Heterocyclic Compounds in Medicinal Chemistry

Contributors: Madia, Valentina Noemi, Ialongo, Davide

Subject Terms: cyclin-dependent kinase, kinase inhibitor, COVID-19, 229E, coronavirus, pyrrole, synthesis, DFT, antioxidant, SH-SY5Y, cellular toxicity, cell protection, benzo[b]furans, benzofurans, anticancer, antibacterial, antifungal, medicinal chemistry, drug discovery, 4-aminocoumarin, Schiff bases, urease inhibition, molecular docking, antibacterial activity, MD simulation, indole, hydrazone, MCF7, apoptosis, kinase inhibition, pyrimidines, building block, antibiotic, antiviral, immunological treatment, neurological disorders, anti-inflammatory, chronic pain, diabetes mellitus, benzofuran, hybrid structure, NSCLC, EGFR, Annona squamosa L., endophytic fungi, MRSA, ADME prediction, public health, molecular docking-coupled dynamics simulation, lipophilicity, diquinothiazines, ADME, chromatography, phenothiazines, anticancer agents, 1H-benzo[d]imidazole, tyrosine kinase inhibitor, multiple kinase inhibitor, cancer, JBJ-125, deep learning, pharmacophore, virtual screening, molecular dynamics, ADMET, 3,5-disubstituted hydantoins, preparative HPLC separation, NMR analysis, absolute configuration, CD/VCD, antiproliferative activity, in silico biological profiling, Research and information: general, Thermodynamics and heat

File Description: application/octet-stream

Access URL: https://directory.doabooks.org/handle/20.500.12854/152840
https://mdpi.com/books/pdfview/book/10045

Phenothiazines boost host control of Mycobacterium avium infection in primary human macrophages

Authors: Kilinç, Gül, Ottenhoff, Tom H.M., Saris, Anno ^{⁎, 1}

Source: In Biomedicine & Pharmacotherapy April 2025 185

Spectroscopic Properties and Biological Activity of Fluphenazine Conjugates with Gold Nanoparticles

Authors: Oliwia Kowalska, Natalia Piergies, Anna Barbasz, Piotr Niemiec, Patrycja Gnacek, Dorota Duraczyńska, Magdalena Oćwieja

Source: Molecules, Vol 29, Iss 24, p 5948 (2024)

Subject Terms: fluphenazine (FPZ), gold nanoparticles (AuNPs), fluphenazine conjugates, neuroleptics, phenothiazines (PTZ), SH-SY5Y human neuroblastoma cells, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/29/24/5948; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/a8a85cb3612f45e2a9921d31ced38652

Poisoning by antidepressants and antipsychotics

Authors: King, Aidan, Thanacoody, Ruben

Source: In Medicine June 2024 52(6):369-371

Determination of pKa values of fluphenazine analogs by reversed-phase high-performance liquid chromatography

Authors: Sobczak Agnieszka, Beata Kaźmierska, Piotr Świątek, Izabela Muszalska-Kolos

Source: Acta Poloniae Pharmaceutica, Vol 80, Iss 2, Pp 245-253 (2023)

Subject Terms: hplc, dissociation constant, pka, phenothiazines, fluphenazine analogs, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.ptfarm.pl/download/?file=File%2FActa_Poloniae%2F2023%2F2%2F245.pdf; https://doaj.org/toc/0001-6837

Access URL: https://doaj.org/article/a5430215a625419a9a1f67342d2c87c1

Repurposing phenothiazines for cancer therapy: compromising membrane integrity in cancer cells

Authors: Syrina Fred Mehrabi, Sabina Elmi, Jesper Nylandsted

Source: Frontiers in Oncology, Vol 13 (2023)

Subject Terms: phenothiazines, repurposing, annexins, membrane biophysical properties, membrane integrity, cancer treatment, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2023.1320621/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/d55abb40bd9f4067b351fd9c449635aa

Study of the Lipophilicity and ADMET Parameters of New Anticancer Diquinothiazines with Pharmacophore Substituents

Authors: Daria Klimoszek, Małgorzata Jeleń, Małgorzata Dołowy, Beata Morak-Młodawska

Source: Pharmaceuticals, Vol 17, Iss 6, p 725 (2024)

Subject Terms: lipophilicity, diquinothiazines, ADME, chromatography, phenothiazines, anticancer agents, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/17/6/725; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/e2795d640e664a42969f21532262ad2b

