Endothelin-1 as a Candidate Biomarker of Systemic Sclerosis: A GRADE-Assessed Systematic Review and Meta-Analysis With Meta-Regression.

Authors: Mangoni, Arduino A^1,2 (AUTHOR) arduino.mangoni@flinders.edu.au, Zinellu, Angelo³ (AUTHOR)

Source: Biomarker Insights. 2/21/2025, p1-15. 15p.

Subject Terms: *PULMONARY arterial hypertension, *SYSTEMIC scleroderma, *INTERSTITIAL lung diseases, *PREPROENDOTHELIN, *DATABASE searching, *LUNGS

An updated overview of Juvenile systemic sclerosis in a French cohort.

Authors: Jacquel, Léa^1,2 (AUTHOR) l.jacquel2@chru-nancy.fr, Bechara, Rouba² (AUTHOR), Terzic, Joëlle² (AUTHOR), Rameau, Anne-Cécile³ (AUTHOR), Chatelus, Emmanuel⁴ (AUTHOR), Rossi-Semerano, Linda⁵ (AUTHOR), Kone-Paut, Isabelle⁵ (AUTHOR), Meinzer, Ulrich⁶ (AUTHOR), Lemelle, Irène⁷ (AUTHOR), Rebelle, Charlotte⁸ (AUTHOR), Urbina, Diego⁹ (AUTHOR), Pillet, Pascal¹⁰ (AUTHOR), Choquet, Pauline¹¹ (AUTHOR), El Maamari, Jad¹² (AUTHOR), Zaloszyc, Ariane² (AUTHOR)

Source: Pediatric Rheumatology. 2/8/2025, Vol. 23 Issue 1, p1-9. 9p.

Subject Terms: *RAYNAUD'S disease, *SYSTEMIC scleroderma, *MEDICAL sciences, *AGE of onset, *ANTINUCLEAR factors

Cardiac Morpho-Functional Changes, Inflammation and Fibrosis in Systemic Sclerosis—A Pilot Study of a Tertiary Center Cohort.

Authors: Dorniak, Karolina¹ (AUTHOR) kdorniak@gumed.edu.pl, Gogulska, Zuzanna² (AUTHOR), Viti, Alessandro³ (AUTHOR), Glińska, Anna⁴ (AUTHOR), Kulawiak-Gałąska, Dorota⁵ (AUTHOR), Fijałkowska, Jadwiga⁴ (AUTHOR), Wojteczek, Anna² (AUTHOR), Wojtowicz, Dagmara¹ (AUTHOR), Sienkiewicz, Katarzyna⁴ (AUTHOR), Hellmann, Marcin¹ (AUTHOR), Smoleńska, Żaneta² (AUTHOR)

Source: Diagnostics (2075-4418). Feb2025, Vol. 15 Issue 3, p393. 9p.

Subject Terms: *CARDIAC magnetic resonance imaging, *SYSTEMIC scleroderma, *ECHOCARDIOGRAPHY, *EARLY diagnosis, *SYMPTOMS

CCL24 and Fibrosis: A Narrative Review of Existing Evidence and Mechanisms.

Authors: Greenman, Raanan¹ (AUTHOR) raanan.greenman@chemomab.com, Weston, Chris J.^2,3 (AUTHOR)

Source: Cells (2073-4409). Jan2025, Vol. 14 Issue 2, p105. 16p.

Subject Terms: *SYSTEMIC scleroderma, *EXTRACELLULAR matrix, *EPITHELIAL cells, *CHRONIC wounds & injuries, *WOUND healing

Lack of association of the PLD4 SNP rs2841277 with systemic sclerosis in a European American population.

Authors: Ma, Yunqing¹ (AUTHOR), Mayes, Maureen D.² (AUTHOR), Guo, Xinjian² (AUTHOR), Assassi, Shervin² (AUTHOR), Zhou, Xiaodong² (AUTHOR) zhouxd@hotmail.com

Source: Scientific Reports. 12/28/2024, Vol. 14 Issue 1, p1-5. 5p.

Subject Terms: *JAPANESE people, *SYSTEMIC scleroderma, *ASIANS, *SINGLE nucleotide polymorphisms, *AMERICANS

The Efficacy and Tolerability of Prostaglandin Analogues in Treating Systemic Sclerosis‐Associated Raynaud Phenomenon: A Systematic Review and Meta‐Analysis.

