A comprehensive overview of recent advances in generative models for antibodies

Authors: Fanxu Meng, Na Zhou, Guangchun Hu, Ruotong Liu, Yuanyuan Zhang, Ming Jing, Qingzhen Hou

Source: Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 2648-2660 (2024)

Subject Terms: Antibody generative model, Therapeutic antibody, Deep learning, Protein sequence, Protein structure, Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2001037024002150; https://doaj.org/toc/2001-0370

Access URL: https://doaj.org/article/78ec974f94564acbad066965e6836843

Fusing a Novel Anti-CTLA-4 Nanobody to the IgG1 Fc Region Strengthens Its Ability to Induce CD8+ T Cell-Mediated Immune Responses Against Solid Tumors

Authors: Li TT, Yang JH, Jiang MJ, Cui HP, Yang XM, Lu XL, Liu AQ

Source: International Journal of Nanomedicine, Vol Volume 19, Pp 12311-12321 (2024)

Subject Terms: nanobody, ctla-4, therapeutic antibody derivative, cell fusion, adoptive immunotherapy, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.dovepress.com/fusing-a-novel-anti-ctla-4-nanobody-to-the-igg1-fc-region-strengthens--peer-reviewed-fulltext-article-IJN; https://doaj.org/toc/1178-2013

Access URL: https://doaj.org/article/04758f093c6a4869b5112b2c99ae7c3f

Novel CXCR2 antibodies exhibit enhanced anti-tumor activity in pancreatic cancer

Authors: Rahimizadeh, Parastou, Kim, Seheon, Yoon, Byeong Jun, Jeong, Younsik, Lim, Seoyoen, Jeon, Hyeyoon, Lim, Hyung Jin, Park, Sang Ho, Park, Sang-In, Kong, Deok-Hoon, Park, Jeong-Ran, Song, Yong Bhum ^⁎

Source: In Biomedicine & Pharmacotherapy April 2025 185

A simple LC-MS/MS assay for the quantification of E6011, a novel anti-fractalkine monoclonal antibody, in cynomolgus monkey serum - comparison with ligand binding assay

Authors: Kita, Kenji ^a, Ono, Haruna ^a, Kojima, Tomoko ^a, Mano, Yuji ^{b, c, ⁎}

Source: In Journal of Pharmaceutical and Biomedical Analysis 15 March 2025 255

Pharmacological blocking of microfibrillar-associated protein 4 reduces retinal neoangiogenesis and vascular leakage

Authors: Schlosser, Anders ¹, Pilecki, Bartosz ¹, Allen, Claire ², Benest, Andrew V. ², Lynch, Amy P. ², Hua, Jing ², Ved, Nikita ², Blackley, Zoe ², Andersen, Thomas L. ^{3, 4, 5}, Hennig, Dorle ¹, Graversen, Jonas H. ¹, Möller, Sören ⁶, Skallerup, Sofie ¹, Ormhøj, Maria ¹, Lange, Clemens ^{7, 8}, Agostini, Hansjürgen T. ⁸, Grauslund, Jakob ⁹, Heegaard, Steffen ^{10, 11}, Dacheva, Ivanka ¹², Koss, Michael ¹², Hu, Wenzheng ¹³, Iglesias, Bibiana ¹³, Lawrence, Matthew S. ¹³, Beck, Hans Christian ¹⁴, Steffensen, Lasse Bach ¹, Laursen, Nick S. ¹⁵, Andersen, Gregers R. ¹⁵, Holmskov, Uffe ¹, Bates, David O. ², Sorensen, Grith L. ^{1, ∗}

Source: In Molecular Therapy 5 March 2025 33(3):1048-1072

Predicting deamidation and isomerization sites in therapeutic antibodies using structure-based in silico approaches

Authors: David Hoffmann, Joschka Bauer, Markus Kossner, Andrew Henry, Anne R. Karow-Zwick, Giuseppe Licari

Source: mAbs, Vol 16, Iss 1 (2024)

Subject Terms: Deamidation, developability, in silico methods, isomerization, quantitative structure-activity relationship, therapeutic antibody, Therapeutics. Pharmacology, RM1-950, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://doaj.org/toc/1942-0862; https://doaj.org/toc/1942-0870

Access URL: https://doaj.org/article/3c09ebb50b6e4afeb85adac939a9278e

TCR-like bispecific antibodies toward eliminating infected hepatocytes in HBV mouse models

Authors: Yang Shi, Zihan Wang, Jingjing Xu, Wenxia Niu, Yubin Wu, Huiyu Guo, Jinmiao Shi, Zonglin Li, Baorong Fu, Yunda Hong, Zikang Wang, Wenjie Guo, Dabing Chen, Xingling Li, Qian Li, Shaojuan Wang, Jiahua Gao, Aling Sun, Yaosheng Xiao, Jiali Cao, Lijuan Fu, Yangtao Wu, Tianying Zhang, Ningshao Xia, Quan Yuan