Evaluation of the Lipophilicity of Angularly Condensed Diquino- and Quinonaphthothiazines as Potential Candidates for New Drugs

Authors: Daria Klimoszek, Małgorzata Jeleń, Beata Morak-Młodawska, Małgorzata Dołowy

Source: Molecules, Vol 29, Iss 7, p 1683 (2024)

Subject Terms: diquinothiazines, quinonaphthothiazines, lipophilicity, ADME, RP-TLC, phenothiazines, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/29/7/1683; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/697363edf1bb4d72a6b4ae81161369d2

Synthesis and Structural Characterization of Novel Dimers of Dipyridothiazine as Promising Antiproliferative Agents

Authors: Emilia Martula, Beata Morak-Młodawska, Małgorzata Jeleń, Patrick N. Okechukwu, Abbirami Balachandran, Prethika Tehirunavukarasu, Kirthani Anamalay, Vaidehi Ulaganathan

Source: Molecules, Vol 28, Iss 22, p 7662 (2023)

Subject Terms: phenothiazines, dimers of dipyridothiazines, structural analysis, anticancer action, selectivity index, cytotoxicity, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/28/22/7662; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/7f209256430d40859a12337a0253d947

Fatal poisoning case involving drug interaction due to the inhibition of cytochrome P450

Authors: Kinoshita Hiroshi, Tanaka Naoko, Kumihashi Mitsuru, Jamal Mostofa, Ito Asuka, Yamashita Tadayoshi, Ameno Kiyoshi

Source: Vojnosanitetski Pregled, Vol 78, Iss 5, Pp 563-566 (2021)

Subject Terms: autopsy, cytochrome p-450 enzyme system, drug interactions, ethanol, forensic pathology, phenothiazines, poisoning, psychotropic drugs, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/0042-8450; https://doaj.org/toc/2406-0720

Access URL: https://doaj.org/article/3e9a972ae40745cf9195e80787420cad

14-Substituted Diquinothiazines as a New Group of Anticancer Agents

Authors: Małgorzata Jeleń, Krystian Pluta, Małgorzata Szmielew, Beata Morak-Młodawska, Kinga Herman, Klaudia Giercuszkiewicz, Anna Kasprzycka, Magdalena Skonieczna

Source: Molecules, Vol 28, Iss 7, p 3248 (2023)

Subject Terms: phenothiazines, diquinothiazines, diazaphenothiazines, anticancer activity, cytotoxicity, apoptosis, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/28/7/3248; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/45465691b0cf4428b2088d6e3478fa71

Polymyxin B combinations with FDA-approved non-antibiotic phenothiazine drugs targeting multi-drug resistance of Gram-negative pathogens

Authors: Maytham Hussein, Xiaohan Hu, Olivia K.A. Paulin, Simon Crawford, Qi Tony Zhou, Mark Baker, Elena K. Schneider-Futschik, Yan Zhu, Jian Li, Tony Velkov

Source: Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 2247-2258 (2020)

Subject Terms: Antimicrobial resistance, Antimicrobial peptides, Phenothiazines, Metabolomics, MDR, Gram-negative, Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2001037020303615; https://doaj.org/toc/2001-0370

Access URL: https://doaj.org/article/4860056b8b054c22ac7edcdc1048a934

Docking and Biological Screening of Bezo[A]phenothiazinones as Novel Inhibitors of Bacterial Peptidogloycan Transpeptidase

Authors: Akachukwu E. Ibezim, Efeturi Onoabedje A., Kovo G. Akpomie

Source: Iranian Journal of Chemistry & Chemical Engineering, Vol 38, Iss 6, Pp 243-250 (2019)

Subject Terms: phenothiazines, antimicrobial, peptidoglycan transpeptidase, docking, binding mode, Chemical engineering, TP155-156, Chemistry, QD1-999

File Description: electronic resource

Relation: http://www.ijcce.ac.ir/article_34223_7bf2d9ecdef99a62aa7667b9cd821a53.pdf; https://doaj.org/toc/1021-9986

Access URL: https://doaj.org/article/1511f04eeccb403c89db078f9e4fb485

The Potential of Phenothiazines against Endodontic Pathogens: A Focus on Enterococcus-Candida Dual-Species Biofilm

