Anticancer drug response prediction integrating multi-omics pathway-based difference features and multiple deep learning techniques.

Authors: Wu, Yang^1,2 (AUTHOR), Chen, Ming^1,2 (AUTHOR), Qin, Yufang^1,2 (AUTHOR) yfqin@shou.edu.cn

Source: PLoS Computational Biology. 3/31/2025, Vol. 21 Issue 3, p1-33. 33p.

Subject Terms: *DNA topoisomerase I, *TRANSFORMER models, *ANTINEOPLASTIC agents, *CHEMICAL models, *DRUG interactions, *DEEP learning

Managing Irinotecan-Induced Diarrhea: A Comprehensive Review of Therapeutic Interventions in Cancer Treatment.

Authors: Yang, Xiaoqin¹ (AUTHOR), Chen, Jiamei^1,2 (AUTHOR), Wang, Yitao^1,2 (AUTHOR), Wu, Yihan^1,2 (AUTHOR) yihanwuone@126.com, Zhang, Jinming¹ (AUTHOR)

Source: Pharmaceuticals (14248247). Mar2025, Vol. 18 Issue 3, p359. 32p.

Subject Terms: *DNA topoisomerase I, *DNA topoisomerase inhibitors, *CHINESE medicine, *DRUG delivery systems, *TREATMENT effectiveness, *IRINOTECAN

Design, Synthesis and Bioactive Evaluation of Topo I/ c-MYC Dual Inhibitors to Inhibit Oral Cancer via Regulating the PI3K/AKT/NF-κB Signaling Pathway.

Authors: Zheng, Bin¹ (AUTHOR), Wang, Yi-Xiao¹ (AUTHOR), Wu, Zi-Yan¹ (AUTHOR), Li, Xin-Wei¹ (AUTHOR), Qin, Li-Qing¹ (AUTHOR), Chen, Nan-Ying¹ (AUTHOR), Su, Gui-Fa¹ (AUTHOR), Su, Jun-Cheng¹ (AUTHOR), Pan, Cheng-Xue¹ (AUTHOR) chengxuepan@163.com

Source: Molecules. Feb2025, Vol. 30 Issue 4, p894. 33p.

Subject Terms: *DNA topoisomerase I, *ORAL cancer, *CELL migration, *CANCER genes, *DRUG target

Phosphine Oxide Indenoquinoline Derivatives: Synthesis and Biological Evaluation as Topoisomerase I Inhibitors and Antiproliferative Agents.

Authors: Rodriguez-Paniagua, Alba¹ (AUTHOR) alba.rodriguezp@ehu.eus, Tesauro, Cinzia² (AUTHOR) ctesauro@mbg.au.dk, Knudsen, Birgitta R.² (AUTHOR) brk@mbg.au.dk, Fuertes, Maria¹ (AUTHOR) maria.fuertes@ehu.eus, Alonso, Concepción¹ (AUTHOR) maria.fuertes@ehu.eus

Source: Molecules. Dec2024, Vol. 29 Issue 24, p5992. 25p.

Subject Terms: *DNA topoisomerase I, *BIOSYNTHESIS, *PHOSPHINE oxides, *CYTOTOXINS, *CELL lines, *ALDIMINES

In Silico Molecular Docking of Aminoglycosides as Topoisomerase 1 Inhibitors: A Computational approach.

Authors: M., Karthikeyan¹ karthikeyanpgt@gmail.com, B. M., Praveen²

Source: South Asian Journal of Experimental Biology. 2024, Vol. 14 Issue 5, p232-241. 10p.

Subject Terms: *DNA topoisomerase I, *DRUG discovery, *MOLECULAR docking, *ANTINEOPLASTIC agents, *DNA ligases, *PROTEIN-ligand interactions

DB-1314, a novel DLL3-targeting ADC with DNA topoisomerase I inhibitor, exhibits promising safety profile and therapeutic efficacy in preclinical small cell lung cancer models.

Authors: Lin, Shengchao¹ (AUTHOR) shengchao.lin@dualitybiologics.com, Zhang, Yu¹ (AUTHOR), Yao, Jun¹ (AUTHOR), Yang, Junjie¹ (AUTHOR), Qiu, Yang¹ (AUTHOR), Zhu, Zhongyuan¹ (AUTHOR), Hua, Haiqing¹ (AUTHOR) haiqing.hua@dualitybiologics.com

Source: Journal of Translational Medicine. 8/14/2024, Vol. 22 Issue 1, p1-13. 13p.

