MiR-147b-3p promotes osteogenesis by targeting NDUFA4 and PI3K/AKT pathway

Authors: Yuanyuan Guo, Kai Shen, Zhijie Li, Changchun Niu, Yang Luo

Source: Journal of Orthopaedic Surgery and Research, Vol 20, Iss 1, Pp 1-16 (2025)

Subject Terms: MiR-147b-3p, Type I coenzyme dehydrogenase 1α subcomplex 4 (NDUFA4), Phosphatidylinositol 3-kinase (PI3K)/AKT pathway, Osteogenesis vertebral compression fractures (OVCF), Orthopedic surgery, RD701-811, Diseases of the musculoskeletal system, RC925-935

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Relation: https://doaj.org/toc/1749-799X

Access URL: https://doaj.org/article/be2b5e17d07e4fc5847f667da6869e90

Icaritin alleviates motor impairment and osteoporosis in Parkinson’s disease mice via the ER-PI3K/Akt pathway

Authors: Xianmei Lin, Xinyu Zhou, Xingman Liu, Lingqiong Xia, Jing Cai, Nanqu Huang, Yong Luo, Weidong Wu

Source: Scientific Reports, Vol 15, Iss 1, Pp 1-12 (2025)

Subject Terms: Parkinson’s disease, Icaritin, Estrogen receptor, Postmenopausal women, Phosphatidylinositol 3-kinase, Protein kinase B, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/6d4d7f0ee8dd4340ab3ae2fe6b5a2939

Impacts of PI3K/protein kinase B pathway activation in reactive astrocytes: from detrimental effects to protective functions

Authors: Ramón Pérez-Núñez, María Fernanda González, Ana María Avalos, Lisette Leyton

Source: Neural Regeneration Research, Vol 20, Iss 4, Pp 1031-1041 (2025)

Subject Terms: inflammation, integrins, neuroprotective, neurotoxic, phosphatidylinositol 3-kinase, reactive astrocytes, signal transduction, thy-1 (cd90), Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://journals.lww.com/10.4103/NRR.NRR-D-23-01756; https://doaj.org/toc/1673-5374; https://doaj.org/toc/1876-7958

Access URL: https://doaj.org/article/9126bf4aab634a41a2063a842291be7d

Lymphoproliferation and hyper-IgM as the first manifestation of activated phosphoinositide 3-kinase δ syndrome: A case report

Authors: Mónica Fernandes-Pineda, Andrés F. Zea-Vera

Source: Biomédica: revista del Instituto Nacional de Salud, Vol 44, Iss Sp. 2, Pp 10-15 (2024)

Subject Terms: immune system diseases, phosphatidylinositol 3-kinase, hyper-igm immunodeficiency syndrome, autoimmunity, human genetics, genetic testing, Medicine, Arctic medicine. Tropical medicine, RC955-962

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Relation: https://revistabiomedica.org/index.php/biomedica/article/view/7436; https://doaj.org/toc/0120-4157

Access URL: https://doaj.org/article/19ff888161b34f88998f6f45ae13f4db

Subunit-Specific Developmental Roles of PI3K in SF1-Expressing Cells

Authors: My Khanh Q. Huynh, Sang Hee Lyoo, Dong Joo Yang, Yun-Hee Choi, Ki Woo Kim

Source: Endocrinology and Metabolism, Vol 39, Iss 5, Pp 793-802 (2024)

Subject Terms: phosphatidylinositol 3-kinase, p110α, p110β, steroidogenic factor 1, development, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: http://www.e-enm.org/upload/pdf/enm-2024-1999.pdf; https://doaj.org/toc/2093-596X; https://doaj.org/toc/2093-5978

Access URL: https://doaj.org/article/f4c17d84e27b40a49807bf6b2f704935

Physiological shear stress suppresses apoptosis in human pulmonary microvascular endothelial cells

