Advances in biomaterial-based tissue engineering for peripheral nerve injury repair

Authors: Xinlei Yao, Tong Xue, Bingqian Chen, Xinyang Zhou, Yanan Ji, Zihui Gao, Boya Liu, Jiawen Yang, Yuntian Shen, Hualin Sun, Xiaosong Gu, Bin Dai

Source: Bioactive Materials, Vol 46, Iss , Pp 150-172 (2025)

Subject Terms: Peripheral nerve injury, Nerve guidance conduits, Peripheral nerve regeneration, Tissue engineering, Biomaterials, Materials of engineering and construction. Mechanics of materials, TA401-492, Biology (General), QH301-705.5

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Relation: http://www.sciencedirect.com/science/article/pii/S2452199X24005346; https://doaj.org/toc/2452-199X

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Unveiling the molecular blueprint of SKP-SCs-mediated tissue engineering-enhanced neuroregeneration

Authors: Hui Zhu, Ying Wang, Siyuan Xu, Yunjian Song, Yifan Li, Yiting Wang, Qiuwen Sun, Muyuan Tong, Tianyi Huang, Yulin Pan, Hongkui Wang, Xi Xu, Chengbin Xue

Source: Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-18 (2024)

Subject Terms: Tissue engineering, Peripheral nerve regeneration, Sciatic nerve injury, Schwann cells, Skin-derived precursors, Weighted gene co-expression network analysis (WGCNA), Biotechnology, TP248.13-248.65, Medical technology, R855-855.5

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Relation: https://doaj.org/toc/1477-3155

Access URL: https://doaj.org/article/cb6bb83ad0714873a7acfbcd3c7cd046

Microsurgery and nerve regeneration: a technical note on intercostal nerves of the swine model

Authors: Nikolaos Giannakopoulos Theodorou, Sotirios Botaitis, Theodosios Birbilis

Source: Egyptian Journal of Neurosurgery, Vol 39, Iss 1, Pp 1-6 (2024)

Subject Terms: Swine, Intercostal nerves, Peripheral nerve regeneration, Surgery, RD1-811, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

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Relation: https://doaj.org/toc/2520-8225

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Research progress in different physical therapies for treating peripheral nerve injuries

Authors: Xiao-Lei Chu, Xiao-Xuan Zhao, Shuai-Yi Liu, Ya-Jie Li, Ning Ding, Min-Qi Liu, Qing-Wen Li, Qi Li

Source: Frontiers in Neurology, Vol 16 (2025)

Subject Terms: peripheral nerve regeneration, ultrasound, electricity, photobiomodulation, aerobic exercise, Neurology. Diseases of the nervous system, RC346-429

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Relation: https://www.frontiersin.org/articles/10.3389/fneur.2025.1508604/full; https://doaj.org/toc/1664-2295

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An immunoregulation PLGA/Chitosan aligned nanofibers with polydopamine coupling basic fibroblast growth factor and ROS scavenging for peripheral nerve regeneration

Authors: Xiaokun Chen, Jihai Xu, Feng Qin, Ziyuan Yang, Xueyuan Li, Miao Yu, Ming Li, Yanhua Wang, Wang Xin

Source: Materials Today Bio, Vol 31, Iss , Pp 101543- (2025)

Subject Terms: Composite nerve conduits, Electrospun nanofibers, Polydopamine, Immune modulation, Peripheral nerve regeneration, Medicine (General), R5-920, Biology (General), QH301-705.5

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Relation: http://www.sciencedirect.com/science/article/pii/S2590006425001012; https://doaj.org/toc/2590-0064

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Development and evaluation of BDNF-loaded PCL/PVA two-layer nerve guidance conduit with enhanced biomechanical and biological properties for peripheral nerve regeneration

Authors: Massoumeh Jabbari Fakhr, Mohsen Eslami Farsani, Leyla Fath-Bayati, Reihaneh Seyedebrahimi, Mehdi Sadrjahani, Fatemeh Kavakebian, Alireza Rezapour

Source: Heliyon, Vol 11, Iss 4, Pp e42792- (2025)

Subject Terms: BDNF, Two-layer nerve guidance conduit, 3D model, Nanofiber, Peripheral nerve regeneration, Science (General), Q1-390, Social sciences (General), H1-99

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Relation: http://www.sciencedirect.com/science/article/pii/S2405844025011739; https://doaj.org/toc/2405-8440

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Unraveling the immune system’s role in peripheral nerve regeneration: a pathway to enhanced healing

