Employing Multifaceted Bioinformatics Strategies for the Discovery of Novel ASK1 Inhibitors Targeting Neurodegenerative Disorders

Authors: Pallavi, Kumar, Pravir

Source: 2024 International Conference on Knowledge Engineering and Communication Systems (ICKECS) Knowledge Engineering and Communication Systems (ICKECS), 2024 International Conference on. 1:1-5 Apr, 2024

Relation: 2024 International Conference on Knowledge Engineering and Communication Systems (ICKECS)

Repurposing the antimalarial chloroquine: a potential therapy for hepatic injury in a rat model of hindlimb ischemia–reperfusion by modulating apoptosis, autophagy, inflammation, and oxidative stress

Authors: Miar M. Sherif, Hanan S. El-Abhar, Hala M. Fawzy, Amany M. Gad, Dalaal M. Abdallah

Source: Future Journal of Pharmaceutical Sciences, Vol 11, Iss 1, Pp 1-15 (2025)

Subject Terms: Hindlimb hypoxia/reperfusion, Chloroquine, TNF-α, MAPK p38, NF-κB p65, Beclin-1, Therapeutics. Pharmacology, RM1-950, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://doaj.org/toc/2314-7253

Access URL: https://doaj.org/article/0e57a55312614c908f4531181250d3b1

Semaglutide, a glucagon-like peptide-1 receptor agonist, inhibits oral squamous cell carcinoma growth through P38 MAPK signaling pathway

Authors: Can Wang, Zhengzheng Wu, Jiaying Zhou, Bin Cheng, Yulei Huang

Source: Journal of Cancer Research and Clinical Oncology, Vol 151, Iss 3, Pp 1-15 (2025)

Subject Terms: GLP-1R, Semaglutide, OSCC, P38 MAPK signaling pathway, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1432-1335

Access URL: https://doaj.org/article/7ba3441ea30449658bac7b0cdd1ee600

Critical Role of p38α MAPK Subclass in the Development of Pain Hypersensitivity After Hind Paw Incision

Authors: Ishikawa D, Yamakita S, Oh-Hashi K, Amaya F

Source: Journal of Pain Research, Vol Volume 18, Pp 869-878 (2025)

Subject Terms: p38 mapk, tissue injury, hyperalgesia, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.dovepress.com/critical-role-of-p38-mapk-subclass-in-the-development-of-pain-hypersen-peer-reviewed-fulltext-article-JPR; https://doaj.org/toc/1178-7090

Access URL: https://doaj.org/article/41d2e64195c34a6c995b38ab75752747

Expression and effect of P38 mitogen-activated protein kinase and transforming growth factor-β in gastric cancer

Authors: YANG Lu, LI Zixin, CHANG Jianlan

Source: Zhongguo linchuang yanjiu, Vol 38, Iss 1, Pp 11-15 (2025)

Subject Terms: p38 mitogen-activated protein kinase, transforming growth factor-β, gastric cancer, tumor metastasis, targeted therapy, Medicine

File Description: electronic resource

Relation: http://zglcyj.ijournals.cn/zglcyj/ch/reader/create_pdf.aspx?file_no=20250103&year_id=2025&quarter_id=1&falg=1; https://doaj.org/toc/1674-8182

Access URL: https://doaj.org/article/4a899001ece740a4b51b01204d350dd4

Testing of a promising gel for the prevention of epidural fibrosis in an experiment on a laminectomy model

Authors: A. P. Zhivotenko, I. A. Shurygina, M. G. Shurygin, O. A. Goldberg, S. N. Larionov, V. A. Sorokovikov

Source: Acta Biomedica Scientifica, Vol 9, Iss 6, Pp 239-248 (2024)

Subject Terms: laminectomy, epidural fibrosis, dura mater, gel composition, p38 map kinase blocker, prevention, experiment, Science

File Description: electronic resource

Relation: https://www.actabiomedica.ru/jour/article/view/5141; https://doaj.org/toc/2541-9420; https://doaj.org/toc/2587-9596

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Mitochondria-targeted antioxidant mitoquinone mitigates vitrification-induced damage in mouse ovarian tissue by maintaining mitochondrial homeostasis via the p38 MAPK pathway

Authors: Tianqi Du, Han Su, Dan Cao, Qingxia Meng, Ming Zhang, Zhenxing Liu, Hong Li

Source: European Journal of Medical Research, Vol 29, Iss 1, Pp 1-14 (2024)

Subject Terms: Mitoquinone, Ovarian tissue cryopreservation, Oxidative stress, Mitochondrial homeostasis, Fertility preservation, p38 MAPK pathway, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2047-783X

