Inverse Correlation between pks -Carrying Escherichia coli Abundance in Colorectal Cancer Liver Metastases and the Number of Organs Involved in Recurrence.

Authors: Shigematsu, Yasuyuki^1,2 (AUTHOR) kentakeuchi-tky@umin.net, Saito, Rumiko^3,4,5 (AUTHOR) rumiko.saito@jfcr.or.jp, Kanda, Hiroaki⁶ (AUTHOR) hkanda@saitama-pho.jp, Takahashi, Yu⁷ (AUTHOR) yu.takahashi@jfcr.or.jp, Takeuchi, Kengo^1,2,8 (AUTHOR), Takahashi, Shunji^3,4 (AUTHOR) s.takahashi-chemotherapy@jfcr.or.jp, Inamura, Kentaro^1,2,9 (AUTHOR) yasuyuki.shigematsu@jfcr.or.jp

Source: Cancers. Sep2024, Vol. 16 Issue 17, p3003. 11p.

Subject Terms: *LIVER tumors, *POLYKETIDES, *RESEARCH funding, *T cells, *COLORECTAL cancer, *BIOCHIPS, *METASTASIS, *ESCHERICHIA coli, *GENES, *IMMUNOHISTOCHEMISTRY, *DISEASE relapse, *CARCINOGENESIS, *C-reactive protein

Designing a highly efficient type III polyketide whole-cell catalyst with minimized byproduct formation.

Authors: Xiang, La^1,2 (AUTHOR), Zhang, Xuanxuan^1,2,3 (AUTHOR), Lei, Yanyan^1,2,3 (AUTHOR), Wu, Jieyuan^1,2,3 (AUTHOR), Yan, Guangru^1,2,3 (AUTHOR), Chen, Wei^1,3 (AUTHOR), Li, Shizhong^1,2,3 (AUTHOR), Wang, Wenzhao⁴ (AUTHOR), Jin, Jian-Ming⁵ (AUTHOR) jinjianming@btbu.edu.cn, Liang, Chaoning^1,2 (AUTHOR) laraineliang@163.com, Tang, Shuang-Yan^1,2 (AUTHOR) tangsy@im.ac.cn

Source: Biotechnology for Biofuels & Bioproducts. 7/3/2024, Vol. 17 Issue 1, p1-12. 12p.

Subject Terms: *POLYKETIDES, *POLYKETIDE synthases, *CATALYSTS, *SYNTHASES, *CHALCONE synthase, *NATURAL products

Enhancement of acyl‐CoA precursor supply for increased avermectin B1a production by engineering meilingmycin polyketide synthase and key primary metabolic pathway genes.

Authors: Yang, Mengyao¹ (AUTHOR), Hao, Yi¹ (AUTHOR), Liu, Gang² (AUTHOR), Wen, Ying¹ (AUTHOR) wen@cau.edu.cn

Source: Microbial Biotechnology. May2024, Vol. 17 Issue 5, p1-14. 14p.

Subject Terms: *ACYL coenzyme A, *POLYKETIDES, *AVERMECTINS, *ACETYLCOENZYME A, *GENES, *CRISPRS, *FATTY acids

The Genus Cladosporium : A Prospective Producer of Natural Products.

Authors: Li, Yanjing¹ (AUTHOR) 15153232290@163.com, Wang, Yifei¹ (AUTHOR) kingsley11f115@163.com, Wang, Han¹ (AUTHOR) h15725209196@163.com, Shi, Ting^1,2 (AUTHOR) shiting@sdust.edu.cn, Wang, Bo¹ (AUTHOR) shiting@sdust.edu.cn

Source: International Journal of Molecular Sciences. Feb2024, Vol. 25 Issue 3, p1652. 43p.

Subject Terms: *NATURAL products, *POLYKETIDES, *CLADOSPORIUM, *CORAL reefs & islands, *DOSAGE forms of drugs, *MARINE ecology, *BIOACTIVE compounds, *ANGIOTENSIN I

Penisimplicins A and B: Novel Polyketide–Peptide Hybrid Alkaloids from the Fungus Penicillium simplicissimum JXCC5.

