Successful treatment of an anti-MDA5 antibody-positive Juvenile Dermatomyositis patient with refractory interstitial lung disease using tofacitinib

Authors: Valentina Natoli, Serena Palmeri, Ana Isabel Rebollo-Giménez, Caterina Matucci-Cerinic, Paola Bocca, Roberta Caorsi, Stefano Volpi, Riccardo Papa, Alessandro Consolaro, Marco Gattorno, Angelo Ravelli, Silvia Rosina

Source: Pediatric Rheumatology Online Journal, Vol 23, Iss 1, Pp 1-5 (2025)

Subject Terms: Juvenile dermatomyositis, Anti-MDA5 antibodies, Interstitial lung disease, Tofacitinib, JAK inhibitors, Type I IFN gene signature, Pediatrics, RJ1-570, Diseases of the musculoskeletal system, RC925-935

File Description: electronic resource

Relation: https://doaj.org/toc/1546-0096

Access URL: https://doaj.org/article/bc8f7efeb0824486b629760a9b5da21f

Serum levels of tumor necrosis factor alpha and interferon alpha in COVID-19 patients and their correlations with disease severity.

Authors: Shorouk Ibrahim, Basem Essa, mona khattab, Ola Ahmed

Source: Microbes and Infectious Diseases, Vol 5, Iss 4, Pp 1253-1263 (2024)

Subject Terms: severe acute respiratory syndrome coronavirus 2 (sars-cov-2), tumor necrosis factor alpha (tnf- α), interferon type i (ifn ), Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://mid.journals.ekb.eg/article_363735_879d48fd5baf9bb7e5a3ab3315fcc567.pdf; https://doaj.org/toc/2682-4132; https://doaj.org/toc/2682-4140

Access URL: https://doaj.org/article/0ede2867785a4a69b8e037ae940d0413

IKKε positively regulates NF-κB, MAPK, and IRF3-mediated type I IFN signaling pathways in Japanese eel (Anguilla japonica)

Authors: Jianjun Feng, Xinwei Peng, Peng Lin, Yilei Wang, Ziping Zhang, Yuankai Xu, Pengfei Zou, Xiaojian Lai, Pengyun Chen, Tianyu Wang

Source: Aquaculture and Fisheries, Vol 9, Iss 6, Pp 908-920 (2024)

Subject Terms: Anguilla japonica, IKKε, Type I IFN, IRF3, NF-κB, MAPK, Aquaculture. Fisheries. Angling, SH1-691

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2468550X23000011; https://doaj.org/toc/2468-550X

Access URL: https://doaj.org/article/e4c42fe394144d04b97d7ec7e84fddf7

TPL2 kinase activity is required for Il1b transcription during LPS priming but dispensable for NLRP3 inflammasome activation

Authors: Denise L. Fahey, Niki Patel, Wendy T. Watford

Source: Frontiers in Immunology, Vol 16 (2025)

Subject Terms: TPL2, Tpl2 kinase, NLRP3 inflammasome, interferons, type I IFN, IL-1b, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2025.1496613/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/67e8f776fe814b9cb735b8cd28e2ede2

Cellular and molecular determinants mediating the dysregulated germinal center immune dynamics in systemic lupus erythematosus

Authors: Spiros Georgakis, Kalliopi Ioannidou, Bernat Bramon Mora, Michail Orfanakis, Cloe Brenna, Yannick D. Muller, Perla M. Del Rio Estrada, Ashish A. Sharma, Giuseppe Pantaleo, Laurence de Leval, Denis Comte, Raphael Gottardo, Constantinos Petrovas

Source: Frontiers in Immunology, Vol 16 (2025)

Subject Terms: T follicular helper cells (TFH), type I IFN, age-associated B cells, germinal center response, IL-4, systemic lupus erythematosus (SLE), Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2025.1530327/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/f717526ca1d64e73bf2a40c7bb691b3b

CD38 deficiency leads to a defective short-lived transcriptomic response to chronic graft-versus-host disease induction, involving purinergic signaling-related genes and distinct transcriptomic signatures associated with lupus

