TransTACs: Transforming antibodies into targeted protein degraders

Authors: Yu Guo, Jinxin Che, Xiaowu Dong

Source: Acta Pharmaceutica Sinica B, Vol 15, Iss 2, Pp 1186-1188 (2025)

Subject Terms: Targeted protein degradation, Membrane and extracellular proteins, Transferrin receptor-targeting chimeras, Protein homeostasis regulation, Tumor therapy, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211383525000061; https://doaj.org/toc/2211-3835

Access URL: https://doaj.org/article/467f53570141436ebde366a8c4b5024c

Proteasome dynamics in response to metabolic changes

Authors: Cordula Enenkel, Oliver P. Ernst

Source: Frontiers in Cell and Developmental Biology, Vol 13 (2025)

Subject Terms: metabolic regulation of proteasome localization, proteasome condensates in membraneless organelles, proteasome storage granules, protein homeostasis (proteostasis), ubiquitin 26S-proteasome system, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2025.1523382/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/4efbfff811fd43b78b274ff7c5169175

How close is autophagy-targeting therapy for Alzheimer's disease to clinical use? A summary of autophagy modulators in clinical studies

Authors: Sofia Miranda Fernandes, Johanna Mayer, Per Nilsson, Makoto Shimozawa

Source: Frontiers in Cell and Developmental Biology, Vol 12 (2025)

Subject Terms: Alzheimer’s disease, protein homeostasis, autophagy modulators, clinical studies, autophagy impairment, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2024.1520949/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/60a5b8b03ddd40028b1f78086e14349b

pSTAT3 transactivates EGFR in maintaining EGFR protein homeostasis and EGFR-TKI resistance

Authors: Ao Juan, Fei Junjie, Wang Guoqiang, Zhang Wenhua, Yu Shuhan, Guo Rongtian, Niu Mengmeng, Chen Hu, Cao Yang, Xiao Zhi-Xiong Jim, Yi Yong

Source: Acta Biochimica et Biophysica Sinica, Vol 57, Pp 310-316 (2024)

Subject Terms: EGFR, pSTAT3, protein homeostasis, EGFR-TKI resistance, Biochemistry, QD415-436, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1672-9145

Access URL: https://doaj.org/article/1f8bd46d5e264c8f9b59808a165c45cd

Using protein turnover assay to explore the drug mechanism of Carfilzomib

Authors: Tao Yonghui, Ding Xinyu, Jia Caiwei, Wang Chengcheng, Li Chuanyin

Source: Acta Biochimica et Biophysica Sinica, Vol 57, Pp 209-222 (2024)

Subject Terms: Carfilzomib, multiple myeloma, profiling, protein homeostasis, Biochemistry, QD415-436, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1672-9145

Access URL: https://doaj.org/article/3281f4615c7e42f69b7f8d24c7a5b517

From Rat Tails to Glycoproteostasis: Motivated by Biology, Enabled by Biophysics, and Lucky

Authors: Gierasch, Lila M.

Source: In Journal of Molecular Biology February 2025

The role of ubiquitination in health and disease

Authors: Yan Liao, Wangzheqi Zhang, Yang Liu, Chenglong Zhu, Zui Zou

Source: MedComm, Vol 5, Iss 10, Pp n/a-n/a (2024)

Subject Terms: protein degradation, protein homeostasis, ubiquitin, ubiquitination, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2688-2663

Access URL: https://doaj.org/article/9aa330ec6819416f8393684e1f74d39e

Responses of the mud snail Cipangopaludina cathayensis to thermal stress: Insights from metabolism, oxidative stress damage, and hepatopancreas transcriptional modulation

Authors: Wei, Jinyou ^{a, b, 1}, Wu, Yangyang ^{a, b, 1}, Cheng, Chunxing ^{a, b}, Tan, Haizhen ^{a, b}, Li, Linli ^{a, b}, Jiang, Jiaoyun ^{a, b, c, ⁎}

Source: In Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics June 2025 54

Recent advances in small molecule inhibitors of deubiquitinating enzymes

Authors: Liu, Pengwei ^{a, b, 1}, Chen, Zhengyang ^{a, b, 1}, Guo, Yiting ^{a, b}, He, Qiaojun ^{a, b, ⁎⁎}, Pan, Chenghao ^{a, b, ⁎}

Source: In European Journal of Medicinal Chemistry 5 April 2025 287

Substrate recognition and cleavage-site preferences of Lon protease

Authors: Cragan, Melanie, Puri, Neha, Karzai, A. Wali ^∗

Source: In Journal of Biological Chemistry April 2025 301(4)

ER stress and viral defense: Advances and future perspectives on plant unfolded protein response in pathogenesis

Authors: Adhikari, Binita ¹, Verchot, Jeanmarie ^{1, ∗}, Brandizzi, Federica ^{2, 3, 4}, Ko, Dae Kwan ^{2, 3, 4, ∗}

Source: In Journal of Biological Chemistry April 2025 301(4)

Structural Variations of Prions and Prion-like Proteins Associated with Neurodegeneration

Authors: Carter Sky Christensen, Sean Wang, Wenshu Li, Danyang Yu, Henry James Li

Source: Current Issues in Molecular Biology, Vol 46, Iss 7, Pp 6423-6439 (2024)

Subject Terms: prions, neurodegeneration, Alzheimer’s disease, protein homeostasis, aggregation, prion-like proteins, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/1467-3045/46/7/384; https://doaj.org/toc/1467-3037; https://doaj.org/toc/1467-3045

