Inhibition of IL-6 trans-signaling promotes post-stroke functional recovery in a sex and dose-dependent manner

Authors: Cassandra Hall, Dustin T. Nguyen, Kate Mendoza, Chunfeng Tan, Anjali Chauhan

Source: Journal of Neuroinflammation, Vol 22, Iss 1, Pp 1-17 (2025)

Subject Terms: IL-6, Trans-signaling, sgp130, Stroke, Sex-difference, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1742-2094

Access URL: https://doaj.org/article/ebefe297dde14d7b92826989935d618e

IL-6 and diabetic kidney disease

Authors: Lei Zhang, Futian Xu, Liyan Hou

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: IL-6, inflammation, diabetic kidney disease, IL-6 classical signaling, IL-6 trans-signaling pathway, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1465625/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/848665c8f5a14b1d992cfd4359dc6724

Targeting inerleukin-6 for renoprotection

Authors: Ekaterina O. Gubernatorova, Mikhail Y. Samsonov, Marina S. Drutskaya, Svetlana Lebedeva, Darya Bukhanova, Maria Materenchuk, Kerim Mutig

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: acute kidney injury, chronic kidney disease, inflammation, anti-cytokine therapy, kidney transplantation, trans-signaling, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1502299/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/1cd2a1d09f4f4162ae90569651107e2f

Exploratory assessment of the effect of systemic administration of soluble glycoprotein 130 on cognitive performance and chemokine levels in a mouse model of experimental traumatic brain injury

Authors: Ian G. Gober, Ashley L. Russell, Tyler J. Shick, Vincent A. Vagni, Jenna C. Carlson, Patrick M. Kochanek, Amy K. Wagner

Source: Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-12 (2024)

Subject Terms: Traumatic brain injury, Interleukin-6, Trans-signaling, Soluble glycoprotein-130, Morris water maze, Cognition, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1742-2094

Access URL: https://doaj.org/article/203db4b4abdf484d8c8eb4b1304705c9

A maternal high-fat diet predisposes to infant lung disease via increased neutrophil-mediated IL-6 trans-signaling

Authors: Curren, Bodie ^{1, 2, 8}, Ahmed, Tufael ^{1, 3, 8}, Rashid, Ridwan B. ¹, Sebina, Ismail ¹, Al Amin Sikder, Md. ^{1, 2}, Howard, Daniel R. ^{1, 2}, Alorro, Mariah ¹, Ullah, Md. Ashik ¹, Bissell, Alec ¹, Rahman, Muhammed Mahfuzur ^{1, 2}, Pearen, Michael A. ¹, Ramm, Grant A. ^{1, 2}, Varelias, Antiopi ^{1, 3, 4}, Rose-John, Stefan ⁵, MacDonald, Kelli P.A. ^{1, 2}, Hoelzle, Robert ⁶, Ó Cuív, Páraic ³, Spann, Kirsten M. ⁷, Dennis, Paul G. ^{4, 6}, Phipps, Simon ^{1, 2, 3, 4, 9, ∗}

Source: In Cell Reports 26 November 2024 43(11)

A common secretomic signature across epithelial cancers metastatic to the pleura supports IL-6 axis therapeutic targeting

Authors: Vera S. Donnenberg, James D. Luketich, Bosko Popov, David L. Bartlett, Albert D. Donnenberg

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: malignant pleural effusion, secretomics, tumor environment, epithelial to mesenchymal transition, IL-6 trans-signaling, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1404373/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/41910254bf454a3fbd96114ec57e262c

MiR-449a antagonizes EMT through IL-6-mediated trans-signaling in laryngeal squamous cancer

Authors: Alessia Maria Cossu, Federica Melisi, Teresa Maria Rosaria Noviello, Lucia Stefania Pasquale, Piera Grisolia, Carla Reale, Marco Bocchetti, Michela Falco, Chiara Tammaro, Nunzio Accardo, Francesco Longo, Salvatore Allosso, Massimo Mesolella, Raffaele Addeo, Francesco Perri, Alessandro Ottaiano, Filippo Ricciardiello, Evzen Amler, Concetta Ambrosino, Gabriella Misso, Michele Ceccarelli, Michele Caraglia, Marianna Scrima

Source: Molecular Therapy: Nucleic Acids, Vol 35, Iss 1, Pp 102140- (2024)

