Rare but specific: 5-bp composite motifs define SMAD binding in BMP signaling.

Authors: Jatzlau, Jerome¹ (AUTHOR), Do, Sophie-Nhi¹ (AUTHOR), Mees, Rebeca A.² (AUTHOR), Mendez, Paul-Lennard¹ (AUTHOR), Khan, Rameez Jabeer² (AUTHOR), Maas, Lukas¹ (AUTHOR), Ruiz, Lidia² (AUTHOR), Martin-Malpartida, Pau² (AUTHOR), Macias, Maria J.^2,3 (AUTHOR) maria.macias@irbbarcelona.org, Knaus, Petra¹ (AUTHOR) petra.knaus@fu-berlin.de

Source: BMC Biology. 3/13/2025, Vol. 23 Issue 1, p1-15. 15p.

Subject Terms: *SMAD proteins, *GENETIC regulation, *GENETIC transcription, *CELLULAR signal transduction, *GENE expression

Silencing SMAD4 inhibits inflammation and ferroptosis in asthma by blocking the IL-17A signaling pathway.

Authors: Rao, Xingyu¹ (AUTHOR), Luo, Hong¹ (AUTHOR), Luo, Kaiyuan¹ (AUTHOR), Hu, Chaohua² (AUTHOR) huchaohua0210@126.com

Source: Respiratory Research. 12/6/2024, Vol. 25 Issue 1, p1-17. 17p.

Subject Terms: *INTERLEUKIN-17, *SMAD proteins, *MEDICAL sciences, *CELLULAR signal transduction, *INTERLEUKIN-13

miRNAs in Signal Transduction of SMAD Proteins in Breast Cancer.

Authors: Sirek, Tomasz^1,2 (AUTHOR) nikola.zmarzly@gmail.com, Sirek, Agata^1,2 (AUTHOR) katarzynakroljatrenga@gmail.com, Borawski, Przemysław³ (AUTHOR) przembor3@gmail.com, Zmarzły, Nikola² (AUTHOR) dariusz.boron@gmail.com, Sułkowska, Joanna² (AUTHOR) chalcarzmichal@gmail.com, Król-Jatręga, Katarzyna^1,2 (AUTHOR) drpiotrossowski@gmail.com, Opławski, Marcin^4,5 (AUTHOR) marcin.oplawski@gmail.com, Boroń, Dariusz^2,4,6,7 (AUTHOR) konraddziobek28@gmail.com, Chalcarz, Michał^2,8,9 (AUTHOR) strojny.ds@gmail.com, Ossowski, Piotr² (AUTHOR) q375@icloud.com, Dziobek, Konrad² (AUTHOR) dominika.bjaniszewska@gmail.com, Strojny, Damian^2,10,11 (AUTHOR) bgrabarek7@gmail.com, Boroń, Kacper² (AUTHOR), Janiszewska-Bil, Dominika² (AUTHOR), Grabarek, Beniamin Oskar^2,12 (AUTHOR)

Source: International Journal of Molecular Sciences. Sep2024, Vol. 25 Issue 18, p10088. 10p.

Subject Terms: *SMAD proteins, *TRANSFORMING growth factors-beta, *REVERSE transcriptase polymerase chain reaction, *CELLULAR signal transduction, *GENE expression

Levosimendan mediates the BMP/Smad axis through upregulation of circUSP34-targeted miR-1298 to alleviate pulmonary hypertension.

Authors: Meng, Qiang¹ (AUTHOR), Song, Linhong^1,2 (AUTHOR), Wang, Hui¹ (AUTHOR), Wang, Gang¹ (AUTHOR), Zhou, Gengxu¹ (AUTHOR) zhougengxu0016@163.com

Source: Respiratory Research. 8/19/2024, Vol. 25 Issue 1, p1-13. 13p.

