Mature microRNA-binding protein QKI promotes microRNA-mediated gene silencing

Authors: Kyung-Won Min, Myung Hyun Jo, Minseok Song, Ji Won Lee, Min Ji Shim, Kyungmin Kim, Hyun Bong Park, Shinwon Ha, Hyejin Mun, Ahsan Polash, Markus Hafner, Jung-Hyun Cho, Dongsan Kim, Ji-Hoon Jeong, Seungbeom Ko, Sungchul Hohng, Sung-Ung Kang, Je-Hyun Yoon

Source: RNA Biology, Vol 21, Iss 1, Pp 350-364 (2024)

Subject Terms: QKI, AGO2, RNA-binding protein, let-7b, Tumour suppressor gene, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1547-6286; https://doaj.org/toc/1555-8584

Access URL: https://doaj.org/article/2031b122a0b248eea1c5236fa50038ff

Selective metabolic regulations by p53 mutant variants in pancreatic cancer

Authors: Sabrina Caporali, Alessio Butera, Alessia Ruzza, Carlotta Zampieri, Marina Bantula’, Sandra Scharsich, Anna-Katerina Ückert, Ivana Celardo, Ian U. Kouzel, Luigi Leanza, Andreas Gruber, Joan Montero, Angelo D’Alessandro, Thomas Brunner, Marcel Leist, Ivano Amelio

Source: Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-17 (2024)

Subject Terms: Tumour suppressor, Gain-of-function, Cancer Metabolism, Anti-oxidant capacity, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/2c9b386036f84eaf9c888f23c8e8570a

Mapping in silico genetic networks of the KMT2D tumour suppressor gene to uncover novel functional associations and cancer cell vulnerabilities

Authors: Yuka Takemon, Erin D. Pleasance, Alessia Gagliardi, Christopher S. Hughes, Veronika Csizmok, Kathleen Wee, Diane L. Trinh, Ryan D. Huff, Andrew J. Mungall, Richard A. Moore, Eric Chuah, Karen L. Mungall, Eleanor Lewis, Jessica Nelson, Howard J. Lim, Daniel J. Renouf, Steven JM. Jones, Janessa Laskin, Marco A. Marra

Source: Genome Medicine, Vol 16, Iss 1, Pp 1-31 (2024)

Subject Terms: Tumour suppressor genes, KMT2D, Genetic networks, Synthetic lethality, WRN inhibitors, Medicine, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1756-994X

Access URL: https://doaj.org/article/2954f6a10f424393a3fd559481966131

Drosophila AHR limits tumor growth and stem cell proliferation in the intestine [version 2; peer review: 2 approved, 2 approved with reservations]

Authors: Brigitta Stockinger, Jean-Paul Vincent, Alex P. Gould, Nicola Laura Diny, Jiawei Sun, Minghua Tsai, Michael Shapiro, Cyrille Alexandre, Ying Li, Adrien Franchet

Source: Wellcome Open Research, Vol 10 (2025)

Subject Terms: aryl hydrocarbon receptor, spineless, Drosophila, intestinal epithelium, tumour suppressor, eng, Medicine, Science

File Description: electronic resource

Relation: https://wellcomeopenresearch.org/articles/10-38/v2; https://doaj.org/toc/2398-502X

Access URL: https://doaj.org/article/74426996e6424c1aa76f904575106242

Loss of PTEN Immunoexpression in Endometrial Carcinoma: A Narrative Review

Authors: Garima Chandrakar, Arvind Bhake

Source: Journal of Clinical and Diagnostic Research, Vol 19, Iss 01, Pp 05-07 (2025)

Subject Terms: atypical endometrial hyperplasia, immunohistochemistry, tumour suppressor gene, Medicine

File Description: electronic resource

Relation: https://jcdr.net/articles/PDF/20482/75346_CE[Ra1]_F(SHU)_QC(SD_SS)_PF1(AG_OM)_PFA(SS)_PB(AG_IS)_PN(IS).pdf; https://doaj.org/toc/2249-782X; https://doaj.org/toc/0973-709X

Access URL: https://doaj.org/article/0ea5e423f6ac46349dcdb97bfbd74db2

TPPP3, a Good Prognostic Indicator, Suppresses Cell Proliferation and Migration in OSCC

