Kinase Inhibitor for Cancer Therapy

Contributors: Musumeci, Francesca

Subject Terms: JAK, synthesis, kinase inhibitory activity, pharmacological uses, binding mode/interactions, choline kinase, lipid metabolism, cisplatin, lung tumors, combinatorial chemotherapy, glioblastoma, Src, pyrazolo [3,4-d]pyrimidine scaffold, EGFR, multiple myeloma, tyrosine kinase, treatment, ibrutinib, gastric cancer, kinase inhibitor, ALK, targeted therapy, JNK3, fragment, saturation transfer difference NMR, X-ray crystallography, breast cancer, nanomedicine, PI3K?, poloxamers, polymeric nanoparticles, TPGS, zanubrutinib, anthracycline, drug resistance, aldo-keto reductase 1C3, ABC drug efflux transporter, Hsp90 inhibitor, co-chaperone, heterocycle molecules, anticancer agents, heat shock proteins, ER stress, PERK, UPR, kinase, inhibitor, cancer, diabetes, small molecule, structure–activity-relationship (SAR), MCL, ROR1, small molecules, apoptosis, AKT1, kinase inhibitors, acute myeloid leukemia, rare disease, molecular modeling, molecular docking, similarity search, MD simulation, computer-aided drug discovery, cutaneous T-cell lymphoma, TWIST1, erufosine, curcumin, synergy, nanotechnology, 3D tissue culture, 3D tumor model, tumor spheroids, drug screening, preclinical study, tyrosine kinase inhibitors, innate immunity, thyroid cancer, tumor-associated macrophages, cytokines, c-Src/Abl dual inhibitors, pyrazolo[3,4-d]pyrimidines, ADME, antiproliferative activity, childhood cancer, kinases, chemical inhibitors, clinical trials, dasatinib, CML, HIV-1, CMV, HIV functional cure, memory-like NK cells, T cells, anti-aging, senolytic, NSCLC, KAN0441571C, erlotinib, TTP, rigosertib, ON-01910.Na, cancer therapy, kinase allosteric inhibition, Plk1, Ras, JNK, PI3K/Akt, microtubule-destabilizing agents, stress-signaling pathways, aptamer, MNK1, therapeutic target, non-small cell lung cancer, antitumor, 4,5,6,7-tetrabromo-N,N-dimethyl-1H-benzimidazol-2-amine (DMAT) derivatives, protein kinase CK2, protein kinase PIM-1, dual protein kinase inhibitors, antitumor activity, autophagy, hepatocellular carcinoma, EGFR/PI3K/AKT/mTOR signaling, animal models, Mathematics and Science, Biology, life sciences, Molecular biology

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Access URL: https://directory.doabooks.org/handle/20.500.12854/139351
https://mdpi.com/books/pdfview/book/9349

Exploration of anti-inflammatory activity of pyrazolo[3,4-d]pyrimidine/1,2,4-oxadiazole hybrids as COX-2, 5-LOX and NO release inhibitors: Design, synthesis, in silico and in vivo studies

Authors: Aziz, Marwa A. ^a, Salem, Ibrahim M. ^b, Al-Awadh, Mohammed A. ^c, Alharbi, Abdulrahman S. ^d, Elsayed Abouzed, Deiaa E. ^e, Allam, Rasha M. ^f, Ahmed, Osama A.A. ^{g, h}, Ibrahim, Tarek S. ^c, Abuo-Rahma, Gamal El-Din A. ^{a, i, ⁎}, Mohamed, Mamdouh F.A. ^{j, ⁎}

Source: In Bioorganic Chemistry March 2025 156

The Synthesis of 1,3,4-Thiadiazoles, 1,3,4-Selenadiazoles and Pyrazolo[3,4-d]pyrimidine Derivatives: Utility of hydrazonoyl bromide and DFT study

Authors: Shaaban A. Elroby, Sobhi M. Gomha, Abdelwahed R. Sayed, Yasser H. Zaki, Mahmoud A. Mohamed

Source: Results in Chemistry, Vol 9, Iss , Pp 101666- (2024)

Subject Terms: Hydrazonoyl bromide, 1,3,4-Thiadiazoles, 1,3,4-Selenadiazoles, Pyrazolo[3,4-d]pyrimidines, DFT, Chemistry, QD1-999

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S221171562400362X; https://doaj.org/toc/2211-7156

Access URL: https://doaj.org/article/5aa435dab2c14a52a27658fd93a1ed2a

Unprecedented synthesis of a 14-membered hexaazamacrocycle

Authors: Anastasia A. Fesenko, Anatoly D. Shutalev

Source: Beilstein Journal of Organic Chemistry, Vol 19, Iss 1, Pp 1728-1740 (2023)

