Anti-atherosclerotic effects of natural compounds targeting lipid metabolism and inflammation: Focus on PPARs, LXRs, and PCSK9

Authors: Marcella Palumbo, Martina Ugolotti, Francesca Zimetti, Maria Pia Adorni

Source: Atherosclerosis Plus, Vol 59, Iss , Pp 39-53 (2025)

Subject Terms: Natural compounds, Atherosclerosis, Cholesterol metabolism, Peroxisome proliferator-activated receptors, Liver X receptors, Proprotein convertase subtilisin/kexin type 9, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2667089524000579; https://doaj.org/toc/2667-0895

Access URL: https://doaj.org/article/d628f781156942b2b2514c6a722b78de

PCSK9 with a gain of function D374Y mutation aggravates atherosclerosis by inhibiting PPARα expression

Authors: Yuan feng Cui, Xiao cui Chen, Tuoluonayi Mijiti, Abidan Abudurusuli, Li hui Deng, Xiang Ma, Bangdang Chen

Source: Scientific Reports, Vol 15, Iss 1, Pp 1-13 (2025)

Subject Terms: Atherosclerosis, Lipoproteins, Proprotein convertase subtilisin/Kexin type 9 Serine protease, Peroxisome proliferator activated receptor alpha, Inflammation, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/7aaf100d25544e159f8c043e9fe79974

The importance of paying attention to the role of lipid-lowering drugs in controlling dengue virus infection

Authors: Omer Qutaiba B. Allela, Mohamad Ghazanfari Hashemi, Seyede Mozhgan Heidari, Radhwan Abdul Kareem, Hayder Naji Sameer, Mohaned Adil, Shaylan Kalavi

Source: Virology Journal, Vol 21, Iss 1, Pp 1-29 (2024)

Subject Terms: Dengue virus, Lipid-lowering drugs, Cholesterol, Statin, Proprotein convertase subtilisin/kexin type 9 (PCSK9), Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://doaj.org/toc/1743-422X

Access URL: https://doaj.org/article/087360f8e4ae41ecbb11a71802619749

Novel insights into the association between genetically proxied inhibition of proprotein convertase subtilisin/kexin type 9 and risk of sarcopenia

Authors: Hongyan Jiang, Lulu Li, Xue Zhang, Jia He, Chuanhuai Chen, Ruimin Sun, Ying Chen, Lijuan Xia, Lei Wen, Yunxiang Chen, Junxiu Liu, Lijiang Zhang, Wanqiang Lv

Source: Journal of Cachexia, Sarcopenia and Muscle, Vol 15, Iss 6, Pp 2417-2425 (2024)

Subject Terms: Mendelian randomization, Older people, Proprotein convertase subtilisin/kexin type 9, Sarcopenia, Therapeutic target prediction, Diseases of the musculoskeletal system, RC925-935, Human anatomy, QM1-695

File Description: electronic resource

Relation: https://doaj.org/toc/2190-5991; https://doaj.org/toc/2190-6009

Access URL: https://doaj.org/article/9dc549598f91401c85f2a275b6875d5b

Analysis of Influencing Factors of Plasma Proprotein Convertase Subtilisin/Kexin Type 9 in Patients with Acute Myocardial Infarction

Authors: JIA Jia, LIU Jiahui, JI Wenjun, ZHENG Bo, WANG Xingang, FAN Fangfang, LI Yin, ZHANG Long, ZHANG Yan

Source: Zhongguo quanke yixue, Vol 27, Iss 36, Pp 4568-4574 (2024)

Subject Terms: proprotein convertase subtilisin/kexin type 9, acute myocardial infarction, cholesterol, coronary artery disease, root cause analysis, Medicine

File Description: electronic resource

Relation: https://www.chinagp.net/fileup/1007-9572/PDF/20240074.pdf; https://doaj.org/toc/1007-9572

Access URL: https://doaj.org/article/f863c83b6e7e4ccf9686f47c080374f7

Novel TECPR2 variant in two cases of hereditary sensory and autonomic neuropathy type 9: insights from genetic characterization and comprehensive literature review