Authors: Simin Yan, Nicolas M. Philip, Samuel T. Murray, Xin Yun, Michael P. Croglio, Karthik Suresh, Mahendra Damarla, Larissa A. Shimoda, Todd M. Kolb

Source: Physiological Reports, Vol 13, Iss 6, Pp n/a-n/a (2025)

Subject Terms: apoptosis, human pulmonary microvascular endothelial cells, phosphatidylinositol 3‐kinase, shear stress, Physiology, QP1-981

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Relation: https://doaj.org/toc/2051-817X

Access URL: https://doaj.org/article/58ed97d54c344fa4987ff2c0ee5b03e8

Single-cell sequencing of facial adipose tissue unveils FKBP5 as a therapeutic target for facial infiltrating lipomatosis

Authors: Hongrui Chen, Bin Sun, Shih-Jen Chang, Zhang Yu, Yajing Qiu, Chen Hua, Xiaoxi Lin

Source: Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-18 (2024)

Subject Terms: Facial infiltrating lipomatosis, Phosphatidylinositol 3-kinase catalytic subunit alpha, Fibro-adipogenic precursor cells, FK506 binding protein 51, Medicine (General), R5-920, Biochemistry, QD415-436

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Relation: https://doaj.org/toc/1757-6512

Access URL: https://doaj.org/article/d44f2a38d3c443489834e4403e5add0e

Androgens Regulate Tau Phosphorylation Through Phosphatidylinositol 3-Kinase–Protein Kinase B–Glycogen Synthase Kinase 3β Signaling

Authors: Yao, Mingzhong ^†, Rosario, Emily R. ^‡, Soper, Jenna Carroll ^§, Pike, Christian J. ^⁎

Source: In Neuroscience 5 March 2025 568:503-518

Unveiling the mechanism of sericin and hydroxychloroquine in suppressing lung oxidative impairment and early carcinogenesis in diethylnitrosamine-induced mice by modulating PI3K/Akt/Nrf2/NF-κB signaling pathway

Authors: El-Samad, Lamia M. ^a, Maklad, Alaa M. ^a, Elkady, Ayman I. ^{a, b}, Hassan, Mohamed A. ^{c, ⁎}

Source: In Biomedicine & Pharmacotherapy January 2025 182

Structural modeling of phosphatidylinositol 3-kinase-γ with novel derivatives of stilbenoids

Authors: Sagar Rathee, Madhan Vishal Rajan, Simran Sharma, Gururao Hariprasad

Source: Biochemistry and Biophysics Reports, Vol 40, Iss , Pp 101861- (2024)

Subject Terms: Phosphatidylinositol 3-kinase γ, Stilbenoids, Drug target, Structural based drug design, Interactions, Potency, Biology (General), QH301-705.5, Biochemistry, QD415-436

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405580824002255; https://doaj.org/toc/2405-5808

Access URL: https://doaj.org/article/a022febbcdec43c5947a1bdcd82cf0a6

The association between endometrial polyps and insulin resistance from the expression of PI3K and AKT proteins perspective

Authors: Xuelin Li, Feifan Wang, Mengzhu Chen, Li Ling, Fengfeng Zhao, Danhong Peng

Source: BMC Women's Health, Vol 24, Iss 1, Pp 1-7 (2024)

Subject Terms: Endometrial polyps, Insulin resistance, Phosphatidylinositol 3-kinase, Protein kinase B, Gynecology and obstetrics, RG1-991, Public aspects of medicine, RA1-1270

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Relation: https://doaj.org/toc/1472-6874

Access URL: https://doaj.org/article/7f860878d5ab4b238aeab30592c4062a

Naringenin, a Food Bioactive Compound, Reduces Oncostatin M Through Blockade of PI3K/Akt/NF-κB Signal Pathway in Neutrophil-like Differentiated HL-60 Cells

Authors: Na-Ra Han, Hi-Joon Park, Seong-Gyu Ko, Phil-Dong Moon

Source: Foods, Vol 14, Iss 1, p 102 (2025)

