Factors affecting the expression and stability of full-length and truncated SRSF3 proteins in human cancer cells

Authors: Sung-How Sue, Shu-Ting Liu, Shih-Ming Huang

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)

Subject Terms: Alternative splicing, Serine/arginine-rich splicing factors, Truncated protein, Premature termination codon, Palmitic acid, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/99f73f8c54874715928ac83985cab311

Developing AAV-delivered nonsense suppressor tRNAs for neurological disorders

Authors: Jiaming Wang, Guangping Gao, Dan Wang

Source: Neurotherapeutics, Vol 21, Iss 4, Pp e00391- (2024)

Subject Terms: AAV, Nonsense mutation, Neurological disorder, Premature termination codon, Suppressor tRNA, Neurology. Diseases of the nervous system, RC346-429

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Relation: http://www.sciencedirect.com/science/article/pii/S1878747924000771; https://doaj.org/toc/1878-7479

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Editorial: Advancing therapeutic strategies: exploring ABC transporters and chemicals affecting their expression and function for disease treatment

Authors: Guido Veit, Michinori Matsuo, Tsukasa Okiyoneda

Source: Frontiers in Pharmacology, Vol 15 (2024)

Subject Terms: ABC transporters, CFTR (cystic fibrosis transmembrane conductance regulator), pharmacological chaperones, missense mutations, premature termination codon (PTC), Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2024.1423979/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/7d9167ebf42f4eb493a4889e34ee602c

Pseudorabies Virus

Contributors: Tang, Yan-Dong, Li, Xiangdong

Subject Terms: pseudorabies virus, Liver X receptors, clathrin-coated pits, viral entry, innate immune response, type I interferons, apoptosis, autophagy, premature termination codon, genetic code expansion, virus isolation, pathogenicity, mortality, inflammatory response, Huaier polysaccharide, antiviral, infection, Vero cell, TMT-based proteomic analysis, differentially expressed proteins, antiviral breeding, genetic modification, nectin1, pig, PRV, disease resistance, seroprevalence, epidemiology, phylogenetic analysis, variants, ICP0 protein, P65, NF-κB signaling pathway, complete genome sequencing, gene recombination, variant strain, genomics, vaccination, transmission, zoonosis, itch, mouse, histamine, dorsal root ganglion, metabolomic analysis, UHPLC-QE-MS, PK-15 cells, latent infection, latency-associated transcripts, non-coding RNA, latency, miRNA, chromatin, immune regulation, variation, human pseudorabies encephalitis, pseudorabies virus (PRV), tegument protein UL13, RIG-I, MDA5, NF-κB, pathogenesis, prevention and control, Aujeszky’s disease, epidemiological characteristics, Research and information: general, Biology, life sciences, Microbiology (non-medical)

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Access URL: https://directory.doabooks.org/handle/20.500.12854/94555
https://mdpi.com/books/pdfview/book/6390

Premature termination codon: a tunable protein translation approach

Authors: Xiyao Cheng, Ting Zhou, Zixin Yang, Jingjing Zhou, Meng Gao, Yongqi Huang, Zhengding Su

Source: BioTechniques, Vol 73, Iss 2, Pp 80-89 (2022)

Subject Terms: apoptosis, cell cycle arrest, gene expression, MMS, p53, premature termination codon, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/0736-6205; https://doaj.org/toc/1940-9818

Access URL: https://doaj.org/article/829a8aae5f3b47078ff904973b24c79e

Readthrough Activators and Nonsense-Mediated mRNA Decay Inhibitor Molecules: Real Potential in Many Genetic Diseases Harboring Premature Termination Codons

Authors: Nesrine Benslimane, Camille Loret, Pauline Chazelas, Frédéric Favreau, Pierre-Antoine Faye, Fabrice Lejeune, Anne-Sophie Lia

Source: Pharmaceuticals, Vol 17, Iss 3, p 314 (2024)

Subject Terms: nonsense mutation, readthrough, premature termination codon (PTC), genetic disease, nonsense-mediated mRNA decay (NMD), translation, Medicine, Pharmacy and materia medica, RS1-441

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Relation: https://www.mdpi.com/1424-8247/17/3/314; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/c9bb724cfe6e47b08f7976b929da6962

Efficient suppression of endogenous CFTR nonsense mutations using anticodon-engineered transfer RNAs

Authors: Wooree Ko, Joseph J. Porter, Matthew T. Sipple, Katherine M. Edwards, John D. Lueck

Source: Molecular Therapy: Nucleic Acids, Vol 28, Iss , Pp 685-701 (2022)

Subject Terms: MT: Oligonucleotides: Therapies and Applications, nonsense suppressor tRNA, cystic fibrosis, CFTR, nonsense mutation, premature termination codon, Therapeutics. Pharmacology, RM1-950

