Analysis of the CRK expressions in bottle gourd (Lagenaria siceraria) under Fusarium oxysporum f. sp. lagenariae stress by using genome-wide identification strategy.

Authors: Sahoo, Preetinanda¹ (AUTHOR), Ullah, Ikram² (AUTHOR), Sahoo, Debarpita¹ (AUTHOR), Bose, Chirasmita¹ (AUTHOR), Zia, Muhammad Amir³ (AUTHOR), Lodhi, Sumaira Salahuddin⁴ (AUTHOR), Seleiman, Mahmoud F.⁵ (AUTHOR), Ali, Nawab⁶ (AUTHOR), Kumar, Gagan⁷ (AUTHOR), Asad, Suhail⁸ (AUTHOR) sohailasad74@gmail.com, Nanda, Satyabrata¹ (AUTHOR) satyabrata.nanda@cutm.ac.in

Source: BMC Genomics. 3/3/2025, Vol. 26 Issue 1, p1-14. 14p.

Subject Terms: *LAGENARIA siceraria, *RECEPTOR-like kinases, *CUCURBITACEAE, *FUSARIUM oxysporum, *PHYSIOLOGICAL stress

Quality Assurance Model for Breast Cancer Prognostication Using the Modified Magee Equations.

Authors: Lagerstrom, Ian¹ ian.t.lagerstrom.mil@health.mil, Neelon, Daniel¹, Wendzel, Nena², Lipkowitz, Stanley³, Moncur, Joel T.⁴, Uiterwaal, Stella F.⁵, Wells, Justin¹

Source: Archives of Pathology & Laboratory Medicine. Mar2025, Vol. 149 Issue 3, pe72-e77. 6p.

Subject Terms: *RISK assessment, *HORMONE receptor positive breast cancer, *PREDICTION models, *CANCER relapse, *PATHOLOGY, *CANCER patients, *DESCRIPTIVE statistics, *QUALITY control, *IMMUNOHISTOCHEMISTRY, *CANCER chemotherapy, *PREDICTION algorithms, *QUALITY assurance, *SENSITIVITY & specificity (Statistics), *EVALUATION, *DISEASE risk factors

Risk-benefits assessment of tamoxifen or raloxifene as chemoprevention for risk reduction of breast cancer among BRCA1 and BRCA2 carriers: a meta-analysis.

Authors: Alwashmi, Ameen S. S.¹ (AUTHOR), Khan, Najeeb Ullah² (AUTHOR) najeebkhan@aup.edu.pk, Chen, Tianhui³ (AUTHOR) chenth@zjcc.org.cn

Source: Scientific Reports. 2/25/2025, Vol. 15 Issue 1, p1-11. 11p.

Subject Terms: *SELECTIVE estrogen receptor modulators, *MEDICAL sciences, *BREAST cancer, *CANCER chemoprevention, *RALOXIFENE

Sigma-1 receptor activation attenuates DOX-induced cardiotoxicity by alleviating endoplasmic reticulum stress and mitochondrial calcium overload via PERK and IP3R-VDAC1-MCU signaling pathways.

Authors: Li, Zixuan^1,2,3 (AUTHOR), Ran, Qian⁴ (AUTHOR), Qu, Chuan^1,2,3 (AUTHOR), Hu, Shan^1,2,3 (AUTHOR), Cui, Shengyu^1,2,3 (AUTHOR), Zhou, You^1,2,3 (AUTHOR), Shen, Bo^1,2,3 (AUTHOR) shenbowhdx@126.com, Yang, Bo^1,2,3 (AUTHOR) yybb112@whu.edu.cn

Source: Biology Direct. 2/25/2025, Vol. 20 Issue 1, p1-19. 19p.

Subject Terms: *ENDOPLASMIC reticulum stress, *SIGMA-1 receptor, *INTRAPERITONEAL injections, *CELLULAR signal transduction, *ENDOPLASMIC reticulum

Safety, efficacy, and cardiovascular benefits of combination therapy with SGLT-2 inhibitors and GLP-1 receptor agonists in patients with diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials.

Authors: Mousavi, Asma^1,2 (AUTHOR), Shojaei, Shayan^1,2 (AUTHOR), Soleimani, Hamidreza^1,2 (AUTHOR), Semirani-Nezhad, Davood³ (AUTHOR), Ebrahimi, Pouya^1,2 (AUTHOR), Zafari, Ali⁴ (AUTHOR), Ebrahimi, Rasoul⁴ (AUTHOR), Roozbehi, Khatere³ (AUTHOR), Harrison, Anil⁵ (AUTHOR), Syed, Mushabbar A.⁶ (AUTHOR), Kuno, Toshiki⁷ (AUTHOR), Askari, Mani Khorsand⁸ (AUTHOR), Almandoz, Jaime P.⁹ (AUTHOR), Jun, John¹⁰ (AUTHOR), Hosseini, Kaveh^1,2 (AUTHOR) kaveh_hosseini130@yahoo.com

Source: Diabetology & Metabolic Syndrome. 2/24/2025, Vol. 17 Issue 1, p1-17. 17p.