Authors: Nicole de Mello Fiallos, Ana Luiza Ribeiro Aguiar, Bruno Nascimento da Silva, Mariana Lara Mendes Pergentino, Marcos Fábio Gadelha Rocha, José Júlio Costa Sidrim, Débora Castelo Branco de Souza Collares Maia, Rossana de Aguiar Cordeiro

Source: Antibiotics, Vol 11, Iss 11, p 1562 (2022)

Subject Terms: Enterococcus faecalis, Candida albicans, biofilm, phenothiazines, periapical periodontitis, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.mdpi.com/2079-6382/11/11/1562; https://doaj.org/toc/2079-6382

Access URL: https://doaj.org/article/bef23ffc92b94bc997a4b9be96da4c4a

Evidence of Calcium Signaling and Modulation of the LmrS Multidrug Resistant Efflux Pump Activity by Ca2 + Ions in S. aureus

Authors: Amy R. Nava, Natalia Mauricio, Angel J. Sanca, Delfina C. Domínguez

Source: Frontiers in Microbiology, Vol 11 (2020)

Subject Terms: efflux pumps, LmrS, prokaryotic calcium transport, calcium homeostasis, phenothiazines, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmicb.2020.573388/full; https://doaj.org/toc/1664-302X

Access URL: https://doaj.org/article/20af11f579d444d5ac1c1b7a5bd45a8e

10H-1,9-diazaphenothiazine and its 10-derivatives: synthesis, characterisation and biological evaluation as potential anticancer agents

Authors: Beata Morak-Młodawska, Krystian Pluta, Małgorzata Latocha, Małgorzata Jeleń, Dariusz Kuśmierz, Kinga Suwińska, Aleksander Shkurenko, Zenon Czuba, Magdalena Jurzak

Source: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 1298-1306 (2019)

Subject Terms: phenothiazines, dipyridothiazines, anticancer activity, gene expressions, 2d nmr spectra, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

Access URL: https://doaj.org/article/11d1184f83e546758e3026d21f5efede

Competition Between Phenothiazines and BH3 Peptide for the Binding Site of the Antiapoptotic BCL-2 Protein

Authors: Aline Lagoeiro do Carmo, Fernanda Bettanin, Michell Oliveira Almeida, Simone Queiroz Pantaleão, Tiago Rodrigues, Paula Homem-de-Mello, Kathia Maria Honorio

Source: Frontiers in Chemistry, Vol 8 (2020)

Subject Terms: apoptosis, cancer, BCL-2, BH3, phenothiazines, docking, Chemistry, QD1-999

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fchem.2020.00235/full; https://doaj.org/toc/2296-2646

Access URL: https://doaj.org/article/40d6212648a04a8dbe7c14618501d7ac

Stability Studies of UV Laser Irradiated Promethazine and Thioridazine after Exposure to Hypergravity Conditions

Authors: Ágota Simon, Tatiana Tozar, Adriana Smarandache, Mihai Boni, Alexandru Stoicu, Alan Dowson, Jack J. W. A. van Loon, Mihail Lucian Pascu

Source: Molecules, Vol 27, Iss 5, p 1728 (2022)

Subject Terms: phenothiazines, laser irradiation, photoactivated drugs, photoproducts, hypergravity, LDC, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/27/5/1728; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/355cd2d623be4ac78a7b6338d9e11451

Carbocyanine-Based Fluorescent and Colorimetric Sensor Array for the Discrimination of Medicinal Compounds

Authors: Anna V. Shik, Irina A. Stepanova, Irina A. Doroshenko, Tatyana A. Podrugina, Mikhail K. Beklemishev

Source: Chemosensors, Vol 10, Iss 2, p 88 (2022)

Subject Terms: colorimetric sensing, fluorimetric sensing, carbocyanine dyes, catalytic redox reactions, discrimination, phenothiazines, Biochemistry, QD415-436

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9040/10/2/88; https://doaj.org/toc/2227-9040

Access URL: https://doaj.org/article/18255296b7654a09941cd72c24ab41b0

Risk of Ovarian Cancer According to Use of Antidepressants, Phenothiazines, and Benzodiazepines (United States)

Authors: Coogan, Patricia F., Rosenberg, Lynn, Palmer, Julie R., Strom, Brian L., Stolley, Paul D., Zauber, Ann G., Shapiro, Samuel

Source: Cancer Causes & Control, 2000 Oct 01. 11(9), 839-845.

Access URL: https://www.jstor.org/stable/3553946