Sex-specific aspects in a population of patients undergoing evaluation for interstitial lung disease with transbronchial cryobiopsy.

Authors: Reinhard, Janna^1,2 (AUTHOR), Polke, Markus^1,2 (AUTHOR), Buschulte, Katharina^1,2 (AUTHOR), Eichinger, Monika^2,3,4 (AUTHOR), Heußel, Claus Peter^2,3 (AUTHOR), Güttlein, Maximilian^2,4 (AUTHOR), Michels-Zetsche, Julia D.^1,2 (AUTHOR), Wielpütz, Mark Oliver^2,4 (AUTHOR), Kahnert, Kathrin^5,6 (AUTHOR), Kontogianni, Konstantina^1,2 (AUTHOR), Klotz, Laura V.^2,7 (AUTHOR), Allgäuer, Michael⁸ (AUTHOR), Herth, Felix J.^1,2 (AUTHOR), Eberhardt, Ralf⁹ (AUTHOR), Kreuter, Michael¹⁰ (AUTHOR), Trudzinski, Franziska C.^1,2 (AUTHOR) franziska.trudzinski@med.uni-heidelberg.de

Source: Scientific Reports. 4/5/2025, Vol. 15 Issue 1, p1-9. 9p.

Subject Terms: *PULMONARY fibrosis, *INTERSTITIAL lung diseases, *IDIOPATHIC pulmonary fibrosis, *HYPERSENSITIVITY pneumonitis, *MEDICAL sciences, *LUNGS

Translational Regulators in Pulmonary Fibrosis: MicroRNAs, Long Non-Coding RNAs, and Transcript Modifications.

Authors: Gill, Sumeen Kaur¹ (AUTHOR), Gomer, Richard H.¹ (AUTHOR) rgomer@tamu.edu

Source: Cells (2073-4409). Apr2025, Vol. 14 Issue 7, p536. 20p.

Subject Terms: *LINCRNA, *IDIOPATHIC pulmonary fibrosis, *RNA modification & restriction, *PULMONARY fibrosis, *GENE expression

Inhibition of Transglutaminase 2 by a Selective Small Molecule Inhibitor Reduces Fibrosis and Improves Pulmonary Function in a Bleomycin Mouse Model.

Authors: Wang, Zhuo¹ (AUTHOR), Sriram, Sriniwas² (AUTHOR), Ugwoke, Cynthia¹ (AUTHOR), Gale, Zoe^1,2 (AUTHOR), Tabrizi, Maral¹ (AUTHOR), Griffin, Martin¹ (AUTHOR)

Source: Cells (2073-4409). Apr2025, Vol. 14 Issue 7, p497. 17p.

Subject Terms: *IDIOPATHIC pulmonary fibrosis, *TRANSFORMING growth factors, *PULMONARY fibrosis, *SMALL molecules, *SMOOTH muscle, *LUNGS

Unravelling the transcriptomic characteristics of bronchoalveolar lavage in post-covid pulmonary fibrosis.

Authors: Ali, Mohammad Shadab¹ (AUTHOR), Hadda, Vijay¹ (AUTHOR) vijayhadda@yahoo.com, Verma, Sonia² (AUTHOR), Chopra, Anita³ (AUTHOR), Mittal, Saurabh¹ (AUTHOR), Madan, Karan¹ (AUTHOR), Tiwari, Pawan¹ (AUTHOR), Suri, Tejas Menon¹ (AUTHOR), Mohan, Anant¹ (AUTHOR)

Source: BMC Medical Genomics. 3/17/2025, Vol. 18 Issue 1, p1-13. 13p.

Subject Terms: *IDIOPATHIC pulmonary fibrosis, *INTERSTITIAL lung diseases, *CELL cycle regulation, *LIFE sciences, *PULMONARY fibrosis

Epidemiology of idiopathic pulmonary fibrosis in central and Western Pennsylvania.

