The Novel Role of the Expression of Toll-like Receptors TLR-5, TLR-6, and TLR-9 and Associated Up-Regulation of Programmed Cell Death 1 Receptor (PD-1) and Its Ligand (PD-L1) in Lung Sepsis.

Authors: Sinos, Georgios¹ (AUTHOR) george_sinos@hotmail.com, Schizas, Dimitrios^1,2 (AUTHOR), Kapelouzou, Alkistis^2,3 (AUTHOR), Frountzas, Maximos^3,4 (AUTHOR), Katsimpoulas, Michalis^2,5 (AUTHOR), Mylonas, Konstantinos S.^1,4 (AUTHOR), Kapetanakis, Emmanouil I.^2,5 (AUTHOR), Papalampros, Alexandros^1,3 (AUTHOR), Liakakos, Theodore^1,4 (AUTHOR), Alexandrou, Andreas^1,5 (AUTHOR)

Source: International Journal of Molecular Sciences. Mar2025, Vol. 26 Issue 5, p2274. 18p.

Subject Terms: *PROGRAMMED cell death 1 receptors, *TOLL-like receptors, *LYMPHOCYTE count, *PROGRAMMED death-ligand 1, *LABORATORY mice

Therapeutic Effects of Alkaloids on Influenza: A Systematic Review and Meta-Analysis of Preclinical Studies.

Authors: Gong, Zhaoyuan¹ (AUTHOR), Hu, Mingzhi (AUTHOR), Zhao, Guozhen¹ (AUTHOR), Liang, Ning¹ (AUTHOR), Zhang, Haili¹ (AUTHOR), Li, Huizhen¹ (AUTHOR) heyitsokj@126.com, Che, Qianzi¹ (AUTHOR), Guo, Jing¹ (AUTHOR), Song, Tian¹ (AUTHOR), Wang, Yanping¹ (AUTHOR), Shi, Nannan (AUTHOR) shinannan@ccebtcm.org.cn, Liu, Bin (AUTHOR)

Source: International Journal of Molecular Sciences. Mar2025, Vol. 26 Issue 5, p1823. 22p.

Subject Terms: *TREATMENT effectiveness, *TOLL-like receptors, *ALKALOIDS, *BODY weight, *CELLULAR signal transduction

Utilizing the subtractive proteomics approach to design ensemble vaccine against Candida lusitaniae for immune response stimulation; a bioinformatics study.

Authors: Naz, Habiba¹ (AUTHOR), Timotheous, Rimsha¹ (AUTHOR), Sarwar, Muhammad Farhan¹ (AUTHOR) mf.sarwar13@gmail.com, Nadeem, Tariq² (AUTHOR), Awan, Mudassar Fareed¹ (AUTHOR), Ali, Sajed¹ (AUTHOR), Awais, Sophia³ (AUTHOR), Ahmed, Irfan⁴ (AUTHOR)

Source: PLoS ONE. 2/6/2025, Vol. 20 Issue 2, p1-34. 34p.

Subject Terms: *TOLL-like receptors, *VACCINE effectiveness, *HUMAN beings, *IMMUNE response, *STRUCTURAL models

Reduced Bone Quality of Sacrum and Lumbal Vertebrae Spongiosa in Toll-like Receptor 2- and Toll-like Receptor 4-Knockout Mice: A Blinded Micro-Computerized Analysis.

Authors: Roth, Kilian¹ (AUTHOR) kilian-roth@gmx.de, Pallua, Johannes Dominikus² (AUTHOR) johannes.pallua@i-med.ac.at, Degenhart, Gerald³ (AUTHOR) gerald.degenhart@i-med.ac.at, De Zordo, Tobias^4,5 (AUTHOR) tobias@de-zordo.net, Kremser, Christian⁴ (AUTHOR) christian.kremser@i-med.ac.at, Reif, Christian⁶ (AUTHOR) christian.reif@tirol-kliniken.at, Streif, Werner⁶ (AUTHOR) werner.streif@i-med.ac.at, Schirmer, Michael^1,7 (AUTHOR) schirmer.michael@icloud.com

Source: Biomolecules (2218-273X). Feb2025, Vol. 15 Issue 2, p239. 14p.