Authors: Xu Zhang, Yanxian Zhang, Yuqing Chen, Yuxiang Ji, Yongmei Lyu, Zengli Miao, Xuchu Duan, Xiaoyu Liu

Source: Frontiers in Immunology, Vol 16 (2025)

Subject Terms: immunity, peripheral nerve injury, peripheral nerve regeneration, immune cells, signaling pathway, immunoactive substances, Immunologic diseases. Allergy, RC581-607

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Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2025.1540199/full; https://doaj.org/toc/1664-3224

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Axonal regeneration and innervation ratio following supercharged end-to-side nerve transfer

Authors: Leopold Harnoncourt, Martin Schmoll, Christopher Festin, Laurenz Pflaum, Markus Breuss, Johanna Klepetko, Dominik C. Dotzauer, Florian J. Jaklin, Udo Maierhofer, Philipp Tratnig-Frankl, Oskar C. Aszmann

Source: Frontiers in Cell and Developmental Biology, Vol 13 (2025)

Subject Terms: peripheral nerve regeneration, nerve transfer, supercharged end-to-side, reversed end-to-side, innervation ratio, Biology (General), QH301-705.5

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Relation: https://www.frontiersin.org/articles/10.3389/fcell.2025.1513321/full; https://doaj.org/toc/2296-634X

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Biomimetic ECM nerve guidance conduit with dynamic 3D interconnected porous network and sustained IGF-1 delivery for enhanced peripheral nerve regeneration and immune modulation

Authors: Teng Wan, Qi-Cheng Li, Feng-Shi Zhang, Xiao-Meng Zhang, Na Han, Pei-Xun Zhang

Source: Materials Today Bio, Vol 30, Iss , Pp 101403- (2025)

Subject Terms: Peripheral nerve regeneration, Interconnected porous networks, IGF-1, Macrophage polarisation, Nerve guidance conduit, Medicine (General), R5-920, Biology (General), QH301-705.5

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Relation: http://www.sciencedirect.com/science/article/pii/S2590006424004642; https://doaj.org/toc/2590-0064

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Chitosan/PLGA-based tissue engineered nerve grafts with SKP-SC-EVs enhance sciatic nerve regeneration in dogs through miR-30b-5p-mediated regulation of axon growth

Authors: Miaomei Yu, Mi Shen, Daiyue Chen, Yan Li, Qiang Zhou, Chunyan Deng, Xinyang Zhou, Qi Zhang, Qianru He, Hongkui Wang, Meng Cong, Haiyan Shi, Xiaosong Gu, Songlin Zhou, Fei Ding

Source: Bioactive Materials, Vol 40, Iss , Pp 378-395 (2024)

Subject Terms: Peripheral nerve regeneration, Skin-derived precursor Schwann cells, Extracellular vesicles, Tissue engineered nerve graft, miR-30b-5p, Sin3a/HDAC complex, Materials of engineering and construction. Mechanics of materials, TA401-492, Biology (General), QH301-705.5

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Relation: http://www.sciencedirect.com/science/article/pii/S2452199X24002305; https://doaj.org/toc/2452-199X

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Increased efficiency of peripheral nerve regeneration using supercritical carbon dioxide-based decellularization in acellular nerve graft

Authors: Soon Jin Choi, Jeonghun Han, Young Ho Shin, Jae Kwang Kim

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)

Subject Terms: Acellular nerve graft, Peripheral nerve regeneration, Supercritical carbon dioxide, Decellularized nerve, Medicine, Science

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Relation: https://doaj.org/toc/2045-2322

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Advanced nerve regeneration enabled by neural conformal electronic stimulators enhancing mitochondrial transport

Authors: Hao Bai, Siqi Zhang, Huiran Yang, Jing Wang, Hongli Chen, Jia Li, Lin Li, Qian Yang, Bo Peng, Ziyi Zhu, Siyuan Ni, Keyin Liu, Wei Lei, Tiger H. Tao, Yafei Feng

Source: Bioactive Materials, Vol 39, Iss , Pp 287-301 (2024)

Subject Terms: Silk materials, Electronic stimulator, Structural reconfiguration, Peripheral nerve regeneration, Mitochondrial transport, Materials of engineering and construction. Mechanics of materials, TA401-492, Biology (General), QH301-705.5

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Relation: http://www.sciencedirect.com/science/article/pii/S2452199X24001993; https://doaj.org/toc/2452-199X

