Leukocyte-specific protein 1 is associated with the stage and tumor immune infiltration of cervical cancer

Authors: Dianqin Xu, Xinzhu Zhou, Shaoju Min, Yu Zhang, Xiaoyu Zhu, Kun Qiao, Luhong Xie, Ji Ren, Yameng Liu, Ziwen Xiao, Yujie Tan

Source: Scientific Reports, Vol 15, Iss 1, Pp 1-14 (2025)

Subject Terms: Cervical cancer, HPV16, Leucocyte-specific protein 1 (LSP1), Tumour infiltrating lymphocytes (TILs), Tumour microenvironment (TME), Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/76f8b31b2a6a47ddb90b6dff3f42b5d4

The chemokine CX3CL1 promotes intraperitoneal tumour growth despite enhanced T-cell recruitment in ovarian cancer

Authors: Stefanie Seitz, Tobias F. Dreyer, Christoph Stange, Katja Steiger, Dirk Wohlleber, Martina Anton, Thuý An Pham, Dominique Sauter-Peschke, Ute Reuning, Gabriele Multhoff, Wilko Weichert, Marion Kiechle, Viktor Magdolen, Holger Bronger

Source: Neoplasia: An International Journal for Oncology Research, Vol 60, Iss , Pp 101130- (2025)

Subject Terms: Chemokines, CX3CL1, Tumour-infiltrating lymphocytes, PARP inhibition, Mouse model, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1476558625000090; https://doaj.org/toc/1476-5586

Access URL: https://doaj.org/article/39f4087d4caa4b088d4e9c5baea8653b

Phenotypic and spatial heterogeneity of CD8+ tumour infiltrating lymphocytes

Authors: Yikan Sun, Eloy Yinwang, Shengdong Wang, Zenan Wang, Fangqian Wang, Yucheng Xue, Wenkan Zhang, Shenzhi Zhao, Haochen Mou, Shixin Chen, Lingxiao Jin, Binghao Li, Zhaoming Ye

Source: Molecular Cancer, Vol 23, Iss 1, Pp 1-21 (2024)

Subject Terms: CD8+ T cells, Tumour-infiltrating lymphocytes, T cell nomenclature, T cell exclusion, Caner immunotypes, Cancer immunotherapy., Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1476-4598

Access URL: https://doaj.org/article/fdda9f8f7434471a9afa3fccca6f7920

Stromal lymphocytes are associated with upgrade of B3 breast lesions

Authors: Tanjina Kader, Elena Provenzano, Madawa W. Jayawardana, Shona Hendry, Jia-Min Pang, Kenneth Elder, David J. Byrne, Lauren Tjoeka, Helen ML. Frazer, Eloise House, Sureshni I. Jayasinghe, Holly Keane, Anand Murugasu, Neeha Rajan, Islam M. Miligy, Michael Toss, Andrew R. Green, Emad A. Rakha, Stephen B. Fox, G. Bruce Mann, Ian G. Campbell, Kylie L. Gorringe

Source: Breast Cancer Research, Vol 26, Iss 1, Pp 1-10 (2024)

Subject Terms: Atypical ductal hyperplasia, Lesions of uncertain malignant potential, B3 lesions, Tumour infiltrating lymphocytes, Stromal lymphocytes, Upgrade, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1465-542X