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Relation: http://www.sciencedirect.com/science/article/pii/S216225312200110X; https://doaj.org/toc/2162-2531

Access URL: https://doaj.org/article/0445ef3dbb6b47ffb9ec0cde44256465

A novel frameshift mutation in DNAH6 associated with male infertility and asthenoteratozoospermia

Authors: Fei Huang, Jun Zeng, Dan Liu, Jing Zhang, Boluo Liang, Jingping Gao, Rong Yan, Xiaobo Shi, Jianlin Chen, Wanjuan Song, Hua-Lin Huang

Source: Frontiers in Endocrinology, Vol 14 (2023)

Subject Terms: infertility, asthenoteratozoospermia, sperm flagella, DNAH6, mutation, premature termination codon, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

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Relation: https://www.frontiersin.org/articles/10.3389/fendo.2023.1122004/full; https://doaj.org/toc/1664-2392

Access URL: https://doaj.org/article/33110b13c0f04bbeb6ccdc267a8264c0

Topical gentamicin 0.1% promotes collagen 7 expression in recessive dystrophic epidermolysis bullosa

Authors: Rahul Mahajan, Seema Manjunath, Manoj G Madakshira, Dipankar De, Sanjeev Handa, Debajyoti Chatterjee, Bishan D Radotra

Source: Indian Dermatology Online Journal, Vol 13, Iss 4, Pp 480-483 (2022)

Subject Terms: epidermolysis bullosa, gentamicin, premature termination codon, Dermatology, RL1-803

File Description: electronic resource

Relation: http://www.idoj.in/article.asp?issn=2229-5178;year=2022;volume=13;issue=4;spage=480;epage=483;aulast=Mahajan; https://doaj.org/toc/2229-5178

Access URL: https://doaj.org/article/4ac06765a07e4869a86920942f4ffb31

Amlexanox: Readthrough Induction and Nonsense-Mediated mRNA Decay Inhibition in a Charcot–Marie–Tooth Model of hiPSCs-Derived Neuronal Cells Harboring a Nonsense Mutation in GDAP1 Gene

Authors: Nesrine Benslimane, Federica Miressi, Camille Loret, Laurence Richard, Angélique Nizou, Ioanna Pyromali, Pierre-Antoine Faye, Frédéric Favreau, Fabrice Lejeune, Anne-Sophie Lia

Source: Pharmaceuticals, Vol 16, Iss 7, p 1034 (2023)

Subject Terms: GDAP1, CMT disease, nonsense mutation, nonsense-mediated decay (NMD), readthrough molecules, premature termination codon (PTC), Medicine, Pharmacy and materia medica, RS1-441

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Relation: https://www.mdpi.com/1424-8247/16/7/1034; https://doaj.org/toc/1424-8247

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Pharmacological Responses of the G542X-CFTR to CFTR Modulators

Authors: Xinxiu Fang, Jiunn-Tyng Yeh, Tzyh-Chang Hwang

Source: Frontiers in Molecular Biosciences, Vol 9 (2022)

Subject Terms: CFTR, premature termination codon, nonsense mutations, CFTR correctors, read-through reagent, Biology (General), QH301-705.5

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Relation: https://www.frontiersin.org/articles/10.3389/fmolb.2022.921680/full; https://doaj.org/toc/2296-889X

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Case Report: Identification Pathogenic Abnormal Splicing of BBS1 Causing Bardet–Biedl Syndrome Type I (BBS1) due to Missense Mutation

Authors: Kai Yan, Yixi Sun, Yanmei Yang, Bei Liu, Minyue Dong

Source: Frontiers in Genetics, Vol 13 (2022)

Subject Terms: Bardet–Biedl syndrome type I, BBS1, alternative splicing, whole-exome sequencing (WES), premature termination codon (PTC), nonsense-mediated decay (NMD), Genetics, QH426-470

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Relation: https://www.frontiersin.org/articles/10.3389/fgene.2022.849562/full; https://doaj.org/toc/1664-8021

Access URL: https://doaj.org/article/6a378ffb9e2d42dcbfd7ebe491db2782

Pharmaceuticals Promoting Premature Termination Codon Readthrough: Progress in Development

Authors: Shan Li, Juan Li, Wenjing Shi, Ziyan Nie, Shasha Zhang, Fengdie Ma, Jun Hu, Jianjun Chen, Peiqiang Li, Xiaodong Xie

Source: Biomolecules, Vol 13, Iss 6, p 988 (2023)

Subject Terms: nonsense mutation, premature termination codon (PTC), translational readthrough-inducing drugs (TRIDs), nonsense suppression, readthrough therapy, Microbiology, QR1-502

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Relation: https://www.mdpi.com/2218-273X/13/6/988; https://doaj.org/toc/2218-273X