Subject Terms: *SMALL cell lung cancer, *DNA topoisomerase I, *ANTIBODY-dependent cell cytotoxicity, *DNA topoisomerase inhibitors, *KRA

Novel Collagen Membrane Formulations with Irinotecan or Minocycline for Potential Application in Brain Cancer.

Authors: Idu, Andreea-Anamaria^1,2 (AUTHOR) anamaria.idu@gmail.com, Albu Kaya, Mădălina Georgiana³ (AUTHOR) albu_mada@yahoo.com, Rău, Ileana¹ (AUTHOR) ileana.rau@upb.ro, Radu, Nicoleta^4,5 (AUTHOR) nicoleta.radu@biotehnologii.usamv.ro, Dinu-Pîrvu, Cristina-Elena^6,7 (AUTHOR) cristina.dinu@umfcd.ro, Ghica, Mihaela Violeta^6,7 (AUTHOR) mihaela.ghica@umfcd.ro

Source: Materials (1996-1944). Jul2024, Vol. 17 Issue 14, p3510. 16p.

Subject Terms: *TREATMENT effectiveness, *DNA topoisomerase I, *DRUG delivery systems, *DRUG bioavailability, *IRINOTECAN

IN SILICO DESIGNING AND SCREENING OF CARBAZOLE DERIVATIVES AS TOPOISOMERASE II INHIBITORS.

Authors: Jose, Elseena¹ elseena_jose@yahoo.com, Francis, Prasanth¹, Joy, Mariya¹, Joseph, Shilpa¹, Sukumaran, Sunitha¹, Baby, Sini¹

Source: Indian Drugs. Jun2024, Vol. 61 Issue 6, p21-37. 17p.

Subject Terms: *DNA topoisomerase II, *DNA topoisomerase I, *MOLECULAR docking, *CARBAZOLE derivatives, *MOLECULAR dynamics

Bioinformatic Analysis of Topoisomerase IIα Reveals Interdomain Interdependencies and Critical C-Terminal Domain Residues.

Authors: Endsley, Clark E.¹ (AUTHOR), Moore, Kori A.¹ (AUTHOR), Townsley, Thomas D.² (AUTHOR), Durston, Kirk K.³ (AUTHOR), Deweese, Joseph E.^1,4 (AUTHOR) jdeweese@fhu.edu

Source: International Journal of Molecular Sciences. Jun2024, Vol. 25 Issue 11, p5674. 19p.

Subject Terms: *C-terminal residues, *DNA topoisomerase I, *UNCERTAINTY (Information theory), *DNA topoisomerase II, *DRUG target, *AMINO acids

Chemoproteomics reveals the epoxidase enzyme for the biosynthesis of camptothecin in Ophiorrhiza pumila.

Authors: Zhang, Tong^1,2 (AUTHOR), Wang, Yan¹ (AUTHOR), Wu, Shiwen¹ (AUTHOR), Tian, Ernuo^1,2 (AUTHOR), Yang, Chengshuai¹ (AUTHOR), Zhou, Zhihua^1,2 (AUTHOR), Yan, Xing^1,2 (AUTHOR) yanxing@cemps.ac.cn, Wang, Pingping¹ (AUTHOR) ppwang@cemps.ac.cn

Source: Journal of Integrative Plant Biology. Jun2024, Vol. 66 Issue 6, p1044-1047. 4p.

Subject Terms: *BIOSYNTHESIS, *DNA topoisomerase I, *ALKALOIDS, *CAMPTOTHECIN, *TRANSCRIPTION factors, *ENZYMES, *METABOLITES, *PLANT enzymes

Peposertib, a DNA-PK Inhibitor, Enhances the Anti-Tumor Efficacy of Topoisomerase II Inhibitors in Triple-Negative Breast Cancer Models.

Authors: Revia, Steffie¹ (AUTHOR) steffie.revia@merckgroup.com, Neumann, Felix¹ (AUTHOR), Jabs, Julia¹ (AUTHOR), Orio, Florian¹ (AUTHOR), Sirrenberg, Christian¹ (AUTHOR), Zimmermann, Astrid¹ (AUTHOR), Amendt, Christiane¹ (AUTHOR), Albers, Joachim¹ (AUTHOR) joachim.albers@merckgroup.com

Source: International Journal of Molecular Sciences. May2024, Vol. 25 Issue 10, p5120. 13p.