Subject Terms: *LABORATORY rats, *SMAD proteins, *CYTOLOGY, *PULMONARY hypertension, *INHIBITION of cellular proliferation

Smad4 and FoxH1 potentially interact to regulate cyp19a1a promoter in the ovary of ricefield eel (Monopterus albus).

Authors: Chen, Qiqi¹ (AUTHOR), Yang, Deying¹ (AUTHOR), Chen, Mingqiang¹ (AUTHOR), Xiong, Jinxin¹ (AUTHOR), Huang, Junjie¹ (AUTHOR), Ding, Wenxiang¹ (AUTHOR), Gao, Kuo¹ (AUTHOR), Lai, Bolin¹ (AUTHOR), Zheng, Li¹ (AUTHOR), Tang, Ziting¹ (AUTHOR), Zhang, Mingwang¹ (AUTHOR), Yan, Taiming¹ (AUTHOR), He, Zhi¹ (AUTHOR) zhihe@sicau.edu.cn

Source: Biology of Sex Differences. 7/30/2024, Vol. 15 Issue 1, p1-11. 11p.

Subject Terms: *GRANULOSA cells, *SMAD proteins, *TRANSCRIPTION factors, *GENETIC transcription regulation, *EGG quality

Clinical and Molecular Characterization of SMAD4 Splicing Variants in Patients with Juvenile Polyposis Syndrome.

Authors: Forte, Giovanna¹ (AUTHOR) giovanna.forte@irccsdebellis.it, Buonadonna, Antonia Lucia¹ (AUTHOR) lucia.buonadonna@irccsdebellis.it, Fasano, Candida¹ (AUTHOR) candida.fasano@irccsdebellis.it, Sanese, Paola¹ (AUTHOR) paola.sanese@irccsdebellis.it, Cariola, Filomena¹ (AUTHOR) filo.cariola@irccsdebellis.it, Manghisi, Andrea¹ (AUTHOR) andrea.manghisi@irccsdebellis.it, Guglielmi, Anna Filomena¹ (AUTHOR) floranna.guglielmi@irccsdebellis.it, Lepore Signorile, Martina¹ (AUTHOR) martina.leporesignorile@irccsdebellis.it, De Marco, Katia¹ (AUTHOR) katia.demarco@irccsdebellis.it, Grossi, Valentina¹ (AUTHOR) valentina.grossi@irccsdebellis.it, Disciglio, Vittoria¹ (AUTHOR) vittoria.disciglio@irccsdebellis.it, Simone, Cristiano^1,2 (AUTHOR) vittoria.disciglio@irccsdebellis.it

Source: International Journal of Molecular Sciences. Jul2024, Vol. 25 Issue 14, p7939. 13p.

Subject Terms: *RNA splicing, *SMAD proteins, *ADENOMATOUS polyps, *GENETIC counseling, *GENETIC variation, *RNA analysis, *FRAMESHIFT mutation

TGF-β Modulated Pathways in Colorectal Cancer: New Potential Therapeutic Opportunities.

Authors: Fasano, Morena¹ (AUTHOR) morena.fasano@unicampania.it, Pirozzi, Mario¹ (AUTHOR) mario.pirozzi@unicampania.it, Miceli, Chiara Carmen¹ (AUTHOR) chiaracarmenmiceli@gmail.com, Cocule, Mariateresa¹ (AUTHOR) mariateresacocule1292@gmail.com, Caraglia, Michele^2,3 (AUTHOR) michele.caraglia@unicampania.it, Boccellino, Mariarosaria² (AUTHOR) mariarosaria.boccellino@unicampania.it, Vitale, Pasquale⁴ (AUTHOR) pasquale.vitale3@aslnapoli2nord.it, De Falco, Vincenzo⁴ (AUTHOR) vincenzo.defalco1@aslnapoli2nord.it, Farese, Stefano¹ (AUTHOR) stefano.farese93@gmail.com, Zotta, Alessia¹ (AUTHOR) alessiazotta@libero.it, Ciardiello, Fortunato¹ (AUTHOR) fortunato.ciardiello@unicampania.it, Addeo, Raffaele⁴ (AUTHOR) raffaele.addeo@aslnapoli2nord.it

Source: International Journal of Molecular Sciences. Jul2024, Vol. 25 Issue 13, p7400. 18p.