Authors: Aysan Moeinafshar, Sahand Tehrani Fateh, Farzad Hashemi-Gorji, Parvaneh Karimzadeh, Elham Gholibeglou, Masoumeh Rostami, Hossein Sadeghi, Mohammad Miryounesi, Mohammad-Reza Ghasemi

Source: BMC Neurology, Vol 24, Iss 1, Pp 1-18 (2024)

Subject Terms: TECPR2, Hereditary sensory and autonomic neuropathy, Hereditary sensory and autonomic neuropathy type 9, HSAN9, Whole-exome sequencing (WES), Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2377

Access URL: https://doaj.org/article/82216a2419d64065b9dce79b597c862c

Safety and efficacy of PCSK9 inhibitors and effect on coronary plaque phenotype in statin-treated patients following acute coronary syndrome: a systematic review and meta-analysis

Authors: Dennis Ievan Hakim, Faqrizal Ria Qhabibi, Muhammad Yusuf, Nasim Amar, Indra Prasetya, Ade Meidian Ambari

Source: The Egyptian Heart Journal, Vol 76, Iss 1, Pp 1-15 (2024)

Subject Terms: Acute coronary syndrome, Atherosclerosis, LDL-C, Proprotein convertase subtilisin/kexin type 9, Statin, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://doaj.org/toc/2090-911X

Access URL: https://doaj.org/article/f65d0dab0c5d46c883658a4b3a2d2a8c

Proprotein convertase subtilisin/kexin type 9: a promising marker of cardiovascular risk in post-menopausal diabetic women in primary prevention

Authors: Michelangelo Rottura, Maria Antonietta Barbieri, Carmine Siniscalchi, Pierpaolo Di Micco, Selene Francesca Anna Drago, Marianna Gigliotti De Fazio, Arrigo Francesco Giuseppe Cicero, Federica Fogacci, Giuseppe Armentaro, Angela Sciacqua, Vincenzo Arcoraci, Natasha Irrera, Egidio Imbalzano

Source: Frontiers in Medicine, Vol 12 (2025)

Subject Terms: Proprotein convertase subtilisin/kexin type 9 (PCSK9), cardiovascular risk, post-menopausal women, diabetes, pulse wave velocity, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmed.2025.1521344/full; https://doaj.org/toc/2296-858X

Access URL: https://doaj.org/article/a0600ef3d31940bb80ec4981fd5232d8

Silencing hepatic PCSK9 via novel chimeric AAV8 mitigates the progression of atherosclerosis by inhibiting inflammation in ApoE−/− mice

Authors: Xiaocui Chen, Minghui Sun, Xiang Ma, Yitong Ma, Bangdang Chen

Source: Molecular Therapy: Methods & Clinical Development, Vol 33, Iss 1, Pp 101390- (2025)

Subject Terms: proprotein convertase subtilisin/kexin type 9, adeno-associated virus, gene therapy, atherosclerosis, inflammation, Genetics, QH426-470, Cytology, QH573-671

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2329050124002067; https://doaj.org/toc/2329-0501

Access URL: https://doaj.org/article/83b948de9646418fbf4b3a3da6f96c8e

Optimal calorie restriction threshold: effect of FATmax exercise combined with different proportions of calorie restriction on hypercholesterolemia

Authors: Yuetong Wu, Li Zhang, Jing Li, Boyang Xue, Wenyuan Shang, Yingli Lu

Source: Frontiers in Physiology, Vol 16 (2025)

Subject Terms: FATmax exercise, calorie restriction, LDL-C, ApoB, proprotein convertase subtilisin kexin type 9 (PCSK9), Physiology, QP1-981

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphys.2025.1510949/full; https://doaj.org/toc/1664-042X

Access URL: https://doaj.org/article/6f5b08973c014a45a92b7f73629105c3

The prevalence of motility-related genes within the human oral microbiota

Authors: Sofia T. Rocha, Dhara D. Shah, Qiyun Zhu, Abhishek Shrivastava

Source: Microbiology Spectrum, Vol 13, Iss 1 (2025)