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Collagen protein-chitosan nerve conduits with neuroepithelial stem cells promote peripheral nerve regeneration

Authors: Chenping Yun, Wei Li, Yongjie Qiao, Hecun Xiao, Baoming Qu, Tao Xu, Tao Li

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)

Subject Terms: Chitosan, Biological scaffolds, Peripheral nerve regeneration, Immune microenvironment, Medicine, Science

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Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/ecd51d4d610a4bd1a9a402de6a4a3376

The Role of Electrical Stimulation in Peripheral Nerve Regeneration: Current Evidence and Future Directions

Authors: Yusha Liu, MD, PhD, Paige M. Fox, MD, PhD

Source: Journal of Hand Surgery Global Online, Vol 6, Iss 5, Pp 718-721 (2024)

Subject Terms: Electrical stimulation, Nerve, Nerve recovery, Peripheral nerve regeneration, Surgery, RD1-811

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Relation: http://www.sciencedirect.com/science/article/pii/S2589514124000525; https://doaj.org/toc/2589-5141

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Characterization of lncRNA and mRNA profiles in the process of repairing peripheral nerve defects with cell-matrixed nerve grafts

Authors: Shanshan Wang, Wei Wang, Hongkui Wang, Yimei Yang, Xingyu Liu, Ye Zhu, Xiyang Cheng, Jingfei Zhong, Meiyuan Li

Source: BMC Genomics, Vol 25, Iss 1, Pp 1-17 (2024)

Subject Terms: Transcriptome, WGCNA, lncRNA, Decellularized extracellular matrix, Peripheral nerve regeneration, Biotechnology, TP248.13-248.65, Genetics, QH426-470

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Relation: https://doaj.org/toc/1471-2164

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Regenerative failure of sympathetic axons contributes to deficits in functional recovery after nerve injury

Authors: Tina Tian, David Kim, Kuai Yu, H. Criss Hartzell, Patricia J. Ward

Source: Neurobiology of Disease, Vol 209, Iss , Pp 106893- (2025)

Subject Terms: Sympathetic nervous system, Peripheral nerve regeneration, Electrical stimulation, Energy charge, Retrograde tracing, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

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Relation: http://www.sciencedirect.com/science/article/pii/S0969996125001093; https://doaj.org/toc/1095-953X

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3D printed biodegradable hydrogel-based multichannel nerve conduits mimicking peripheral nerve fascicules

Authors: Maeng, Woo-Youl ^{a, b, c, 1}, Lee, Yerim ^{a, d, 1}, Chen, Szu-Han ^e, Kim, Kyung Su ^{a, d}, Sung, Daeun ^a, Tseng, Wan-Ling ^e, Kim, Gyu-Nam ^{a, d}, Koh, Young-Hag ^{a, d}, Hsueh, Yuan-Yu ^{e, f, ⁎⁎}, Koo, Jahyun ^{a, d, ⁎}

Source: In Materials Today Bio April 2025 31

E-jet 3D printed aligned nerve guidance conduits incorporated with decellularized extracellular matrix hydrogel encapsulating extracellular vesicles for peripheral nerve repair

Authors: Fan, Na ^{a, 1}, Song, Da ^{b, c, 1}, Ding, Huairong ^{b, c}, Yang, Hongli ^d, Xu, Cong ^d, Wang, Chao ^e, Yang, Yikun ^{d, ⁎}

Source: In Acta Biomaterialia 1 March 2025 194:122-139

Preferential motor reinnervation is modulated by both repair site and distal nerve environments

Authors: Li, C. ^{a, 1}, Rassekh, N. ^{a, 1}, O'Daly, A. ^{a, 1}, Kebaisch, F. ^a, Wolinsky, R. ^a, Vyas, A. ^a, Skolasky, R. ^a, Hoke, A. ^{b, c}, Brushart, T. ^{a, b, ⁎}

Source: In Experimental Neurology March 2025 385

Immune regulated fibrous membrane loaded FK506 enhances peripheral nerve regeneration

Authors: Xing, Dan ^{a, b, c, 1}, Xu, Minhui ^{d, e, f, 1}, Shuang, Xueqin ^{d, e, f}, Li, Jiao Jiao ^g, Sun, Di ^h, Wang, Yanhua ^{d, e, i, ⁎}, Li, Ming ^{d, e, f, ⁎}, Feng, Shiqing ^{a, b, c, ⁎}, Ning, Guangzhi ^{a, b, c, ⁎}

Source: In Chemical Engineering Journal 1 February 2025 505