Authors: Alahmari, Hana^1,2,3 (AUTHOR) drhana.s@hotmail.com, Jazayeri, Hila² (AUTHOR), Johnson, Sindhu R.^2,3 (AUTHOR), Pal, Rishi (AUTHOR) rishipal@kgmcindia.edu

Source: International Journal of Rheumatology. 12/23/2024, Vol. 2024, p1-17. 17p.

Subject Terms: *RAYNAUD'S disease, *SYSTEMIC scleroderma, *CAPILLARY flow, *BLOOD flow, *HEALING

Analysis of hsa_circ_0136256 as a biomarker for fibrosis in systemic sclerosis.

Authors: Sun, Xiaolin^1,2,3 (AUTHOR), Wang, Baoyue⁴ (AUTHOR), Ding, Lili⁴ (AUTHOR), Wang, Yongfu⁴ (AUTHOR) wyf18686198868@163.com, Xu, Mingguo^1,2,3 (AUTHOR) 18938690175@163.com

Source: BMC Biotechnology. 11/13/2024, Vol. 24 Issue 1, p1-15. 15p.

Subject Terms: *MONONUCLEAR leukocytes, *SYSTEMIC scleroderma, *MTOR protein, *CIRCULAR RNA, *NUCLEOTIDE sequencing

Explainable fully automated CT scoring of interstitial lung disease for patients suspected of systemic sclerosis by cascaded regression neural networks and its comparison with experts.

Authors: Jia, Jingnan¹ (AUTHOR), Hernández-Girón, Irene¹ (AUTHOR), Schouffoer, Anne A.² (AUTHOR), de Vries-Bouwstra, Jeska K.² (AUTHOR), Ninaber, Maarten K.³ (AUTHOR), Korving, Julie C.⁴ (AUTHOR), Staring, Marius¹ (AUTHOR), Kroft, Lucia J. M.⁴ (AUTHOR), Stoel, Berend C.¹ (AUTHOR) b.c.stoel@lumc.nl

Source: Scientific Reports. 11/4/2024, Vol. 14 Issue 1, p1-16. 16p.

Subject Terms: *INTERSTITIAL lung diseases, *SYSTEMIC scleroderma, *DEEP learning, *COMPUTED tomography, *QUANTITATIVE research, *LUNGS

Salirasib Inhibits the Expression of Genes Involved in Fibrosis in Fibroblasts of Systemic Sclerosis Patients.

Authors: Sadeghi Shaker, Mina^1,2 (AUTHOR), Rokni, Mohsen^1,2,3 (AUTHOR), Kavosi, Hoda^2,4 (AUTHOR), Enayati, Samaneh² (AUTHOR), Madreseh, Elham^2,5 (AUTHOR), Mahmoudi, Mahdi^2,4 (AUTHOR), Farhadi, Elham^2,4 (AUTHOR) farhadie@tums.ac.ir, Vodjgani, Mohammad¹ (AUTHOR) vojganim@tums.ac.ir

Source: Immunity, Inflammation & Disease. Nov2024, Vol. 12 Issue 11, p1-10. 10p.

Subject Terms: *SYSTEMIC scleroderma, *GENE expression, *EXTRACELLULAR matrix, *PROTEIN expression, *MATRIX metalloproteinases

Radiation-induced morphea of the breast – characterization and treatment of fibroblast dysfunction with repurposed mesalazine.

Authors: Künzel, Stephan R.^1,2,3,4 (AUTHOR) stephan.kuenzel@tu-dresden.de, Klapproth, Erik¹ (AUTHOR), Zimmermann, Nick³ (AUTHOR), Kämmerer, Susanne¹ (AUTHOR), Schubert, Mario¹ (AUTHOR), Künzel, Karolina¹ (AUTHOR), Hoffmann, Maximilian¹ (AUTHOR), Drukewitz, Stephan^5,6 (AUTHOR), Vehlow, Anne^7,8 (AUTHOR), Eitler, Jiri⁴ (AUTHOR), Arriens, Marieke⁴ (AUTHOR), Thiel, Jessica⁴ (AUTHOR), Kronstein-Wiedemann, Romy⁴ (AUTHOR), Tietze, Maximiliane⁴ (AUTHOR), Beissert, Stefan³ (AUTHOR), Renner, Bertold² (AUTHOR), El-Armouche, Ali^1,2 (AUTHOR), Günther, Claudia³ (AUTHOR) claudia.guenther@ukdd.de

Source: Scientific Reports. 10/30/2024, Vol. 14 Issue 1, p1-17. 17p.

