Regorafenib enhances M1/M2 macrophage polarization by inhibiting the secretion of plasminogen activator inhibitor-1 in head and neck squamous cell carcinoma

Authors: Chen, Yu-Hsin ^{a, b, c}, Lee, Yi-Mei ^{a, b}, Ou, Da-Liang ^{c, d}, Hsu, Chia-Lang ^{c, e}, Hsu, Chiun ^{c, f, g}, Chen, Chun-Nan ^a, Ko, Jenq-Yuh ^a, Tan, Ching-Ting ^{a, b, h, i, ⁎}

Source: In Life Sciences 1 December 2024 358

Carbon monoxide attenuates cellular senescence-mediated pulmonary fibrosis via modulating p53/PAI-1 pathway

Authors: Wang, Qianqian ^{a, c, 1}, Li, Aohan ^{a, 1}, Li, Qian ^{a, 1}, Li, Jiaxin ^{a, b}, Wang, Qi ^a, Wu, Siyuan ^a, Meng, Jiaojiao ^a, Liu, Changpeng ^a, Wang, Dan ^{a, c, ⁎⁎}, Chen, Yingqing ^{a, c, ⁎}

Source: In European Journal of Pharmacology 5 October 2024 980

Spontaneous bleeding in chronic kidney disease: global coagulation assays may predict bleeding risk

Authors: Rowena Brook, Julie Wang, David Barit, Prahlad Ho, Hui Yin Lim

Source: Research and Practice in Thrombosis and Haemostasis, Vol 8, Iss 5, Pp 102520- (2024)

Subject Terms: chronic kidney disease, coagulation, fibrin, global coagulation assays, hemorrhage, plasminogen activator inhibitor 1, Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2475037924002152; https://doaj.org/toc/2475-0379

Access URL: https://doaj.org/article/ad0ff848359744818b2bb9620478f8c3

Self-reported dietary omega-3 polyunsaturated fatty acids are associated with adipose tissue markers and glucose metabolism in apparently healthy subjects

Authors: Juan Reyes-Barrera, Aida X. Medina-Urrutia, Horacio Osorio-Alonso, Esteban Jorge-Galarza, Gabriela Olvera-Mayorga, Néstor A. Sánchez-Ortiz, Abraham S. Arellano-Buendía, José E. Márquez-García, Felipe Santibáñez-Escobar, Elizabeth Pérez-Rodríguez, Margarita Torres-Tamayo, Omar Granados-Portillo, Ivan Torre-Villalvazo, Juan G. Juárez-Rojas

Source: Annals of Human Biology, Vol 49, Iss 7-8, Pp 291-298 (2022)

Subject Terms: eicosapentaenoic fatty acid, docosahexaenoic fatty acid, resistin, plasminogen activator inhibitor 1, adipose tissue, Biology (General), QH301-705.5, Human anatomy, QM1-695, Physiology, QP1-981

File Description: electronic resource

Relation: https://doaj.org/toc/0301-4460; https://doaj.org/toc/1464-5033

Access URL: https://doaj.org/article/075f82cb04fc416c8d391212a7728b8c

The Role of Fibrinolytic System in Health and Disease

Contributors: Kwaan, Hau C.

Subject Terms: COVID-19, fibrinolysis, renin-aldosterone-angiotensin-system (RAAS), plasminogen activator inhibitor 1 (PAI-1), urokinase plasminogen activator, urokinase plasminogen activator receptor, plasminogen activator inhibitor-1, acute lung injury and repair and pleural injury and pleural organization, PAI-1, cardiovascular disease, cancer, inflammation, fibrosis, aging, obstructive sleep apnoea, OSA, coagulation, platelets, brown adipose tissue, obesity, plasminogen activation, immune response, thrombin activatable fibrinolysis inhibitor, TAFI, proCPU, proCPB, proCPR, carboxypeptidase, uPA, uPAR, PA system, tissue-type plasminogen activator (tPA), urokinase-type plasminogen activator (uPA), neurodegeneration, thrombin, shear, clot retraction, Factor XIII, clot stability, NETs, plasmin, plasminogen activator, PAI-2, antiplasmin, Research and information: general, Biology, life sciences

