Evaluation of the immunological functions of placental alkaline phosphatase in vivo using ALPP transgenic mice

Authors: Tse-Ching Chen, Kwai-Fong Ng, Ning Chen, Yi-Ling Pan, Chun-An Cheng, Hsiao-Chun Wu, Yi-Jen Hsueh, Nien-Yi Chiang, Hsi-Hsien Lin

Source: Frontiers in Immunology, Vol 16 (2025)

Subject Terms: placental alkaline phosphatase, phagocytosis, sepsis, skin graft rejection, transgenic mouse, Immunologic diseases. Allergy, RC581-607

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Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2025.1499388/full; https://doaj.org/toc/1664-3224

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CRISPR-mediated megabase-scale transgene de-duplication to generate a functional single-copy full-length humanized DMD mouse model

Authors: Yu C. J. Chey, Mark A. Corbett, Jayshen Arudkumar, Sandra G. Piltz, Paul Q. Thomas, Fatwa Adikusuma

Source: BMC Biology, Vol 22, Iss 1, Pp 1-15 (2024)

Subject Terms: CRISPR-Cas9, Duchenne muscular dystrophy, Humanized mouse model, Zygote microinjection, Transgenic mouse model, Dystrophin, Biology (General), QH301-705.5

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Relation: https://doaj.org/toc/1741-7007

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Hepatic stellate cells in zone 1 engage in capillarization rather than myofibroblast formation in murine liver fibrosis

Authors: Muhammad Ashfaq Khan, Julian Fischer, Leon Harrer, Fabian Schwiering, Dieter Groneberg, Andreas Friebe

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)

Subject Terms: Lineage tracing, Pericyte, Smooth muscle myosin heavy chain, Liver lobule, Transgenic mouse, Medicine, Science

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Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/091f823e807f4d8987d870c715dd14b5

SerpinB2 deficiency is associated with delayed mammary tumor development and decreased pro-tumorigenic macrophage polarization

Authors: Yin Ji Piao, Hoe Suk Kim, Hyelim Kim, Jun Shen, Woo Kyung Moon

Source: BMC Cancer, Vol 24, Iss 1, Pp 1-14 (2024)

Subject Terms: SerpinB2, Breast cancer, MMTV-PyMT transgenic mouse, Tumor-associated macrophage, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

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Relation: https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/276a1b403e454f82b057889992ed0ec1

Designing and Evaluating Circadian Experiments on Mouse Skin

Authors: Duan, Junyan ^{1, 2}, Karri, Satya Swaroop ^{3, 4}, Forouzesh, Kiarash ^{3, 4}, Mortimer, Thomas ⁵, Plikus, Maksim V. ^{1, 2, 6, 7}, Benitah, Salvador Aznar ^{5, 8}, Takahashi, Joseph S. ^{9, 10}, Andersen, Bogi ^{1, 3, 4, ∗}

Source: In Journal of Investigative Dermatology March 2025 145(3):484-493

Transgenic mice expressing the human CDHR3 receptor: A sensitive RV-C infection model for the evaluation of vaccines and therapeutics

Authors: Zhou, Zhenhong ^{a, b, 1}, Zhu, Rui ^{a, b, 1}, Yang, Hongwei ^{a, b}, Deng, Weixi ^{a, b}, Zhang, Zijie ^{a, b}, Li, Yue ^{a, b}, Xu, Jiaxin ^{a, b}, Yan, Ziyang ^{a, b}, Wang, Ruoxi ^{a, b}, Chang, Sijia ^c, Yin, Zhichao ^c, Wu, Yuanyuan ^{a, b}, Zhang, Dongqing ^{a, b}, Fang, Mujin ^{a, b}, Liu, Che ^{a, b}, Que, Yuqiong ^{a, b}, Zhang, Jun ^{a, b}, Xia, Ningshao ^{a, b}, Wang, Yingbin ^{a, b, ⁎⁎}, Xu, Longfa ^{a, b, ⁎⁎⁎}, Cheng, Tong ^{a, b, ⁎}

Source: In Antiviral Research March 2025 235

TCR transgenic clone selection guided by immune receptor analysis and single-cell RNA expression of polyclonal responders

Authors: Nincy Debeuf, Sahine Lameire, Manon Vanheerswynghels, Julie Deckers, Caroline De Wolf, Wendy Toussaint, Rein Verbeke, Kevin Verstaen, Hamida Hammad, Stijn Vanhee, Bart N Lambrecht

Source: eLife, Vol 13 (2024)