Subject Terms: *SYSTEMIC scleroderma, *RADIOTHERAPY complications, *DRUG repositioning, *RNA sequencing, *MESALAMINE, *BREAST, *HYPERTROPHIC scars

Comparative transcriptomic analysis validates iPSC derived in-vitro progressive fibrosis model as a screening tool for drug discovery and development in systemic sclerosis.

Authors: Nathan, Shyam¹ (AUTHOR), Wang, Yifei¹ (AUTHOR), D'ambrosio, Matthew² (AUTHOR), Paul, Reeba² (AUTHOR), Lyu, Huimin² (AUTHOR), Delic, Denis³ (AUTHOR), Bretschneider, Tom⁴ (AUTHOR), Falana, Kimberly¹ (AUTHOR), Li, Li² (AUTHOR) frank.li@boehringer-ingelheim.com, Vijayaraj, Preethi¹ (AUTHOR) preethi.vijayaraj@boehringer-ingelheim.com

Source: Scientific Reports. 10/18/2024, Vol. 14 Issue 1, p1-14. 14p.

Subject Terms: *SYSTEMIC scleroderma, *PLURIPOTENT stem cells, *GENE expression, *DRUG discovery, *WOUND healing

An overview of the role of chemokine CX3CL1 (Fractalkine) and CX3C chemokine receptor 1 in systemic sclerosis.

Authors: Pezeshkian, Fatemehsadat¹ (AUTHOR), Shahriarirad, Reza² (AUTHOR), Mahram, Hadiseh¹ (AUTHOR) hadisemahram@gmail.com

Source: Immunity, Inflammation & Disease. Oct2024, Vol. 12 Issue 10, p1-13. 13p.

Subject Terms: *SCLERODERMA (Disease), *SYSTEMIC scleroderma, *RHEUMATISM, *INTERSTITIAL lung diseases, *CHEMOKINE receptors

Nipping ageing in the bud.

Authors: Lawton, Graham (AUTHOR)

Source: New Scientist. 5/20/2023, Vol. 258 Issue 3439, p38-42. 5p. 5 Color Photographs.

Subjects: CELLULAR aging, BUDS, SYSTEMIC scleroderma, MACULAR degeneration, LUNGS, GONADS, WOUND healing, KNEE joint, DIABETIC nephropathies

Prevalence and gender - specific analysis of a systemic sclerosis cohort in Latvia.

Authors: Ivanova, Kristine^1,2,3 (AUTHOR) kivanova1603@gmail.com, Ribakova, Olga⁴ (AUTHOR), Mihailova, Anna^5,6 (AUTHOR), Mozeitovica, Evelina⁷ (AUTHOR), Kadisa, Anda^5,8,9 (AUTHOR), Zepa, Julija^3,5 (AUTHOR), Kenina, Viktorija^2,10,11,12 (AUTHOR), Kurjane, Natalja^2,10,13,14 (AUTHOR), Bulina, Inita^3,5,15 (AUTHOR)

Source: Orphanet Journal of Rare Diseases. 9/30/2024, Vol. 19 Issue 1, p1-9. 9p.

Subject Terms: *SYSTEMIC scleroderma, *AGE groups, *INTERSTITIAL lung diseases, *RHEUMATISM, *AUTOIMMUNE diseases

Spatial Transcriptomics Identifies Cellular and Molecular Characteristics of Scleroderma Skin Lesions: Pilot Study in Juvenile Scleroderma.

Authors: Liu, Tianhao^1,2 (AUTHOR) tianhao@pitt.edu, Esencan, Deren^1,3 (AUTHOR) esencand2@upmc.edu, Salgado, Claudia M.^1,4 (AUTHOR) claudia.salgado@miami.edu, Zhao, Chongyue¹ (AUTHOR) chz113@pitt.edu, Lai, Ying-Ju⁵ (AUTHOR) yil346@pitt.edu, Hutchins, Theresa^1,3 (AUTHOR) hutchinstr@upmc.edu, Sanyal, Anwesha^1,3 (AUTHOR) sanyala@upmc.edu, Chen, Wei^1,5 (AUTHOR) wei.chen@pitt.edu, Torok, Kathryn S.^1,3 (AUTHOR) wei.chen@pitt.edu

Source: International Journal of Molecular Sciences. Sep2024, Vol. 25 Issue 17, p9182. 18p.