Subject Terms: MT: non-coding RNAs, microRNAs, gene expression, LSCC, metastases miR-449a, IL-6 trans-signaling, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2162253124000271; https://doaj.org/toc/2162-2531

Access URL: https://doaj.org/article/d6b96f056ecb41df998974deaab3436d

The Alzheimer’s disease-linked protease BACE1 modulates neuronal IL-6 signaling through shedding of the receptor gp130

Authors: Stephan A. Müller, Merav D. Shmueli, Xiao Feng, Johanna Tüshaus, Neele Schumacher, Ryan Clark, Brad E. Smith, An Chi, Stefan Rose-John, Matthew E. Kennedy, Stefan F. Lichtenthaler

Source: Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-20 (2023)

Subject Terms: IL-6 receptor subunit beta, Secretase, IL-6R, Shedding, Trans-signaling, VCAM1, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

File Description: electronic resource

Relation: https://doaj.org/toc/1750-1326

Access URL: https://doaj.org/article/7fa094553b0842b2823d05e839ed3787

CYT387 restores Th17/Treg cell balance and inhibits mature osteoclast cell formation by regulating SOX-5 signaling in rheumatoid arthritis

Authors: Susmita Srivastava, Mahaboobkhan Rasool

Source: Bangladesh Journal of Pharmacology, Vol 18, Iss 4 (2023)

Subject Terms: T helper 17 (Th17) cell, osteoclastogenesis, CYT387, IL-6 trans-signaling, janus kinases, rheumatoid arthritis, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://asiajol.info/index.php/BJP/article/view/68901; https://doaj.org/toc/1991-0088

Access URL: https://doaj.org/article/be35f2af41754e038ccd51a2c8ddb549

IL-6 trans-signaling inhibitor sgp130Fc suppresses inflammation and regulates immune cells in mice with sepsis

Authors: SHI Dan-dan, JIANG Su-fang, WANG Qian, ZHAO Peng-bo, LIU Ya

Source: Jichu yixue yu linchuang, Vol 42, Iss 12, Pp 1895-1899 (2022)

Subject Terms: sepsis, il-6 trans-signaling, cellular immunity, humoral immunity, inflammatory factor, Medicine

File Description: electronic resource

Relation: http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2022-42-12-1895.pdf; https://doaj.org/toc/1001-6325

Access URL: https://doaj.org/article/0d4161fd24974c6e8a4eb7e69ed0abd1

Defining the role of Interleukin-6 for the development of perioperative neurocognitive disorders: Evidence from clinical and preclinical studies

Authors: Odmara L. Barreto Chang, Mervyn Maze

Source: Frontiers in Aging Neuroscience, Vol 14 (2023)

Subject Terms: perioperative neurocognitive disorder, IL-6, IL-6 trans-signaling, aging, neuroinflammation, Olamkicept, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnagi.2022.1097606/full; https://doaj.org/toc/1663-4365

Access URL: https://doaj.org/article/545d24575b1244a49fd9d34ba29d56cd

Modulation of Pro-Inflammatory IL-6 Trans-Signaling Axis by Splice Switching Oligonucleotides as a Therapeutic Modality in Inflammation

Authors: Dhanu Gupta, Sara Orehek, Janne Turunen, Liz O’Donovan, Michael J. Gait, Samir El-Andaloussi, Matthew J. A. Wood

Source: Cells, Vol 12, Iss 18, p 2285 (2023)

Subject Terms: inflammation, nucleic acid therapies, IL-6 trans-signaling, oligonucleotides, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/12/18/2285; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/5a318b60e70e48a49a8ececc4099cc3d

