, Bradley P., Gillentine, Madelyn A., Wilfert, Amy B., Perez-Jurado, Luis A., Kvarnung, Malin, Sleyp, Yoeri, Earl, Rachel K., Rosenfeld, Jill A., Geisheker, Madeleine R., Han, Lin, Du, Bing, Barnett, Chris, Thompson, Elizabeth, Shaw, Marie, Carroll, Renee, Friend, Kathryn, Catford, Rachael, Palmer, Elizabeth E., Zou, Xiaobing, Ou, Jianjun, Li, Honghui, Guo, Hui, Gerdts, Jennifer, Avola, Emanuela, Calabrese, Giuseppe, Elia, Maurizio, Greco, Donatella, Lindstrand, Anna, Nordgren, Ann, Anderlid, Britt-Marie, Vandeweyer, Geert, Van Dijck, Anke, Van der Aa, Nathalie, McKenna, Brooke, Hancarova, Miroslava, Bendova, Sarka, Havlovicova, Marketa, Malerba, Giovanni, Bernardina, Bernardo Dalla, Muglia, Pierandrea, van Haeringen, Arie, Hoffer, Mariette J. V., Franke, Barbara, Cappuccio, Gerarda, Delatycki, Martin, Lockhart, Paul J., Manning, Melanie A., Liu, Pengfei, Scheffer, Ingrid E., Brunetti-Pierri, Nicola, Rommelse, Nanda, Amaral, David G., Santen, Gijs W. E., Trabetti, Elisabetta, Sedláček, Zdeněk, Michaelson, Jacob J., Pierce, Karen, Courchesne, Eric, Kooy, R. Frank, Nordenskjöld, Magnus, Romano, Corrado, Peeters, Hilde, Bernier, Raphael A., Gecz, Jozef, Xia, Kun, Eichler, Evan E.

Source: Nature communications. 11(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100178454291.0x000001&indx=1&recIds=ETOCvdc_100178454291.0x000001

Large-scale targeted sequencing identifies risk genes for neurodevelopmental disorders

Authors: Wang, Tianyun, Hoekzema, Kendra, Vecchio, Davide, Wu, Huidan, Sulovari, Arvis, Coe, Bradley P., Gillentine, Madelyn A., Wilfert, Amy B., Perez-Jurado, Luis A., Kvarnung, Malin, Sleyp, Yoeri, Earl, Rachel K., Rosenfeld, Jill A., Geisheker, Madeleine R., Han, Lin, Du, Bing, Barnett, Chris, Thompson, Elizabeth, Shaw, Marie, Carroll, Renee, Friend, Kathryn, Catford, Rachael, Palmer, Elizabeth E., Zou, Xiaobing, Ou, Jianjun, Li, Honghui, Guo, Hui, Gerdts, Jennifer, Avola, Emanuela, Calabrese, Giuseppe, Elia, Maurizio, Greco, Donatella, Lindstrand, Anna, Nordgren, Ann, Anderlid, Britt-Marie, Vandeweyer, Geert, Van Dijck, Anke, Van der Aa, Nathalie, McKenna, Brooke, Hancarova, Miroslava, Bendova, Sarka, Havlovicova, Marketa, Malerba, Giovanni, Bernardina, Bernardo Dalla, Muglia, Pierandrea, van Haeringen, Arie, Hoffer, Mariette J. V., Franke, Barbara, Cappuccio, Gerarda, Delatycki, Martin, Lockhart, Paul J., Manning, Melanie A., Liu, Pengfei, Scheffer, Ingrid E., Brunetti-Pierri, Nicola, Rommelse, Nanda, Amaral, David G., Santen, Gijs W. E., Trabetti, Elisabetta, Sedláček, Zdeněk, Michaelson, Jacob J., Pierce, Karen, Courchesne, Eric, Kooy, R. Frank, Nordenskjöld, Magnus, Romano, Corrado, Peeters, Hilde, Bernier, Raphael A., Gecz, Jozef, Xia, Kun, Eichler, Evan E.

Source: Nature communications. 11(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100177914432.0x000001&indx=1&recIds=ETOCvdc_100177914432.0x000001

Tauopathy in the young autistic brain: novel biomarker and therapeutic target

Authors: Grigg, Iris, Ivashko-Pachima, Yanina, Hait, Tom Aharon, Korenková, Vlasta, Touloumi, Olga, Lagoudaki, Roza, Van Dijck, Anke, Marusic, Zlatko, Anicic, Mirna, Vukovic, Jurica, Kooy, R. Frank, Grigoriadis, Nikolaos, Gozes, Illana

Source: Translational psychiatry. 10(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100172023076.0x000001&indx=1&recIds=ETOCvdc_100172023076.0x000001

Chromatin remodeler Activity-Dependent Neuroprotective Protein (ADNP) contributes to syndromic autism.

Authors: D'Incal, Claudio Peter, Van Rossem, Kirsten Esther, De Man, Kevin, Konings, Anthony, Van Dijck, Anke, Rizzuti, Ludovico, Vitriolo, Alessandro, Testa, Giuseppe, Gozes, Illana, Vanden Berghe, Wim, Kooy, R. Frank

Source: Clinical Epigenetics; 3/21/2023, Vol. 15 Issue 1, p1-28, 28p

Subject Terms: ZINC-finger proteins, CHROMATIN-remodeling complexes, CYTOSKELETAL proteins, AUTISM, CHROMATIN, PROTEINS, INTELLECTUAL disabilities

Gait deviations in rare genetic syndromes: is there a common denomitator for patients with Dravet, HVDAS and TSC?

Authors: Van De Walle, Patricia, Jansen, An, Schoonjans, An-Sofie, Van Dijck, Anke, Puts, Colette, van Hal, Iris, Weren, Marijn, Esra, Kinaci, Hallemans, Ann

Source: In Gait & Posture September 2023 106 Supplement 1:S240-S241