Combining molecular characteristics and therapeutic analysis of PDOs predict clinical responses and guide PDAC personalized treatment

Authors: Peng Li, Minli Huang, Mengyao Li, Gen Li, Yifan Ma, Yong Zhao, Xiaowu Wang, Yongbin Zhang, Changhong Shi

Source: Journal of Experimental & Clinical Cancer Research, Vol 44, Iss 1, Pp 1-19 (2025)

Subject Terms: Patient-derived organoids (PDOs), Pancreatic ductal adenocarcinoma (PDAC), Genomic diversity, Personalized treatment, Immunotherapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/4c25b0f4241746c99b892a6f30cc4807

Differential expression of CD175 and CA19-9 in pancreatic adenocarcinoma

Authors: Jane J. Cheng, Yasuyuki Matsumoto, Gabrielle E. Dombek, Kathryn A. Stackhouse, Ana Sofia Ore, Jonathan N. Glickman, Jamie Heimburg-Molinaro, Richard D. Cummings

Source: Scientific Reports, Vol 15, Iss 1, Pp 1-11 (2025)

Subject Terms: Tumor-associated carbohydrate antigens (TACAs), CD175, Sialyl-Lewis a (CA19-9), CA19-9, Sialyl-Lewis x (CD15s), Pancreatic ductal adenocarcinoma (PDAC), Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/5a613fbe105c41919c1f376a24bf2017

Selecting Optimal Substrate Mounts in Terahertz Time Domain Spectroscopic Imaging of Murine Radiation-Treated Pancreatic Ductal Adenocarcinoma

Authors: Chakraborty, Debamitra, Mills, Bradley N., Cheng, Jing, Komissarov, Ivan, Gerber, Scott A., Sobolewski, Roman

Source: 2022 IEEE Western New York Image and Signal Processing Workshop (WNYISPW) Western New York Image and Signal Processing Workshop (WNYISPW), 2022 IEEE. :1-4 Nov, 2022

Relation: 2022 IEEE Western New York Image and Signal Processing Workshop (WNYISPW)

A dormant cancer mouse model established by combining preimmune strategy with mVenus-p27K- system

Authors: Musitaba MUTAILIFU, WANG Junjie, QIAN Yunzhen, CHEN Suyuan, SHAO Da, ZHANG Zhigang, LI Dongxue

Source: Shanghai Jiaotong Daxue xuebao. Yixue ban, Vol 44, Iss 9, Pp 1104-1114 (2024)

Subject Terms: pancreatic ductal adenocarcinoma (pdac), dormant cancer cell, preimmunized mouse, mvenus-p27k- system, animal model, Medicine

File Description: electronic resource

Relation: https://xuebao.shsmu.edu.cn/article/2024/1674-8115/1674-8115-2024-44-9-1104.shtml; https://doaj.org/toc/1674-8115

Access URL: https://doaj.org/article/d99722cb31a74969a0af800a8e9c1fbb

Prolonged survival by combination treatment with a standardized herbal extract from Japanese Kampo-medicine (Juzentaihoto) and gemcitabine in an orthotopic transplantation pancreatic cancer model

Authors: Joanna Napp, Paulina Siebel, Hans Rausch, Kenny Kuchta, Thomas Efferth, Frauke Alves, Volker Ellenrieder, Silke Cameron

Source: Frontiers in Oncology, Vol 14 (2024)

Subject Terms: Kampo medicine, Juzentaihoto, gemcitabine, pancreatic ductal adenocarcinoma (PDAC), orthotopic transplantation PDAC mouse model, murine KPC pancreatic tumor cells, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2024.1454291/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/96cc2359c48944f9bf2c3f4faa247314

Microbiome and pancreatic cancer: time to think about chemotherapy

Authors: Juliana de Castilhos, Katharina Tillmanns, Jana Blessing, Arnelyn Laraño, Vadim Borisov, Christoph K. Stein-Thoeringer

Source: Gut Microbes, Vol 16, Iss 1 (2024)

Subject Terms: Pancreatic Ductal Adenocarcinoma (PDAC), microbiome, chemotherapy efficacy, microbial metabolism, tumor microenvironment, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: https://doaj.org/toc/1949-0976; https://doaj.org/toc/1949-0984

Access URL: https://doaj.org/article/37fdae0a1e9f4ec192dcb780e64dede5

An insight to PDAC tumor heterogeneity across pancreatic subregions using computed tomography images

Authors: Sehrish Javed, Touseef Ahmad Qureshi, Lixia Wang, Linda Azab, Srinivas Gaddam, Stephen J. Pandol, Debiao Li

Source: Frontiers in Oncology, Vol 14 (2024)

Subject Terms: pancreatic ductal adenocarcinoma (PDAC), tumor heterogeneity, pancreatic subregions, radiomics, pancreas cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2024.1378691/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/f510e79c189b4c1397445ab6070a3d35

Validation of a targeted next-generation sequencing panel for pancreatic ductal adenocarcinomas