Subject Terms: *COLORECTAL cancer, *SMAD proteins, *EXTRACELLULAR matrix, *DIAGNOSIS, *CELL nuclei

Studying the Effect of the Host Genetic Background of Juvenile Polyposis Development Using Collaborative Cross and Smad4 Knock-Out Mouse Models.

Authors: Zohud, Osayd¹ (AUTHOR) osaydzohud@mail.tau.ac.il, Midlej, Kareem¹ (AUTHOR) kareemmidlej@mail.tau.ac.il, Lone, Iqbal M.¹ (AUTHOR) iqbalzoo84@gmail.com, Nashef, Aysar^2,3 (AUTHOR) dr.aysarn@gmail.com, Abu-Elnaaj, Imad^2,4 (AUTHOR) iabu@poria.health.gov.il, Iraqi, Fuad A.¹ (AUTHOR) fuadi@tauex.tau.ac.il

Source: International Journal of Molecular Sciences. Jun2024, Vol. 25 Issue 11, p5812. 22p.

Subject Terms: *KNOCKOUT mice, *SMAD proteins, *MICE, *K-nearest neighbor classification, *INTESTINAL polyps, *LABORATORY mice, *MACHINE learning, *GENETIC variation

Loss of tumor-derived SMAD4 enhances primary tumor growth but not metastasis following BMP4 signalling.

Authors: Chi, Lap Hing^1,2 (AUTHOR), Redfern, Andrew D.³ (AUTHOR), Roslan, Suraya⁴ (AUTHOR), Street, Ian P.⁵ (AUTHOR), Burrows, Allan D.^1,2 (AUTHOR), Anderson, Robin L.^1,2,6,7 (AUTHOR) robin.anderson@onjcri.org.au

Source: Cell Communication & Signaling. 4/30/2024, Vol. 22 Issue 1, p1-18. 18p.

Subject Terms: *SMAD proteins, *BREAST, *BONE morphogenetic proteins, *METASTATIC breast cancer, *TUMOR growth, *METASTASIS

Detrimental Effect of T261I and R287W SMAD3 Variants on Early Osteoarthritis: A Potential Anti‐Inflammatory Molecule for Personalized Treatment.

Authors: V, Janakiraman¹ (AUTHOR), M, Sudhan¹ (AUTHOR), Ahmad, Sheikh F.² (AUTHOR), Al‐Mazroua, Haneen A.² (AUTHOR), Ahmed, Shiek S. S. J.¹ (AUTHOR) dr.shiekahmed@care.edu.in

Source: Advanced Theory & Simulations. Apr2025, Vol. 8 Issue 4, p1-14. 14p.

Subject Terms: *OSTEOARTHRITIS, *SMAD proteins, *ANTI-inflammatory agents, *CYTOKINES, *MOLECULAR docking, *INDIVIDUALIZED medicine

Effect of Ziyu Ointment on TGF-β/Smad signal pathway in granulation tissue of wound healing rats.

Authors: WANG Xia¹, LIU Zhiqing², QIN Zhijuan¹, JIN Yanxia¹, JIA Zijuan¹, GUO Sun¹, GAO Yuanyuan³, LI Ling³

Source: Chinese Journal of Immunology. Feb2025, Vol. 41 Issue 2, p387-392. 6p.

Subject Terms: *LABORATORY rats, *SMAD proteins, *GRANULATION tissue, *TISSUE wounds, *WOUND healing

The 12-bp indel in the SMAD family member 2 gene is associated with goat growth traits.