File Description: application/octet-stream

Access URL: https://directory.doabooks.org/handle/20.500.12854/87541
https://mdpi.com/books/pdfview/book/5739

Association of Celiac Disease and Plasminogen Activator Inhibitor-1 Polymorphism

Authors: Nur Ramoğlu, Zuhal Çalışkan, Minenur Kalyoncu, Deniz Ağırbaşlı

Source: Genel Tıp Dergisi, Vol 32, Iss 5, Pp 601-604 (2022)

Subject Terms: çölyak hastalığı, plazminojen aktivatör inhibitörü 1, polimorfizm, tromboz, celiac disease, plasminogen activator inhibitor 1, polymorphizm, thrombosis, Medicine (General), R5-920

File Description: electronic resource

Relation: https://dergipark.org.tr/tr/download/article-file/2712402; https://doaj.org/toc/2602-3741

Access URL: https://doaj.org/article/5ff3156145d14ec0b31c286071fb806c

Plasminogen activator inhibitor 1 and gestational diabetes: the causal relationship

Authors: Gaber El-Saber Batiha, Hayder M. Al-kuraishy, Thabat J. Al-Maiahy, Ali K. Al-Buhadily, Hebatallah M. Saad, Ali I. Al-Gareeb, Jesus Simal-Gandara

Source: Diabetology & Metabolic Syndrome, Vol 14, Iss 1, Pp 1-6 (2022)

Subject Terms: Plasminogen activator inhibitor 1, Gestational diabetes, Hypofibrinolysis, Thrombotic complications, Nutritional diseases. Deficiency diseases, RC620-627

File Description: electronic resource

Relation: https://doaj.org/toc/1758-5996

Access URL: https://doaj.org/article/6455815b91044957b695acf6185a4b51

Association of arterial stiffness with a prothrombotic state in uncomplicated nondiabetic hypertensive patients

Authors: Gabriele Brosolo, Andrea Da Porto, Luca Bulfone, Antonio Vacca, Nicole Bertin, Cinzia Vivarelli, Leonardo A. Sechi, Cristiana Catena

Source: Frontiers in Cardiovascular Medicine, Vol 10 (2023)

Subject Terms: augmentation index, coagulation, D-dimer, fibrinogen, plasminogen activator-inhibitor 1, pulse-wave velocity, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcvm.2023.1119516/full; https://doaj.org/toc/2297-055X

Access URL: https://doaj.org/article/2b5a517dbfe14fd18f76ad662bb5ba18

The 4G/5G polymorphism of plasminogen activator inhibitor type 1 is a predictor of allergic cough

Authors: Rui Tang, Xiaohong Lyu, Hong Li, Jinlyu Sun

Source: Frontiers in Genetics, Vol 14 (2023)

Subject Terms: allergy and immunology, gene polymorphism, plasminogen activator inhibitor 1, cough, Hypersensitivity, Genetics, QH426-470

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fgene.2023.1139813/full; https://doaj.org/toc/1664-8021

Access URL: https://doaj.org/article/33fe98b890734edb940f46fa94f9ccae

Association of Polymorphisms of F2 (rs3136520) and PAI-1(rs6090) Genes with Recurrent Pregnancy Loss in Iranian Azeri Women

Authors: Mahsa Yousefian, Seyed Abdolhamid Angaji, Elham Siasi, Seyed Ali Rahmani, Shamci Abbasalizadeh Khiaban

Source: پزشکی بالینی ابن سینا, Vol 28, Iss 2, Pp 118-125 (2021)

Subject Terms: coagulation factors, plasminogen activator inhibitor 1, recurrent abortion, thrombophilia, Medicine

File Description: electronic resource

Relation: http://sjh.umsha.ac.ir/article-1-2252-en.html; https://doaj.org/toc/2588-722X; https://doaj.org/toc/2588-7238

Access URL: https://doaj.org/article/d6f1ddf606264cca9389effb7cdc8a7f

The susceptibility of SERPINE1 rs1799889 SNP in diabetic vascular complications: a meta-analysis of fifty-one case-control studies

Authors: JingYi Chen, ChuanNan Zhai, ZhiQian Wang, Rui Li, WenJing Wu, Kai Hou, Mohammad Alzogool, Yan Wang, HongLiang Cong

