Improving systemic delivery of oncolytic virus by cellular carriers

Authors: Ziyi Peng, Muhammad Kalim, Yong Lu

Source: Cancer Biology & Medicine, Vol 21, Iss 12, Pp 1104-1119 (2024)

Subject Terms: oncolytic virotherapy, oncolytic virus, systemic delivery, cellular carriers, tumor-specific targeting, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.cancerbiomed.org/content/21/12/1104; https://doaj.org/toc/2095-3941

Access URL: https://doaj.org/article/4908ea40c05d40a2be58c8962d176c51

Systemic delivery of AAV5, AAV8, and AAV9 packaging a C5-12-microdystrophin-FLAG expression cassette in non-human primates

Authors: Mengping Liu, Erica Cook, Yanshan Dai, Erich Ehlert, Francois du Plessis, Jacek Lubelski, Bogdan G. Sleczka, Petia Shipkova, Zhuyin Li, Joshua Gamse, David Gordon, Leonard P. Adam, Paul C. Levesque, Glen B. Banks

Source: Molecular Therapy: Methods & Clinical Development, Vol 33, Iss 1, Pp 101411- (2025)

Subject Terms: adeno-associated virus, promoter, systemic delivery, non-human primate, dystrophin, AAV, Genetics, QH426-470, Cytology, QH573-671

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2329050125000063; https://doaj.org/toc/2329-0501

Access URL: https://doaj.org/article/d663094d0bda41b49e3aaa82e7a23c9e

Highly efficient in vivo hematopoietic stem cell transduction using an optimized self-complementary adeno-associated virus

Authors: Charlesworth, Carsten T. ¹, Homma, Shota ^{1, 2}, Amaya, Anais K. ³, Dib, Carla ^{1, 3}, Vaidyanathan, Sriram ⁷, Tan, Tze-Kai ^{1, 5}, Miyauchi, Masashi ^{1, 2}, Nakauchi, Yusuke ^{1, 4}, Suchy, Fabian P. ^{1, 2}, Wang, Sicong ¹, Igarashi, Kyomi J. ^{1, 2}, Cromer, M. Kyle ⁶, Dudek, Amanda M. ^{1, 3}, Amorin, Alvaro ^{1, 3}, Czechowicz, Agnieszka ^{1, 3, ∗}, Wilkinson, Adam C. ^{8, ∗∗}, Nakauchi, Hiromitsu ^{1, 2, 9, ∗∗∗}

Source: In Molecular Therapy - Methods & Clinical Development 13 March 2025 33(1)

CAG-targeted brain-permeable therapy tested in biallelic humanized polyQ mouse models

Authors: Surdyka, Magdalena ^{1, 5}, Kalinowska-Pośka, Żaneta ^{1, 5}, Niewiadomska-Cimicka, Anna ², Jesion, Ewelina ¹, Fiszer, Agnieszka ¹, Singer-Mikosch, Elisabeth ³, Fievet, Lorraine ², Przybyl, Lukasz ¹, Caron, Nicholas S. ⁴, Hayden, Michael R. ⁴, Nguyen, Huu Phuc ³, Trottier, Yvon ², Figiel, Maciej ^{1, ∗}

Source: In Molecular Therapy - Nucleic Acids 10 June 2025 36(2)

AAV-aMTD-Parkin, a therapeutic gene delivery cargo, enhances motor and cognitive functions in Parkinson's and Alzheimer’s diseases

Authors: Seokwon Lee, Mingu Kang, Seungwoo Lee, Sangsun Yoon, Yeonjin Cho, Dongjae Min, Daye Ann, Jisoo Shin, Young-Ki Paik, Daewoong Jo

Source: Pharmacological Research, Vol 208, Iss , Pp 107326- (2024)

Subject Terms: Adeno-associated virus, Therapeutic-molecule systemic delivery technolog, Advanced macromolecule transduction Domain, Parkinson's disease, Alzheimer's disease, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1043661824002718; https://doaj.org/toc/1096-1186

Access URL: https://doaj.org/article/8f6146f5ef7943478e92efe6870a44d1

Systemic Treatment for Postnatal, Juvenile, and Runted Adult Mice by Retrobulbar Sinus Injection

Authors: Darwin Romero, author¹, Randy J. Chandler, author¹

Source: Journal of Visualized Experiments. (207)