Access URL: https://doaj.org/article/c37fa5157cf349f998eafa5ec0bd0fe2

A High-Throughput Assay for In Vitro Determination of Release Factor-Dependent Peptide Release from a Pretermination Complex by Fluorescence Anisotropy—Application to Nonsense Suppressor Screening and Mechanistic Studies

Authors: Mikel D. Ghelfi, Saleem Y. Bhat, Hong Li, Barry S. Cooperman

Source: Biomolecules, Vol 13, Iss 2, p 242 (2023)

Subject Terms: premature termination codon, readthrough, termination, translation readthrough-inducing drug (TRID), high-throughput screening (HTS), ataluren, Microbiology, QR1-502

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Relation: https://www.mdpi.com/2218-273X/13/2/242; https://doaj.org/toc/2218-273X

Access URL: https://doaj.org/article/d59e387027ee41c0b0e2be0187997711

What Can RNA-Based Therapy Do for Monogenic Diseases?

Authors: Luka A. Clarke, Margarida D. Amaral

Source: Pharmaceutics, Vol 15, Iss 1, p 260 (2023)

Subject Terms: personalized medicine, monogenic disorders, premature termination codon mutations, splicing mutations, mRNA, antisense oligonucleotides, Pharmacy and materia medica, RS1-441

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Relation: https://www.mdpi.com/1999-4923/15/1/260; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/19f8df4aff7945b08c237b0fb156498b

Exploring the Diverse Functional and Regulatory Consequences of Alternative Splicing in Development and Disease

Authors: M. Brandon Titus, Adeline W. Chang, Eugenia C. Olesnicky

Source: Frontiers in Genetics, Vol 12 (2021)

Subject Terms: alternative splicing, RNA localization, splicing factors, RNA binding proteins, poison exons, premature termination codon (PTC), Genetics, QH426-470

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Relation: https://www.frontiersin.org/articles/10.3389/fgene.2021.775395/full; https://doaj.org/toc/1664-8021

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Premature termination codon readthrough upregulates progranulin expression and improves lysosomal function in preclinical models of GRN deficiency

Authors: Jonathan Frew, Alireza Baradaran-Heravi, Aruna D. Balgi, Xiujuan Wu, Tyler D. Yan, Steve Arns, Fahimeh S. Shidmoossavee, Jason Tan, James B. Jaquith, Karen R. Jansen-West, Francis C. Lynn, Fen-Biao Gao, Leonard Petrucelli, Howard H. Feldman, Ian R. Mackenzie, Michel Roberge, Haakon B. Nygaard

Source: Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-19 (2020)

Subject Terms: Progranulin, GRN, Frontotemporal lobar degeneration, Nonsense mutation, Premature termination codon, Readthrough, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

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Relation: http://link.springer.com/article/10.1186/s13024-020-00369-5; https://doaj.org/toc/1750-1326

Access URL: https://doaj.org/article/a734b9c2da774facb813e45baefeeee9

MMADHC premature termination codons in the pathogenesis of cobalamin D disorder: Potential of translational readthrough reconstitution

Authors: Leire Torices, Javier de las Heras, Juan Carlos Arango-Lasprilla, Jesús M. Cortés, Caroline E. Nunes-Xavier, Rafael Pulido

Source: Molecular Genetics and Metabolism Reports, Vol 26, Iss , Pp 100710- (2021)

Subject Terms: Methylmalonic aciduria, Homocystinuria, cblD, MMADHC, Translational readthrough, Premature termination codon, Medicine (General), R5-920, Biology (General), QH301-705.5

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Relation: http://www.sciencedirect.com/science/article/pii/S2214426921000045; https://doaj.org/toc/2214-4269

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Cap-Binding Protein 1-Mediated and Eukaryotic Translation Initiation Factor 4E-Mediated Pioneer Rounds of Translation in Yeast

Authors: Gao, Qinshan, Das, Biswadip, Sherman, Fred, Maquat, Lynne E.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2005 Mar . 102(12), 4258-4263.

Access URL: https://www.jstor.org/stable/3374969

CITRIC: cold-inducible translational readthrough in the chloroplast of Chlamydomonas reinhardtii using a novel temperature-sensitive transfer RNA

Authors: Rosanna Young, Saul Purton

Source: Microbial Cell Factories, Vol 17, Iss 1, Pp 1-12 (2018)

Subject Terms: Microalgae, Chloroplast, Industrial biotechnology, Inducible expression, tRNA, Premature termination codon, Microbiology, QR1-502

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Relation: http://link.springer.com/article/10.1186/s12934-018-1033-5; https://doaj.org/toc/1475-2859

Access URL: https://doaj.org/article/9128ffe765ee487584d1cc683cf1d919