Tofogliflozin attenuates renal lipid deposition and inflammation via PPARα upregulation mediated by miR-21a impairment in diet-induced steatohepatitic mice

Authors: Sae Nishihara, Masahiro Koseki, Katsunao Tanaka, Takashi Omatsu, Ayami Saga, Hiroshi Sawabe, Hiroyasu Inui, Takeshi Okada, Tohru Ohama, Daisuke Okuzaki, Yoshihiro Kamada, Masafumi Ono, Makoto Nishida, Mikio Watanabe, Yasushi Sakata

Source: Endocrine Journal, Vol 71, Iss 11, Pp 1055-1067 (2024)

Subject Terms: tofogliflozin, chronic kidney disease (ckd), inflammation, peroxisome proliferator activated receptor alpha (pparα), micro-rna-21(mir-21), Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: https://www.jstage.jst.go.jp/article/endocrj/71/11/71_EJ24-0087/_html/-char/en; https://doaj.org/toc/1348-4540

Access URL: https://doaj.org/article/c8547725ada84510b6ac63c3efbd6bcb

Spatial Transcriptomic Study Reveals Heterogeneous Metabolic Adaptation and a Role of Pericentral PPARα/CAR/Ces2a Axis During Fasting in Mouse Liver

Authors: Shiguan Wang, Bowen Xu, Jinyuan Liang, Yawei Feng, Penghu Han, Jing Shen, Xinying Li, Mengqi Zheng, Tingguo Zhang, Cuijuan Zhang, Ping Mi, Yi Zhang, Zhiping Liu, Shiyang Li, Detian Yuan

Source: Advanced Science, Vol 11, Iss 41, Pp n/a-n/a (2024)

Subject Terms: constitutive androstane receptor (CAR), fasting response, liver zonation, metabolic heterogeneity, peroxisome proliferator‐activated receptor alpha (Pparα), spatial transcriptomics, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2198-3844

Access URL: https://doaj.org/article/86ae09b61b4a4b199f6a6a5d1138824c

Staphylococcus aureus oleate hydratase produces ligands that activate host PPARα

Authors: Christopher D. Radka, Matthew W. Frank, Tyler S. Simmons, Cydney N. Johnson, Jason W. Rosch, Charles O. Rock

Source: Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)

Subject Terms: oleate hydratase, hydroxy fatty acid, macrophage, Staphylococcus aureus, peroxisome proliferator activated receptor alpha (PPARα), fatty acid oxidation (FAO), Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcimb.2024.1352810/full; https://doaj.org/toc/2235-2988

Access URL: https://doaj.org/article/70f3502acdec48fe9505c1796b4179e0

Evaluation of Transcriptomic Responses in Livers of Mice Exposed to the Short-Chain PFAS Compound HFPO-DA

Authors: Melissa M. Heintz, Grace A. Chappell, Chad M. Thompson, Laurie C. Haws

Source: Frontiers in Toxicology, Vol 4 (2022)

Subject Terms: dose-response, GenX, HFPO-DA, per and polyfluoroalkyl substances (PFAS), peroxisome proliferator-activated receptor alpha (PPARα), transcriptomics, Toxicology. Poisons, RA1190-1270

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/ftox.2022.937168/full; https://doaj.org/toc/2673-3080

Access URL: https://doaj.org/article/d689d5df4c3846ae9e1640cd9bf92500

Early microRNA indicators of PPARα pathway activation in the liver

Authors: Brian N. Chorley, Gleta K. Carswell, Gail Nelson, Virunya S. Bhat, Charles E. Wood

Source: Toxicology Reports, Vol 7, Iss , Pp 805-815 (2020)

Subject Terms: MicroRNAs, Biomarkers, Mode of action (MOA), Adverse outcome pathway (AOP), Benchmark dose (BMD), Peroxisome proliferator-activated receptor alpha (PPARα), Toxicology. Poisons, RA1190-1270

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2214750020303395; https://doaj.org/toc/2214-7500

Access URL: https://doaj.org/article/a9271998c08d4068b9fb687ebf508ef9