Subject Terms: *SYSTEMIC scleroderma, *TRANSCRIPTOMES, *RNA sequencing, *GENE expression, *CELL analysis

The Phenotypes and Functions of Neutrophils in Systemic Sclerosis.

Authors: Luo, Jiao^1,2 (AUTHOR) luojiao@ncmc.edu.cn, Xie, Zhongming^1,2 (AUTHOR) xiezhongming@ncmc.edu.cn, Duan, Lihua^1,2 (AUTHOR) lh-duan@163.com

Source: Biomolecules (2218-273X). Sep2024, Vol. 14 Issue 9, p1054. 12p.

Subject Terms: *SYSTEMIC scleroderma, *CONNECTIVE tissue diseases, *NATURAL immunity, *NEUTROPHILS, *IMMUNE system

The Novel Cytokine Interleukin-41/Meteorin-like Is Reduced in Diffuse Systemic Sclerosis.

Authors: Freedman, Paul¹ (AUTHOR), Schock, Bettina² (AUTHOR) b.schock@qub.ac.uk, O'Reilly, Steven¹ (AUTHOR) b.schock@qub.ac.uk

Source: Cells (2073-4409). Jul2024, Vol. 13 Issue 14, p1205. 7p.

Subject Terms: *CONNECTIVE tissue diseases, *SYSTEMIC scleroderma, *PULMONARY fibrosis, *AMP-activated protein kinases, *ADIPOSE tissues

Toll-like Receptor Homologue CD180 Ligation of B Cells Upregulates Type I IFN Signature in Diffuse Cutaneous Systemic Sclerosis.

Authors: Erdő-Bonyár, Szabina¹ (AUTHOR) erdo-bonyar.szabina@pte.hu, Rapp, Judit¹ (AUTHOR) rapp.judit@pte.hu, Subicz, Rovéna¹ (AUTHOR) berki.timea@pte.hu, Filipánits, Kristóf² (AUTHOR) filipanits.kristof@pte.hu, Minier, Tünde² (AUTHOR) minier.tunde@pte.hu, Kumánovics, Gábor² (AUTHOR) kumanovics.gabor@pte.hu, Czirják, László² (AUTHOR) czirjak.laszlo@pte.hu, Berki, Tímea¹ (AUTHOR) simon.diana@pte.hu, Simon, Diána¹ (AUTHOR)

Source: International Journal of Molecular Sciences. Jul2024, Vol. 25 Issue 14, p7933. 12p.

Subject Terms: *B cells, *SYSTEMIC scleroderma, *TOLL-like receptors, *IMMUNOLOGIC memory, *TYPE I interferons, *INTERFERON receptors, *ANTIBODY formation, *B cell receptors

Clinical and autoantibody profiles of systemic sclerosis patients: A cross-sectional study from North India.

Authors: Ghosh, Shounak¹ drshounakghosh91@gmail.com, Tanna, Dhaval¹, Telang, Kaustubh¹, Dhuria, Shahzeene¹, Gupta, Rajiva¹

Source: Indian Journal of Dermatology, Venereology & Leprology. Jul/Aug2024, Vol. 90 Issue 4, p440-446. 7p.

Subject Terms: *PULMONARY arterial hypertension, *SYSTEMIC scleroderma, *INTERSTITIAL lung diseases, *SCLERODERMA (Disease), *SKIN diseases

A study of the reliability and construct validity of the 1-minute sit-to-stand test for individuals with systemic sclerosis.

Authors: Laursen, Jakob¹ (AUTHOR), Christensen, Amalie¹ (AUTHOR), Egsgaard, Simon¹ (AUTHOR), Søndergaard, Klaus² (AUTHOR), Mechlenburg, Inger^2,3 (AUTHOR), Brincks, John¹ (AUTHOR) jobr@via.dk

Source: Physiotherapy Theory & Practice. Jul2024, p1-8. 8p. 2 Illustrations.

Subject Terms: *SYSTEMIC scleroderma, *TEST validity, *INTRACLASS correlation, *STATISTICAL reliability, *UNIVERSITY hospitals

Geographic Terms: DENMARK