Subject Terms: *DNA topoisomerase I, *TRIPLE-negative breast cancer, *DNA topoisomerase II, *IRINOTECAN, *PATIENT experience, *BREAST cancer, *TREATMENT effectiveness

The Potential Role of Phytochemicals of Juniperus procera in the Treatment of Ovarian Cancer and the Inhibition of Human Topoisomerase II Alpha Activity.

Authors: Al-Zahrani, Ateeq A¹ (AUTHOR) aaalzahrani@uqu.edu.sa

Source: Bioinformatics & Biology Insights. 4/25/2024, p1-7. 7p.

Subject Terms: *DNA topoisomerase I, *DNA topoisomerase II, *PHYTOCHEMICALS, *FRUIT extracts, *ALPHA rhythm, *OVARIAN cancer, *JUNIPERS, *CANCER treatment

DB-1310, an ADC comprised of a novel anti-HER3 antibody conjugated to a DNA topoisomerase I inhibitor, is highly effective for the treatment of HER3-positive solid tumors.

Authors: Li, Xi¹ (AUTHOR) xi.li@dualitybiologics.com, Yao, Jun¹ (AUTHOR), Qu, Chen¹ (AUTHOR), Luo, Lan¹ (AUTHOR), Li, Bing¹ (AUTHOR), Zhang, Yu¹ (AUTHOR), Zhu, Zhongyuan¹ (AUTHOR), Qiu, Yang¹ (AUTHOR), Hua, Haiqing¹ (AUTHOR) haiqing.hua@dualitybiologics.com

Source: Journal of Translational Medicine. 4/17/2024, Vol. 22 Issue 1, p1-13. 13p.

Subject Terms: *DNA topoisomerase I, *DNA topoisomerase inhibitors, *EPIDERMAL growth factor receptors, *NON-small-cell lung carcinoma, *COLON cancer, *PROSTATE cancer, *ANDROGEN receptors

In Vitro Antibacterial, DPPH Radical Scavenging Activities, and In Silico Molecular Modeling of Isolated Compounds from the Roots of Clematis hirsuta.

Authors: Duguma, Tolessa¹ (AUTHOR), Melaku, Yadessa¹ (AUTHOR), Garg, Ankita¹ (AUTHOR), Ensermu, Urgessa² (AUTHOR)

Source: Advances in Pharmacological & Pharmaceutical Sciences. 3/25/2024, Vol. 2024, p1-14. 14p.

Subject Terms: *DNA topoisomerase I, *THIN layer chromatography, *RADICALS (Chemistry), *CLEMATIS, *NORMAL-phase chromatography, *DNA topoisomerase II

Geographic Terms: ETHIOPIA

Variation of Structure and Cellular Functions of Type IA Topoisomerases across the Tree of Life.

Authors: Tan, Kemin¹ (AUTHOR) ktan@anl.gov, Tse-Dinh, Yuk-Ching^2,3 (AUTHOR) ktan@anl.gov

Source: Cells (2073-4409). Mar2024, Vol. 13 Issue 6, p553. 20p.

Subject Terms: *DNA topoisomerase I, *SINGLE-strand DNA breaks, *CELL physiology, *CELL anatomy, *NUCLEIC acids, *PROTEIN domains

Synthesis of Amides Based on Biologically Active (5Z,9Z)-Eicosa-5,9-dienoic Acid.

Authors: Makarova, E. Kh.¹ (AUTHOR) makarovaelina87@gmail.com, Makarov, A. A.¹ (AUTHOR), Dzhemilev, U. M.² (AUTHOR), D'yakonov, V. A.² (AUTHOR)

Source: Russian Journal of Organic Chemistry. Mar2024, Vol. 60 Issue 3, p437-441. 5p.

Subject Terms: *DNA topoisomerase I, *AMIDES, *ACIDS, *GRIGNARD reagents

Phytochemical Characterization and Anticancer Screening of Cladophora goensis and Cladophora glomerata Extracts.

Authors: Sundaramoorthy, Sharanya¹ (AUTHOR) shanu.dhivya@gmail.com, Dakshinamoorthy, Anusha¹ (AUTHOR), L. V. K. S., Bhaskar² (AUTHOR)

Source: Journal of Pharmacology & Pharmacotherapeutics. Mar2024, Vol. 15 Issue 1, p78-88. 11p.