Source: BMC Endocrine Disorders, Vol 21, Iss 1, Pp 1-18 (2021)

Subject Terms: SERPINE1, rs1799889, 4G/5G polymorphism, Plasminogen activator inhibitor 1, Diabetes, Diabetic vascular disease, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: https://doaj.org/toc/1472-6823

Access URL: https://doaj.org/article/813ce7cd7ab74ffbbc59694b32831648

PAI-1 Overexpression in Valvular Interstitial Cells Contributes to Hypofibrinolysis in Aortic Stenosis

Authors: Magdalena Kopytek, Michał Ząbczyk, Piotr Mazur, Anetta Undas, Joanna Natorska

Source: Cells, Vol 12, Iss 10, p 1402 (2023)

Subject Terms: aortic stenosis, fibrinolysis, LDL, nuclear factor kappa B, plasminogen activator inhibitor 1, valve interstitial cells, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/12/10/1402; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/230d911fc5ca41e98db5aa0496c7841b

Fibrinolytic assays in bleeding of unknown cause: Improvement in diagnostic yield

Authors: Lars L. F. G. Valke, Danielle Meijer, Laurens Nieuwenhuizen, Britta A. P. Laros‐van Gorkom, Nicole M. A. Blijlevens, Waander L. vanHeerde, Saskia E. M. Schols

Source: Research and Practice in Thrombosis and Haemostasis, Vol 6, Iss 2, Pp n/a-n/a (2022)

Subject Terms: bleeding of unknown cause, fibrin clot lysis time, fibrinolysis, plasminogen activator inhibitor 1, tissue plasminogen activator, tranexamic acid, Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://doaj.org/toc/2475-0379

Access URL: https://doaj.org/article/1aaa3b7a8b554993927dd62d5d67e237

Development and application of global assays of hyper‐ and hypofibrinolysis

Authors: Anton Ilich, Denis F. Noubouossie, Michael Henderson, Patrick Ellsworth, Kathleen F. Molitor, Elena Campello, Shannon Meeks, Amy Dunn, Myung S. Park, Rafal Pawlinski, Paolo Simioni, Amy Shapiro, Nigel S. Key

Source: Research and Practice in Thrombosis and Haemostasis, Vol 4, Iss 1, Pp 46-53 (2020)

Subject Terms: euglobulin clot lysis time, fibrinolysis, hemophilia, plasminogen, plasminogen activator inhibitor 1, Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://doaj.org/toc/2475-0379

Access URL: https://doaj.org/article/900e4ab51d71429d996a029b893c09f7

Apolipoprotein E and plasminogen activator inhibitor 1 gene polymorphism in children with chronic renal insufficiency associated with cardiovascular disease

Authors: Bahia Hassan Moustafa, Ahmed Badr, Abeer Selim, Rania Samy, Nasser Gamal

Source: Egyptian Pediatric Association Gazette, Vol 67, Iss 1, Pp 1-11 (2019)

Subject Terms: Apolipoprotein E gene, Plasminogen activator inhibitor 1 gene, Chronic renal failure, Cardiovascular disease, Pediatrics, RJ1-570

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s43054-019-0011-9; https://doaj.org/toc/2090-9942

Access URL: https://doaj.org/article/ce7da14809b4450a8f5d94d6aea5734a

IMPACT OF CARRIAGE OF 4G/5G PAI-1 AND GLYCOPROTEIN IIB/IIIA POLYMORPHISM ON DEVELOPMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN A PATIENT WITH PSORIASIS VULGARIS. Clinical Case.