Authors: Marie-Lucie Racu, Andrea Alex Schiavo, Claude Van Campenhout, Nancy De Nève, Thomas Masuy, Calliope Maris, Christine Decaestecker, Myriam Remmelink, Isabelle Salmon, Nicky D'Haene

Source: Experimental and Molecular Pathology, Vol 139, Iss , Pp 104920- (2024)

Subject Terms: Pancreatic ductal adenocarcinoma (PDAC), Next-generation sequencing (NGS), Copy number alteration (CNA), Chromosome 18 loss of heterozygosity (LOH), Pathology, RB1-214

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S001448002400039X; https://doaj.org/toc/1096-0945

Access URL: https://doaj.org/article/60caf256d47f4ab1a2308a8d5e394c37

3D pancreatic ductal adenocarcinoma desmoplastic model: Glycolysis facilitating stemness via ITGAV-PI3K-AKT-YAP1

Authors: Guan, Xiaoqi ^{a, b, 1}, Wu, Di ^{a, b, 1}, Zhu, Hongyu ^{a, b, 1}, Zhu, Biwen ^{a, b}, Wang, Zhen ^{a, b}, Xing, Haowei ^{a, b}, Zhang, Xue ^{b, c}, Yan, Jiashuai ^{a, b}, Guo, Yibing ^{b, ⁎}, Lu, Yuhua ^{a, ⁎}

Source: In Biomaterials Advances May 2025 170

Multiscale deep learning radiomics for predicting recurrence-free survival in pancreatic cancer: A multicenter study

Authors: Gu, Qianbiao ^a, Sun, Huiling ^b, Liu, Peng ^c, Hu, Xiaoli ^d, Yang, Jiankang ^e, Chen, Yong ^f, Xing, Yan ^{a, ⁎}

Source: In Radiotherapy and Oncology April 2025 205

SCANPatient: study protocol for a multi-centre, batched, stepped wedge, comparative effectiveness, randomised clinical trial of synoptic reporting of computerised tomography (CT) scans assessing cancers of the pancreas

Authors: Lin Li, Jessica Kasza, Ariadna Recasens, Liane Ioannou, Elysia Greenhill, Neil Merrett, David Cavallucci, Samantha Ellis, Helen Madgwick, Hyun Soo Ko, Lorraine Chantrill, Benjamin Loveday, Mehrdad Nikfarjam, Daniel Croagh, Jessica Yang, Andrew Dwyer, John Zalcberg, Charles Pilgrim, SCANPatient Authorship Group

Source: Trials, Vol 25, Iss 1, Pp 1-17 (2024)

Subject Terms: Pancreatic ductal adenocarcinoma (PDAC), Resectability, Computerised tomography (CT) scans, Synoptic reporting, Randomised controlled trial, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/1745-6215

Access URL: https://doaj.org/article/8155d023b1684df7b7f5d68e3d09af14

Prognostic Value of Histone Acetyl Transferase 1 (HAT-1) and Inflammatory Signatures in Pancreatic Cancer

Authors: Miguel A. Ortega, Laura Jiménez-Álvarez, Oscar Fraile-Martinez, Cielo Garcia-Montero, Luis G. Guijarro, Leonel Pekarek, Silvestra Barrena-Blázquez, Ángel Asúnsolo, Laura López-González, María Del Val Toledo-Lobo, Melchor Álvarez-Mon, Miguel A. Saez, Alberto Gutiérrez-Calvo, Raúl Díaz-Pedrero

Source: Current Issues in Molecular Biology, Vol 46, Iss 5, Pp 3839-3865 (2024)

Subject Terms: pancreatic ductal adenocarcinoma (PDAC), prognostic biomarkers, histone acetyl transferase 1 (HAT-1), interleukin 10 (IL-10), Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/1467-3045/46/5/239; https://doaj.org/toc/1467-3037; https://doaj.org/toc/1467-3045

Access URL: https://doaj.org/article/5acad8944341418cb6d4cb4a72cfade4

Management of Peritoneal Metastasis in Patients with Pancreatic Ductal Adenocarcinoma

Authors: Grace Wu, Oliver J. Standring, Daniel A. King, Sepideh Gholami, Craig E. Devoe, Cornelius A. Thiels, Travis E. Grotz, Matthew J. Weiss, Richard L. Whelan, Mustafa Raoof, Danielle K. DePeralta

Source: Current Oncology, Vol 32, Iss 2, p 103 (2025)

Subject Terms: pancreatic ductal adenocarcinoma (PDAC), peritoneal metastases, intraperitoneal chemotherapy, cytoreductive surgery (CRS), heated intraperitoneal chemotherapy (HIPEC), pressurized intraperitoneal aerosolized chemotherapy (PIPAC), Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.mdpi.com/1718-7729/32/2/103; https://doaj.org/toc/1198-0052; https://doaj.org/toc/1718-7729

Access URL: https://doaj.org/article/11c29728d38443908c2ea163e8cdb8f9

Unraveling the gut microbiome’s contribution to pancreatic ductal adenocarcinoma: mechanistic insights and therapeutic perspectives