Subject Terms: *TOLL-like receptors, *LUMBAR vertebrae, *BONE remodeling, *CANCELLOUS bone, *SPONDYLOARTHROPATHIES, *SACRUM

TLR4 Inhibition Attenuated LPS‐Induced Proinflammatory Signaling and Cytokine Release in Mouse Hearts and Cardiomyocytes.

Authors: Wiger, Christine W.¹ (AUTHOR), Ranheim, Trine^2,3 (AUTHOR), Arnesen, Henriette¹ (AUTHOR), Vaage, Jarle^1,3,4 (AUTHOR), Pischke, Søren E.³ (AUTHOR), Yndestad, Arne^2,3 (AUTHOR), Stensløkken, Kåre‐Olav¹ (AUTHOR) k.o.stenslokken@medisin.uio.no, Torp, May‐Kristin^1,5 (AUTHOR)

Source: Immunity, Inflammation & Disease. Jan2025, Vol. 13 Issue 1, p1-11. 11p.

Subject Terms: *TOLL-like receptors, *CYTOKINES, *MYOCARDIAL reperfusion, *HEART development, *INHIBITION (Chemistry), *CYTOKINE release syndrome, *ENDOTOXINS

Immunostimulatory Effects of Guanine-Quadruplex Topologies as Scaffolds for CpG Oligodeoxynucleotides.

Authors: Pathak, Soumitra^1,2 (AUTHOR) pathak.soumitra@nims.go.jp, Le, Nguyen Bui Thao^1,2 (AUTHOR) jtef1940@tmd.ac.jp, Oyama, Taiji^3,4 (AUTHOR) ikebu@cc.tuat.ac.jp, Odahara, Yusuke⁵ (AUTHOR) s2220202@u.tsukuba.ac.jp, Momotake, Atsuya⁵ (AUTHOR) amomotak@chem.tsukuba.ac.jp, Ikebukuro, Kazunori⁴ (AUTHOR), Kataoka-Hamai, Chiho¹ (AUTHOR) kataoka.chiho@nims.go.jp, Yoshikawa, Chiaki^1,2 (AUTHOR) yoshikawa.chiaki@nims.go.jp, Kawakami, Kohsaku¹ (AUTHOR) kawakami.kohsaku@nims.go.jp, Kaizuka, Yoshihisa¹ (AUTHOR) kaizuka.yoshihisa@nims.go.jp, Yamazaki, Tomohiko^1,2 (AUTHOR) yamazaki.tomohiko@nims.go.jp

Source: Biomolecules (2218-273X). Jan2025, Vol. 15 Issue 1, p95. 16p.

Subject Terms: *CPG nucleotides, *TOLL-like receptors, *IMMUNE response, *CLINICAL medicine, *NUCLEASES

Role of Toll-like receptor 2 during infection of Leptospira spp: A systematic review.

Authors: Kappagoda, Chamila¹ (AUTHOR), Senavirathna, Indika² (AUTHOR), Agampodi, Thilini^1,3 (AUTHOR), Agampodi, Suneth Buddhika^3,4 (AUTHOR) sunethagampodi@yahoo.com

Source: PLoS ONE. 12/27/2024, Vol. 19 Issue 12, p1-22. 22p.

Subject Terms: *LEPTOSPIROSIS, *TOLL-like receptors, *REACTIVE nitrogen species, *IN vivo studies, *ANIMAL experimentation

TLR7 Promotes Acute Inflammatory-Driven Lung Dysfunction in Influenza-Infected Mice but Prevents Late Airway Hyperresponsiveness.

Authors: Miles, Mark A.¹ (AUTHOR) mark.miles@rmit.edu.au, Liong, Stella¹ (AUTHOR) stella.liong@rmit.edu.au, Liong, Felicia¹ (AUTHOR) felicia.liong@rmit.edu.au, Trollope, Gemma S.¹ (AUTHOR) gemma.trollope@rmit.edu.au, Wang, Hao¹ (AUTHOR) hao.wang@rmit.edu.au, Brooks, Robert D.² (AUTHOR) robbrooksbd@gmail.com, Bozinovski, Steven¹ (AUTHOR) steven.bozinovski@rmit.edu.au, O'Leary, John J.^3,4 (AUTHOR), Brooks, Doug A.² (AUTHOR) doug.brooks@unisa.edu.au, Selemidis, Stavros¹ (AUTHOR) stavros.selemidis@rmit.edu.au

Source: International Journal of Molecular Sciences. Dec2024, Vol. 25 Issue 24, p13699. 20p.