Subject Terms: *GLUCAGON-like peptide-1 receptor, *MAJOR adverse cardiovascular events, *TYPE 2 diabetes, *GLUCAGON-like peptide-1 agonists, *RANDOMIZED controlled trials

Time moving 100-fold slower: time distortion as a diagnostic clue in anti-NMDA receptor encephalitis.

Authors: Hirata, Risa¹ (AUTHOR) risahirata525@gmail.com, Wada, Hisashi¹ (AUTHOR), Yamamoto, Kazunori¹ (AUTHOR), Sogi, Yuji¹ (AUTHOR), Muzuta, Hiroto¹ (AUTHOR), Isaka, Yu¹ (AUTHOR), Funayama, Michitaka² (AUTHOR)

Source: BMC Neurology. 2/24/2025, Vol. 25 Issue 1, p1-6. 6p.

Subject Terms: *ANTI-NMDA receptor encephalitis, *TIME perception, *MIDDLE-aged men, *METHYL aspartate receptors, *MEDICAL sciences

RIPK1 is required for ZBP1-driven necroptosis in human cells.

Authors: Amusan, Oluwamuyiwa T.¹ (AUTHOR), Wang, Shuqi¹ (AUTHOR), Yin, Chaoran² (AUTHOR), Koehler, Heather S.³ (AUTHOR), Li, Yixun¹ (AUTHOR), Tenev, Tencho⁴ (AUTHOR), Wilson, Rebecca⁴ (AUTHOR), Bellenie, Benjamin⁵ (AUTHOR), Zhang, Ting² (AUTHOR), Wang, Jian^1,6 (AUTHOR), Liu, Chang⁷ (AUTHOR), Seong, Kim¹ (AUTHOR), Poorbaghi, Seyedeh L.¹ (AUTHOR), Yates, Joseph¹ (AUTHOR), Shen, Yuchen¹ (AUTHOR), Upton, Jason W.⁸ (AUTHOR), Meier, Pascal⁴ (AUTHOR), Balachandran, Siddharth² (AUTHOR), Guo, Hongyan¹ (AUTHOR) hongyan.guo@lsuhs.edu

Source: PLoS Biology. 2/21/2025, Vol. 23 Issue 2, p1-23. 23p.

Subject Terms: *RECEPTOR-interacting proteins, *VIRUS diseases, *CARRIER proteins, *HUMAN beings, *MICE

Comparative efficacy of different antihypertensive drug classes for stroke prevention: A network meta-analysis of randomized controlled trials.

Authors: Yu, Ding¹ (AUTHOR), Li, Jun-xia² (AUTHOR), Cheng, Yuan³ (AUTHOR), Wang, Han-dong⁴ (AUTHOR), Ma, Xin-di⁵ (AUTHOR), Ding, Tao³ (AUTHOR) domdt2019@126.com, Zhu, Zhong-ning² (AUTHOR) zzn1970@hotmail.com

Source: PLoS ONE. 2/21/2025, Vol. 20 Issue 2, p1-28. 28p.

Subject Terms: *ANGIOTENSIN-receptor blockers, *STROKE, *HYPERTENSION, *ADRENERGIC receptors, *ANTIHYPERTENSIVE agents, *CALCIUM antagonists, *ACE inhibitors

Association of glucagon-like peptide-1 receptor agonists with cardiovascular and kidney outcomes in type 2 diabetic kidney transplant recipients.

Authors: Lin, Li-Chun¹ (AUTHOR), Chen, Jui-Yi^2,3 (AUTHOR), Huang, Thomas Tao-Min^4,5 (AUTHOR), Wu, Vin-Cent^4,5,6 (AUTHOR) q91421028@ntu.edu.tw

Source: Cardiovascular Diabetology. 2/21/2025, Vol. 24 Issue 1, p1-14. 14p.

Subject Terms: *MAJOR adverse cardiovascular events, *GLUCAGON-like peptide-1 receptor, *TYPE 2 diabetes, *MEDICAL sciences, *ADVERSE health care events

Use of semaglutide in a 54-year-old patient with cocaine abuse and weight loss: a case report.