Subject Terms: amidrazones, hexaazamacrocycles, pyrazolo[3,4-d]pyrimidines, ring contraction, self-assembly, Science, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://doaj.org/toc/1860-5397

Access URL: https://doaj.org/article/0eea5ac1d2934ecc862e9c8bc51b40ca

Sweet Cherry Extract as Permeation Enhancer of Tyrosine Kinase Inhibitors: A Promising Prospective for Future Oral Anticancer Therapies

Authors: Federica Poggialini, Chiara Vagaggini, Annalaura Brai, Claudia Pasqualini, Anna Carbone, Francesca Musumeci, Silvia Schenone, Elena Dreassi

Source: Pharmaceuticals, Vol 16, Iss 11, p 1527 (2023)

Subject Terms: tyrosine kinase, pyrazolo[3,4-d]pyrimidines, cancer, oral drug delivery, permeation enhancers, nutraceuticals, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/16/11/1527; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/0c24052588a24c2d985bde16104856df

Identification and Biological Characterization of the Pyrazolo[3,4-d]pyrimidine Derivative SI388 Active as Src Inhibitor

Authors: Claudia Contadini, Claudia Cirotti, Anna Carbone, Mehrdad Norouzi, Annarita Cianciusi, Emmanuele Crespan, Cecilia Perini, Giovanni Maga, Daniela Barilà, Francesca Musumeci, Silvia Schenone

Source: Pharmaceuticals, Vol 16, Iss 7, p 958 (2023)

Subject Terms: Src kinase, glioblastoma, radiotherapy resistance, pyrazolo[3,4-d]pyrimidines, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/16/7/958; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/cb6c5b3f3a3c4429a456fa6d37613bc6

Biological Evaluation and In Vitro Characterization of ADME Profile of In-House Pyrazolo[3,4-d]pyrimidines as Dual Tyrosine Kinase Inhibitors Active against Glioblastoma Multiforme

Authors: Federica Poggialini, Chiara Vagaggini, Annalaura Brai, Claudia Pasqualini, Emmanuele Crespan, Giovanni Maga, Cecilia Perini, Noemi Cabella, Lorenzo Botta, Francesca Musumeci, Maria Frosini, Silvia Schenone, Elena Dreassi

Source: Pharmaceutics, Vol 15, Iss 2, p 453 (2023)

Subject Terms: glioblastoma, tyrosine kinase, c-Src/Abl dual inhibitors, pyrazolo[3,4-d]pyrimidines, ADME, antiproliferative activity, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/15/2/453; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/ccd671932b5b41839203be632d83a138

Novel pyrazolo[3,4-d]pyrimidines: design, synthesis, anticancer activity, dual EGFR/ErbB2 receptor tyrosine kinases inhibitory activity, effects on cell cycle profile and caspase-3-mediated apoptosis

Authors: Mai Maher, Asmaa E. Kassab, Ashraf F. Zaher, Zeinab Mahmoud

Source: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 532-546 (2019)

Subject Terms: pyrazolo[3,4-d]pyrimidines, design, synthesis, anticancer activity, egfr, erbb2, caspase-3, cell cycle arrest profile, apoptosis, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

Access URL: https://doaj.org/article/12096bd2d87e4a23b588a00d03e46241

Design, Synthesis, and Biological Evaluation of a Novel VEGFR-2 Inhibitor Based on a 1,2,5-Oxadiazole-2-Oxide Scaffold with MAPK Signaling Pathway Inhibition

Authors: Mater H. Mahnashi, Fardous F. El-Senduny, Mohammed Abdulrahman Alshahrani, Mahrous A. Abou-Salim

Source: Pharmaceuticals, Vol 15, Iss 2, p 246 (2022)

Subject Terms: pyrazolo[3,4-d]pyrimidines, furoxan, VEGFR-2, DAF-FM DA, MAPK, metastasis, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/15/2/246; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/ccb199febb934fdc8f552c034cc49b83

Synthesis and Antibacterial Evaluation of New Pyrazolo[3,4-d]pyrimidines Kinase Inhibitors

Authors: Chiara Greco, Rosa Catania, Dario Leonardo Balacco, Vincenzo Taresco, Francesca Musumeci, Cameron Alexander, Alan Huett, Silvia Schenone

Source: Molecules, Vol 25, Iss 22, p 5354 (2020)

Subject Terms: pyrazolo[3,4-d]pyrimidines, kinase inhibitors, antimicrobials, β-lactam antibiotics, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/25/22/5354; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/c9da2ab5ddbb4753a6c9b8af1e1997e5

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