Authors: Mercedes Zubiaur, Laura C. Terrón-Camero, Fernando Gordillo-González, Eduardo Andrés-León, Alicia Barroso-del Jesús, Luz María Canet-Antequera, María M. Pérez Sánchez-Cañete, África Martínez-Blanco, Marilú Domínguez-Pantoja, María Botia-Sánchez, Sonia Pérez-Cabrera, Nerea Bello-Iglesias, Antonio Alcina, Ana-Clara Abadía-Molina, Fuencisla Matesanz, Esther Zumaquero, Ramón Merino, Jaime Sancho

Source: Frontiers in Immunology, Vol 16 (2025)

Subject Terms: CD38, purinergic-signaling, cGAS-STING, NLRP3-inflammasome, type I IFN signature, cGVHD lupus model, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2025.1441981/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/8c87c83a29754473b940a177f28723d0

DDO-adjuvanted influenza A virus nucleoprotein mRNA vaccine induces robust humoral and cellular type 1 immune responses and protects mice from challenge

Authors: Victoria Gnazzo, Hanaa Saleh, Ítalo A. Castro, Adrianus C. M. Boon, Amelia K. Pinto, James D. Brien, Carolina B. López

Source: mBio, Vol 16, Iss 2 (2025)

Subject Terms: mRNA vaccine, adjuvants, type I IFN, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2150-7511

Access URL: https://doaj.org/article/b0b6963221674176bca137c5104221b1

Therapeutic plasma exchange accelerates immune cell recovery in severe COVID-19

Authors: Aurelie Guironnet-Paquet, Hind Hamzeh-Cognasse, Frederic Berard, Fabrice Cognasse, Jean Christophe Richard, Hodane Yonis, Mehdi Mezidi, Olivier Desebbe, Bertrand Delannoy, Sophie Demeret, Clemence Marois, Samir Saheb, Quoc Viet Le, Mathieu Schoeffler, Paul Simon Pugliesi, Sophie Debord, Paul Bastard, Aurélie Cobat, Jean Laurent Casanova, Rémi Pescarmona, Sébastien Viel, Jean François Nicolas, Audrey Nosbaum, Marc Vocanson, Olivier Hequet

Source: Frontiers in Immunology, Vol 15 (2025)

Subject Terms: COVID-19, therapeutic plasma exchange, immune response, anti-type I IFN autoantibodies, cytokine storm, adaptive immunity, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1492672/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/f8bec48c7b6c4b0e82171710c5c57348

Corrigendum: A zebrafish model of Ifih1-driven Aicardi–Goutières syndrome reproduces the interferon signature and the exacerbated inflammation of patients

Authors: Beatriz Bernal-Bermúdez, Alicia Martínez-López, Francisco J. Martínez-Morcillo, Sylwia D. Tyrkalska, Teresa Martínez-Menchón, Pablo Mesa-del-Castillo, María L. Cayuela, Victoriano Mulero, Diana García-Moreno

Source: Frontiers in Immunology, Vol 15 (2025)

Subject Terms: type I IFN, IFIH1, zebrafish avatar, autoimmunity, drug screening, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1544703/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/436fcdde6e7a49ed94b8cfdaf07825fe