Subject Terms: *CYTOTOXIC T cells, *TOLL-like receptors, *RESPIRATORY diseases, *INFLUENZA A virus, *PNEUMONIA

Aged Garlic Extract (AGE) and Its Constituent S-Allyl-Cysteine (SAC) Inhibit the Expression of Pro-Inflammatory Genes Induced in Bronchial Epithelial IB3-1 Cells by Exposure to the SARS-CoV-2 Spike Protein and the BNT162b2 Vaccine.

Authors: Gasparello, Jessica¹ (AUTHOR) jessica.gasparello@gmail.com, Papi, Chiara¹ (AUTHOR) chiara.papi@unife.it, Marzaro, Giovanni² (AUTHOR) giovanni.marzaro@univr.it, Macone, Alberto³ (AUTHOR) alberto.macone@uniroma1.it, Zurlo, Matteo¹ (AUTHOR) matteo.zurlo@unife.it, Finotti, Alessia¹ (AUTHOR) alessia.finotti@unife.it, Agostinelli, Enzo^4,5 (AUTHOR) enzo.agostinelli@uniroma1.it, Gambari, Roberto¹ (AUTHOR) enzo.agostinelli@uniroma1.it

Source: Molecules. Dec2024, Vol. 29 Issue 24, p5938. 19p.

Subject Terms: *GARLIC, *TOLL-like receptors, *EPITHELIAL cells, *VITRONECTIN, *TRADITIONAL medicine

TLR4-dependent neuroinflammation mediates LPS-driven food-reward alterations during high-fat exposure.

Authors: Huwart, Sabrina J. P.^1,2 (AUTHOR), Fayt, Clémence^1,2 (AUTHOR), Gangarossa, Giuseppe^3,4 (AUTHOR), Luquet, Serge³ (AUTHOR), Cani, Patrice D.^1,2,5 (AUTHOR), Everard, Amandine^1,2 (AUTHOR) amandine.everard@uclouvain.be

Source: Journal of Neuroinflammation. 11/23/2024, Vol. 21 Issue 1, p1-14. 14p.

Subject Terms: *REWARD (Psychology), *TOLL-like receptors, *DOPAMINE receptors, *GUT microbiome, *EATING disorders

VBNC Cronobacter sakazakii survives in macrophages by resisting oxidative stress and evading recognition by macrophages.

Authors: Liu, Yuanyuan¹ (AUTHOR), Zhang, Jingfeng¹ (AUTHOR), Zhao, Haoqing¹ (AUTHOR), Zhong, Feifeng¹ (AUTHOR), Li, Jianyu¹ (AUTHOR), Zhao, Lichao¹ (AUTHOR) zlc@scau.edu.cn

Source: BMC Microbiology. 11/6/2024, Vol. 24 Issue 1, p1-11. 11p.

Subject Terms: *TOLL-like receptors, *IMMUNE recognition, *ELLAGIC acid, *CRONOBACTER, *MACROPHAGES

The Role of Neuroinflammation in Shaping Neuroplasticity and Recovery Outcomes Following Traumatic Brain Injury: A Systematic Review.

Authors: Calderone, Andrea¹ (AUTHOR) andrea.calderone95@gmail.com, Latella, Desirèe² (AUTHOR) desiree.latella@irccsme.it, Cardile, Davide² (AUTHOR) davide.cardile@irccsme.it, Gangemi, Antonio² (AUTHOR) antonio.gangemi@irccsme.it, Corallo, Francesco² (AUTHOR) francesco.corallo@irccsme.it, Rifici, Carmela² (AUTHOR) carmela.rifici@irccsme.it, Quartarone, Angelo² (AUTHOR) angelo.quartarone@irccsme.it, Calabrò, Rocco Salvatore² (AUTHOR) roccos.calabro@irccsme.it

Source: International Journal of Molecular Sciences. Nov2024, Vol. 25 Issue 21, p11708. 19p.

Subject Terms: *BRAIN injuries, *TOLL-like receptors, *PYRIN (Protein), *DRUG therapy, *NEUROREHABILITATION

Gestational Diabetes Mellitus-Induced Inflammation in the Placenta via IL-1β and Toll-like Receptor Pathways.