Authors: Wijayanti, Dwi^1,2 (AUTHOR), Bai, Yangyang¹ (AUTHOR), Zhu, Haijing³ (AUTHOR), Qu, Lei³ (AUTHOR), Guo, Zhengang^1,4 (AUTHOR) gzg0857@163.com, Lan, Xianyong¹ (AUTHOR) lanxianyong79@126.com

Source: Animal Biotechnology. Dec2023, Vol. 34 Issue 9, p4271-4280. 10p.

Subject Terms: *SMAD proteins, *GOAT breeds, *GOATS, *CELLULAR signal transduction, *DELETION mutation, *BONE growth

SMAD4 variants and its genotype–phenotype correlations to juvenile polyposis syndrome.

Authors: Cao, Kimberley^1,2 (AUTHOR) kimberley.cao@mh.org.au, Plazzer, John-Paul¹ (AUTHOR), Macrae, Finlay^1,2 (AUTHOR)

Source: Hereditary Cancer in Clinical Practice. 12/8/2023, Vol. 21 Issue 1, p1-64. 64p.

Subject Terms: *SMAD proteins, *JUVENILE idiopathic arthritis, *HEREDITARY nonpolyposis colorectal cancer, *MISSENSE mutation, *GASTROINTESTINAL hemorrhage, *ONLINE databases, *DISEASE risk factors

Adolescent exposure to sucrose increases cocaine‐mediated behaviours in adulthood via Smad3.

Authors: Gancarz, Amy M.^1,2,3 (AUTHOR) agancarz@csub.edu, Parmar, Raveena¹ (AUTHOR), Shwani, Treefa² (AUTHOR), Cobb, Moriah M.¹ (AUTHOR), Crawford, Michelle N.¹ (AUTHOR), Watson, Jacob R.¹ (AUTHOR), Evans, Lisa¹ (AUTHOR), Kausch, Michael A.^1,2 (AUTHOR), Werner, Craig T.² (AUTHOR), Dietz, David M.^2,3 (AUTHOR)

Source: Addiction Biology. Dec2023, Vol. 28 Issue 12, p1-17. 17p.

Subject Terms: *SUCROSE, *SMAD proteins, *ADULTS, *TEENAGERS, *NUCLEUS accumbens

The long non-coding RNA LINC00707 interacts with Smad proteins to regulate TGFβ signaling and cancer cell invasion.

Authors: Gélabert, Caroline¹ (AUTHOR), Papoutsoglou, Panagiotis^1,2 (AUTHOR), Golán, Irene¹ (AUTHOR), Ahlström, Eric¹ (AUTHOR), Ameur, Adam³ (AUTHOR), Heldin, Carl-Henrik¹ (AUTHOR), Caja, Laia¹ (AUTHOR) laia.caja@imbim.uu.se, Moustakas, Aristidis¹ (AUTHOR) aris.moustakas@imbim.uu.se

Source: Cell Communication & Signaling. 10/2/2023, Vol. 21 Issue 1, p1-26. 26p.

Subject Terms: *SMAD proteins, *LINCRNA, *CANCER cells, *MITOGEN-activated protein kinases, *KRUPPEL-like factors, *RNA-protein interactions, *TRANSFORMING growth factors

circEIF3I facilitates the recruitment of SMAD3 to early endosomes to promote TGF-β signalling pathway-mediated activation of MMPs in pancreatic cancer.

Authors: Zhao, Zhongjie^1,2 (AUTHOR), Yang, Wenbo^1,2 (AUTHOR), Kong, Rui^1,2 (AUTHOR), Zhang, Yangyang^1,2 (AUTHOR), Li, Le^1,2 (AUTHOR), Song, Zengfu³ (AUTHOR), Chen, Hongze^1,2 (AUTHOR), Luo, Yan^1,2 (AUTHOR), Zhang, Tao⁴ (AUTHOR), Cheng, Chundong^1,2 (AUTHOR), Li, Guanqun^1,2 (AUTHOR), Liu, Danxi^1,2 (AUTHOR), Geng, Xinglong^1,2 (AUTHOR), Chen, Hua^1,2 (AUTHOR), Wang, Yongwei^1,2 (AUTHOR), Pan, Shangha² (AUTHOR), Hu, Jisheng^1,2 (AUTHOR) hujisheng0816@126.com, Sun, Bei^1,2 (AUTHOR) sunbei70@tom.com

Source: Molecular Cancer. 9/9/2023, Vol. 22 Issue 1, p1-18. 18p.