The Role of Toll-Like Receptors (TLRs) in Infection and Inflammation 2.0

Contributors: Kircheis, Ralf, Planz, Oliver

Subject Terms: Toll-like receptor, COVID-19, SARS-CoV-2, innate immunity, host genetics, MYD88, CCL4, CCL20, CCR2, atherosclerosis, statin, toll-like receptor, TLR agonist, HIV-1, co-infection, HBV, HCV, Toll-like receptor 2, dimerization, homodimerization, heterodimerization, inflammation, neuroinflammation, neurodegeneration, TLRs, TLR-4, lethal COVID-19, lung disease, macrophage shift, ARDS, CD68, galectin-3, CD163, M1 macrophages, M2 macrophages, immune-to-brain communication, lung–brain axis, lipopolysaccharide, acute respiratory distress syndrome, cytokines, lipid mediators, omega-3 fatty acids, resolvin E1 receptors, TNFα, cfDNA, TLR (toll-like receptor) 9, cathelicidin anti-microbial peptide, adipocyte, adipose tissue, Toll-like receptors, immunity, adaptive immunity, ligands, toll-like receptor (TLR), myeloid differentiation factor-2 (MD-2), TLR4/MD-2, Omicron, spike protein, cytokine storm, NF-kappa B, TLR, brain, neurogenesis, blood–brain barrier, behavior, cognition, TLR7, NOD2, synergy, type I IFN, experimental autoimmune encephalomyelitis, complement, C5a, sepsis, heart dysfunction, arrhythmia, cardiomyocytes, neutrophils, Research and information: general, Biology, life sciences

File Description: application/octet-stream

Access URL: https://directory.doabooks.org/handle/20.500.12854/152864
https://mdpi.com/books/pdfview/book/10053

Pseudorabies Virus, Volume II

Contributors: Tang, Yan-Dong, Li, Xiangdong

Subject Terms: pseudorabies virus, prevention, treatment, drugs, drug targets, Glycyrrhiza polysaccharide, antiviral activity, attachment, internalization, heat shock protein 27, cyclic GMP-AMP synthase, cGAS-STING signaling pathway, ubiquitination, ISG15 knockout mice, in vivo, susceptibility, type I IFN, impair, wildlife, cross-host transmission, vaccination, human, pig, complete genome sequence, comparative genomics, virus modification, virus-vectored vaccines, recombinant PRV, swine infectious disease, latent infection, reactivation, thermoregulation, in vitro model, UL54, PRV variant, variation, vaccine, Bartha-K61, immunity protection, triplex real-time RT-PCR, porcine epidemic diarrhea virus, porcine rotavirus, porcine deltacoronavirus, Enterococcus faecium, immunization, intravenous, classical strain, phylogenetic analysis, recombination, pathogenicity, human infection, antiviral drugs, brincidofovir, Biology, life sciences

File Description: application/octet-stream

Access URL: https://directory.doabooks.org/handle/20.500.12854/139415
https://mdpi.com/books/pdfview/book/9416

Development and characterization of high-efficiency cell-adapted live attenuated vaccine candidate against African swine fever

Authors: Min Ho Kim, Ashan Subasinghe, Yongkwan Kim, Hyeok-Il Kwon, Yehjin Cho, Kiramage Chathuranga, Ji-Won Cha, Ji-Yoon Moon, Ji-Hyeon Hong, Jin Kim, Seung-Chul Lee, Niranjan Dodantenna, Nuwan Gamage, W. A. Gayan Chathuranga, Yeonji Kim, In-Joong Yoon, Joo Young Lee, In Pil Mo, Weonhwa Jheong, Sung-Sik Yoo, Jong-Soo Lee

Source: Emerging Microbes and Infections, Vol 13, Iss 1 (2024)

Subject Terms: African swine fever, CA-CAS-01-A cell, live-attenuated virus, ASFV-MEC-01, vaccine, Type I IFN, MGF100-1R, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2222-1751

Access URL: https://doaj.org/article/50301f8d82c34cb4a269715b8323b9ed

The complex interplay between encephalomyocarditis virus and the host defence system

Authors: Jingying Xie, Adi Idris, Ruofei Feng

Source: Virulence, Vol 15, Iss 1 (2024)

Subject Terms: Encephalomyocarditis virus, innate immune response, type I IFN, inflammatory responses, apoptosis, autophagy, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://doaj.org/toc/2150-5594; https://doaj.org/toc/2150-5608

Access URL: https://doaj.org/article/0acf382eed274435b057d9797278aadc

ADP-heptose attenuates Helicobacter pylori-induced dendritic cell activation

Authors: Theresa Neuper, Tobias Frauenlob, Hieu-Hoa Dang, Peter W. Krenn, Gernot Posselt, Christof Regl, Nikolaus Fortelny, Veronika Schäpertöns, Michael S. Unger, Gunda Üblagger, Daniel Neureiter, Iris Mühlbacher, Michael Weitzendorfer, Franz Singhartinger, Klaus Emmanuel, Christian G. Huber, Silja Wessler, Fritz Aberger, Jutta Horejs-Hoeck

