Final analysis of the GMALL-PH-01 trial: phase II study of standard chemotherapy in combination with dasatinib in first line treatment of Philadelphia chromosome positive acute lymphoblastic leukemia.

Authors: Lang, Fabian¹ (AUTHOR) f.lang@med.uni-frankfurt.de, Voss, Andreas² (AUTHOR), Kobbe, Guido³ (AUTHOR), Junghanss, Christian⁴ (AUTHOR), Beck, Joachim⁵ (AUTHOR), Viardot, Andreas⁶ (AUTHOR), Wendelin, Knut⁷ (AUTHOR), Panse, Jens⁸ (AUTHOR), Heberling, Lisa⁹ (AUTHOR), Vucinic, Vladan¹⁰ (AUTHOR), Böll, Boris¹¹ (AUTHOR), Topp, Max¹² (AUTHOR), Hoelzer, Dieter¹ (AUTHOR), Serve, Hubert¹ (AUTHOR), Goekbuget, Nicola¹ (AUTHOR), Ottmann, Oliver G.¹³ (AUTHOR), Pfeifer, Heike¹ (AUTHOR)

Source: Leukemia & Lymphoma. Feb2025, p1-9. 9p. 3 Illustrations.

Subject Terms: *PHILADELPHIA chromosome, *HEMATOPOIETIC stem cell transplantation, *LYMPHOBLASTIC leukemia, *CONSOLIDATION chemotherapy, *INDUCTION chemotherapy

The Many Faces of Philadelphia: A Mature T-Cell Lymphoma with Variant Philadelphia-Translocation and Duplication of the Philadelphia Chromosome.

Authors: Vida, Livia¹ (AUTHOR) vida.livia@pte.hu, Horváth, Bálint¹ (AUTHOR), Egyed, Miklós² (AUTHOR), Kajtár, Béla¹ (AUTHOR) kajtar.bela@pte.hu, Alizadeh, Hussain³ (AUTHOR)

Source: Hematology Reports. Feb2025, Vol. 17 Issue 1, p1. 9p.

Subject Terms: *T-cell lymphoma, *PHILADELPHIA chromosome, *CHROMOSOME duplication, *OVERALL survival, *GENETIC testing

Autophagy and Cancer: Insights into Molecular Mechanisms and Therapeutic Approaches for Chronic Myeloid Leukemia.

Authors: Kausar, Mohd Adnan¹ (AUTHOR) biotechzeeshan@gmail.com, Anwar, Sadaf¹ (AUTHOR), Khan, Yusuf Saleem² (AUTHOR) y.salem@uoh.edu.sa, Saleh, Ayman A.³ (AUTHOR) aym.ali@uoh.edu.sa, Ahmed, Mai Ali Abdelfattah⁴ (AUTHOR) mai.ahmed@uoh.edu.sa, Kaur, Simran⁵ (AUTHOR) s.kaur010707@gmail.com, Iqbal, Naveed⁶ (AUTHOR) n.ulhaq@uoh.edu.sa, Siddiqui, Waseem Ahmad⁷ (AUTHOR) waseem.ibu@amu.ac.in, Najm, Mohammad Zeeshan⁵ (AUTHOR) ma.kausar@uoh.edu.sa

Source: Biomolecules (2218-273X). Feb2025, Vol. 15 Issue 2, p215. 23p.

Subject Terms: *DRUG resistance in cancer cells, *PHILADELPHIA chromosome, *CHRONIC myeloid leukemia, *PROTEIN-tyrosine kinase inhibitors, *CELL survival

B-Lymphoblastic Leukemia Presenting with an Isoderivative Philadelphia Chromosome—A Rare Case Report and Review of Literature.

Authors: Mansoor, Neelum¹ (AUTHOR) neelum.mansoor@tih.org.pk, Maqsood, Sidra² (AUTHOR), Zehra, Syeda Ambareen¹ (AUTHOR), Bakri, Imad³ (AUTHOR)

Source: Indian Journal of Medical & Paediatric Oncology. Feb2025, Vol. 46 Issue 1, p109-113. 5p.

Subject Terms: *PHILADELPHIA chromosome, *LYMPHOBLASTIC leukemia, *FLUORESCENCE in situ hybridization, *CHROMOSOME analysis, *ACUTE leukemia

Unusually indolent CML: a stable non-responder without complete cytogenetic remission for 30 years including 17 years on tyrosine kinase inhibitor therapy.

Authors: Shen, Qiudan¹ (AUTHOR), Tang, Guilin¹ (AUTHOR), Haddad, Fadi G.² (AUTHOR), Chen, Wenbo³ (AUTHOR), Wang, Wei J.¹ (AUTHOR), Wang, Wei¹ (AUTHOR), Wei, Qing¹ (AUTHOR), Medeiros, L. Jeffrey¹ (AUTHOR), Hu, Shimin¹ (AUTHOR) shu1@mdanderson.org

Source: Leukemia & Lymphoma. Jan2025, p1-4. 4p. 1 Illustration.