Subject Terms: Oncostatin M, Naringenin, Phosphatidylinositol 3-kinase, Akt, nuclear factor-κB, Chemical technology, TP1-1185

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Relation: https://www.mdpi.com/2304-8158/14/1/102; https://doaj.org/toc/2304-8158

Access URL: https://doaj.org/article/af0f1f6498174fa6b3be7d16f8ae701a

Natural β-carotene based nanodrug: A promising phosphatidylinositol 3-kinase targeting strategy to treat oral carcinogenesis

Authors: Wang, Xing ^{a, 1, ⁎}, Wan, Zhuo ^{b, 1}, Yang, Shuo ^c, Ma, Lili ^d, Zhan, Qi ^e, Jin, Jianqiu ^{f, ⁎}, Yuan, Zuoying ^{b, g, ⁎⁎}

Source: In Chemical Engineering Journal 1 October 2024 497

Inhibition of infantile hemangioma growth and promotion of apoptosis via VEGF/PI3K/Akt axis by 755-nm long-pulse alexandrite laser

Authors: Chen Ke, Changhan Chen, Ming Yang, Hao Chen, Youhui Ke, Liqun Li

Source: Biomedical Journal, Vol 47, Iss 4, Pp 100675- (2024)

Subject Terms: Vascular endothelial growth factor A, Laser therapy, Infantile hemangioma, Phosphatidylinositol 3-kinase /protein kinase B signaling pathway, Medicine (General), R5-920, Biology (General), QH301-705.5

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Relation: http://www.sciencedirect.com/science/article/pii/S2319417023001129; https://doaj.org/toc/2319-4170

Access URL: https://doaj.org/article/e4b1fcd6b51e4c8d9e651c14342b181d

AP2M1 inhibits proliferation and invasion of diffuse large B-cell lymphoma cells

Authors: LI Yuanchun, YAN Xueqian, FAN Dan, JI Yueru, XIAO Fang, GAO Jing

Source: Jichu yixue yu linchuang, Vol 44, Iss 3, Pp 308-316 (2024)

Subject Terms: diffuse large b-cell lymphoma, adaptor related protein complex 2 subunit μ1(ap2m1), epidermal growth factor receptor, phosphatidylinositol 3-kinase, protein kinase b, Medicine

File Description: electronic resource

Relation: http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2024-44-3-308.pdf; https://doaj.org/toc/1001-6325

Access URL: https://doaj.org/article/91ada9b363d64c57ade9cc1b41a1d716

Gene-Silencing Therapeutic Approaches Targeting PI3K/Akt/mTOR Signaling in Degenerative Intervertebral Disk Cells: An In Vitro Comparative Study Between RNA Interference and CRISPR–Cas9

Authors: Masao Ryu, Takashi Yurube, Yoshiki Takeoka, Yutaro Kanda, Takeru Tsujimoto, Kunihiko Miyazaki, Hiroki Ohnishi, Tomoya Matsuo, Naotoshi Kumagai, Kohei Kuroshima, Yoshiaki Hiranaka, Ryosuke Kuroda, Kenichiro Kakutani

Source: Cells, Vol 13, Iss 23, p 2030 (2024)

Subject Terms: intervertebral disk, disk degeneration, nucleus pulposus (NP) cells, phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling, autophagy, RNA interference (RNAi), Cytology, QH573-671

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Relation: https://www.mdpi.com/2073-4409/13/23/2030; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/2c2946945e674ebba5f9a96aa48e8276

Research progress of signaling pathways in gastric cancer metastasis

Authors: YANG Jiaoyang, SHU Gege, LI Dongbao, ZHOU Jin

Source: Jichu yixue yu linchuang, Vol 43, Iss 11, Pp 1707-1712 (2023)

Subject Terms: gastric cancer, metastasis, transforming growth factor-β(tgfβ), phosphatidylinositol 3-kinase(pi3k), signaling pathway, Medicine