Authors: Linkov, Faina¹ (AUTHOR) Linkovf@duq.edu, Chang, Yue-Fang² (AUTHOR), Ramanan, Harshitha¹ (AUTHOR), Morgan, Richard S.³ (AUTHOR), McTigue, Kathleen M.⁴ (AUTHOR), Dimmock, Anne E. F.⁵ (AUTHOR), Bascom, Rebecca⁵ (AUTHOR), Kass, Daniel J.⁶ (AUTHOR)

Source: Respiratory Research. 3/10/2025, Vol. 26 Issue 1, p1-10. 10p.

Subject Terms: *IDIOPATHIC pulmonary fibrosis, *EPIDEMIOLOGY, *DISEASE prevalence, *PULMONARY fibrosis, *HEALTH care industry

Geographic Terms: PENNSYLVANIA

Dysregulated metabolic pathways of pulmonary fibrosis and the lipids associated with the effects of nintedanib therapy.

Authors: Shimizu, Yasuo¹ (AUTHOR) yasuo-s@dokkyomed.ac.jp, Horibata, Yasuhiro² (AUTHOR), Domae, Mariko² (AUTHOR), Nakamura, Yusuke¹ (AUTHOR), Yokoyama, Tatsuya¹ (AUTHOR), Arai, Ryo¹ (AUTHOR), Shiobara, Taichi¹ (AUTHOR), Takemasa, Akihiro¹ (AUTHOR), Koike, Ryosuke¹ (AUTHOR), Uchida, Nobuhiko¹ (AUTHOR), Masawa, Meitetsu¹ (AUTHOR), Tei, Rinna¹ (AUTHOR), Watanabe, Taiji¹ (AUTHOR), Morita, Hiroko¹ (AUTHOR), Miyoshi, Masaaki¹ (AUTHOR), Soda, Sayo¹ (AUTHOR), Niho, Seiji¹ (AUTHOR), Igami, Ko³ (AUTHOR), Sugimoto, Hiroyuki² (AUTHOR)

Source: Respiratory Research. 4/28/2025, Vol. 26 Issue 1, p1-16. 16p.

Subject Terms: *PULMONARY fibrosis, *LIPID metabolism, *GLYCEROPHOSPHOLIPIDS, *TREATMENT effectiveness, *LIPID analysis, *METABOLISM, *LIPIDS

Alveolar cell composition in interstitial lung disease and the development of a pulmonary progressive fibrosing phenotype: a retrospective cohort study.

Authors: Simons, Iris A.^1,2,3 (AUTHOR), Boerrigter, Bart G.⁴ (AUTHOR), Hovestadt, Maud C.M.¹ (AUTHOR), Mooij-Kalverda, Kirsten A.^1,5 (AUTHOR), Zhang, Shiqi^3,6 (AUTHOR), Boers, Leonoor S.^3,6 (AUTHOR), van der Zee, Anke H. Maitland–¹ (AUTHOR), Nossent, Esther J.^4,7 (AUTHOR), Duitman, Jan Willem^1,2,3 (AUTHOR) j.w.duitman@amsterdamumc.nl

Source: Respiratory Research. 4/28/2025, Vol. 26 Issue 1, p1-11. 11p.

Subject Terms: *INTERSTITIAL lung diseases, *PULMONARY fibrosis, *BRONCHOALVEOLAR lavage, *DISEASE progression, *COHORT analysis, *T-cell exhaustion, *T helper cells

Dehydrocorydaline attenuates bleomycin-induced pulmonary fibrosis by inhibiting fibroblast activation.

Authors: He, Jianhan¹ (AUTHOR) hejianhan1234@163.com, Yue, Huihui¹ (AUTHOR) 307362048@qq.com, Zhang, Shufei² (AUTHOR) 2076270844@qq.com, Dong, Ruihan¹ (AUTHOR) dongruihan1998@126.com, Zhang, Fengqin¹ (AUTHOR) Fengqinz96@163.com, Wang, Xuewen¹ (AUTHOR) wang_xvv@163.com, Wang, Ke¹ (AUTHOR) wangke@tjh.tjmu.edu.cn, Zhang, Huilan¹ (AUTHOR) huilanz76@hust.edu.cn, Yang, Danlei¹ (AUTHOR) danleiyang@aliyun.com, Dong, Zhaoxing³ (AUTHOR) dongkm@hotmail.com, Liu, Huiguo¹ (AUTHOR) hgliu@tjh.tjmu.edu.cn

Source: Respiratory Research. 4/12/2025, Vol. 26 Issue 1, p1-16. 16p.