Source: Emerging Microbes and Infections, Vol 13, Iss 1 (2024)

Subject Terms: Hepatitis B virus, TCR-like antibody, bispecific antibody, therapeutic antibody, HBsAg suppression, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2222-1751

Access URL: https://doaj.org/article/18b931e271c3464da761aa50c7b8336b

Synergy between Lactobacillus murinus and anti-PcrV antibody delivered in the airways to boost protection against Pseudomonas aeruginosa

Authors: Thomas Sécher, Mélanie Cortes, Chloé Boisseau, Marie-Thérèse Barba Goudiaby, Aubin Pitiot, Christelle Parent, Muriel Thomas, Nathalie Heuzé-Vourc’h

Source: Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 4, Pp 101330- (2024)

Subject Terms: P. aeruginosa, pneumonia, probiotic, airway delivery, therapeutic antibody, Genetics, QH426-470, Cytology, QH573-671

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2329050124001463; https://doaj.org/toc/2329-0501

Access URL: https://doaj.org/article/f1c3bfbcfcf040ff95e275b228a240ef

Systematic analysis of Fc mutations designed to enhance binding to Fc-gamma receptors

Authors: Geoff Hale, Alastair Douglas Davy, Ian Wilkinson

Source: mAbs, Vol 16, Iss 1 (2024)

Subject Terms: DSF, Fc region, Fc receptor, therapeutic antibody, antibody engineering, FcγRI, Therapeutics. Pharmacology, RM1-950, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://doaj.org/toc/1942-0862; https://doaj.org/toc/1942-0870

Access URL: https://doaj.org/article/510b104248724183bfa4bd7e26ced614

Systematic analysis of Fc mutations designed to reduce binding to Fc-gamma receptors

Authors: Geoff Hale, Jelle De Vos, Alastair Douglas Davy, Koen Sandra, Ian Wilkinson

Source: mAbs, Vol 16, Iss 1 (2024)

Subject Terms: DSF, Fc region, Fc receptor, Fc silent, therapeutic antibody, antibody engineering, Therapeutics. Pharmacology, RM1-950, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://doaj.org/toc/1942-0862; https://doaj.org/toc/1942-0870

Access URL: https://doaj.org/article/62ff2163c22f4831b54f543b2073ecdf

Development of Fully Human Antibodies Targeting SIRPα and PLA2G7 for Cancer Therapy

Authors: Seungmin Shin, Du-San Baek, John W. Mellors, Dimiter S. Dimitrov, Wei Li

Source: Antibodies, Vol 14, Iss 1, p 21 (2025)

Subject Terms: therapeutic antibody, human SIRPα, human PLA2G7, cancer, inflammatory disorders, cardiovascular diseases, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4468/14/1/21; https://doaj.org/toc/2073-4468

Access URL: https://doaj.org/article/c981960b76154565a4c9d9267332ac98

Inhaled Treatment of Respiratory Infections

Contributors: Kwok, Philip Chi Lip, Chow, Michael

Subject Terms: phage therapy, spray drying, bacterial lung infections, environmental humidity, aerosol performance, inhalation, hydroxychloroquine, coronavirus disease 2019 (COVID-19), vibrating mesh nebuliser, aerosol, droplet, packing density, product density, small porous particles, corrugated particles, angiotensin-(1–7), Mycoplasma pneumoniae, asthma, inflammation, macrophages, capreomycin, dry powder aerosol, pulmonary delivery, tuberculosis, antifungal drugs, invasive fungal disease, animal model, antifungal prophylaxis, therapeutic antibody, aggregates, immunogenicity, polymeric micelles, Soluplus®, rifampicin, curcumin, inhalable nanoformulation, active drug targeting, Mycobacterium tuberculosis, dry powder inhaler, immune regulation, isoniazid, mannose conjugation, macrophage phenotype, next-generation impactor, nasal spray, liquid film translocation, supine position, wall liquid-holding capacity, nasopharynx, mucosal immunization, drug combination, inhalable dry powders, resistance development, synergistic effect, cyclosporine-A, spray-drying, SARS-CoV-2, cytokine storm, transplant rejection, ARDS, COVID-19, C-ARDS, plasminogen, lung in vitro model, immunomodulating activity, Psychopharmacology

File Description: application/octet-stream

Access URL: https://directory.doabooks.org/handle/20.500.12854/137582
https://mdpi.com/books/pdfview/book/8767

Molecular mechanisms of avian immunoglobulin gene diversification and prospect for industrial applications

Authors: Hidetaka Seo, Kouji Hirota, Kunihiro Ohta

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: gene conversion, somatic hypermutation, homologous recombination, DNA damage tolerance, monoclonal antibody, therapeutic antibody, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1453833/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/822c1d7dd5214b5b945a9f3543d5e567

Recent approaches of antibody therapeutics in androgenetic alopecia

Authors: Su-Eon Jin, Jino Kim, Jong-Hyuk Sung

Source: Frontiers in Pharmacology, Vol 15 (2024)