Subject Terms: SARS-CoV-2, TCR transgenic mouse, single-cell RNA analysis, VDJseq, Medicine, Science, Biology (General), QH301-705.5

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Relation: https://elifesciences.org/articles/98344; https://doaj.org/toc/2050-084X

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Exogenous expression of ATP8, a mitochondrial encoded protein, from the nucleus in vivo

Authors: David V. Begelman, Bhavna Dixit, Carly Truong, Christina D. King, Mark A. Watson, Birgit Schilling, Martin D. Brand, Amutha Boominathan

Source: Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 4, Pp 101372- (2024)

Subject Terms: allotopic expression, mitochondrial DNA mutation, mtDNA, ATP8 gene, transgenic mouse, in vivo gene therapy, Genetics, QH426-470, Cytology, QH573-671

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Relation: http://www.sciencedirect.com/science/article/pii/S2329050124001888; https://doaj.org/toc/2329-0501

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Therapeutic potential of Simvastatin in ALS: Enhanced axonal integrity and motor neuron survival through Apoa4 and Alb modulation

Authors: Song Luo, Xiaorui Wang, Bo Ma, Dongliang Liu, Li Li, Lijin Wang, Ning Ding, Liangyu Zou, Jie Wang, Jialin Pan, Daoqian Sang, Huadong Zhou, Hongdang Qu, Yi Lu, Lijuan Yang

Source: Biomolecules & Biomedicine (2024)

Subject Terms: Simvastatin, amyotrophic lateral sclerosis, transgenic mouse model, Apoa4, Alb, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.bjbms.org/ojs/index.php/bjbms/article/view/11218; https://doaj.org/toc/2831-0896; https://doaj.org/toc/2831-090X

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Editorial: Lighting up cellular dynamics with fluorescent biosensors: design and applications in pathophysiology

Authors: Kazunori Kanemaru, Mariangela Panniello, Bianca Calì, Chiara Nardin

Source: Frontiers in Physiology, Vol 15 (2024)

Subject Terms: optical sensing, fluorescence microscopy, optogenetics, signalling pathways, transgenic mouse models, second messengers, Physiology, QP1-981

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphys.2024.1517919/full; https://doaj.org/toc/1664-042X

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Dynamic pathology in various disease-model mice using multiphoton laser scanning microscopy

Authors: Yuhki Koike, Yuki Sato, Koki Higashi, Yuka Nagano, Shimura Tadanobu, Takahito Kitajima, Kohei Matsushita, Yoshinaga Okugawa, Akira Mizoguchi, Yuji Toiyama

Source: Journal of Pediatric Surgery Open, Vol 8, Iss , Pp 100125- (2024)

Subject Terms: Multi-photon laser-scanning microscopy, Dynamic pathology, Intravital imaging, Green fluorescent protein, Transgenic mouse, Organ stabilizing system, Pediatrics, RJ1-570, Surgery, RD1-811

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Relation: http://www.sciencedirect.com/science/article/pii/S2949711624000108; https://doaj.org/toc/2949-7116

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A longitudinal MRI analysis reveals altered brain connectivity and microstructural changes in a transgenic mouse model of Alzheimer's disease

Authors: Ricardo Magalhães, Fernanda Marques, Erwan Selingue, Fawzi Boumezbeur, Sébastien Mériaux, Nuno Sousa

Source: Neurobiology of Disease, Vol 201, Iss , Pp 106679- (2024)

Subject Terms: Alzheimer's disease, Magnetic resonance imaging, Fractional anisotropy, Transgenic mouse model of AD (J20), Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

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Relation: http://www.sciencedirect.com/science/article/pii/S0969996124002791; https://doaj.org/toc/1095-953X

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A novel mouse model reproducing frontal alterations related to the prodromal stage of dementia with LEWY bodies

Authors: Estelle Schueller, Iris Grgurina, Brigitte Cosquer, Elodie Panzer, Noémie Penaud, Anne Pereira de Vasconcelos, Aline Stéphan, Karine Merienne, Jean-Christophe Cassel, Chantal Mathis, Frédéric Blanc, Olivier Bousiges, Anne-Laurence Boutillier

Source: Neurobiology of Disease, Vol 201, Iss , Pp 106676- (2024)

Subject Terms: Dementia with Lewy bodies, Transgenic mouse model, α-Synuclein, Prodromal stage, Human cohort, Frontal cortex, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

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Relation: http://www.sciencedirect.com/science/article/pii/S0969996124002766; https://doaj.org/toc/1095-953X