Subject Terms: *PULMONARY fibrosis, *FIBROBLASTS, *BLEOMYCIN, *TRANSFORMING growth factors-beta, *NATURAL products, *CORYDALIS, *TREATMENT effectiveness

High matrix stiffness promotes senescence of type II alveolar epithelial cells by lysosomal degradation of lamin A/C in pulmonary fibrosis.

Authors: Ba, Junhui¹ (AUTHOR), Zheng, Changyu² (AUTHOR), Lai, Yimei³ (AUTHOR), He, Xin⁴ (AUTHOR), Pan, Yuxi⁵ (AUTHOR), Zhao, Yanqiu⁶ (AUTHOR), Xie, Huihui³ (AUTHOR), Wu, Benquan¹ (AUTHOR) wubq@mail.sysu.edu.cn, Deng, Xiao³ (AUTHOR) dxpathology@163.com, Wang, Nan^2,4,7 (AUTHOR) wangnan@sysush.com

Source: Respiratory Research. 4/9/2025, Vol. 26 Issue 1, p1-13. 13p.

Subject Terms: *PULMONARY fibrosis, *CELLULAR aging, *PULMONARY alveoli, *CHLOROQUINE, *AUTOPHAGY, *LAMINS, *EXTRACELLULAR matrix

A bioinformatics approach combined with experimental validation analyzes the efficacy of azithromycin in treating SARS-CoV-2 infection in patients with IPF and COPD.

Authors: Xie, Yining^1,2 (AUTHOR), Chen, Guangshu¹ (AUTHOR), Wu, Weiling¹ (AUTHOR), Wen, Xueman¹ (AUTHOR), Lai, Meizheng¹ (AUTHOR), Che, Li³ (AUTHOR) Cherry20170908@sina.com, Ran, Jianmin¹ (AUTHOR) ran_jianmin@ext.jnu.edu.cn

Source: Scientific Reports. 4/11/2025, Vol. 15 Issue 1, p1-13. 13p.

Subject Terms: *SARS-CoV-2, *IDIOPATHIC pulmonary fibrosis, *CHRONIC obstructive pulmonary disease, *DRUG therapy, *DRUG target

The effective-compound compatibility of JHF inhibits fibroblast activation in pulmonary fibrosis by enhancing PINK1/PARK2-mediated mitophagy.

Authors: Bai, Yunping^1,2,3 (AUTHOR), Yin, Xiaohong^1,2,3 (AUTHOR), Zhang, Qin^1,2,4 (AUTHOR), Sang, Xingjie^1,2,3 (AUTHOR), Wu, Wenjing^1,2,3 (AUTHOR), Shao, Dong^1,2,3 (AUTHOR), Zhao, Peng^1,2,4 (AUTHOR), Li, Jiansheng^1,2,3 (AUTHOR) li_js8@163.com

Source: Scientific Reports. 4/8/2025, Vol. 15 Issue 1, p1-14. 14p.

Subject Terms: *LABORATORY rats, *PULMONARY fibrosis, *SUPEROXIDE dismutase, *NUCLEAR factor E2 related factor, *FIBROBLASTS

Design, development, and preclinical evaluation of pirfenidone-loaded nanostructured lipid carriers for pulmonary delivery.

Authors: Chettupalli, Ananda Kumar¹ (AUTHOR) anandphd88@gmail.com, Kakkerla, Anitha² (AUTHOR), Jadi, Rajendra Kumar³ (AUTHOR), Uppu, Pavani⁴ (AUTHOR), Ghazwani, Mohammed⁵ (AUTHOR) myghazwani@kku.edu.sa, Hani, Umme⁶ (AUTHOR), Amarachinta, Padmanabha Rao³ (AUTHOR), Sarvani, Peri³ (AUTHOR), Haque, M. Akiful⁷ (AUTHOR)

Source: Scientific Reports. 4/4/2025, Vol. 15 Issue 1, p1-23. 23p.