Authors: Borislav Dimitrov, Kalina Ilieva, Dimitar Gospodinov, Regina Komsa-Penkova

Source: Journal of IMAB, Vol 25, Iss 2, Pp 2537-2543 (2019)

Subject Terms: also affects many other tissues and organs. Recent advances in psoriatic research highlighted that psoriatic patients are at higher risk to develop the chronic obstructive pulmonary disease (COPD). We report a case of a Caucasian man of 62 years’ age with plaque psoriasis diagnosed more than 20 years who developed psoriasis specific comorbidities: COPD in 2005 and later in 2006 arterial hypertension and ischemic cardiomyopathy disease. The patient’s blood parameters were specific for psoriasis and metabolic syndrome with high total cholesterol 6.13 mmol/L, high triglycerides 2.37 mmol/L, high LDL 4.7 mmol/L, low HDL-cholesterol 0.79 mmol/L. Enzyme-linked immunosorbent assay (ELISA) analysis demonstrated elevated serum plasminogen activator inhibitor 1 (PAI-1) levels – 63.21 ng/ml (ref.5-40 ng/mL). The DNA analysis revealed a carriage of heterozygous polymorphism in PAI-1 4G/5G and a carriage of heterozygous polymorphism PlA1/PlA2 in the gene for glycoprotein IIb/IIIa. This case on psoriasis and comorbidity is an example concerning the possible connection of impact of inherited factors with an increased risk of COPD., psoriasis, COPD, ischaemic heart disease, 4G/5G PAI-1, PlA1/PlA2, Dentistry, RK1-715, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.journal-imab-bg.org/issues-2019/issue2/JofIMAB-2019-25-2p2537-2543.pdf; https://doaj.org/toc/1312-773X

Access URL: https://doaj.org/article/03634770ba694d8d89f07a869f107def

Serpins in Hemostasis as Therapeutic Targets for Bleeding or Thrombotic Disorders

Authors: Elsa P. Bianchini, Claire Auditeau, Mahita Razanakolona, Marc Vasse, Delphine Borgel

Source: Frontiers in Cardiovascular Medicine, Vol 7 (2021)

Subject Terms: serpin (serine proteinase inhibitor), antithrombin (AT), protein Z-dependent protease inhibitor (ZPI), plasminogen activator inhibitor 1 (PAI-1), therapy, protease nexin I (PN-1), Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcvm.2020.622778/full; https://doaj.org/toc/2297-055X

Access URL: https://doaj.org/article/a52d27ff2b99443c804feab96c17b848

Targeting PAI-1 in Cardiovascular Disease: Structural Insights Into PAI-1 Functionality and Inhibition

Authors: Machteld Sillen, Paul J. Declerck

Source: Frontiers in Cardiovascular Medicine, Vol 7 (2020)

Subject Terms: plasminogen activator inhibitor 1 (PAI-1), PAI-1 inhibitors, serpin (serine proteinase inhibitor), fibrinolyisis, cardiovascular disease, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcvm.2020.622473/full; https://doaj.org/toc/2297-055X

Access URL: https://doaj.org/article/686f58e62cc149758ae1a91ce331d8cd

Diabetes mellitus - factors that contribute to the occurrence, diagnosis and management of the disease

Authors: Čizmić Milica, Ristić Petar, Đuran Zoran, Karajović Jelena, Zoranović Uroš, Nenezić Nemanja

Source: Vojnosanitetski Pregled, Vol 76, Iss 5, Pp 537-542 (2019)

Subject Terms: diabetes mellitus, type 2, vitamin D, antibodies, plasminogen activator inhibitor 1, inflammation mediators, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/0042-8450; https://doaj.org/toc/2406-0720

Access URL: https://doaj.org/article/b6f12d8fe6314ea3a2b9b1b2dadac0d0

Acute fibrinolysis shutdown occurs early in septic shock and is associated with increased morbidity and mortality: results of an observational pilot study

Authors: Felix Carl Fabian Schmitt, Vasil Manolov, Jakob Morgenstern, Thomas Fleming, Stefan Heitmeier, Florian Uhle, Mohammed Al-Saeedi, Thilo Hackert, Thomas Bruckner, Herbert Schöchl, Markus Alexander Weigand, Stefan Hofer, Thorsten Brenner

Source: Annals of Intensive Care, Vol 9, Iss 1, Pp 1-15 (2019)

Subject Terms: Fibrinolysis shutdown, Rotational thromboelastometry, Point-of-care testing, Thrombin–antithrombin, Plasminogen activator inhibitor 1, Tissue plasminogen activator, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13613-019-0499-6; https://doaj.org/toc/2110-5820

Access URL: https://doaj.org/article/31f2cce893104c00a271c0b9ce8abe04