Access URL: https://doaj.org/article/b48a3f6e9ea54a189ccefd102db6473b

Updates on Breast Cancer

Contributors: Cassano, Enrico, Pesapane, Filippo

Subject Terms: ductal carcinoma in situ (DCIS), invasive breast carcinoma, breast, biopsy, overtreatment, active surveillance, Contrast-Enhanced Mammography (CEM), Dynamic Contrast Magnetic Resonance Imaging (DCE-MRI), radiomics, artificial intelligence, breast tumor segmentation, convolutional neural network, deep learning, X-ray images, breast cancer, brain metastasis, tissue-specific metastasis, organotropism, cancer metabolism, oxidative phosphorylation (OXPHOS), mitochondria, cyclooxygenase 7b (Cox7b), hereditary breast cancer, cancer susceptibility genes, PALB2, aberrant splicing, functional assay, minigenes, clinical interpretation, cyclin-dependent kinase inhibitor 4 and 6, HER2-low, palbociclib, circulating tumor cells, neoplastic cells, circulating, neoplasms/diagnosis, circulating/pathology, breast neoplasms/pathology, biomarkers, tumor, blood, liquid biopsy, AhR, agonist, ligand, TCDD, triple-negative breast cancer, exploratory subgroup discovery, chemoimmunotherapy, bone metastases, bone scan, follow-up, prognosis, survival, SETD7, molecular subtypes, gene expression, biological processes, HER2, antibody-drug conjugate, trastuzumab-deruxtecan, T-Dxd, communication, decision-making, patient empowerment, ONEST, observers needed to evaluate subjective tests, TILs, sTILs, tumour-infiltrating lymphocytes, triple-negative, reproducibility, international immuno-oncology biomarker working group, European Working Group for Breast Screening Pathology, breast-conserving surgery, radiation, de-escalation, early breast cancer, metastatic breast cancer, BRCA, NGS, HRD score, homologous recombination deficiency, mutational signature, PARPi, platinum salts, metastasis, secretome, immune modulation, tumor microenvironment, drug resistance, therapeutic targets, precision oncology, Medicine and Nursing, Diseases and disorders, Oncology

File Description: application/octet-stream

Access URL: https://directory.doabooks.org/handle/20.500.12854/139330
https://mdpi.com/books/pdfview/book/9327

Morpho-phenotypic characterization of melanoma brain metastases immune microenvironment: A multicentre retrospective study

Authors: Filippo Nozzoli, Marco Gessi, Filippo Ugolini, Sara Simi, Luca Tinunin, Luigi Francesco Iannone, Alice Esposito, Giovanni Muscas, Alessandro Della Puppa, Isabella Ciardetti, Nicola Pimpinelli, Vincenzo De Giorgi, Isacco Desideri, Lorenzo Livi, Laura Doni, Giovanni Schinzari, Ernesto Rossi, Mario Mandalà, Daniela Massi

Source: EJC Skin Cancer, Vol 2, Iss , Pp 100263- (2024)

Subject Terms: Melanoma, brain metastasis, tumour associated astrogliosis, tumour infiltrating lymphocytes (TILs), tumour associated macrophages (TAMs), tumor microenvironment (TME), Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2772611824002519; https://doaj.org/toc/2772-6118

Access URL: https://doaj.org/article/aaf276776272453cab39caebadf3f781

Immune checkpoint therapy responders display early clonal expansion of tumor infiltrating lymphocytes

Authors: Joel Kidman, Rachael M. Zemek, John-William Sidhom, Debora Correa, Nicola Principe, Fezaan Sheikh, Vanessa S. Fear, Catherine A. Forbes, Abha Chopra, Louis Boon, Ayham Zaitouny, Emma de Jong, Robert A. Holt, Matt Jones, Michael J. Millward, Timo Lassmann, Alistair R.R. Forrest, Anna K. Nowak, Mark Watson, Richard A. Lake, W. Joost Lesterhuis, Jonathan Chee

Source: OncoImmunology, Vol 13, Iss 1 (2024)

Subject Terms: Immune checkpoint therapy, T cells, T cell receptor (TCR) sequencing, tumour-infiltrating lymphocytes, immune repertoire, machine learning, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/f60545e051804f9796499b61db90824e

Case report: Triple-negative breast cancer with low tumour-infiltrating lymphocytes infiltration and good prognosis: a case of Tall Cell Carcinoma with Reversed Polarity and review of the literature

Authors: Shuoying Jiao, Junpeng Chen, Jiumei Shen, Ajing Peng, Ruifu Chen, Baoyong Lai, Chunhua Luo, Yingyi Fan, Xiaohua Pei

Source: Frontiers in Oncology, Vol 14 (2024)

Subject Terms: triple-negative breast cancer, Tall Cell Carcinoma with Reversed Polarity, tumour-infiltrating lymphocytes, cancer-associated fibroblasts, case report, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2024.1455893/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/6064299f940047a092a45c4d970d5334

Revolutionizing the treatment for nasopharyngeal cancer: the impact, challenges and strategies of stem cell and genetically engineered cell therapies

Authors: Chin-King Looi, Ee-Mun Loo, Heng-Chee Lim, Yik-Ling Chew, Kok-Yong Chin, Shiau-Chuen Cheah, Bey Hing Goh, Chun-Wai Mai