Subject Terms: *CHRONIC myeloid leukemia, *PHILADELPHIA chromosome, *LEUKOCYTES, *BLOOD cell count, *FLUORESCENCE in situ hybridization

The Influence of Genetic Polymorphisms in Cytochrome P450 (CYP1A1 and 2D6) Gene on the Susceptibility to Philadelphia Negative Chronic Myeloid Leukemia in Sudanese Patients.

Authors: Elderdery, Abozer Y.¹ (AUTHOR) ayelderdery@ju.edu.sa, Idris, Hadeil M. E.² (AUTHOR), Alruwaili, Saud Nahar L.³ (AUTHOR), Tebien, Entesar M.² (AUTHOR), Alsrhani, Abdullah¹ (AUTHOR), Alenazy, Fawaz O.¹ (AUTHOR), Alzahrani, Badr¹ (AUTHOR), Manni, Emad¹ (AUTHOR), Elkhalifa, Ahmed M. E.⁴ (AUTHOR), Mills, Jeremy⁵ (AUTHOR) jeremy.mills@port.ac.uk

Source: International Journal of Molecular Sciences. Dec2024, Vol. 25 Issue 24, p13493. 11p.

Subject Terms: *PHILADELPHIA chromosome, *CHRONIC myeloid leukemia, *CYTOCHROME P-450, *CYTOCHROME P-450 CYP1A1, *CYTOCHROME P-450 CYP2D6

A review of immunotargeted therapy for Philadelphia chromosome positive acute lymphoblastic leukaemia: making progress in chemotherapy-free regimens.

Authors: Xiong, Zhen-Yu^1,2 (AUTHOR), Shen, Yao-Jia³ (AUTHOR), Zhang, Shi-Zhong^1,2 (AUTHOR) zhangsz@ctgu.edu.cn, Zhu, Hong-Hu^1,2,4,5 (AUTHOR) zhuhhdoc@163.com

Source: Hematology. Dec2024, Vol. 29 Issue 1, p1-15. 15p.

Subject Terms: *HEMATOPOIETIC stem cell transplantation, *PHILADELPHIA chromosome, *PROTEIN-tyrosine kinase inhibitors, *CHIMERIC antigen receptors, *LYMPHOBLASTIC leukemia

Investigating the role of non-synonymous variant D67N of ADGRE2 in chronic myeloid leukemia.

Authors: Afzal, Ayesha¹ (AUTHOR), Jamshaid, Harooma¹ (AUTHOR), Badshah, Yasmin¹ (AUTHOR) yasmeenb_1982@yahoo.com, Shabbir, Maria¹ (AUTHOR), Trembley, Janeen H.^2,3,4 (AUTHOR), Zafar, Sameen¹ (AUTHOR), Kamal, Ghulam Murtaza¹ (AUTHOR), Afsar, Tayyaba⁵ (AUTHOR), Husain, Fohad Mabood⁶ (AUTHOR), Razak, Suhail⁵ (AUTHOR) smarazi@ksu.edu.sa

Source: BMC Cancer. 11/5/2024, Vol. 24 Issue 1, p1-13. 13p.

Subject Terms: *PHILADELPHIA chromosome, *CHRONIC myeloid leukemia, *SINGLE nucleotide polymorphisms, *HEMATOPOIETIC stem cells, *G protein coupled receptors

Advances in the treatment of adults with newly diagnosed B-cell acute lymphoblastic leukemia: the role of frontline immunotherapy-based regimens.

Authors: Short, Nicholas J.¹ (AUTHOR) nshort@mdanderson.org, Kantarjian, Hagop¹ (AUTHOR), Jabbour, Elias¹ (AUTHOR)

Source: Leukemia & Lymphoma. Oct2024, Vol. 65 Issue 10, p1405-1417. 13p.

Subject Terms: *HEMATOPOIETIC stem cell transplantation, *PHILADELPHIA chromosome, *LYMPHOBLASTIC leukemia, *OLDER people, *ACUTE leukemia

Chronic myeloid leukemia during pregnancy complicated by dengue infection and pulmonary embolism.

Authors: Wickramasinghe, Wasanthi¹ (AUTHOR) wasanthi123@yahoo.com, Weerawardena, Anoma² (AUTHOR), Ranaweera, Prabhodhana³ (AUTHOR), Gooneratne, Lallindra⁴ (AUTHOR), Wijeyaratne, Chandrika⁵ (AUTHOR)

Source: Indian Journal of Cancer. Oct-Dec2024, Vol. 61 Issue 4, p832-835. 4p.