Subject Terms: *DNA topoisomerase I, *ESTROGEN receptors, *CLADOPHORA, *EPIDERMAL growth factor receptors, *ELECTRON impact ionization, *PEROXISOME proliferator-activated receptors, *MOLECULAR interactions

Lactoferricin B Combined with Antibiotics Exhibits Leukemic Selectivity and Antimicrobial Activity.

Authors: Lica, Jan Jakub^1,2 (AUTHOR) 24556@gumed.edu.pl, Gucwa, Katarzyna³ (AUTHOR) katarzyna.gucwa@ug.edu.pl, Heldt, Mateusz⁴ (AUTHOR) mateusz.heldt@gmail.com, Stupak, Anna⁵ (AUTHOR) anna.stupak@polpharmabiologics.com, Maciejewska, Natalia⁴ (AUTHOR) nat.maciejewska@gmail.com, Ptaszyńska, Natalia² (AUTHOR) anna.legowska@ug.edu.pl, Łęgowska, Anna² (AUTHOR) agata.domagalska@ug.edu.pl, Pradhan, Bhaskar⁶ (AUTHOR) bhaskar.pradhan@wum.edu.pl, Gitlin-Domagalska, Agata² (AUTHOR) dawid.debowski@ug.edu.pl, Dębowski, Dawid² (AUTHOR) krzysztof.rolka@ug.edu.pl, Jakóbkiewicz-Banecka, Joanna⁷ (AUTHOR) 24556@gumed.edu.pl, Rolka, Krzysztof² (AUTHOR)

Source: Molecules. Feb2024, Vol. 29 Issue 3, p678. 14p.

Subject Terms: *DNA topoisomerase I, *ANTI-infective agents, *ANTIMICROBIAL peptides, *ANTIBIOTICS, *REACTIVE oxygen species, *ANTINEOPLASTIC agents, *ANTIFUNGAL agents, *ANTIPARASITIC agents

In Silico Study of Camptothecin-Based Pro-Drugs Binding to Human Carboxylesterase 2.

Authors: Beierlein, Frank^1,2 (AUTHOR) anselm.horn@fau.de, Horn, Anselm H. C.^2,3 (AUTHOR) heinrich.sticht@fau.de, Sticht, Heinrich³ (AUTHOR), Mokhir, Andriy⁴ (AUTHOR) andriy.mokhir@fau.de, Imhof, Petra¹ (AUTHOR) petra.imhof@fau.de

Source: Biomolecules (2218-273X). Feb2024, Vol. 14 Issue 2, p153. 19p.

Subject Terms: *CAMPTOTHECIN, *DNA topoisomerase I, *MOLECULAR dynamics, *MOLECULAR docking, *IRINOTECAN, *CARBOXYLESTERASES, *CANCER cells

Trastuzumab rezetecan, a HER2-directed antibody–drug conjugate, in patients with advanced HER2-mutant non-small-cell lung cancer (HORIZON-Lung): phase 2 results from a multicentre, single-arm study.

Authors: Li, Ziming¹ (AUTHOR), Wang, Yan² (AUTHOR), Sun, Yuping³ (AUTHOR), Wang, Linlin⁴ (AUTHOR), Li, Xingya⁵ (AUTHOR), Sun, Longhua⁶ (AUTHOR), He, Zhiyi⁷ (AUTHOR), Yang, Haiyan⁸ (AUTHOR), Wang, Yongsheng⁹ (AUTHOR), Wang, Qiming¹⁰ (AUTHOR), Song, Zhengbo¹¹ (AUTHOR), Hong, Wei¹² (AUTHOR), Wang, Yong¹³ (AUTHOR), Xia, Guohao¹⁴ (AUTHOR), Yu, Yan¹⁵ (AUTHOR), Peng, Min¹⁶ (AUTHOR), Song, Yong¹⁷ (AUTHOR), Wang, Donglin¹⁸ (AUTHOR), Meng, Rui¹⁹ (AUTHOR), Fang, Jian²⁰ (AUTHOR)

Source: Lancet Oncology. Apr2025, Vol. 26 Issue 4, p437-446. 10p.

Subject Terms: *LEUKOCYTE count, *DNA topoisomerase I, *INTERSTITIAL lung diseases, *DNA topoisomerase inhibitors, *CHRONIC obstructive pulmonary disease