Authors: Zgutka, Katarzyna¹ (AUTHOR), Tkacz, Marta¹ (AUTHOR), Tomasiak, Patrycja² (AUTHOR), Piotrowska, Katarzyna³ (AUTHOR), Ustianowski, Przemysław⁴ (AUTHOR), Pawlik, Andrzej³ (AUTHOR), Tarnowski, Maciej¹ (AUTHOR) maciejt@pum.edu.pl

Source: International Journal of Molecular Sciences. Nov2024, Vol. 25 Issue 21, p11409. 15p.

Subject Terms: *GESTATIONAL diabetes, *TOLL-like receptors, *BLOOD plasma, *MATERNAL health, *INSULIN resistance

Transcriptomic analysis of spleen-derived macrophages in response to lipopolysaccharide shows dependency on the MyD88-independent pathway in Chinese giant salamanders (Andrias davidianus).

Authors: Deng, Jie¹ (AUTHOR), Han, Mengdi² (AUTHOR), Gong, Jingyu² (AUTHOR), Ma, Hongying¹ (AUTHOR), Hao, Yinting² (AUTHOR), Fang, Cheng¹ (AUTHOR), Zhang, Han¹ (AUTHOR), Li, Jia² (AUTHOR), Jiang, Wei¹ (AUTHOR) jiangwei197981@ms.xab.ac.cn

Source: BMC Genomics. 10/28/2024, Vol. 25 Issue 1, p1-12. 12p.

Subject Terms: *DENSITY gradient centrifugation, *TOLL-like receptors, *GRAM-negative bacteria, *ADAPTOR proteins, *MACROPHAGE activation, *TRANSFORMING growth factors, *MYELOID differentiation factor 88

Immunological Strategies in Gastric Cancer: How Toll-like Receptors 2, -3, -4, and -9 on Monocytes and Dendritic Cells Depend on Patient Factors?

Authors: Kos, Marek¹ (AUTHOR) marek.kos@umlub.pl, Bojarski, Krzysztof² (AUTHOR) k.bojarski@szpital.leczna.pl, Mertowska, Paulina³ (AUTHOR) paulina.mertowska@umlub.pl, Mertowski, Sebastian³ (AUTHOR) ewelina.grywalska@umlub.pl, Tomaka, Piotr⁴ (AUTHOR) p.tomaka@szpital.leczna.pl, Dziki, Łukasz⁵ (AUTHOR) lukasz.dziki@umed.lodz.pl, Grywalska, Ewelina³ (AUTHOR)

Source: Cells (2073-4409). Oct2024, Vol. 13 Issue 20, p1708. 29p.

Subject Terms: *TOLL-like receptors, *DENDRITIC cells, *STOMACH cancer, *IMMUNE response, *CANCER invasiveness

Allelic, Genotypic, and Haplotypic Analysis of Cytokine IL17A, IL17F, and Toll-like Receptor TLR4 Gene Polymorphisms in Metabolic-Dysfunction-Associated Steatotic Liver Disease: Insights from an Exploratory Study.

Authors: Coste, Sorina-Cezara¹ (AUTHOR) secara.sorina@umfcluj.ro, Hilda Orășan, Olga¹ (AUTHOR) hilda.orasan@umfcluj.ro, Cozma, Angela¹ (AUTHOR) angelacozma@umfcluj.ro, Negrean, Vasile¹ (AUTHOR) vasile.negrean@umfcluj.ro, Alexescu, Teodora Gabriela¹ (AUTHOR) teodora.alexescu@umfcluj.ro, Perne, Mirela Georgiana¹ (AUTHOR) alb.mirela@umfcluj.ro, Ciulei, George¹ (AUTHOR) george.ciulei@umfcluj.ro, Hangan, Adriana Corina² (AUTHOR) adriana.hangan@umfcluj.ro, Lucaciu, Roxana Liana³ (AUTHOR) liana.lucaciu@umfcluj.ro, Iancu, Mihaela⁴ (AUTHOR) miancu@umfcluj.ro, Procopciuc, Lucia-Maria⁵ (AUTHOR) lprocopciuc@umfcluj.ro

Source: Life (2075-1729). Oct2024, Vol. 14 Issue 10, p1327. 20p.

