OAT10/SLC22A13 Acts as a Renal Urate Re-Absorber: Clinico-Genetic and Functional Analyses With Pharmacological Impacts

Authors: Yu Toyoda, Yusuke Kawamura, Akiyoshi Nakayama, Keito Morimoto, Seiko Shimizu, Yuki Tanahashi, Takashi Tamura, Takaaki Kondo, Yasufumi Kato, Kimiyoshi Ichida, Hiroshi Suzuki, Nariyoshi Shinomiya, Yasushi Kobayashi, Tappei Takada, Hirotaka Matsuo

Source: Frontiers in Pharmacology, Vol 13 (2022)

Subject Terms: uricosuric agent, urate reabsorption inhibitor, urate-lowering therapy, losartan, renal urate handling, lesinurad, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2022.842717/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/ea97d17ed7d34b7ca38d72bf4f4c0f3e

Pharmacokinetic/pharmacodynamic modeling and simulation of dotinurad, a novel uricosuric agent, in healthy volunteers

Authors: Keisuke Motoki, Takako Igarashi, Koichi Omura, Hiroshi Nakatani, Takashi Iwanaga, Ikumi Tamai, Tetsuo Ohashi

Source: Pharmacology Research & Perspectives, Vol 7, Iss 6, Pp n/a-n/a (2019)

Subject Terms: dotinurad, PK/PD model, URAT1, uric acid, uricosuric agent, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/2052-1707

Access URL: https://doaj.org/article/b9ea3ab961124792a230d353d3e30473

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