Source: Gut Microbes, Vol 16, Iss 1 (2024)

Subject Terms: Dendritic cells, H. pylori, ADP-heptose, type I IFN, TLR2, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: https://doaj.org/toc/1949-0976; https://doaj.org/toc/1949-0984

Access URL: https://doaj.org/article/71409594e0d44f3793c2a852288917da

A novel functional IKBKE variant activating NFAT in a patient with polyarthritis and a remittent fever

Authors: Saeko Yamada, Yasuo Nagafuchi, Mamiko Yamada, Hisato Suzuki, Bunki Natsumoto, Mineto Ota, Ikuo Takazawa, Hiroaki Hatano, Masanori Kono, Hiroaki Harada, Hirofumi Shoda, Tomohisa Okamura, Kenjiro Kosaki, Keishi Fujio

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: IKBKE, the inhibitor of κB kinase ϵ (IKKϵ), rare variant, T cell, type I IFN, NFκB, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1475179/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/795e72926e734b94bacef5fe13f5d9b6

Serum amyloid P component suppresses porcine epidemic diarrhea virus replication through TLR4-mediated IFN-β signaling pathway

Authors: Lu, Xinchang ^a, Zhu, Huixin ^a, Liu, Mingyu ^a, Xu, Yufan ^a, Yang, Zhen ^a, Bai, Juan ^{a, b}, Jiang, Ping ^{a, b}, Wang, Xianwei ^{a, b, ⁎}

Source: In Veterinary Microbiology May 2025 304

Pseudorabies virus UL38 attenuates the cGAS-STING signaling pathway by recruiting Tollip to promote STING for autophagy degradation

Authors: Zhenfang Yan, Jingying Xie, Zhengyang Hou, Yaxin Zhang, Jiayu Yue, Xiangbo Zhang, Lei Chen, Yanmei Yang, Xiangrong Li, Huixia Li, Ruofei Feng

Source: Virology Journal, Vol 21, Iss 1, Pp 1-12 (2024)

Subject Terms: UL38 protein, type I IFN signaling pathway, STING, Selective autophagy, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://doaj.org/toc/1743-422X

Access URL: https://doaj.org/article/5e46383ca2b24e3e97117213ec008fae

HDAC6 Facilitates PRV and VSV Infection by Inhibiting Type I Interferon Production

Authors: Hu Zheng, Xiaohui Yang, Haiwen Zhong, Changxu Song, Zhenfang Wu, Huaqiang Yang

Source: Viruses, Vol 17, Iss 1, p 90 (2025)

Subject Terms: HDAC6, PRV, VSV, Type I IFN, antiviral immunity, host-virus interaction, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4915/17/1/90; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/ae4f25f552304fa3bb4f9ff06e7380b8

Regulation of human interferon signaling by transposon exonization

Authors: Pasquesi, Giulia Irene Maria ^{1, 2}, Allen, Holly ¹, Ivancevic, Atma ¹, Barbachano-Guerrero, Arturo ¹, Joyner, Olivia ¹, Guo, Kejun ³, Simpson, David M. ¹, Gapin, Keala ¹, Horton, Isabella ¹, Nguyen, Lily L. ^{1, 4}, Yang, Qing ^{1, 5}, Warren, Cody J. ^{1, 6}, Florea, Liliana D. ⁷, Bitler, Benjamin G. ⁴, Santiago, Mario L. ³, Sawyer, Sara L. ¹, Chuong, Edward B. ^{1, 2, 8, ∗}

Source: In Cell 26 December 2024 187(26):7621-7636

Long non-coding RNA SUN2-AS1 acts as a negative regulator of ISGs transcription to promote flavivirus infection

Authors: Yang, Chao ^{a, b}, Chen, Weikang ^{c, ⁎⁎}, Huang, Yanxia ^{a, ⁎}

Source: In Virology December 2024 600