Authors: Eileen Tabrizi, Fatemeh Pourteymour Fard Tabrizi, Gehad Mahmoud Khaled, Michael P. Sestito, Saeid Jamie, Brian A. Boone

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: pancreatic ductal adenocarcinoma (PDAC), microbiome, immune modulation, dysbiosis, antibiotic therapy, bacteriotherapy, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1434771/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/c071935cf6c74ab4a3fa37b8eaee3576

The Co-Localization of NLRP3 and ASC Specks Does Not Automatically Entail NLRP3 Inflammasome Functionality in PDAC Cell Lines

Authors: Heléne Lindholm, Matthew Herring, Maria Faresjö, Johan Haux, Ferenc Szekeres, Katarina Ejeskär

Source: International Journal of Translational Medicine, Vol 4, Iss 2, Pp 224-237 (2024)

Subject Terms: pancreatic ductal adenocarcinoma (PDAC), cancer, inflammasome, NLRP3, PYCARD, ASC, Computer applications to medicine. Medical informatics, R858-859.7

File Description: electronic resource

Relation: https://www.mdpi.com/2673-8937/4/2/13; https://doaj.org/toc/2673-8937

Access URL: https://doaj.org/article/75ff956dd79240d48c27c19d9d6ce075

Development and validation of a model for predicting the expression of Ki-67 in pancreatic ductal adenocarcinoma with radiological features and dual-energy computed tomography quantitative parameters

Authors: Youjia Wen, Zuhua Song, Qian Li, Dan Zhang, Xiaojiao Li, Jiayi Yu, Zongwen Li, Xiaofang Ren, Jiayan Zhang, Qian Liu, Jie Huang, Dan Zeng, Zhuoyue Tang

Source: Insights into Imaging, Vol 15, Iss 1, Pp 1-12 (2024)

Subject Terms: Dual-energy computed tomography (DECT), Pancreatic ductal adenocarcinoma (PDAC), Ki-67, Prognosis, Nomogram, Medical physics. Medical radiology. Nuclear medicine, R895-920

File Description: electronic resource

Relation: https://doaj.org/toc/1869-4101

Access URL: https://doaj.org/article/5fc993506c674e50b1bb247a50b4dcf7

Diagnostic and prognostic significance of tissue lncRNA HOTAIR and hexokinase 2 mRNA expression in patients with pancreatic ductal adenocarcinoma

Authors: Ghada Salah, Manar Obada, Dina Sweed, Ibrahim Abdelkader Salama, Ashraf Khalil, Shimaa Abdelsattar

Source: Egyptian Liver Journal, Vol 14, Iss 1, Pp 1-12 (2024)

Subject Terms: Pancreatic ductal adenocarcinoma (PDAC), HOX transcript antisense RNA (lncRNA HOTAIR), Hexokinase 2 (HK2), Polymerase chain reaction (PCR), Surgery, RD1-811, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: https://doaj.org/toc/2090-6226

Access URL: https://doaj.org/article/28ee8b5faed34482baafac83d5fb5a78

Expression of adhesion G protein-coupled receptor F1 in pancreatic ductal adenocarcinoma and its mechanism of promoting cancer progression

Authors: CHEN Suyuan, Musitaba Mutailifu, LI Dongxue, ZHANG Zhigang

Source: Shanghai Jiaotong Daxue xuebao. Yixue ban, Vol 44, Iss 1, Pp 23-34 (2024)

Subject Terms: pancreatic ductal adenocarcinoma (pdac), adhesion g protein-coupled receptor f1 (adgrf1), immunity, tumor-promoting effect, Medicine

File Description: electronic resource

Relation: https://xuebao.shsmu.edu.cn/article/2024/1674-8115/1674-8115-2024-44-1-23.shtml; https://doaj.org/toc/1674-8115

Access URL: https://doaj.org/article/b6aa4c992106446a80d7de5becd0ed20

Small non-coding RNAs and pancreatic ductal adenocarcinoma: Linking diagnosis, pathogenesis, drug resistance, and therapeutic potential

Authors: Fuller, Ryan N. ^{a, b}, Morcos, Ann ^{a, b}, Bustillos, Joab Galvan ^{a, c}, Molina, David Caba ^c, Wall, Nathan R. ^{a, b, ⁎}

Source: In BBA - Reviews on Cancer September 2024 1879(5)

TP53 missense mutation reveals gain-of-function properties in small-sized KRAS transformed pancreatic ductal adenocarcinoma

Authors: Yiran Zhou, Jiabin Jin, Yuchen Ji, Jiaqiang Zhang, Ningzhen Fu, Mengmin Chen, Jun Wang, Kai Qin, Yu Jiang, Dongfeng Cheng, Xiaxing Deng, Baiyong Shen

Source: Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-15 (2023)

Subject Terms: Pancreatic ductal adenocarcinoma (PDAC), TP53 mutation subtype, Gain-of-function properties, Survival outcomes, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1479-5876

Access URL: https://doaj.org/article/a83fd937bfe142fab9a3f42cc7f8612f