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: nasopharyngeal carcinoma, stem cell, chimeric antigen receptor (CAR)-T cell, engineered T cell receptor-T (TCR-T) cell, tumour-infiltrating lymphocytes (TIL), natural killer (Nk) cell, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1484535/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/4cef446874884264a4edf8ef291c940c

High tumour-infiltrating lymphocytes correlate with distinct gene expression profile and favourable survival in single hormone receptor-positive breast cancer

Authors: Aleksandra Ciarka, Michał Kunc, Marta Popęda, Aleksandra Łacko, Barbara Radecka, Marcin Braun, Joanna Pikiel, Maria Litwiniuk, Katarzyna Pogoda, Ewa Iżycka-Świeszewska, Anna Zeller, Magdalena Niemira, Rafał Pęksa, Wojciech Biernat, Elżbieta Senkus

Source: Contemporary Oncology, Vol 28, Iss 1, Pp 75-83 (2024)

Subject Terms: gene expression, tumour infiltrating lymphocytes, prognosis, breast cancer, Medicine

File Description: electronic resource

Relation: https://www.termedia.pl/High-tumour-infiltrating-lymphocytes-correlate-with-distinct-gene-expression-profile-and-favourable-survival-in-single-hormone-receptor-positive-breast-cancer,3,54090,1,1.html; https://doaj.org/toc/1428-2526; https://doaj.org/toc/1897-4309

Access URL: https://doaj.org/article/747de89e46a2493a8139c1c93606b528

Machine learning evaluation of immune infiltrate through digital tumour score allows prediction of survival outcome in a pooled analysis of three international stage III colon cancer cohortsResearch in context

Authors: Julie Lecuelle, Caroline Truntzer, Debora Basile, Luigi Laghi, Luana Greco, Alis Ilie, David Rageot, Jean-François Emile, Fréderic Bibeau, Julien Taïeb, Valentin Derangere, Come Lepage, François Ghiringhelli

Source: EBioMedicine, Vol 105, Iss , Pp 105207- (2024)

Subject Terms: Tumour infiltrating lymphocytes, Machine learning, Colonic neoplasms, Biomarkers, Prognosis, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396424002421; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/f4866831da2d49b389ebad9f61f0d2b7

Individualising radiation therapy decisions in breast cancer patients based on tumour infiltrating lymphocytes and genomic biomarkers

Authors: Melanie Machiels, Redouane Oulkadi, Trine Tramm, Shane R. Stecklein, Navita Somaiah, Alex De Caluwé, Jonathan Klein, William T. Tran, Roberto Salgado

Source: Breast, Vol 71, Iss , Pp 13-21 (2023)

Subject Terms: Breast cancer, Radiation therapy, Gene expression profile, Tumour infiltrating lymphocytes, Genomically adjusted radiation dose, Personalised radiation therapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0960977623005143; https://doaj.org/toc/1532-3080

Access URL: https://doaj.org/article/d5afeaacfc5942c99871c6665e2d94b3

The immune microenvironment characterisation and dynamics in hormone receptor–positive breast cancer before and after neoadjuvant endocrine therapy

Authors: Gizem Oner, Glenn Broeckx, Christophe Van Berckelaer, Karen Zwaenepoel, Sevilay Altintas, Zafer Canturk, Wiebren Tjalma, Zwi Berneman, Marc Peeters, Patrick Pauwels, Peter A. vanDam

Source: Cancer Medicine, Vol 12, Iss 17, Pp 17901-17913 (2023)

Subject Terms: biomarkers, breast cancer, endocrine therapy, hormone receptor, neoadjuvant, tumour‐infiltrating lymphocytes, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2045-7634

Access URL: https://doaj.org/article/191b42cd16644c468f4e0ac985be28d8

The expression profiles of signature genes from CD103+LAG3+ tumour-infiltrating lymphocyte subsets predict breast cancer survival

Authors: Zi-An Xia, Can Lu, Can Pan, Jia Li, Jun Li, Yitao Mao, Lunquan Sun, Jiang He

Source: BMC Medicine, Vol 21, Iss 1, Pp 1-18 (2023)

Subject Terms: Large-scale data analysis, Tumour-infiltrating lymphocytes, CD103, LAG3, Immunotherapy, Chemotherapy, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1741-7015