Subject Terms: *SMAD proteins, *PANCREATIC cancer, *ENDOSOMES, *FLUORESCENCE in situ hybridization, *RNA-protein interactions

SMAD Proteins in TGF-β Signalling Pathway in Cancer: Regulatory Mechanisms and Clinical Applications.

Authors: Wang, Qi¹ (AUTHOR) eric_wang0305@outlook.com, Xiong, Fei¹ (AUTHOR) sillcon2008@hotmail.com, Wu, Guanhua¹ (AUTHOR) ghwu95@163.com, Wang, Da¹ (AUTHOR) a123131515@163.com, Liu, Wenzheng¹ (AUTHOR) liu15927464856@163.com, Chen, Junsheng¹ (AUTHOR) cjs9800@163.com, Qi, Yongqiang² (AUTHOR) a15972066440@163.com, Wang, Bing¹ (AUTHOR) t0013008@aliyun.com, Chen, Yongjun¹ (AUTHOR) yjchen@tjh.tjmu.edu.cn

Source: Diagnostics (2075-4418). Sep2023, Vol. 13 Issue 17, p2769. 27p.

Subject Terms: *SMAD proteins, *CELLULAR signal transduction, *CLINICAL medicine, *POST-translational modification, *T helper cells, *TRANSCRIPTION factors

Smad4 Heterozygous Knockout Effect on Pancreatic and Body Weight in F1 Population Using Collaborative Cross Lines.

Authors: Zohud, Osayd¹ (AUTHOR) osaydzohud@mail.tau.ac.il, Lone, Iqbal M.¹ (AUTHOR) iqbalzoo84@gmail.com, Midlej, Kareem¹ (AUTHOR) kareemmidlej@mail.tau.ac.il, Nashef, Aysar^2,3,4 (AUTHOR) dr.aysarn@gmail.com, Iraqi, Fuad A.¹ (AUTHOR) fuadi@tauex.tau.ac.il

Source: Biology (2079-7737). Nov2024, Vol. 13 Issue 11, p918. 13p.

Subject Terms: *SMAD proteins, *KNOCKOUT mice, *PANCREATIC diseases, *PANCREATIC cancer, *GENETIC variation, *TUMOR suppressor genes

Anti-Müllerian hormone signaling in the ovary involves stromal fibroblasts: a study in humans and mice provides novel insights into the role of ovarian stroma.

Authors: Spector, Itay¹ (AUTHOR), Derech-Haim, Sanaz^1,2 (AUTHOR), Boustanai, Ilana¹ (AUTHOR), Safrai, Myriam¹ (AUTHOR), Meirow, Dror^1,2 (AUTHOR) meirow@tauex.tau.ac.il

Source: Human Reproduction. Nov2024, Vol. 39 Issue 11, p2551-2564. 14p.

Subject Terms: *SMAD proteins, *ANTI-Mullerian hormone, *CELL populations, *GRANULOSA cells, *GENE expression

Loss of function SMAD4 nonstop mutations in human cancer.

Authors: Bauer, Anna H^1,2 (AUTHOR), Basta, David W¹ (AUTHOR), Hornick, Jason L¹ (AUTHOR), Dong, Fei¹ (AUTHOR) fdong1@bwh.harvard.edu

Source: Histopathology. Jun2023, Vol. 82 Issue 7, p1098-1104. 7p.

Subject Terms: *SMAD proteins, *LUNGS, *STOP codons, *TUMOR suppressor genes, *MISSENSE mutation, *GENETIC mutation, *PROTEIN expression