Availability: http://www.jove.com/video/66809

A double‐edged sword: The complex interplay between engineered nanoparticles and platelets

Authors: Yathreb Asaad, Danielle Nemcovsky‐Amar, Josué Sznitman, Pierre H. Mangin, Netanel Korin

Source: Bioengineering & Translational Medicine, Vol 9, Iss 4, Pp n/a-n/a (2024)

Subject Terms: drug carriers, hemostasis, nanoparticles, physicochemical parameters, platelets, systemic delivery, Chemical engineering, TP155-156, Biotechnology, TP248.13-248.65, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/2380-6761

Access URL: https://doaj.org/article/ebda135d545c4aab97df7ea2aa1930fe

Duchenne muscular dystrophy disease severity impacts skeletal muscle progenitor cells systemic delivery

Authors: Kholoud K. Saleh, Corey Switzler, Michael R. Hicks, Lily Gane, Devin E. Gibbs, April D. Pyle

Source: Frontiers in Physiology, Vol 14 (2023)

Subject Terms: skeletal muscle, systemic delivery, duchenne muscular dystrophy, skeletal muscle progenitor cells, intra-arterial cell delivery, Physiology, QP1-981

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphys.2023.1190524/full; https://doaj.org/toc/1664-042X

Access URL: https://doaj.org/article/bdf29d450e674c85a2834e3287f041bb

Local oncolytic adenovirotherapy produces an abscopal effect via tumor-derived extracellular vesicles

Authors: Kakiuchi, Yoshihiko ¹, Kuroda, Shinji ^{1, 2, ∗}, Kanaya, Nobuhiko ¹, Kumon, Kento ¹, Tsumura, Tomoko ¹, Hashimoto, Masashi ¹, Yagi, Chiaki ¹, Sugimoto, Ryoma ¹, Hamada, Yuki ¹, Kikuchi, Satoru ^{1, 3}, Nishizaki, Masahiko ¹, Kagawa, Shunsuke ^{1, 3}, Tazawa, Hiroshi ^{1, 2}, Urata, Yasuo ⁴, Fujiwara, Toshiyoshi ¹

Source: In Molecular Therapy 6 October 2021 29(10):2920-2930

Editorial: Intranasal Drug Delivery: Challenges and Opportunities

Authors: Ana Fortuna, Katharina Schindowski, Fabio Sonvico

Source: Frontiers in Pharmacology, Vol 13 (2022)

Subject Terms: intranasal, nose to brain, systemic delivery, nasal epithelia, nasal formulations, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2022.868986/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/8988764af0c3454db73dab5e0589b54f

Efficacy of Trunk Injected Imidacloprid and Oxytetracycline in Managing Huanglongbing and Asian Citrus Psyllid in Infected Sweet Orange (Citrus sinensis) Trees

Authors: Leigh Archer, Jawwad Qureshi, Ute Albrecht

Source: Agriculture, Vol 12, Iss 10, p 1592 (2022)

Subject Terms: citrus greening, systemic delivery, chemotherapy, bactericide, Agriculture (General), S1-972

File Description: electronic resource

Relation: https://www.mdpi.com/2077-0472/12/10/1592; https://doaj.org/toc/2077-0472

Access URL: https://doaj.org/article/abc8617d97c44569bb71e1280c39dd65

Local and systemic delivery of mRNA encoding survivin-T34A by lipoplex for efficient colon cancer gene therapy

Authors: Zhang X, Men K, Zhang Y, Zhang R, Yang L, Duan X

Source: International Journal of Nanomedicine, Vol Volume 14, Pp 2733-2751 (2019)

Subject Terms: mRNA gene therapy, colon cancer, non-viral vector, systemic delivery, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.dovepress.com/local-and-systemic-delivery-of-mrna-encoding-survivin-t34a-by-lipoplex-peer-reviewed-article-IJN; https://doaj.org/toc/1178-2013

Access URL: https://doaj.org/article/f96a93c8e95e43cbae6d657cd631d78a

Site-Specific Considerations on Engineered T Cells for Malignant Gliomas

Authors: Nirmeen Elmadany, Obada T. Alhalabi, Michael Platten, Lukas Bunse

Source: Biomedicines, Vol 10, Iss 7, p 1738 (2022)

Subject Terms: CARs, CAR T cells, glioma, glioblastoma, intrathecal delivery, systemic delivery, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/10/7/1738; https://doaj.org/toc/2227-9059