Authors: Wang, Qing-Yuan¹ (AUTHOR), Gao, Yang² (AUTHOR), Yao, Jian-Neng³ (AUTHOR) yaojianneng@kmmu.edu.cn, Zhou, Li² (AUTHOR) zhou2018@scuec.edu.cn, Chen, He-Ping² (AUTHOR) zhou2018@scuec.edu.cn, Liu, Ji-Kai² (AUTHOR) zhou2018@scuec.edu.cn

Source: Molecules. Feb2024, Vol. 29 Issue 3, p613. 12p.

Subject Terms: *PENICILLIUM, *POLYKETIDES, *ACETYLCHOLINESTERASE, *COMPUTATIONAL chemistry, *FUNGI, *DATA analysis, *MOIETIES (Chemistry)

Tailoring modifications in labrenzin synthesis: a‐la‐carte production of pathway intermediates.

Authors: Kačar, Dina¹ (AUTHOR), Cañedo, Librada M.² (AUTHOR), Rodríguez, Pilar² (AUTHOR), Schleissner, Carmen³ (AUTHOR), de la Calle, Fernando² (AUTHOR), García, José Luis¹ (AUTHOR), Galán, Beatriz¹ (AUTHOR) bgalan@cib.csic.es

Source: Microbial Biotechnology. Jan2024, Vol. 17 Issue 1, p1-11. 11p.

Subject Terms: *POLYKETIDES, *ECOLOGICAL niche, *GENE clusters, *ANTINEOPLASTIC agents, *DRUG development, *NATURAL products, *POLYKETIDE synthases

Stereoselective Syntheses of Highly Substituted Tetrahydrofurans based on Matteson Homologations.

Authors: Tost, Markus¹ (AUTHOR), Kazmaier, Uli^1,2 (AUTHOR) u.kazmaier@mx.uni-saarland.de

Source: Chemistry - A European Journal. Mar2025, p1. 6p. 8 Illustrations.

Subject Terms: *NATURAL products, *POLYKETIDES

Total Synthesis of (−)‐Cordycicadin D and 3,4‐trans‐Cordycicadins A and B: Entry to the 3,4‐trans‐Fused Cordycicadin Framework.

Authors: Hunt, Liam R.^1,2 (AUTHOR), Grant, Phillip S.¹ (AUTHOR), Shimokura, Grace K.¹ (AUTHOR), Furkert, Daniel P.^1,2 (AUTHOR) d.furkert@auckland.ac.nz, Brimble, Margaret A.^1,2 (AUTHOR) m.brimble@auckland.ac.nz

Source: Angewandte Chemie. 2/10/2025, Vol. 137 Issue 7, p1-6. 6p.

Subject Terms: *POLYKETIDES, *CHEMICAL synthesis, *STEREOCHEMISTRY, *NATURAL products, *LACTONE derivatives, *BIOSYNTHESIS

Koninginins X-Z, Three New Polyketides from Trichoderma koningiopsis SC-5.

Authors: Peng, Weiwei^1,2 (AUTHOR) pww199802@163.com, Tan, Jianbing^1,2 (AUTHOR) tanjb1009@csu.edu.cn, Sang, Zihuan^1,2,3 (AUTHOR) sangzihuan123@163.com, Huang, Yuantao⁴ (AUTHOR) hyt951232@163.com, Xu, Li^1,2 (AUTHOR) 217211012@csu.edu.cn, Zheng, Yuting^1,2 (AUTHOR) 217211011@csu.edu.cn, Qin, Siyu^1,2 (AUTHOR) siyuqin1226@163.com, Tan, Haibo^1,2,3 (AUTHOR) tanhaibo@scbg.ac.cn, Zou, Zhenxing^1,2 (AUTHOR) tanhaibo@scbg.ac.cn

Source: Molecules. Dec2023, Vol. 28 Issue 23, p7848. 11p.

