Key residues in the VDAC2-BAK complex can be targeted to modulate apoptosis.

Authors: Yuan, Zheng^1,2 (AUTHOR), van Delft, Mark F.^1,2 (AUTHOR), Li, Mark Xiang³ (AUTHOR), Sumardy, Fransisca¹ (AUTHOR), Smith, Brian J.⁴ (AUTHOR), Huang, David C. S.^1,2 (AUTHOR), Lessene, Guillaume^1,2,5 (AUTHOR), Khakam, Yelena¹ (AUTHOR), Jin, Ruitao^4,6 (AUTHOR), He, Sitong⁴ (AUTHOR), Smith, Nicholas A.⁴ (AUTHOR), Birkinshaw, Richard W.^1,2 (AUTHOR) birkinshaw.r@wehi.edu.au, Czabotar, Peter E.^1,2 (AUTHOR) birkinshaw.r@wehi.edu.au, Dewson, Grant^1,2 (AUTHOR) birkinshaw.r@wehi.edu.au

Source: PLoS Biology. 5/2/2024, Vol. 22 Issue 5, p1-20. 20p.

Subject Terms: *MITOCHONDRIAL membranes, *APOPTOSIS, *CELL death, *BCL-2 proteins, *MITOCHONDRIAL proteins, *CANCER cells, *MITOCHONDRIA, *DRUG development

The transcription factor IRF4 represses proapoptotic BMF and BIM to licence multiple myeloma survival

Authors: Fedele, Pasquale L., Liao, Yang, Gong, Jia-nan, Yao, Yuan, van Delft, Mark F., Low, Michael S. Y., Tai, Lin, Herold, Marco J., Jackson, Jacob T., Teh, Charis E., Tan, Tania, O'Reilly, Lorraine A., Tellier, Julie, Grigoriadis, George, Huang, David C. S., Shi, Wei, Nutt, Stephen L., Willis, Simon N.

Source: Leukemia. 35(7):2114-2118

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100193112464.0x000001&indx=1&recIds=ETOCvdc_100193112464.0x000001

Improved drug target deconvolution with PISA‐DIA using an extended, overlapping temperature gradient.

Authors: Emery‐Corbin, Samantha J., Yousef, Jumana M., Adhikari, Subash, Sumardy, Fransisca, Nhu, Duong, van Delft, Mark F., Lessene, Guillaume, Dziekan, Jerzy, Webb, Andrew I., Dagley, Laura F.

Source: Proteomics; Aug2024, Vol. 24 Issue 16, p1-11, 11p

BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis

Authors: McArthur, Kate, Whitehead, Lachlan W., Heddleston, John M., Li, Lucy, Padman, Benjamin S., Oorschot, Viola, Geoghegan, Niall D., Chappaz, Stephane, Davidson, Sophia, San Chin, Hui, Lane, Rachael M., Dramicanin, Marija, Saunders, Tahnee L., Sugiana, Canny, Lessene, Romina, Osellame, Laura D., Chew, Teng-Leong, Dewson, Grant, Lazarou, Michael, Ramm, Georg, Lessene, Guillaume, Ryan, Michael T., Rogers, Kelly L., van Delft, Mark F., Kile, Benjamin T.

Source: Science, 2018 Feb . 359(6378), 883-883.

Access URL: https://www.jstor.org/stable/26401535

Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design

Authors: Brouwer, Jason M., Lan, Ping, Cowan, Angus D., Bernardini, Jonathan P., Birkinshaw, Richard W., van Delft, Mark F., Sleebs, Brad E., Robin, Adeline Y., Wardak, Ahmad, Tan, Iris K., Reljic, Boris, Lee, Erinna F., Fairlie, W. Douglas, Call, Melissa J., Smith, Brian J., Dewson, Grant, Lessene, Guillaume, Colman, Peter M., Czabotar, Peter E.

Source: In Molecular Cell 16 November 2017 68(4):659-672

BAK/BAX-Mediated Apoptosis Is a Myc-Induced Roadblock to Reprogramming

Authors: Kim, Esther J.Y., Anko, Minna-Liisa, Flensberg, Christoffer, Majewski, Ian J., Geng, Fan-Suo, Firas, Jaber, Huang, David C.S., van Delft, Mark F., Heath, Joan K.

Source: Stem cell reports. 10(2):331-338

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100130998960.0x000001&indx=1&recIds=ETOCvdc_100130998960.0x000001

Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production

Authors: White, Michael J., McArthur, Kate, Metcalf, Donald, Lane, Rachael M., Cambier, John C., Herold, Marco J., van Delft, Mark F., Bedoui, Sammy, Lessene, Guillaume, Ritchie, Matthew E., Huang, David C.S., Kile, Benjamin T.

Source: In Cell 18 December 2014 159(7):1549-1562

Enhanced stability of Mcl1, a prosurvival Bcl2 relative, blunts stress-induced apoptosis, causes male sterility, and promotes tumorigenesis

Authors: Okamoto, Toru, Coultas, Leigh, Metcalf, Donald, van Delft, Mark F., Glaser, Stefan P., Takiguchi, Megumi, Strasser, Andreas, Bouillet, Philippe, Adams, Jerry M., Huang, David C. S.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2014 Jan 01. 111(1), 261-266.