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Relation: http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2023-43-11-1707.pdf; https://doaj.org/toc/1001-6325

Access URL: https://doaj.org/article/10511dd06f014c5ca3ab6b5b82cec16c

Molecular Mechanisms and Therapies of Colorectal Cancer

Contributors: Cave, Donatella Delle, Ottaiano, Alessandro

Subject Terms: colorectal cancer, miRNA, ceRNA, lncRNA, circRNA, sponging, noninvasive biomarkers, MiR-199b, tumor suppressor, prognosis, LARC, HOX, HOXB9, colorectal liver metastases, metastatic colorectal cancer, structural variants, common fragile sites, platinum therapy, stalled replication fork, surgical oncology, liver regeneration, immunology, hepatic tissue-resident memory T cells, liver neoplasms, neoplasm metastasis, proteomics, biomarkers, mass spectrometry, microRNA, hypoxia, hypoxia-regulated microRNAs, fatty acid synthase, lipid metabolism, colorectal cancer initiation, Apc mutation, epigenetics, methylation, biomarker, S-Adenosylmethionine, breast cancer, Notch, metastasis, EMT, targeted sequencing, inflammatory bowel diseases, colitis-associated cancer, phosphatidylinositol 3-kinase, sortilin, neurotensin, neurotensin receptor-3, soluble sortilin, cell signaling, cell morphology, colorectal carcinoma, early onset CRC, multi-omics, lymphovascular invasion, perineural invasion, DNA damage repair, DNA replication repair, MMR, base excision repair, FASN, CTLA4, HAVCR2, TGF-β signaling, targeting therapy, immune-suppressive, barrier properties, colon, heterogeneity, cytokines, tumor necrosis factor alpha, interleukin 10, tight junction proteins, 1,2-dimethylhydrazine, rat, epithelial-to-mesenchymal transition, tumor-associated macrophages, Medicine and Nursing, Oncology

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Access URL: https://directory.doabooks.org/handle/20.500.12854/96735
https://mdpi.com/books/pdfview/book/6681

Targeted next-generation sequencing for detection of PIK3CA mutations in archival tissues from patients with Klippel–Trenaunay syndrome in an Asian population

Authors: Yuki Sasaki, Kosuke Ishikawa, Kanako C. Hatanaka, Yumiko Oyamada, Yusuke Sakuhara, Tadashi Shimizu, Tatsuro Saito, Naoki Murao, Tomohiro Onodera, Takahiro Miura, Taku Maeda, Emi Funayama, Yutaka Hatanaka, Yuhei Yamamoto, Satoru Sasaki

Source: Orphanet Journal of Rare Diseases, Vol 18, Iss 1, Pp 1-12 (2023)

Subject Terms: Capillary malformations, High-throughput nucleotide sequencing, Klippel–Trenaunay Syndrome, Limb hypertrophy, Lymphatic abnormalities, Phosphatidylinositol 3-Kinase, Medicine

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Relation: https://doaj.org/toc/1750-1172

Access URL: https://doaj.org/article/b88c018bb5c14062bd0c85b60103e7c1

Roles of increased NUCKS1 expression in endometriosis

Authors: Bo Li, Bocen Chen, Xiaoli Wang, Man Xiao, Kan Zhang, Wenjiao Ye, Da Zhao, Xiaohua Wang, Yan Yu, Jun Li, Xun Xu, Wenhui Zhang, Yanhua Zhang

Source: BMC Women's Health, Vol 23, Iss 1, Pp 1-10 (2023)

Subject Terms: NUCKS1, Endometriosis, Phosphatidylinositol 3-Kinase, NF-kappa B, Gynecology and obstetrics, RG1-991, Public aspects of medicine, RA1-1270

File Description: electronic resource

Relation: https://doaj.org/toc/1472-6874

Access URL: https://doaj.org/article/bb40002c585248cb9072f30db4e7a811