Subject Terms: *INTERLEUKIN-17, *TOLL-like receptors, *GENETIC polymorphisms, *GENOTYPES, *ALLELES

Rheum ribes Uygulamasının Diyabetik Ratların Karaciğer ve Böbreklerinde TLR2 ve TLR4'ün İmmunohistokimyasal Lokalizasyonu Üzerine Etkisi.

Alternate Title: Effect of Rheum ribes Application on Immunohistochemical Localizations of TLR2 and TLR4 in the Liver and Kidneys of Diabetic Rats.

Authors: AKGÜN, Ayhan¹ ayhan.akgun@igdir.edu.tr, DEPREM, Turgay²

Source: Journal of Faculty of Veterinary Medicine, Erciyes University / Erciyes Üniversitesi Veteriner Fakültesi Dergisi. 2024, Vol. 21 Issue 3, p148-154. 7p.

Subject Terms: *TOLL-like receptors, *LIVER cells, *PEOPLE with diabetes, *DIABETES, *KIDNEYS

Mastitis Pathogens Mannheimia haemolytica , Staphylococcus aureus , and Streptococcus uberis Selectively Alter TLR Gene Transcription in Sheep Mammary Epithelial Cells.

Authors: Tassi, Riccardo¹ (AUTHOR) helen.todd@moredun.ac.uk, Todd, Helen¹ (AUTHOR), Ballingall, Keith T.¹ (AUTHOR) keith.ballingall@moredun.ac.uk

Source: Microbiology Research. Sep2024, Vol. 15 Issue 3, p1772-1783. 12p.

Subject Terms: *GENETIC transcription, *TOLL-like receptors, *EPITHELIAL cells, *GENE expression, *BACTERIAL diseases, *MAMMARY glands, *MANNHEIMIA haemolytica

Modulation of the Toll-like Receptor 3-Mediated Intestinal Immune Response by Water Kefir.

Authors: Dentice Maidana, Stefania¹ (AUTHOR) stefi.dentice@gmail.com, Ortiz Moyano, Ramiro¹ (AUTHOR) rortiz@cerela.org.ar, Elean, Mariano¹ (AUTHOR) melean@cerela.org.ar, Imamura, Yoshiya^2,3 (AUTHOR) yoshiya.imamura.p8@dc.tohoku.ac.jp, Albarracín, Leonardo¹ (AUTHOR) lalbarracin@herrera.unt.edu.ar, Namai, Fu^2,3 (AUTHOR) fu.namai.a3@tohoku.ac.jp, Suda, Yoshihito⁴ (AUTHOR) suda@myu.ac.jp, Nishiyama, Keita^2,3 (AUTHOR) keita.nishiyama.a6@tohoku.ac.jp, Villena, Julio^1,2 (AUTHOR) jcvillena@cerela.org.ar, Kitazawa, Haruki^2,3 (AUTHOR) jcvillena@cerela.org.ar

Source: Microbiology Research. Sep2024, Vol. 15 Issue 3, p1239-1250. 12p.

Subject Terms: *TOLL-like receptors, *INTRAPERITONEAL injections, *KEFIR, *NATURAL immunity, *DRINKING water

Pulmonary Administration of TLR2/6 Agonist after Allergic Sensitization Inhibits Airway Hyper-Responsiveness and Recruits Natural Killer Cells in Lung Parenchyma.

Authors: Devulder, Justine¹ (AUTHOR) j.devulder@imperial.ac.uk, Barrier, Mathieu¹ (AUTHOR) anne.tsicopoulos@pasteur-lille.fr, Carrard, Julie¹ (AUTHOR) patricia.de-nadai@pasteur-lille.fr, Amniai, Latiffa¹ (AUTHOR), Plé, Coline¹ (AUTHOR), Marquillies, Philippe¹ (AUTHOR), Ledroit, Valérie¹ (AUTHOR), Ryffel, Bernhard² (AUTHOR) bernhard.ryffel@cnrs-orleans.fr, Tsicopoulos, Anne¹ (AUTHOR), de Nadai, Patricia¹ (AUTHOR), Duez, Catherine¹ (AUTHOR) catherine.duez@inserm.fr

Source: International Journal of Molecular Sciences. Sep2024, Vol. 25 Issue 17, p9606. 19p.

Subject Terms: *CELL physiology, *TOLL-like receptors, *LUNG diseases, *IMMUNE system, *MUCUS