Subject Terms: androgenetic alopecia, therapeutic antibody, prolactin receptor, interleukin-6 receptor, C-X-C motif chemokine ligand 12, dickkopf 1, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2024.1434961/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/bba5365674bc4ec99d89fa1a6ba7d62f

Enhanced therapeutic potential of antibody fragment via IEDDA-mediated site-specific albumin conjugation

Authors: Eun Byeol Go, Jae Hun Lee, Jeong Haeng Cho, Na Hyun Kwon, Jong-il Choi, Inchan Kwon

Source: Journal of Biological Engineering, Vol 18, Iss 1, Pp 1-12 (2024)

Subject Terms: Single-chain variable fragment, Therapeutic antibody, Human serum albumin, Site-specific conjugation, Half-life extension, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1754-1611

Access URL: https://doaj.org/article/f6190c0324714d5ab25c6d715ffe904d

Monitoring M-Protein, Therapeutic Antibodies, and Polyclonal Antibodies in a Multiparametric Mass Spectrometry Assay Provides Insight into Therapy Response Kinetics in Patients with Multiple Myeloma

Authors: Charissa Wijnands, Peter G. A. Karel, Jolein Gloerich, Gad Armony, Anastasia Tzasta, Corrie M. de Kat Angelino, Luciano Di Stefano, Vincent Bonifay, Theo M. Luider, Martijn M. VanDuijn, Sandra J. Croockewit, Elizabeth A. de Kort, Daan A. R. Castelijn, Claudia A. M. Stege, Hans J. C. T. Wessels, Alain J. van Gool, Niels W. C. J. van de Donk, Joannes F. M. Jacobs

Source: Pharmaceutics, Vol 17, Iss 1, p 135 (2025)

Subject Terms: multiple myeloma, therapeutic drug monitoring, minimal residual disease, therapy response kinetics, therapeutic antibody, bispecific antibody, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/17/1/135; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/cab40b0cc8c5402e8115fcf34fba0341

Development of Effective Medical Countermeasures Against the Main Biowarfare Agents: The Importance of Antibodies

Authors: Arnaud Avril, Sophie Guillier, Christine Rasetti-Escargueil

Source: Microorganisms, Vol 12, Iss 12, p 2622 (2024)

Subject Terms: medical countermeasure, biodefense, botulinum neurotoxins (BoNTs), antitoxin, antibodies, therapeutic antibody, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2076-2607/12/12/2622; https://doaj.org/toc/2076-2607

Access URL: https://doaj.org/article/b8d18c4a277d40ec8326e01ae2b1a9a7

A non-human primate derived anti-P-selectin glycoprotein ligand-1 antibody curtails acute pancreatitis by alleviating the inflammatory responses

Authors: Yuhan Li, Xiangqing Ding, Xianxian Wu, Longfei Ding, Yuhui Yang, Xiaoliang Jiang, Xing Liu, Xu Zhang, Jianrong Su, Jianqing Xu, Zhiwei Yang

Source: Acta Pharmaceutica Sinica B, Vol 13, Iss 11, Pp 4461-4476 (2023)

Subject Terms: Acute pancreatitis, PSGL-1, Non-human primate, Monoclonal antibody, Therapeutic antibody RH001-6, Adhesion of leukocytes to endothelial cells, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211383523002903; https://doaj.org/toc/2211-3835

Access URL: https://doaj.org/article/fd8b87e6c0f5485d83787337d19a5afc

Immune-based, multifaceted inactivation of pathogenic T lymphocytes in treating autoimmune diseases

Authors: Victor Ivanovich Seledtsov, Galina V. Seledtsova, Alexei A. von Delwig

Source: Exploration of Immunology, Vol 3, Iss 5, Pp 506-512 (2023)

Subject Terms: autoimmune disease, memory t-cell, t-cell vaccination, therapeutic antibody, oral immunotherapy, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.explorationpub.com/Journals/ei/Article/1003117; https://doaj.org/toc/2768-6655

Access URL: https://doaj.org/article/d9b5aac3bdc04ce98636de516656ca77

Hypoxia‐activated ADCC‐enhanced humanized anti‐CD147 antibody for liver cancer imaging and targeted therapy with improved selectivity

Authors: Fang‐Zheng Qi, Hui‐Shan Su, Bo Wang, Luo‐Meng Qian, Yang Wang, Chen‐Hui Wang, Ya‐Xin Hou, Ping Chen, Qing Zhang, Dong‐Mei Li, Hao Tang, Jian‐Li Jiang, Hui‐Jie Bian, Zhi‐Nan Chen, Si‐He Zhang

Source: MedComm, Vol 5, Iss 3, Pp n/a-n/a (2024)

Subject Terms: cluster of differentiation 147, hypoxia activation, liver cancer, on‐target off‐tumor toxicity, therapeutic antibody, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2688-2663

Access URL: https://doaj.org/article/ebc7e3f5a09f438d88815a172b1fdfa3