Authors: Romeo, V. M.^1,2,3 (AUTHOR) vincenzomaria.romeo@unipa.it

Source: Journal of Medical Case Reports. 2/17/2025, Vol. 19 Issue 1, p1-6. 6p.

Subject Terms: *GLUCAGON-like peptide-1 receptor, *COCAINE-induced disorders, *COCAINE abuse, *REWARD (Psychology), *MEDICAL sciences

MEGA PROTAC, MEGA DOCK-based PROTAC mediated ternary complex formation pipeline with sequential filtering and rank aggregation: MEGA PROTAC, MEGA DOCK-based PROTAC mediated...: S. Y. Ugurlu et al.

Authors: Ugurlu, Sadettin Y.¹ (AUTHOR), McDonald, David² (AUTHOR), Enisoglu, Ramazan³ (AUTHOR), Zhu, Zexuan⁴ (AUTHOR), He, Shan^1,2 (AUTHOR) s.he.1@bham.ac.uk

Source: Scientific Reports. 2/14/2025, Vol. 15 Issue 1, p1-25. 25p.

Subject Terms: *UBIQUITIN ligases, *SIGNAL recognition particle receptor, *TERNARY forms, *CHEMICAL structure, *MOIETIES (Chemistry)

Exploring the Potential of Non-Cellular Orthobiologic Products in Regenerative Therapies for Stifle Joint Diseases in Companion Animals.

Authors: Guerra-Gomes, Maria^1,2,3,4,5 (AUTHOR) csbaptista93@gmail.com, Ferreira-Baptista, Carla^2,5 (AUTHOR) pgomes@fmd.up.pt, Barros, Joana¹ (AUTHOR) joana.barros@ineb.up.pt, Alves-Pimenta, Sofia^3,4 (AUTHOR), Gomes, Pedro^2,5 (AUTHOR), Colaço, Bruno^3,4 (AUTHOR) bcolaco@utad.pt

Source: Animals (2076-2615). Feb2025, Vol. 15 Issue 4, p589. 25p.

Subject Terms: *INTERLEUKIN-1 receptor antagonist protein, *STIFLE joint, *JOINTS (Anatomy), *HINDLIMB, *JOINT diseases

Long term cost-effectiveness analysis of IDegLira in the treatment of type 2 diabetes patients compared to GLP-1RA added to basal insulin after IDegLira entered the national reimbursement drug list in China.

Authors: Xiao, Dunming^1,2 (AUTHOR), Weng, Junling^1,2 (AUTHOR), Zhang, Lei³ (AUTHOR), Xing, Chang⁴ (AUTHOR), Wei, Yan^1,2 (AUTHOR) yanwei@fudan.edu.cn, Chen, Yingyao^1,2 (AUTHOR) yychen@shmu.edu.cn

Source: PLoS ONE. 2/6/2025, Vol. 20 Issue 2, p1-14. 14p.

Subject Terms: *GLUCAGON-like peptide-1 receptor, *MEDICAL economics, *TYPE 2 diabetes, *MYOCARDIAL ischemia, *CORONARY disease

Recombinant CD80 fusion protein combined with discoidin domain receptor 1 inhibitor for cancer treatment.

Authors: Wang, Songna^1,2 (AUTHOR), Hu, Pinliang³ (AUTHOR), Zhang, Xuyao² (AUTHOR), Fan, Jiajun² (AUTHOR), Zou, Jing³ (AUTHOR), Hong, Weidong³ (AUTHOR), Huang, Xuan^1,2 (AUTHOR), Pan, Danjie² (AUTHOR), Chen, Huaning² (AUTHOR), Ju, Dianwen² (AUTHOR), Zhu, Yi Zhun¹ (AUTHOR), Ye, Li^1,2 (AUTHOR) lye@must.edu.mo

Source: Applied Microbiology & Biotechnology. 2/7/2025, Vol. 109 Issue 1, p1-14. 14p.

Subject Terms: *DISCOIDIN domain receptor 1, *CHIMERIC proteins, *IMMUNE checkpoint inhibitors, *MEDICAL sciences, *TUMOR growth, *T cells

The role of glucagon-like peptide-1 receptor (GLP-1R) agonists in enhancing endothelial function: a potential avenue for improving heart failure with preserved ejection fraction (HFpEF).

Authors: Hullon, Darshan¹ (AUTHOR) darshanhullon@gmail.com, Subeh, Ghasaq K.² (AUTHOR), Volkova, Yelizaveta³ (AUTHOR), Janiec, Karolina⁴ (AUTHOR) karolinajaniec93@gmail.com, Trach, Adam³ (AUTHOR), Mnevets, Ruslan^3,5 (AUTHOR)

Source: Cardiovascular Diabetology. 2/7/2025, Vol. 24 Issue 1, p1-15. 15p.