Targeting STAT3 and STAT5 in Cancer

Contributors: Moriggl, Richard, Gunning, Patrick, Keserü, György Miklós

Subject Terms: multiple myeloma, STAT3, S3I-1757, nanoparticle, CD38, siRNA/RNAi, polyethylenimine, PEI, lipopolyplex, siRNA delivery, glioma, glioblastoma, STAT5, AKT, ERK1/2, prolactin, androgens, prostate cancer, knockout, escape mechanisms, stem/progenitor cells, cell hierarchy, cancer, CD4+ T cells, CD8+ T cells, myeloid cells, immune check point, hepatitis C virus (HCV), cirrhosis, hepatocellular carcinoma (HCC), endoplasmic reticulum (ER) stress, oxidative stress (OS), unfolded protein response (UPR), microRNA-122 (miR-122), nuclear factor erythroid 2-related factor 2 (NRF2), signal transducer and activator of transcription 3 (STAT3), hepatocyte nuclear factor 4 alpha (HNF4A), solid cancers, cell cycle, apoptosis, inflammation, mitochondria, stemness, tumor suppression, melanoma, autoimmune disease, immunotherapy, tumor–immune cell interactions, breast cancer, PD-L1, M2 macrophages, NK cells, STAT3 inhibitor XIII, hedging, transaction costs, dynamic programming, risk management, post-decision state variable, cancer progression, cancer-stem cell, cytokine, therapy resistance, metastasis, immunosuppression, tumor microenvironment, proliferation, tyrosine kinase 2, JAK family of protein tyrosine kinases, signal transducer and activator of transcription, cytokine receptor signaling, gain-of-function mutation, tumorigenesis, ADAM17, interleukin-6, trans-signaling, epidermal growth factor receptor (EGF-R), shedding, metalloprotease, tumor necrosis factor alpha (TNFα), inflammation associated cancer, colon cancer, lung cancer, SH2 domain, mutations, autosomal-dominant hyper IgE syndrome, inflammatory hepatocellular adenomas, T-cell large granular lymphocytic leukemia, T-cell prolymphocytic leukemia, growth hormone insensitivity syndrome, nuclear pore complex, nuclear transport receptors, nucleocytoplasmic shuttling, targeting, tumor-associated macrophages, adoptive T cell therapy, immune suppression, STAT transcription factors, JAK, STAT, T-PLL, T-cell leukemia, meta-analysis, STAT5B signaling, small-molecule inhibitors, cancer models, companion animals, comparative oncology, pharmacological inhibitor, STAT5 signaling, chemotherapy resistance, myeloid leukemia, heat shock proteins, chaperones, stabilization, targeted therapy, ovarian cancer, hematopoietic cancers, therapeutic targeting, pharmacological inhibitors, mTOR, Bone Marrow Failure Syndromes, lymphocytes, lymphoma, T-cells, RHOA, NGS, MPN, JAK2 V617F, neoplastic stem cells, Research and information: general, Biology, life sciences

File Description: application/octet-stream

Access URL: https://directory.doabooks.org/handle/20.500.12854/69075
https://mdpi.com/books/pdfview/book/2844

Matrix Metalloproteinase

Contributors: Ågren, Magnus S., Keller, Ulrich

Subject Terms: hemagglutinin-B, transwell co-cultures, matrix metalloproteinases, TNF-α, matrix metalloproteinase, peritoneal mesothelial cell, gastric cancer, metastatic dissemination, MT4-MMP, cancer, diseases, aggrecan, aggrecanase, ADAMTS, cartilage, arthritis, MMP-2, MMP-9, inhibitor, allodynia, caspase-3, neuropathic, pain, dorsal root ganglion, spinal nerve ligation, tuberculosis, tuberculous meningitis, HIV-TB-associated IRIS, extracellular matrix breakdown, adult, pediatric, lung, central nervous system, matrix-metalloproteinase, monocytes, inflammation, phagocytosis, apoptosis, blood sampling, anticoagulants, high-molecular-weight heparin, IL-16, sICAM-1, IL-8, T cells, a disintegrin and metalloproteinase, EMMPRIN, CD147, ectodomain shedding, MMPs, PTMs, glycosylation, phosphorylation, glycosaminoglycans, interleukin, IL-6, IL-11, trans-signaling, metalloproteases, ADAM, MMP, meprin, matrix metalloproteinases (MMPs), protease, signaling, invasion, chemokine, cytokine, proteomics, interferon, Agkistrodon venom, metalloproteinase, fibrinogen, antithrombotic, metabolomics, extracellular matrix, cytokines, proteinases, interstitial collagens, wound healing, Research and information: general, Biology, life sciences

File Description: application/octet-stream

Access URL: https://directory.doabooks.org/handle/20.500.12854/68994
https://mdpi.com/books/pdfview/book/2762

Serum level of soluble interleukin 6 receptor is a useful biomarker for identification of treatment‐resistant major depressive disorder