Subject Terms: *PHYSICAL & theoretical chemistry, *IDIOPATHIC pulmonary fibrosis, *RESPIRATORY therapy, *PARTICLE size distribution, *SURFACE topography

Immunological Features and Potential Biomarkers of Systemic Sclerosis–Associated Interstitial Lung Disease and Idiopathic Pulmonary Fibrosis.

Authors: Shao, Shuai¹ (AUTHOR), Cao, Siyu¹ (AUTHOR), Chen, Yusha¹ (AUTHOR), Zhang, Zhijin¹ (AUTHOR), Zhaohui, Tong¹ (AUTHOR) tongzhaohuicy@sina.com

Source: Clinical Respiratory Journal. Apr2025, Vol. 19 Issue 4, p1-14. 14p.

Subject Terms: *INTERSTITIAL lung diseases, *IDIOPATHIC pulmonary fibrosis, *T-cell receptor genes, *JAK-STAT pathway, *T cells, *BIOMARKERS, *SYSTEMIC scleroderma, *IMMUNOLOGY

Computer-Aided Evaluation of Interstitial Lung Diseases.

Authors: Colombi, Davide¹ (AUTHOR) colombidavide@gmail.com, Marvisi, Maurizio² (AUTHOR), Ramponi, Sara^2,3 (AUTHOR), Balzarini, Laura^1,2 (AUTHOR), Mancini, Chiara² (AUTHOR), Milanese, Gianluca³ (AUTHOR), Silva, Mario³ (AUTHOR), Sverzellati, Nicola³ (AUTHOR), Uccelli, Mario¹ (AUTHOR), Ferrozzi, Francesco¹ (AUTHOR)

Source: Diagnostics (2075-4418). Apr2025, Vol. 15 Issue 7, p943. 15p.

Subject Terms: *INTERSTITIAL lung diseases, *PULMONARY fibrosis, *ARTIFICIAL intelligence, *MEDICAL screening, *MEDICAL personnel

Immunotherapeutic targeting of aging‐associated isoDGR motif in chronic lung inflammation.

Authors: Kalailingam, Pazhanichamy^1,2 (AUTHOR) pazhanichamy.k@ntu.edu.sg, Ngan, SoFong Cam³ (AUTHOR), Iyappan, Ranjith³ (AUTHOR), Nehchiri, Afra³ (AUTHOR), Mohd‐Kahliab, Khalilatul‐Hanisah² (AUTHOR), Lee, Benjamin Sian Teck² (AUTHOR), Sharma, Bhargy² (AUTHOR), Machan, Radek⁴ (AUTHOR), Bo, Sint Thida² (AUTHOR), Chambers, Emma S.⁵ (AUTHOR), Fajardo, Val A.³ (AUTHOR), Macpherson, Rebecca E. K.³ (AUTHOR), Liu, Jian³ (AUTHOR), Klentrou, Panagiota³ (AUTHOR), Tsiani, Evangelia Litsa³ (AUTHOR), Lim, Kah Leong⁶ (AUTHOR), Su, I. Hsin² (AUTHOR), Gao, Yong‐Gui² (AUTHOR), Richar, A. Mark⁷ (AUTHOR), Kalaria, Raj N.⁸ (AUTHOR)

Source: Aging Cell. Apr2025, Vol. 24 Issue 4, p1-20. 20p.

Subject Terms: *PULMONARY fibrosis, *CELLULAR aging, *PNEUMONIA, *PULMONARY edema, *GENE targeting, *LUNGS

Melittin alleviates bleomycin-induced pulmonary fibrosis in vivo through regulating TGF-β1/Smad2/3 and AMPK/SIRT1/PGC-1α signaling pathways.

Authors: Jia-Wang Yu^1,2, Wei-Hua Lu^1,3 lwh683@126.com

Source: Iranian Journal of Basic Medical Sciences. Apr2025, Vol. 28 Issue 4, p426-433. 8p.