Subject Terms: *POLYKETIDES, *TRICHODERMA, *ENDOPHYTIC fungi, *CIRCULAR dichroism, *SINGLE crystals, *X-ray diffraction, *CANDIDA albicans

Natural Polyketides Act as Promising Antifungal Agents.

Authors: Wang, Li¹ (AUTHOR) 2231257@tongji.edu.cn, Lu, Hui¹ (AUTHOR) luhui2019@tongji.edu.cn, Jiang, Yuanying¹ (AUTHOR) luhui2019@tongji.edu.cn

Source: Biomolecules (2218-273X). Nov2023, Vol. 13 Issue 11, p1572. 37p.

Subject Terms: *POLYKETIDES, *ANTIFUNGAL agents, *MYCOSES, *PYRIDINE derivatives, *DRUG resistance, *POLYETHERS, *CLINICAL medicine

Combined Metabolome and Transcriptome Analysis of Creamy Yellow and Purple Colored Panax notoginseng Roots.

Authors: He, Muhan¹ (AUTHOR) 2013020321@ynftc.edu.cn, Zhang, Guanghui² (AUTHOR) zgh73107310@163.com, Huo, Dongfang¹ (AUTHOR) 2019025961@ynftc.edu.cn, Yang, Shengchao² (AUTHOR) shengchaoyang@163.com

Source: Life (2075-1729). Oct2023, Vol. 13 Issue 10, p2100. 14p.

Subject Terms: *POLYKETIDES, *PANAX, *ANTHOCYANINS, *TRANSCRIPTOMES, *CHINESE medicine, *FLAVONOIDS, *GINSENOSIDES

Geographic Terms: NEPAL, YUNNAN Sheng (China), MYANMAR

The Genomic-Driven Discovery of Glutarimide-Containing Derivatives from Burkholderia gladioli.

Authors: Chen, Hanna^1,2 (AUTHOR) chenhannahappy@163.com, Bai, Xianping¹ (AUTHOR) xpbai201812479@163.com, Sun, Tao¹ (AUTHOR) suntao_go@126.com, Wang, Xingyan¹ (AUTHOR) 202012620@mail.sdu.edu.cn, Zhang, Youming^1,3 (AUTHOR) zhangyouming@sdu.edu.cn, Bian, Xiaoying¹ (AUTHOR) zhangyouming@sdu.edu.cn, Zhou, Haibo¹ (AUTHOR) zhangyouming@sdu.edu.cn

Source: Molecules. Oct2023, Vol. 28 Issue 19, p6937. 12p.

Subject Terms: *POLYKETIDES, *BURKHOLDERIA, *GENE expression, *GLADIOLUS, *GENE clusters, *NATURAL products

Polyketide Synthase Gene Domain Exploration of Marine Sponge Symbiont Bacteria Collected From Weh Island.

Authors: Santosa, Sukmawan Fajar^1,2, Nazaruddin, Nazaruddin¹, Sari, Wahyu Eka², Febriani, Febriani¹ febriani@usk.ac.id

Source: Biosaintifika: Journal of Biology & Biology Education. Aug2023, Vol. 15 Issue 2, p246-254. 9p.

Subject Terms: *SPONGES (Invertebrates), *POLYKETIDES, *BACTERIA, *SEAWATER, *METABOLITES, *BACTERIAL genes, *MARINE bacteria, *SYMBIODINIUM

Geographic Terms: ACEH (Indonesia), INDONESIA

Profiling Chemobiological Connection between Natural Product and Target Space Based on Systematic Analysis.

Authors: Wang, Disheng¹ (AUTHOR), Li, Xue¹ (AUTHOR), Miao, Yicheng¹ (AUTHOR), Zhang, Qiang¹ (AUTHOR) zhangq@nwsuaf.edu.cn

Source: International Journal of Molecular Sciences. Jul2023, Vol. 24 Issue 14, p11265. 16p.