Subject Terms: *GLUCAGON-like peptide-1 receptor, *ENDOTHELIUM diseases, *HEART failure, *VENTRICULAR ejection fraction, *DIABETES

A Hypothesis That Glucagon-like Peptide-1 Receptor Agonists Exert Immediate and Multifaceted Effects by Activating Adenosine Monophosphate-Activate Protein Kinase (AMPK).

Authors: Schooling, C. Mary^1,2 (AUTHOR) cms1@hku.hk, Yang, Guoyi¹ (AUTHOR), Soliman, Ghada A.² (AUTHOR), Leung, Gabriel M.¹ (AUTHOR)

Source: Life (2075-1729). Feb2025, Vol. 15 Issue 2, p253. 8p.

Subject Terms: *GLUCAGON-like peptide-1 receptor, *GLUCAGON-like peptide-1 agonists, *AMP-activated protein kinases, *LOW-calorie diet, *PROTEIN kinases, *SALICYLATES, *METFORMIN

X-Ray Irradiation Induces Oxidative Stress and Upregulates Intestinal Nrf2-Mrp2 Pathway, Leading to Decreased Intestinal Absorption of Valsartan.

Authors: Teng, Yunhua¹ (AUTHOR) tengyh847@163.com, Ma, Jiaojiao² (AUTHOR) 19861402016@163.com, Zhang, Junxia² (AUTHOR) jxzhang1204@163.com, Liang, Bohan¹ (AUTHOR) a1026894769@163.com, Zhang, Aijie¹ (AUTHOR) zhangaijie1986@163.com, Li, Yanjie¹ (AUTHOR) 15102274665@163.com, Dong, Shiqi¹ (AUTHOR) dongsq1314@126.com, Fan, Huirong¹ (AUTHOR) fanhuirong@irm-cams.ac.cn

Source: Pharmaceutics. Feb2025, Vol. 17 Issue 2, p268. 21p.

Subject Terms: *ANGIOTENSIN-receptor blockers, *DRUG absorption, *INTESTINAL absorption, *SMALL intestine, *ANTIHYPERTENSIVE agents

Advances in Oral Biomacromolecule Therapies for Metabolic Diseases.

Authors: Jiao, Qiuxia¹ (AUTHOR), Huang, Yuan² (AUTHOR), He, Jinhan^1,2 (AUTHOR), Xu, Yining^1,2 (AUTHOR) yiningxu@scu.edu.cn

Source: Pharmaceutics. Feb2025, Vol. 17 Issue 2, p238. 33p.

Subject Terms: *GLUCAGON-like peptide-1 receptor, *FIBROBLAST growth factors, *ORAL drug administration, *GASTROINTESTINAL diseases, *GLUCAGON-like peptide-1 agonists

SA4503 Mitigates Adriamycin-Induced Nephropathy via Sigma-1 Receptor in Animal and Cell-Based Models.

Authors: Tagashira, Hideaki¹ (AUTHOR) htagashira@med.akita-u.ac.jp, Chida, Shinsuke² (AUTHOR) schida@med.akita-u.ac.jp, Bhuiyan, Md. Shenuarin^3,4 (AUTHOR) shenu.bhuiyan@lsuhs.edu, Fukunaga, Kohji⁵ (AUTHOR) kfukunaga@tohoku.ac.jp, Numata, Tomohiro¹ (AUTHOR) htagashira@med.akita-u.ac.jp

Source: Pharmaceuticals (14248247). Feb2025, Vol. 18 Issue 2, p172. 19p.

Subject Terms: *SIGMA-1 receptor, *MOLECULAR chaperones, *KIDNEY glomerulus diseases, *NEPHROTIC syndrome, *DOXORUBICIN

Farnesoid X Receptor Attenuates the Tumorigenicity of Liver Cancer Stem Cells by Inhibiting STAT3 Phosphorylation.

Authors: Ye, Wenling^1,2 (AUTHOR), Zhao, Yang² (AUTHOR), Wang, Yibo² (AUTHOR), Wang, Yahan² (AUTHOR), Zhang, Huan² (AUTHOR), Wang, Fengling^1,2 (AUTHOR) wangfl@henu.edu.cn, Chen, Weidong^1,2 (AUTHOR) wangfl@henu.edu.cn

Source: International Journal of Molecular Sciences. Feb2025, Vol. 26 Issue 3, p1122. 20p.

Subject Terms: *FARNESOID X receptor, *CANCER stem cells, *HEPATOCELLULAR carcinoma, *LIVER cancer, *STAT proteins