Authors: Katsuhiko Yamasaki, Tomonori Hasegawa, Masatoshi Takeda

Source: Neuropsychopharmacology Reports, Vol 40, Iss 2, Pp 130-137 (2020)

Subject Terms: cytokines, IL‐6 trans‐signaling system, major depressive disorder, soluble IL‐6 receptor, treatment‐resistant depression, Therapeutics. Pharmacology, RM1-950, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://doaj.org/toc/2574-173X

Access URL: https://doaj.org/article/fe4e4c9d8c624717a816a0fa136d9e49

Interleukin-6 Trans-signaling: A Pathway With Therapeutic Potential for Diabetic Retinopathy

Authors: Shruti Sharma

Source: Frontiers in Physiology, Vol 12 (2021)

Subject Terms: interleukin-6, IL-6 trans-signaling, sgp130Fc, inflammation, diabetic retinopathy, Physiology, QP1-981

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphys.2021.689429/full; https://doaj.org/toc/1664-042X

Access URL: https://doaj.org/article/d84857dbdaba496589381aabfc728469

Relationship of Soluble Interleukin-6 Receptors With Asthma: A Mendelian Randomization Study

Authors: Yoshihiko Raita, Zhaozhong Zhu, Carlos A. Camargo, Robert J. Freishtat, Debby Ngo, Liming Liang, Kohei Hasegawa

Source: Frontiers in Medicine, Vol 8 (2021)

Subject Terms: interleukin-6, soluble interleukin-6 receptor, trans-signaling pathway, asthma, Mendelian randomization, GWAS, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmed.2021.665057/full; https://doaj.org/toc/2296-858X

Access URL: https://doaj.org/article/96404f26f9604915ada0e8ecb7e1454a

Cannabis Use Is Associated With Increased Levels of Soluble gp130 in Schizophrenia but Not in Bipolar Disorder

Authors: Attila Szabo, Ibrahim A. Akkouh, Thor Ueland, Trine Vik Lagerberg, Ingrid Dieset, Thomas Bjella, Pål Aukrust, Stephanie Le Hellard, Anne-Kristin Stavrum, Ingrid Melle, Ole A. Andreassen, Srdjan Djurovic

Source: Frontiers in Psychiatry, Vol 11 (2020)

Subject Terms: Cannabis, immune modulation, sgp130, IL-6 trans-signaling, schizophrenia, bipolar disorder, Psychiatry, RC435-571

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fpsyt.2020.00642/full; https://doaj.org/toc/1664-0640

Access URL: https://doaj.org/article/701872f5c7cc48f38edbfcfda2922537

Interleukin-6 trans-signaling inhibition prevents oxidative stress in a mouse model of early diabetic retinopathy

Authors: Rebekah Robinson, Mukund Srinivasan, Arul Shanmugam, Alexander Ward, Veena Ganapathy, Justin Bloom, Ashok Sharma, Shruti Sharma

Source: Redox Biology, Vol 34, Iss , Pp 101574- (2020)

Subject Terms: Diabetic retinopathy, Oxidative stress, IL-6 trans-signaling, Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213231720300720; https://doaj.org/toc/2213-2317

Access URL: https://doaj.org/article/c23f643302b24b8eb177792147344ab1

ADAM17 selectively activates the IL‐6 trans‐signaling/ERK MAPK axis in KRAS‐addicted lung cancer

Authors: Mohamed I Saad, Sultan Alhayyani, Louise McLeod, Liang Yu, Mohammad Alanazi, Virginie Deswaerte, Ke Tang, Thierry Jarde, Julian A Smith, Zdenka Prodanovic, Michelle D Tate, Jesse J Balic, D Neil Watkins, Jason E Cain, Steven Bozinovski, Elizabeth Algar, Tomohiro Kohmoto, Hiromichi Ebi, Walter Ferlin, Christoph Garbers, Saleela Ruwanpura, Irit Sagi, Stefan Rose‐John, Brendan J Jenkins

Source: EMBO Molecular Medicine, Vol 11, Iss 4, Pp 1-19 (2019)

Subject Terms: ADAM17, ERK MAPK, IL‐6 trans‐signaling, KRAS, lung adenocarcinoma, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/651450bcc02047a78683c22380e772e6