Access URL: https://doaj.org/article/45bb697b7ed54e13a2b9b8a6876044af

Trunk Injection as a Tool to Deliver Plant Protection Materials—An Overview of Basic Principles and Practical Considerations

Authors: Leigh Archer, Jonathan H. Crane, Ute Albrecht

Source: Horticulturae, Vol 8, Iss 6, p 552 (2022)

Subject Terms: horticultural crops, crop protection, endotherapy, chemotherapy, systemic delivery, Plant culture, SB1-1110

File Description: electronic resource

Relation: https://www.mdpi.com/2311-7524/8/6/552; https://doaj.org/toc/2311-7524

Access URL: https://doaj.org/article/2cf80e594554403bb4469981dc504e68

A pH- and Bioreducible Cationic Copolymer with Amino Acids and Piperazines for Adenovirus Delivery

Authors: Thavasyappan Thambi, Jeongmin Lee, A-Rum Yoon, Dayananda Kasala, Chae-Ok Yun

Source: Pharmaceutics, Vol 14, Iss 3, p 597 (2022)

Subject Terms: adenovirus, systemic delivery, nonimmunogenic polymer, tumor-targeted delivery, cancer gene therapy, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/14/3/597; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/36e11bf710d345ecb1b88f00d855a222

A Unique Core–Shell Structured, Glycol Chitosan-Based Nanoparticle Achieves Cancer-Selective Gene Delivery with Reduced Off-Target Effects

Authors: Bei Cheng, Hye-Hyun Ahn, Hwanhee Nam, Zirui Jiang, Feng J. Gao, Il Minn, Martin G. Pomper

Source: Pharmaceutics, Vol 14, Iss 2, p 373 (2022)

Subject Terms: molecular-genetic imaging, reporter–probe pair, gene delivery, systemic delivery, toxicity, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/14/2/373; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/5b3f1e186ead44b4bce17988f03ed13d

Systemic antimiR-337-3p delivery inhibits cerebral ischemia-mediated injury

Authors: Xiaomin Wang, Yalikun Suofu, Berkcan Akpinar, Sergei V. Baranov, Jinho Kim, Diane L. Carlisle, Yu Zhang, Robert M. Friedlander

Source: Neurobiology of Disease, Vol 105, Iss , Pp 156-163 (2017)

Subject Terms: Neuroprotection, Stroke, microRNA, LNA, Anti-mRNA, Systemic delivery, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996117301018; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/d006a4077c2344ea9e3abf7979ae052d

Systemic delivery of factor IX messenger RNA for protein replacement therapy

Authors: Ramaswamy, Suvasini, Tonnu, Nina, Tachikawa, Kiyoshi, Limphong, Pattraranee, Vega, Jerel B., Karmali, Priya P., Chivukula, Pad, Verma, Inder M.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2017 Mar 01. 114(10), E1941-E1950.

Access URL: https://www.jstor.org/stable/26480126

Regional Delivery of Anti-PD-1 Agent for Colorectal Liver Metastases Improves Therapeutic Index and Anti-Tumor Activity

Authors: Louis F. Chai, John C. Hardaway, Kara R. Heatherton, Kyle P. O’Connell, Mikayla C. Lopes, Benjamin A. Rabinowitz, Chandra C. Ghosh, Prajna Guha, David Jaroch, Bryan F. Cox, Steven C. Katz

Source: Vaccines, Vol 9, Iss 8, p 807 (2021)

Subject Terms: liver metastasis, regional delivery, PD-1, PD-L1, myeloid-derived suppressor cells, systemic delivery, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2076-393X/9/8/807; https://doaj.org/toc/2076-393X

Access URL: https://doaj.org/article/6fb5f456cae4492f8c6c1e505c93455d

Efficient Intravenous Tumor Targeting Using the αvβ6 Integrin-Selective Precision Virotherapy Ad5NULL-A20

Authors: James A. Davies, Gareth Marlow, Hanni K. Uusi-Kerttula, Gillian Seaton, Luke Piggott, Luned M. Badder, Richard W. E. Clarkson, John D. Chester, Alan L. Parker

Source: Viruses, Vol 13, Iss 5, p 864 (2021)

Subject Terms: adenovirus, oncolytic, virotherapy, targeting, αvβ6 integrin, systemic delivery, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4915/13/5/864; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/0de1c5c44a1c4abe94c824c0b12e335e