Subject Terms: *PHILADELPHIA chromosome, *CHRONIC myeloid leukemia, *MYELOPROLIFERATIVE neoplasms, *DENGUE, *PULMONARY embolism

Insights into existing and futuristic treatment approach for chronic myeloid leukaemia.

Authors: Tyagi, Sourabh¹ (AUTHOR), Singh, Anu² (AUTHOR), Sharma, Naveen³ (AUTHOR), Chaturvedi, Rupesh¹ (AUTHOR), Kushwaha, Hemant Ritturaj¹ (AUTHOR)

Source: Indian Journal of Medical Research. May2024, Vol. 159 Issue 5, p1-16. 16p.

Subject Terms: *CHRONIC myeloid leukemia, *PHILADELPHIA chromosome, *HEMATOPOIETIC stem cells, *PROTEIN-tyrosine kinase inhibitors, *GENE fusion

Archived Cytogenetic Cell Pellets Used to Detect a BCR::ABL1 Driver Mutation Eight Years before Disease Presentation.

Authors: Sasi, Ramakrishnan¹ (AUTHOR), Spruill, Michelle¹ (AUTHOR), Perrotta, Peter L.¹ (AUTHOR)

Source: Case Reports in Hematology. 3/20/2024, Vol. 2024, p1-5. 5p.

Subject Terms: *SYMPTOMS, *PHILADELPHIA chromosome, *CHRONIC myeloid leukemia, *FLUORESCENCE in situ hybridization, *HEMATOLOGIC malignancies

CD146 Molecule Expression in B Cells Acute Lymphoblastic Leukemia (B-ALLs): A Flow-Cytometric Marker for an Accurate Diagnostic Workup.

Authors: Laganà, Alessandro¹, Totaro, Matteo¹, Laura Bisegna, Maria¹, Elia, Loredana¹, Intoppa, Stefania¹, Beldinanzi, Marco¹, Matarazzo, Mabel¹, di Trani, Mariangela¹, Costa, Alessandro², Maglione, Raffaele¹, Mandelli, Biancamaria¹, Chiaretti, Sabina¹, Martelli, Maurizio¹, Stefania De Propris, Maria¹ depropris@bce.uniroma1.it

Source: Mediterranean Journal of Hematology & Infectious Diseases. 2024, Vol. 16 Issue 1, p1-9. 9p.

Subject Terms: *PHILADELPHIA chromosome, *LYMPHOBLASTIC leukemia, *PROTEIN-tyrosine kinase inhibitors, *ACUTE leukemia, *B cells

Efficacy and safety of olverembatinib as maintenance therapy after allogeneic hematopoietic cell transplantation in Philadelphia chromosome–positive acute lymphoblastic leukemia.

Authors: Kong, Jun¹ (AUTHOR), Zheng, Feng-Mei¹ (AUTHOR), Yan, Chen-Hua¹ (AUTHOR), Wang, Jing-Zhi¹ (AUTHOR), Fu, Hai-Xia¹ (AUTHOR), Wang, Zhi-Dong¹ (AUTHOR), Suo, Pan¹ (AUTHOR), Hu, Guan-Hua¹ (AUTHOR), Lv, Meng¹ (AUTHOR), Chen, Huan¹ (AUTHOR), Mo, Xiao-Dong¹ (AUTHOR), Xu, Lan-Ping¹ (AUTHOR), Zhang, Xiao-Hui¹ (AUTHOR), Huang, Xiao-Jun^1,2,3 (AUTHOR), Wang, Yu^1,4 (AUTHOR) ywyw3172@sina.com

Source: Annals of Hematology. Jan2025, Vol. 104 Issue 1, p801-808. 8p.

Subject Terms: *PHILADELPHIA chromosome, *LYMPHOBLASTIC leukemia, *ADJUVANT treatment of cancer, *MYELOSUPPRESSION, *ANTINEOPLASTIC agents, *HEMATOPOIETIC stem cell transplantation, *SURVIVAL rate

Comparative analysis of BCR::ABL1 p210 mRNA transcript quantification and ratio to ABL1 control gene converted to the International Scale by chip digital PCR and droplet digital PCR for monitoring patients with chronic myeloid leukemia.

Authors: Saisaard, Wannachai¹ (AUTHOR), Owattanapanich, Weerapat^1,2 (AUTHOR) weerapato36733@gmail.com

Source: Clinical Chemistry & Laboratory Medicine. Jan2025, Vol. 63 Issue 2, p279-290. 12p.

Subject Terms: *PHILADELPHIA chromosome, *CHRONIC myeloid leukemia, *PROTEIN-tyrosine kinase inhibitors, *GENE fusion, *PATIENT monitoring

A review on characterization of BCR – ABL transcript variants for molecular monitoring of chronic myeloid leukemia phenotypes.