Subject Terms: bacterial motility, gliding motility, type 9 secretion system, flagella, type IV pilus, oral microbiota, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2165-0497

Access URL: https://doaj.org/article/61c3c46f29954331932e425f8ce43e5a

Integrated bioinformatics analysis identifies PCSK9 as a prognosticator correlated with lipid metabolism in pancreatic adenocarcinoma

Authors: Siqi Zhou, Qiyuan Guo, Aotian Chen, Xihan Li, Xiaoping Zou

Source: World Journal of Surgical Oncology, Vol 22, Iss 1, Pp 1-12 (2024)

Subject Terms: Pancreatic cancer, Proprotein convertase subtilisin/kexin type 9, Tumorigenesis and progression, Tumor immunotherapy, Surgery, RD1-811, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1477-7819

Access URL: https://doaj.org/article/2ea145eb7dee46d1b4cb863223b989b3

Natural phytochemicals as small-molecule proprotein convertase subtilisin/kexin type 9 inhibitors

Authors: Je-Wen Liou, Pei-Yi Chen, Wan-Yun Gao, Jui-Hung Yen

Source: Tzu-Chi Medical Journal, Vol 36, Iss 4, Pp 360-369 (2024)

Subject Terms: atherosclerotic cardiovascular diseases, hypercholesterolemia, low-density lipoprotein receptor, proprotein convertase subtilisin/kexin type 9, phytochemicals, Medicine

File Description: electronic resource

Relation: https://journals.lww.com/10.4103/tcmj.tcmj_46_24; https://doaj.org/toc/1016-3190; https://doaj.org/toc/2223-8956

Access URL: https://doaj.org/article/d9192fc35f1b4bb1bf28bf8e7eb63c93

Genetic association of lipid and lipid-lowering drug target genes with atopic dermatitis: a drug target Mendelian randomization study

Authors: Qinwang Niu, Tongtong Zhang, Rui Mao, Nana Zhao, Sui Deng

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)

Subject Terms: Atopic dermatitis, Serum lipid, Mendelian randomization, Genome-wide association study, Beta nerve growth factor, Proprotein convertase subtilisin/kexin type 9, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/5b624e49267646ceb4c9d61063934cce

A novel deletion in the BLOC1S6 Gene Associated with Hermansky-Pudlak syndrome type 9 (HPS-9)

Authors: Seyyed Mohammad Kahani, Ali Rabbizadeh Saray, Mir Salar Kahaei, Ali Dehghani, Pouria Mohammadi, Masoud Garshasbi

Source: BMC Genomics, Vol 25, Iss 1, Pp 1-14 (2024)

Subject Terms: Albinism, Hermansky-pudlock syndrome type 9, Whole exome sequencing, Primer-walking, GAP-PCR, Biotechnology, TP248.13-248.65, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2164

Access URL: https://doaj.org/article/41e03dc6fff14af98a32c56322293656

Roles of Transporters and Receptors in Drug Delivery to the Brain in Health and Disease

Contributors: Fricker, Gert, Puris, Elena

Subject Terms: amyotrophic lateral sclerosis, blood–brain barrier, brain microvascular endothelial cells, C9orf72 gene, proteomics, blood brain barrier, receptor-mediated transcytosis, low-density lipoprotein receptor family, low-density lipoprotein receptor-related protein 1, proprotein convertase subtilisin/kexin type 9, central nervous system drug delivery, therapeutic blood–brain barrier modification, metformin, ischemic stroke, repurposing, transporters, in vitro, BBB, co-culture, P-GP, Octs, permeability, ABC transporters, brain microvessels, peripheral tissues and vessels, gene expression patterns, RNA-seq, WesTM analysis, across species, choroid plexus, epithelial cell, lactate, monocarboxylate transporter, thyroid hormone, blood-brain barrier, P-glycoprotein, copper, bis(thiosemicarbazone), CNS drug delivery, tight junction proteins, adenosine receptor signaling, adenosine receptor agonists, adenosine receptor antagonist, uptake transporters, pharmacokinetics, glucuronide, conjugate metabolite, uridine diphosphate-glucuronosyltransferase, organic anion-transporting polypeptide, BBB penetration, Kp,uu,brain prediction, MDR1, BCRP, ABCB1 knock-out, preclinical MDR1, species differences, MDR1 inhibitors, Medicine and Nursing, Manufacturing industries