Subject Terms: *NATURAL products, *POLYKETIDES, *DRUG repositioning, *DRUG design, *BIOLOGICAL classification, *DEEP learning, *OLIGOPEPTIDES

The Outstanding Chemodiversity of Marine-Derived Talaromyces.

Authors: Nicoletti, Rosario^1,2 (AUTHOR) annarita.falanga@unina.it, Bellavita, Rosa³ (AUTHOR) rosa.bellavita@unina.it, Falanga, Annarita² (AUTHOR)

Source: Biomolecules (2218-273X). Jul2023, Vol. 13 Issue 7, p1021. 31p.

Subject Terms: *TALAROMYCES, *POLYKETIDES, *AXENIC cultures, *METABOLITES, *PLANT communities, *ISOCOUMARINS

Penioctadecatrienoic A: A New Polyketide from Endophytic Fungus Penicillium pinophilum J70.

Authors: Juan Wang^1,2, Jianlin He², Xin Liu^1,2, Bihong Hong², Miao Yu¹ yumiao913@163.com, Siwen Niu² niusi123@126.com

Source: Records of Natural Products. Jul/Aug2023, Vol. 17 Issue 4, p737-742. 6p.

Subject Terms: *POLYKETIDES, *ENDOPHYTIC fungi, *PENICILLIUM, *ANTI-inflammatory agents, *STAPHYLOCOCCUS aureus, *LIPOPOLYSACCHARIDES, *ANTIBACTERIAL agents

Defensive polyketides produced by an abundant gastropod are candidate keystone molecules in estuarine ecology.

Authors: Scesa, Paul¹, Nguyen, Helen², Weiss, Paige², Rodriguez, Alejandra P.², Garchow, Matthew², Ohlemacher, Shannon I.³, Prappas, Evangelia², Caplins, Serena A.⁴, Bewley, Carole A.³, Bohnert, Laine⁵, Zellmer, Amanda J.⁵, Wood, Eric M.², Schmidt, Eric W.¹, Krug, Patrick J.² pkrug@calstatela.edu

Source: Science Advances. Nov2024, Vol. 10 Issue 44, p1-18. 18p.

Subject Terms: *ESTUARINE ecology, *POLYKETIDES, *GASTROPODA, *METABOLITES, *MOLECULES, *PREDATION, *TIDAL flats

Total Syntheses of β‐ and γ‐Naphthocyclinones.

Authors: Ando, Yoshio¹ (AUTHOR) yando@chem.titech.ac.jp, Hoshino, Taiju¹ (AUTHOR), Tanaka, Nozomi¹ (AUTHOR), Maturi, Mark M.¹ (AUTHOR), Nakazawa, Yusuke¹ (AUTHOR), Fukazawa, Takumi¹ (AUTHOR), Ohmori, Ken¹ (AUTHOR), Suzuki, Keisuke^1,2 (AUTHOR)

Source: Angewandte Chemie. Oct2024, p1. 8p. 12 Illustrations.

Subject Terms: *NATURAL products, *POLYKETIDES, *FUNCTIONAL groups, *RING formation (Chemistry), *DIMERS

The Chemistry of Angucyclines.

Authors: Vysloužilová, Denisa¹ (AUTHOR), Kováč, Ondřej¹ (AUTHOR) ondrej.kovac@upol.cz

Source: ChemPlusChem. Oct2024, Vol. 89 Issue 10, p1-14. 14p.

Subject Terms: *NATURAL products, *POLYKETIDES, *CHEMISTS, *PHOTOOXIDATION, *STREPTOMYCES

Natural products with γ-pyrone scaffold from Streptomyces.

Authors: Magar, Rubin Thapa¹, Sohng, Jae Kyung^1,2, sohng@sunmoon.ac.kr

Source: Applied Microbiology & Biotechnology; 9/24/2024, Vol. 108 Issue 1, p1-12, 12p