Access URL: https://doaj.org/article/285c7edfa62c41228d226bef30b3f707

Association of androgen receptor and tumour-infiltrating lymphocytes with bone recurrence in triple-negative breast cancer

Authors: Petra Ilenič, Ajda Herman, Erik Langerholc, Barbara Gazić, Boštjan Šeruga

Source: Journal of Bone Oncology, Vol 44, Iss , Pp 100518- (2024)

Subject Terms: Androgen receptor, Tumour-infiltrating lymphocytes, Bone recurrence, Triple-negative breast cancer, Diseases of the musculoskeletal system, RC925-935, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2212137423000519; https://doaj.org/toc/2212-1374

Access URL: https://doaj.org/article/008c4d1ddc4b4b6c8bb13a5cb22f6635

Pediatric Brain Tumours: Lessons from the Immune Microenvironment

Authors: Betty Yao, Alberto Delaidelli, Hannes Vogel, Poul H. Sorensen

Source: Current Oncology, Vol 30, Iss 5, Pp 5024-5046 (2023)

Subject Terms: tumour immune microenvironment, pediatric brain tumour, immunotherapy, medulloblastoma, pediatric high-grade glioma, tumour-infiltrating lymphocytes, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.mdpi.com/1718-7729/30/5/379; https://doaj.org/toc/1198-0052; https://doaj.org/toc/1718-7729

Access URL: https://doaj.org/article/d3be6e31314e401f98284991090f1880

Heterogeneity of PD-L1 expression and CD8 lymphocyte infiltration in metastatic colorectal cancer and their prognostic significance

Authors: Xin, Haisong ^b, Zhou, Chaoxi ^b, Wang, Guanglin ^b, Liu, Yan ^c, Zhang, Juan ^b, Liu, Youqiang ^b, Li, Baokun ^b, Zhang, Jianfeng ^b, Su, Mingming ^b, Li, Zhihan ^b, Wang, Guiying ^{a, b, *}

Source: In Heliyon February 2023 9(2)

Deep learning-based scoring of tumour-infiltrating lymphocytes is prognostic in primary melanoma and predictive to PD-1 checkpoint inhibition in melanoma metastasesResearch in context

Authors: Eftychia Chatziioannou, Jana Roßner, Thazin New Aung, David L. Rimm, Heike Niessner, Ulrike Keim, Lina Maria Serna-Higuita, Irina Bonzheim, Luis Kuhn Cuellar, Dana Westphal, Julian Steininger, Friedegund Meier, Oltin Tiberiu Pop, Stephan Forchhammer, Lukas Flatz, Thomas Eigentler, Claus Garbe, Martin Röcken, Teresa Amaral, Tobias Sinnberg

Source: EBioMedicine, Vol 93, Iss , Pp 104644- (2023)

Subject Terms: Cutaneous melanoma, Prognostic biomarkers, Predictive biomarkers, Tumour-infiltrating lymphocytes, Digital pathology, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396423002098; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/35c191c0b266487cb0126f25360675a8

SPP1 is a biomarker of cervical cancer prognosis and involved in immune infiltration

Authors: Guo Qian, He Wei, Nie Dan, Li Wuzhi, Zhan Ping

Source: Romanian Journal of Laboratory Medicine, Vol 30, Iss 3, Pp 281-292 (2022)

Subject Terms: bioinformatics analysis, spp1, tumour infiltrating lymphocytes, cervical cancer, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2284-5623

Access URL: https://doaj.org/article/c7567a037b0b4b90b913cf2a932d31c9

PD‐L1 and PD‐L2 expression in pancreatic ductal adenocarcinoma and their correlation with immune infiltrates and DNA damage response molecules

Authors: Yue Zhang, Xianlong Chen, Shengwei Mo, Heng Ma, Zhaohui Lu, Shuangni Yu, Jie Chen

Source: The Journal of Pathology: Clinical Research, Vol 8, Iss 3, Pp 257-267 (2022)

Subject Terms: pancreatic ductal adenocarcinoma, PD‐L1, PD‐L2, tumour‐infiltrating lymphocytes, DNA damage response, Pathology, RB1-214

File Description: electronic resource

Relation: https://doaj.org/toc/2056-4538

Access URL: https://doaj.org/article/c96e2d2945094b838400bf3e50c94360