File Description: application/octet-stream

Access URL: https://directory.doabooks.org/handle/20.500.12854/152942
https://mdpi.com/books/pdfview/book/10229

Dietary Supplements in Cardiovascular and Metabolic Diseases

Contributors: Trimarco, Bruno, Santulli, Gaetano

Subject Terms: chronic fatigue syndrome, coenzyme Q10, myalgic encephalomyelitis, mitochondria, nonrestorative sleep, NADH, quality of life, aging, 20-HETE, furegrelate, HET0016, indomethacin, NS-398, SQ-29,548, thromboxane-A2, hypercholesterolemia, red yeast rice (RYR), bergamot polyphenolic fraction (BPF), malondialdehyde (MDA), oxidative stress, proprotein convertase subtilisin/kexin type 9 (PCSK9), astaxanthin, cardiometabolic disease, metabolic syndrome, systematic review, meta-analysis, dietary supplement, nutraceutical compound, cholesterol, artichoke, bergamot, water-soluble tomato concentrate, platelet apoptosis, crossover clinical trial, glucosamine, cardiovascular disease, osteoarthritis, epidemiology, diabetes, insulin resistance, lipid accumulation, inflammation, reactive oxygen species (ROS), SGLT2 inhibitors, nutraceutical supplementation, cardiovascular risk, carbonyl, cytokine, chemokine, nutraceutical, parsley, pentosidine, prebiotic, protein carbonyl, rosemary, savory, short-chain fatty acid, trimethylamine N-oxide, post-acute COVID-19 syndrome, SARS-CoV-2, 6 min walk test, handgrip strength, flow-mediated dilation, nitric oxide, nutraceuticals, oral supplement, persistent symptoms, mulberry, Morus alba, 1-deoxynojirimycin, DNJ, dietary supplements, PLS regression, salt loading, endothelial cell, mitochondrial dysfunction, polyphenols, stroke, SHRSP, 2-aminoethanesulfonic acid, energy drinks, metabolism, supplements, tauric acid, taurine, Mathematics and Science, Biology, life sciences

File Description: application/octet-stream

Access URL: https://directory.doabooks.org/handle/20.500.12854/139373
https://mdpi.com/books/pdfview/book/9371

DHDH-mediated D-xylose metabolism induces immune evasion in triple-negative breast cancer

Authors: Wu, Huai-liang ^{1, 2, 3, 4}, Gong, Yue ^{1, 2, 4, ∗}, Ling, Yun-xiao ^{1, 2}, Wu, Si-yu ^{1, 2}, Ji, Peng ^{1, 2}, Zhao, Qian ^{1, 2}, He, Li-Hua ^{1, 2}, Shao, Zhi-Ming ^{1, 2}, Jiang, Yi-Zhou ^{1, 2, ∗∗}, Liu, Guang-yu ^{1, 2, 5, ∗∗∗}

Source: In Med 14 March 2025 6(3)

Effects of PCSK9 inhibitors on cancer, diabetes, and cardiovascular diseases

Authors: Nejabat, Mojgan ¹, Hadizadeh, Farzin ², Almahmeed, Wael ³, Sahebkar, Amirhossein ^{4, 5, ⁎}

Source: In Drug Discovery Today March 2025 30(3)

Long-Term Lipid Lowering With Evolocumab in Older Individuals

Authors: Al Said, Samer ^a, O’Donoghue, Michelle L. ^a, Ran, Xinhui ^a, Murphy, Sabina A. ^a, Atar, Dan ^b, Keech, Anthony ^c, Flores-Arredondo, Jose H. ^d, Wang, Bei ^d, Sabatine, Marc S. ^a, Giugliano, Robert P. ^{a, ∗}

Source: In Journal of the American College of Cardiology 11 February 2025 85(5):504-512