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Comparative study on the expression characteristics of transgenes inserted into the Gt(ROSA)26Sor and H11 loci in mice

Authors: Yu Zhilan, Shi Jiahao, Zhang Jingyu, Wu Youbing, Shen Ruling, Fei Jian

Source: Acta Biochimica et Biophysica Sinica, Vol 56, Pp 1687-1698 (2024)

Subject Terms: transgenic mouse, knockin, Gt(ROSA)26Sor, H11, gene expression, Biochemistry, QD415-436, Genetics, QH426-470

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Relation: https://doaj.org/toc/1672-9145

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ATT-Myc Transgenic Mouse Model and Gene Expression Identify Genotoxic and Non-Genotoxic Chemicals That Accelerating Liver Tumor Growth in Short-Term Toxicity

Authors: Mahmoud Elalfy, Jürgen Borlak, Ahmed Jaafar Aljazzar, Mona G. Elhadidy

Source: Biomedicines, Vol 13, Iss 3, p 743 (2025)

Subject Terms: DEN, HCC, c-Met/HGF signaling, SOD1, NRF2, ATT-Myc transgenic mouse model of liver cancer, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/13/3/743; https://doaj.org/toc/2227-9059

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Parkin deficiency aggravates inflammation-induced acute lung injury by promoting necroptosis in alveolar type II cells

Authors: Quan, Meiyu ^{a, 1}, Guo, Qiang ^{b, 1}, Yan, Xihua ^b, Yu, Chenhua ^c, Yang, Linglong ^c, Zhang, Yuting ^d, Li, Jiaqi ^c, Weng, Qiongxia ^b, Liu, Bin ^a, Li, Quan ^b, Dong, Li ^a, Chen, Junjie ^a, Lou, Zhenkun ^e, Jin, Xuru ^d, Chen, Chengshui ^{d, ⁎}, Zhang, Jin-San ^{c, d, e, ⁎}

Source: In Chinese Medical Journal - Pulmonary and Critical Care Medicine December 2024 2(4):265-278

Functional characterization of human IL-8 in vascular stenosis using a novel humanized transgenic mouse model

Authors: Zhang, Wei ^{a, b, ⁎}, Pan, Lihua ^{a, b, c}, Wu, Xiaoliang ^b, Slivano, Orazio J. ^b, Dong, Kunzhe ^d, Long, Xiaochun ^b

Source: In Vascular Pharmacology December 2024 157

Comparative analysis of two independent Myh6-Cre transgenic mouse lines

Authors: Amanda Davenport, Chase W. Kessinger, Ryan D. Pfeiffer, Nikita Shah, Richard Xu, E. Dale Abel, Nathan R. Tucker, Zhiqiang Lin

Source: Journal of Molecular and Cellular Cardiology Plus, Vol 9, Iss , Pp 100081- (2024)

Subject Terms: Cre-loxP system, Myh6-Cre, tdTomato reporter, Transgenic mouse line, Genomic position effect, Diseases of the circulatory (Cardiovascular) system, RC666-701

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Relation: http://www.sciencedirect.com/science/article/pii/S2772976124000217; https://doaj.org/toc/2772-9761

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Motor deficits and brain pathology in the Parkinson’s disease mouse model hA53Ttg

Authors: Livia Breznik, Magdalena Daurer, Roland Rabl, Tina Loeffler, Estibaliz Etxeberria-Rekalde, Joerg Neddens, Stefanie Flunkert, Manuela Prokesch

Source: Frontiers in Neuroscience, Vol 18 (2024)

Subject Terms: Parkinson’s disease, α-synuclein, motor skills, neuroinflammation, neurodegeneration, transgenic mouse, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

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Relation: https://www.frontiersin.org/articles/10.3389/fnins.2024.1462041/full; https://doaj.org/toc/1662-453X

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In vivo characterization of a podocyte-expressed short podocin isoform

Authors: Linus Butt, David Unnersjö-Jess, Dervla Reilly, Robert Hahnfeldt, Markus M. Rinschen, Katarzyna Bozek, Bernhard Schermer, Thomas Benzing, Martin Höhne

Source: BMC Nephrology, Vol 24, Iss 1, Pp 1-14 (2023)

Subject Terms: Podocin, Podocin isoform, Transgenic mouse, Slit-diaphragm morphology, Diseases of the genitourinary system. Urology, RC870-923

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Relation: https://doaj.org/toc/1471-2369

Access URL: https://doaj.org/article/0724fc4b52414f4ba1addf3e1cc01f23