Subject Terms: *STAINS & staining (Microscopy), *PULMONARY fibrosis, *IMMUNOSTAINING, *MELITTIN, *EXTRACELLULAR matrix

A Targeted Mass Spectrometric Approach to Evaluate the Anti-Inflammatory Activity of the Major Metabolites of Foeniculum vulgare Mill. Waste in Human Bronchial Epithelium.

Authors: Crescenzi, Maria Assunta^1,2 (AUTHOR), Gallart-Ayala, Hector^2,3 (AUTHOR), Stellato, Cristiana^3,4 (AUTHOR), Popolo, Ada^1,4 (AUTHOR), Ivanisevic, Julijana^1,3 (AUTHOR), Piacente, Sonia^1,2 (AUTHOR), Montoro, Paola^1,3 (AUTHOR) pmontoro@unisa.it

Source: Molecules. Apr2025, Vol. 30 Issue 7, p1407. 16p.

Subject Terms: *CHRONIC obstructive pulmonary disease, *IDIOPATHIC pulmonary fibrosis, *QUINIC acid, *FENNEL, *INFLAMMATION

Human umbilical cord mesenchymal stem cell-derived microvesicles alleviate pulmonary fibrosis by inhibiting monocyte‒macrophage migration through ERK1/2 signaling-mediated suppression of CCL2 expression.

Authors: Liang, Xiuping¹ (AUTHOR), Li, Yanhong¹ (AUTHOR), Wu, Yinlan¹ (AUTHOR), Wu, Tong¹ (AUTHOR), Huang, Deying¹ (AUTHOR), Tang, Ziyi¹ (AUTHOR), Cheng, Lu² (AUTHOR), Tan, Chunyu¹ (AUTHOR), Liao, Ronghui¹ (AUTHOR), Zhao, Jing¹ (AUTHOR), Liao, Zehui³ (AUTHOR), Luo, Yubin¹ (AUTHOR) luoyubin2016@163.com, Liu, Yi¹ (AUTHOR) yiliu8999@wchscu.cn

Source: Stem Cell Research & Therapy. 3/24/2025, Vol. 16 Issue 1, p1-16. 16p.

Subject Terms: *PULMONARY fibrosis, *MESENCHYMAL stem cells, *ENZYME-linked immunosorbent assay, *EXTRACELLULAR matrix, *STAINS & staining (Microscopy)

Treatment rechallenge is safe and leads to better survival in pancreatic cancer patients with interstitial pneumonitis.

Authors: Yu, Hung-Yuan^1,2,3 (AUTHOR), Lee, Chun-Yang^2,3 (AUTHOR), Hu, Yen-Chi^2,3,4 (AUTHOR), Lin, Le-Gin^3,5 (AUTHOR), Chao, Yee^3,6 (AUTHOR), Li, Chung-Pin^1,2,3,7 (AUTHOR) cpli@vghtpe.gov.tw

Source: BMC Cancer. 3/19/2025, Vol. 25 Issue 1, p1-9. 9p.

Subject Terms: *INTERSTITIAL lung diseases, *PULMONARY fibrosis, *DISEASE risk factors, *MEDICAL sciences, *ADULT respiratory distress syndrome

Genetic insights into idiopathic pulmonary fibrosis: a multi-omics approach to identify potential therapeutic targets.

Authors: Wen, Zhuofeng¹ (AUTHOR), Liang, Weixuan² (AUTHOR), Yang, Ziyang³ (AUTHOR), Liu, Junjie⁴ (AUTHOR), Yang, Jing¹ (AUTHOR), Xu, Runge² (AUTHOR), Lin, Keye² (AUTHOR), Pan, Jia² (AUTHOR), Chen, Zisheng¹ (AUTHOR) 502463784@qq.com

Source: Journal of Translational Medicine. 3/16/2025, Vol. 23 Issue 1, p1-20. 20p.

Subject Terms: *LOCUS (Genetics), *IDIOPATHIC pulmonary fibrosis, *GENE expression, *GENOME-wide association studies, *MENDELIAN randomization