Impact of LS Mutation on Pharmacokinetics of Preventive HIV Broadly Neutralizing Monoclonal Antibodies: A Cross-Protocol Analysis of 16 Clinical Trials in People without HIV

Authors: Bryan T. Mayer, Lily Zhang, Allan C. deCamp, Chenchen Yu, Alicia Sato, Heather Angier, Kelly E. Seaton, Nicole Yates, Julie E. Ledgerwood, Kenneth Mayer, Marina Caskey, Michel Nussenzweig, Kathryn Stephenson, Boris Julg, Dan H. Barouch, Magdalena E. Sobieszczyk, Srilatha Edupuganti, Colleen F. Kelley, M. Juliana McElrath, Huub C. Gelderblom, Michael Pensiero, Adrian McDermott, Lucio Gama, Richard A. Koup, Peter B. Gilbert, Myron S. Cohen, Lawrence Corey, Ollivier Hyrien, Georgia D. Tomaras, Yunda Huang

Source: Pharmaceutics, Vol 16, Iss 5, p 594 (2024)

Subject Terms: monoclonal antibodies, LS mutation, two-compartment model, population pharmacokinetics modeling, HIV prevention, targeted maximum likelihood estimation (TMLE), Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/16/5/594; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/34ca5d472d9b40e7a742cd8a83e9c15b

Simultaneous Semi-Mechanistic Population Pharmacokinetic Modeling Analysis of Enalapril and Enalaprilat Serum and Urine Concentrations From Child Appropriate Orodispersible Minitablets

Authors: Muhammad Faisal, Willi Cawello, Bjoern B. Burckhardt, Jan de Hoon, Stephanie Laer, LENA Consortium

Source: Frontiers in Pediatrics, Vol 7 (2019)

Subject Terms: enalapril, enalaprilat, heart failure, population pharmacokinetics modeling analysis, NONMEM, orodispersible mini-tablets, Pediatrics, RJ1-570

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fped.2019.00281/full; https://doaj.org/toc/2296-2360

Access URL: https://doaj.org/article/8a63134b5d524c8e93bb47088beac1b1

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