Access URL: https://doaj.org/article/99ba7402254f47f7bacc8058bd737e6b

Renal Implications of Dysregulated Protein Homeostasis: Insights into Ubiquitin–Proteasome and Autophagy Systems

Authors: Charlotte Delrue, Marijn M. Speeckaert

Source: Biomolecules, Vol 15, Iss 3, p 349 (2025)

Subject Terms: ubiquitin–proteasome system, autophagy, chronic kidney disease, protein homeostasis, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-273X/15/3/349; https://doaj.org/toc/2218-273X

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Nucleoporin Nsp1 surveils the phase state of FG-Nups

Authors: Otto, Tegan A. ¹, Bergsma, Tessa ^{1, 4}, Dekker, Maurice ^{2, 4}, Mouton, Sara N. ¹, Gallardo, Paola ¹, Wolters, Justina C. ³, Steen, Anton ¹, Onck, Patrick R. ², Veenhoff, Liesbeth M. ^{1, 5, ∗}

Source: In Cell Reports 22 October 2024 43(10)

Peroxiredoxin 4 deficiency induces accelerated ovarian aging through destroyed proteostasis in granulosa cells

Authors: Zou, Xiaofei ¹, Liang, Xiuru ¹, Dai, Wangjuan ¹, Zhu, Ting, Wang, Chaoyi, Zhou, Yutian, Qian, Yi, Yan, Zhengjie, Gao, Chao, Gao, Li, Cui, Yugui, Liu, Jiayin, Meng, Yan ^⁎

Source: In BBA - Molecular Basis of Disease October 2024 1870(7)

Transcriptomic analyses of Pinctada fucata martensii responses under stress of titanium dioxide nanoparticles

Authors: Fengfeng Li, Jiaen Liu, Zixin Gao, Chuangye Yang, Liwei Sun, Yongshan Liao, Yuewen Deng

Source: Frontiers in Marine Science, Vol 11 (2024)

Subject Terms: TiO2-NPs, Pinctada fucata martensii, transcriptomics, protein homeostasis, oxidative stress, Science, General. Including nature conservation, geographical distribution, QH1-199.5

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Relation: https://www.frontiersin.org/articles/10.3389/fmars.2024.1462589/full; https://doaj.org/toc/2296-7745

Access URL: https://doaj.org/article/726b7bb9f569432992a1d25554e9e05b

Mitochondrial inorganic polyphosphate is required to maintain proteostasis within the organelle

Authors: Renata T. Da Costa, Pedro Urquiza, Matheus M. Perez, YunGuang Du, Mei Li Khong, Haiyan Zheng, Mariona Guitart-Mampel, Pia A. Elustondo, Ernest R. Scoma, Vedangi Hambardikar, Beatrix Ueberheide, Julian A. Tanner, Alejandro Cohen, Evgeny V. Pavlov, Cole M. Haynes, Maria E. Solesio

Source: Frontiers in Cell and Developmental Biology, Vol 12 (2024)

Subject Terms: mitochondria, mitochondrial inorganic polyphosphate, polyP, protein homeostasis, proteostasis, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2024.1423208/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/88ee7d20f5ac4d03baa5fa1375c6926b

Exploring the origins of neurodevelopmental proteasomopathies associated with cardiac malformations: are neural crest cells central to certain pathological mechanisms?

Authors: Virginie Vignard, Alban-Elouen Baruteau, Bérénice Toutain, Sandra Mercier, Bertrand Isidor, Richard Redon, Jean-Jacques Schott, Sébastien Küry, Stéphane Bézieau, Anne H. Monsoro-Burq, Frédéric Ebstein

Source: Frontiers in Cell and Developmental Biology, Vol 12 (2024)

Subject Terms: neurodevelopmental proteasomopathies, cardiac malformations, craniofacial anomalies, neural crest cells, protein homeostasis, compensatory pathways, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2024.1370905/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/8ec98747cd9e4fccb622ac05f5cea598

Handelin alleviates cachexia‐ and aging‐induced skeletal muscle atrophy by improving protein homeostasis and inhibiting inflammation

Authors: Hui‐Jie Zhang, Ben‐Hui Wang, Xiang Wang, Chun‐Ping Huang, Si‐Man Xu, Jia‐Li Wang, Tian‐E Huang, Wan‐Li Xiao, Xiao‐Li Tian, Xin‐Qiang Lan, Qi‐Quan Wang, Yang Xiang

Source: Journal of Cachexia, Sarcopenia and Muscle, Vol 15, Iss 1, Pp 173-188 (2024)

Subject Terms: Aging, Cachexia, Handelin, Inflammation, Protein homeostasis, Skeletal muscle atrophy, Diseases of the musculoskeletal system, RC925-935, Human anatomy, QM1-695

File Description: electronic resource

Relation: https://doaj.org/toc/2190-5991; https://doaj.org/toc/2190-6009

Access URL: https://doaj.org/article/1c0f560da4bb418e8e19c5e7e54403fb

Targeting Protein Aggregation in ALS

Authors: Michele Perni, Benedetta Mannini

Source: Biomolecules, Vol 14, Iss 10, p 1324 (2024)

Subject Terms: neurodegeneration, amyotrophic lateral sclerosis, drug discovery, clinical trials, protein aggregation, protein homeostasis, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-273X/14/10/1324; https://doaj.org/toc/2218-273X

Access URL: https://doaj.org/article/a93f50660b4d45dab8076f6854bbf70f