Authors: Xiao, Ting ^a, Rahhal, Omar ^a, Wang, Liping ^a, Deng, Zhiyuan ^a, Wang, Ran ^b, Xu, Xinghuanyu ^a, Qi, Lu ^{a, ⁎}, Tang, Zhangui ^{a, ⁎}

Source: In International Dental Journal April 2025 75(2):970-983

Recurrent disruption of tumour suppressor genes in cancer by somatic mutations in cleavage and polyadenylation signals

Authors: Yaroslav Kainov, Fursham Hamid, Eugene V Makeyev

Source: eLife, Vol 13 (2024)

Subject Terms: somatic mutations, cleavage, tumour suppressor, polyadenylation, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/99040; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/ba3679c9a97a4f9ab7a46e1d9592a785

Comparative molecular dynamics simulation of apo and holo forms of the P53 mutant C176F: a structural perspective

Authors: R. Hephzibah Cathryn, C. George Priya Doss

Source: Journal of Taibah University for Science, Vol 18, Iss 1 (2024)

Subject Terms: P53, tumour suppressor, zinc binding residues, DNA-binding domain, zinc finger, molecular dynamic simulation, Science (General), Q1-390

File Description: electronic resource

Relation: https://doaj.org/toc/1658-3655

Access URL: https://doaj.org/article/cc34cc7f08a44a18a41dd2c24f7da223

LKB1 biology: assessing the therapeutic relevancy of LKB1 inhibitors

Authors: Charles B. Trelford, Trevor G. Shepherd

Source: Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-20 (2024)

Subject Terms: Tumour Suppressor, Liver Kinase B1 (LKB1), STE-20-related Kinase Adaptor Protein (STRAD), Mouse Protein 25 (MO25), Adenosine Monophosphate-Activated Protein Kinase (AMPK), Adenosine Monophosphate-Activated Protein Kinase-related Kinases (ARKs), Medicine, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1478-811X

Access URL: https://doaj.org/article/177eccc9e3384d40af0f4e11a5e253a0

Chlorine containing tetrahydropyrimidines: Synthesis, characterization, anticancer activity and mechanism of action

Authors: Milović, Emilija ^a, Matić, Ivana Z. ^b, Petrović, Nina ^{b, c}, Pašić, Ivana ^b, Stanojković, Tatjana ^b, Petrović, Miloš R. ^d, Bogdanović, Goran A. ^c, Ari, Ferda ^e, Janković, Nenad ^{a, ⁎}

Source: In Bioorganic Chemistry December 2024 153

Understanding the role of miRNAs in cervical cancer pathogenesis and therapeutic responses

Authors: Prashant Chauhan, Sreepoorna Pramodh, Arif Hussain, Deena Elsori, Sorabh Lakhanpal, Rahul Kumar, Mohammed Alsaweed, Danish Iqbal, Pratibha Pandey, Ayoub Al Othaim, Fahad Khan

Source: Frontiers in Cell and Developmental Biology, Vol 12 (2024)

Subject Terms: tumour suppressor, miRNAs, cervical cancer, oncogenic mirnas, signalling pathway, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2024.1397945/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/a73aea291fdc4a04aac3615f56a7b3bd

Modulation of Autophagy by Oncosuppressor FAM46C and Its Implications for Cancer Therapy: An Intriguing Perspective

Authors: Nicola Manfrini

Source: Biomolecules, Vol 15, Iss 2, p 196 (2025)

Subject Terms: TENT5C, tumour suppressor, multiple myeloma, autophagy, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-273X/15/2/196; https://doaj.org/toc/2218-273X

Access URL: https://doaj.org/article/d8bfea27176c4c27989660ffbb3b6463

Human nucleolar protein 7 (NOL7) is required for early pre-rRNA accumulation and pre-18S rRNA processing

Authors: Mason A. McCool, Carson J. Bryant, Hannah Huang, Lisa M. Ogawa, Katherine I. Farley-Barnes, Samuel B. Sondalle, Laura Abriola, Yulia V. Surovtseva, Susan J. Baserga

Source: RNA Biology, Vol 20, Iss 1, Pp 257-271 (2023)