Authors: Zenebe, Benyam¹ (AUTHOR) benyam.zenebe@aau.edu.et, Nigussie, Helen¹ (AUTHOR), Belay, Gurja¹ (AUTHOR), Seboka, Nigussie¹ (AUTHOR)

Source: Hematology. Dec2023, Vol. 28 Issue 1, p1-17. 17p.

Subject Terms: *CHRONIC myeloid leukemia, *PHILADELPHIA chromosome, *CHRONIC leukemia, *HUMAN chromosomes, *PLURIPOTENT stem cells, *PHENOTYPES, *CHROMOSOME duplication

A potentially new thromboembolic event scoring system in polycythaemia vera patients: An audit of the Hungarian Philadelphia negative chronic myeloproliferative neoplasia register.

Authors: Karadi, Eva¹ (AUTHOR), Dombi, Peter² (AUTHOR), Korom, Viktoria Gyorine¹ (AUTHOR), Kovacs, Eszter¹ (AUTHOR), Herczeg, Jozsef¹ (AUTHOR), Andrikovics, Hajnalka³ (AUTHOR), Illes, Arpad⁴ (AUTHOR), Demeter, Judit⁵ (AUTHOR), Homor, Lajos⁶ (AUTHOR), Udvardy, Miklós⁴ (AUTHOR), Egyed, Miklós¹ (AUTHOR) dregyedmiklos@yahoo.com

Source: European Journal of Haematology. Aug2023, Vol. 111 Issue 2, p263-270. 8p.

Subject Terms: *THROMBOEMBOLISM, *PHILADELPHIA chromosome, *POLYCYTHEMIA vera, *TUMORS, *MYELOPROLIFERATIVE neoplasms, *MYELOFIBROSIS

A Retrospective Analysis of Autologous Stem Cell Transplantation Outcomes in Adult Philadelphia Chromosome Positive-Acute Lymphoblastic Leukemia.

Authors: Satti, Kiran Kumar¹ (AUTHOR), Mehra, Nikita^1,2 (AUTHOR) m.nikita@cancerinstitutewia.org, Kalaiyarasi, Jayachandran Perumal¹ (AUTHOR), Radhakrishnan, Venkataraman¹ (AUTHOR), Karunakaran, Parathan¹ (AUTHOR), Rathinam, Krishna¹ (AUTHOR), Mani, Samson² (AUTHOR), Ganesan, Prasanth³ (AUTHOR)

Source: Indian Journal of Medical & Paediatric Oncology. Aug2023, Vol. 44 Issue 4, p408-413. 6p.

Subject Terms: *STEM cell transplantation, *PHILADELPHIA chromosome, *LYMPHOBLASTIC leukemia, *HEMATOPOIETIC stem cell transplantation, *TREATMENT effectiveness

FISH-negative BCR::ABL1-positive e19a2 chronic myeloid leukaemia: the most cryptic of insertions.

Authors: May, Philippa C.^1,2 (AUTHOR), Reid, Alistair G.³ (AUTHOR), Robinson, Mark E.⁴ (AUTHOR), Khorashad, Jamshid S.⁵ (AUTHOR), Milojkovic, Dragana^1,6 (AUTHOR), Claudiani, Simone^1,6 (AUTHOR), Willis, Fenella⁷ (AUTHOR), Apperley, Jane F.^1,6 (AUTHOR), Innes, Andrew J.^1,6 (AUTHOR) a.innes@imperial.ac.uk

Source: BMC Medical Genomics. 7/26/2023, Vol. 16 Issue 1, p1-6. 6p.

Subject Terms: *CHRONIC myeloid leukemia, *PHILADELPHIA chromosome, *CHROMOSOME analysis, *GENE fusion, *WHOLE genome sequencing, *CHRONIC leukemia, *MYELOFIBROSIS

Warm Autoimmune Hemolytic Anemia as First Presentation of Chronic Myeloid Leukemia: A Case Report.

Authors: Tawalbeh, Ahmad¹ (AUTHOR), Al-Mashdali, Abdulrahman² (AUTHOR) aalmashdali@hamad.qa, Al-Sabbagh, Ahmad³ (AUTHOR), Ellahi, Anil Y.² (AUTHOR), Yassin, Mohamed A.² (AUTHOR)

Source: Case Reports in Oncology. Dec2024, Vol. 17 Issue 1, p1351-1357. 7p. 3 Illustrations.

Subject Terms: *PHILADELPHIA chromosome, *AUTOIMMUNE hemolytic anemia, *CHRONIC myeloid leukemia, *MYELOPROLIFERATIVE neoplasms, *CHRONIC lymphocytic leukemia