Access URL: https://www.jstor.org/stable/23770532

The Dendritic Cell Receptor Clec9A Binds Damaged Cells via Exposed Actin Filaments

Authors: Zhang, Jian-Guo, Czabotar, Peter E., Policheni, Antonia N., Caminschi, Irina, San Wan, Soo, Kitsoulis, Susie, Tullett, Kirsteen M., Robin, Adeline Y., Brammananth, Rajini, van Delft, Mark F., Lu, Jinhua, O'Reilly, Lorraine A., Josefsson, Emma C., Kile, Benjamin T., Chin, Wei Jin, Mintern, Justine D., Olshina, Maya A., Wong, Wilson, Baum, Jake, Wright, Mark D., Huang, David C.S., Mohandas, Narla, Coppel, Ross L., Colman, Peter M., Nicola, Nicos A., Shortman, Ken, Lahoud, Mireille H.

Source: In Immunity 20 April 2012 36(4):646-657

A Novel BH3 Ligand That Selectively Targets Mcl-1 Reveals That Apoptosis Can Proceed without Mcl-1 Degradation

Authors: Lee, Erinna F., Czabotar, Peter E., van Delft, Mark F., Michalak, Ewa M., Boyle, Michelle J., Willis, Simon N., Puthalakath, Hamsa, Bouillet, Philippe, Colman, Peter M., Huang, David C. S., Fairlie, W. Douglas

Source: The Journal of Cell Biology, 2008 Jan . 180(2), 341-355.

Access URL: https://www.jstor.org/stable/20475766

Structural Insights into the Degradation of Mcl-1 Induced by BH3 Domains

Authors: Czabotar, Peter E., Lee, Erinna F., van Delft, Mark F., Day, Catherine L., Smith, Brian J., Huang, David C. S., Fairlie, W. Douglas, Hinds, Mark G., Colman, Peter M.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2007 Apr 01. 104(15), 6217-6222.

Access URL: https://www.jstor.org/stable/25427358

Apoptosis Initiated When BH3 Ligands Engage Multiple Bcl-2 Homologs, Not Bax or Bak

Authors: Willis, Simon N., Fletcher, Jamie I., Kaufmann, Thomas, van Delft, Mark F., Chen, Lin, Czabotar, Peter E., Ierino, Helen, Lee, Erinna F., Fairlie, W. Douglas, Bouillet, Philippe, Strasser, Andreas, Kluck, Ruth M., Adams, Jerry M., Huang, David C. S.

Source: Science, 2007 Feb 01. 315(5813), 856-859.

Access URL: https://www.jstor.org/stable/20038966

Methods and compositions for identifying, classifying and monitoring subject having Bcl-2 family inhibitor-resistant tumors and cancers

VDAC2 enables BAX to mediate apoptosis and limit tumor development

Authors: Chin, Hui San, Li, Mark X., Tan, Iris K. L., Ninnis, Robert L., Reljic, Boris, Scicluna, Kristen, Dagley, Laura F., Sandow, Jarrod J., Kelly, Gemma L., Samson, Andre L., Chappaz, Stephane, Khaw, Seong L., Chang, Catherine, Morokoff, Andrew, Brinkmann, Kerstin, Webb, Andrew, Hockings, Colin, Hall, Cathrine M., Kueh, Andrew J., Ryan, Michael T., Kluck, Ruth M., Bouillet, Philippe, Herold, Marco J., Gray, Daniel H. D., Huang, David C. S., van Delft, Mark F., Dewson, Grant

Source: Nature communications. 9(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100129870329.0x000001&indx=1&recIds=ETOCvdc_100129870329.0x000001

METHODS AND COMPOSITIONS FOR IDENTIFYING, CLASSIFYING AND MONITORING SUBJECT HAVING BCL-2 FAMILY INHIBITOR-RESISTANT TUMORS AND CANCERS

Mitochondrial E3 ubiquitin ligase MARCHF5 controls BAK apoptotic activity independently of BH3-only proteins

Authors: Huang, Allan Shuai, Chin, Hui San, Reljic, Boris, Djajawi, Tirta M., Tan, Iris K. L., Gong, Jia-Nan, Stroud, David A., Huang, David C. S., van Delft, Mark F., Dewson, Grant

Source: Cell Death and Differentiation; March 2023, Vol. 30 Issue: 3 p632-646, 15p

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized

Authors: van Delft, Mark F., Wei, Andrew H., Mason, Kylie D., Vandenberg, Cassandra J., Chen, Lin, Czabotar, Peter E., Willis, Simon N., Scott, Clare L., Day, Catherine L., Cory, Suzanne, Adams, Jerry M., Roberts, Andrew W., Huang, David C.S.

Source: In Cancer Cell 2006 10(5):389-399

The Lck inhibitor, AMG-47a, blocks necroptosis and implicates RIPK1 in signalling downstream of MLKL.

Authors: Jacobsen, Annette V., Pierotti, Catia L., Lowes, Kym N., Au, Amanda E., Zhang, Ying, Etemadi, Nima, Fitzgibbon, Cheree, Kersten, Wilhelmus J. A., Samson, André L., van Delft, Mark F., Huang, David C. S., Sabroux, Hélène Jousset, Lessene, Guillaume, Silke, John, Murphy, James M.

Source: Cell Death & Disease; Apr2022, Vol. 13 Issue 4, p1-11, 11p

Peroxisome Proliferator-activated Receptor γ Ligands Differentially Modulate Muscle Cell Differentiation and MyoD Gene Expression via Peroxisome Proliferator-activated Receptor γ-dependent and -independent Pathways

Authors: Hunter, John G. ^‡, van Delft, Mark F. ^‡, Rachubinski, Richard A. ^{§, ¶}, Capone, John P. ^{‡, ‖}

Source: In Journal of Biological Chemistry 12 October 2001 276(41):38297-38306

The BCL-2 Family Proteins: Insights Into Their Mechanism of Action and Therapeutic Potential

Authors: van Delft, Mark F., Dewson, Grant

Source: In Reference Module in Life Sciences 2017