Subject Terms: ribosome biogenesis, pre-ribosomal rna processing, rna polymerase i, nucleolus, rrna, oncogene, tumour suppressor, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1547-6286; https://doaj.org/toc/1555-8584

Access URL: https://doaj.org/article/0f2473f5a93643898a438c2a7374f3f6

Synthetic lethal approaches to target cancers with loss of PTEN function

Authors: Ayse Ertay, Rob M. Ewing, Yihua Wang

Source: Genes and Diseases, Vol 10, Iss 6, Pp 2511-2527 (2023)

Subject Terms: Cancer, PTEN, Synthetic lethality, Tumour suppressor gene, WDHD1, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352304223000120; https://doaj.org/toc/2352-3042

Access URL: https://doaj.org/article/d50609b485dc4021912b4fd86d6f79c1

CRISPR/dCAS9-mediated DNA demethylation screen identifies functional epigenetic determinants of colorectal cancer

Authors: Juan Ramón Tejedor, Alfonso Peñarroya, Javier Gancedo-Verdejo, Pablo Santamarina-Ojeda, Raúl F. Pérez, Sara López-Tamargo, Ana Díez-Borge, Juan J. Alba-Linares, Nerea González-del-Rey, Rocío G. Urdinguio, Cristina Mangas, Annalisa Roberti, Virginia López, Teresa Morales-Ruiz, Rafael R. Ariza, Teresa Roldán-Arjona, Mónica Meijón, Luis Valledor, María Jesús Cañal, Daniel Fernández-Martínez, María Fernández-Hevia, Paula Jiménez-Fonseca, Luis J. García-Flórez, Agustín F. Fernández, Mario F. Fraga

Source: Clinical Epigenetics, Vol 15, Iss 1, Pp 1-17 (2023)

Subject Terms: DNA methylation, Gene expression, Epigenetics, Tumour suppressor gene, CRISPR screen, Colorectal cancer, Medicine, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1868-7083

Access URL: https://doaj.org/article/95cb022c2afa458ba4a52e0c37ea095b

FDFT1 repression by piR-39980 prevents oncogenesis by regulating proliferation and apoptosis through hypoxia in tongue squamous cell carcinoma

Authors: Chattopadhyay, Trisha, Mallick, Bibekanand ^⁎

Source: In Life Sciences 15 September 2023 329

COMMD3 loss drives invasive breast cancer growth by modulating copper homeostasis

Authors: Janelle L. Hancock, Murugan Kalimutho, Jasmin Straube, Malcolm Lim, Irma Gresshoff, Jodi M. Saunus, Jason S. Lee, Sunil R. Lakhani, Kaylene J. Simpson, Ashley I. Bush, Robin L. Anderson, Kum Kum Khanna

Source: Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-16 (2023)

Subject Terms: Breast cancer, Tumour suppressor, 3D screen, COMMD3, Copper signalling, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/d9fe64d800bf4622bdc3d1e38364ba23

G‐quadruplex‐enhanced circular single‐stranded DNA (G4‐CSSD) adsorption of miRNA to inhibit colon cancer progression

Authors: Haidong Wu, Weilong Zhong, Ronghua Zhang, Yuping Ding, Chunhua Qu, Keguan Lai, Zheng Pang, Shan Yin, Guangling Zhang, Shuang Chen

Source: Cancer Medicine, Vol 12, Iss 8, Pp 9774-9787 (2023)

Subject Terms: circular single‐stranded DNA, colon cancer, G quadruplex, microRNA inhibitor, tumour suppressor gene, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2045-7634

Access URL: https://doaj.org/article/baa80a45496d4a25a4a8b3552ba6ab58

Malathion alters the transcription of target genes of the tumour suppressor tp53 and cancerous processes in Colossoma macropomum: Mechanisms of DNA damage response, oxidative stress and apoptosis

Authors: de Souza, Samara Silva ^{a, b, ∗}, da Costa, Jaqueline Custódio ^{a, b}, da Silva, Grazyelle Sebrenski ^{b, c}, de Almeida-Val, Vera Maria Fonseca ^b

Source: In Chemico-Biological Interactions 1 April 2023 374

Genetic predisposition to cancer

Authors: Evans, D Gareth, Woodward, Emma R.

Source: In Medicine January 2023 51(1):75-79