Access URL: https://doaj.org/article/3026f96635f14406a48b57b0876f1be6

Her2 promotes early dissemination of breast cancer by inhibiting the p38 pathway through the downregulation of MAP3K4

Authors: Guanwen Wang, Ping Wen, Ting Xue, Yuxin Huang, Qing Shao, Ningning Zhang, Fanli Qu, Jing Wang, Nan Wang, Xiaohua Zeng

Source: Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-16 (2024)

Subject Terms: Breast cancer, Her2, Early dissemination, p38, MAP3K4, HOXB13, Medicine, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1478-811X

Access URL: https://doaj.org/article/25accc8f4605486cb40ea6f16d6c1b1a

CD2AP deficiency aggravates Alzheimer’s disease phenotypes and pathology through p38 MAPK activation

Authors: Yan-Yan Xue, Zhe-Sheng Zhang, Rong-Rong Lin, Hui-Fen Huang, Ke-Qing Zhu, Dian-Fu Chen, Zhi-Ying Wu, Qing-Qing Tao

Source: Translational Neurodegeneration, Vol 13, Iss 1, Pp 1-21 (2024)

Subject Terms: Alzheimer’s disease, CD2AP, P38 MAPK, Synaptic injury, Tau, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2047-9158

Access URL: https://doaj.org/article/c85e367037164d4482bf5a534a01e05d

The link between osteoporosis and frozen shoulder: exploring the therapeutic effect of TAK715 on reversing fibrosis and protecting against osteoporosis via the p38 MAPK signaling pathway

Authors: Xinhao Li, Yan Yan, Zhuo Wang, Jingyi Hou, Yuhan Meng, Dedong Cui, Yi Long, Ming Li, Rui Yang

Source: BMC Musculoskeletal Disorders, Vol 25, Iss 1, Pp 1-22 (2024)

Subject Terms: Osteoporosis (OP), Frozen Shoulder (FS), P38 MAPK, TAK715, Diseases of the musculoskeletal system, RC925-935

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2474

Access URL: https://doaj.org/article/e65d1119b8834b96819b765515e91ed6

Resveratrol treats peri-implantitis in mice via inhibiting the MAPKs/NF-κB signaling pathway

Authors: LIU Senqing, ZHANG Hua, CHEN Yanyan, HE Haipeng, HUANG Jiamin, YUAN Jingyi, HU Tianyong, DU Ruitian

Source: 口腔疾病防治, Vol 32, Iss 11, Pp 845-852 (2024)

Subject Terms: peri-implantitis, resveratrol, animal model, p38 mitogen activated protein kinase, nuclear factor kappa-b, Medicine

File Description: electronic resource

Relation: https://www.kqjbfz.com/fileup/2096-1456/PDF/2096-1456（2024）11-0845-08.pdf; https://doaj.org/toc/2096-1456

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DLK1 and DLK2, two non-canonical ligands of NOTCH receptors, differentially modulate the osteogenic differentiation of mesenchymal C3H10T1/2 cells

Authors: María-Milagros Rodríguez-Cano, María-Julia González-Gómez, Eva-María Monsalve, María-José M. Díaz-Guerra, Moustapha Kassem, Jorge Laborda, María-Luisa Nueda, Victoriano Baladrón

Source: Biological Research, Vol 57, Iss 1, Pp 1-17 (2024)

Subject Terms: DLK, NOTCH, Mesenchymal C3H10T1/2 cells, Osteogenesis, ERK1/2 MAPK, p38 MAPK, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/0717-6287

Access URL: https://doaj.org/article/59d36de7aa4e4b6cadcd8748f02b433b

GSK3179106 ameliorates lipopolysaccharide-induced inflammation and acute lung injury by targeting P38 MAPK

Authors: Bin Zheng, Mengying Li, Enhong Lan, Wenting Ding, Lijiao Gao, Yue Tang, Xinyi Wu, Bing Zhang, Yali Zhang, Xiaona Zhu, Hui Zhang

Source: Respiratory Research, Vol 25, Iss 1, Pp 1-12 (2024)

Subject Terms: Acute lung injury, P38 MAPK kinase, Sepsis, GSK3179106, Lipopolysaccharide, Diseases of the respiratory system, RC705-779

File Description: electronic resource

Relation: https://doaj.org/toc/1465-993X

Access URL: https://doaj.org/article/aafe4882ad7a48a5a9920420485b4b8b

The relationship mammalian p38 with human health and its homolog Hog1 in response to environmental stresses in Saccharomyces cerevisiae

Authors: Gang Du, Kaifang Zheng, Cunying Sun, Mingyue Sun, Jie Pan, Dan Meng, Wenqiang Guan, Hui Zhao

Source: Frontiers in Cell and Developmental Biology, Vol 13 (2025)

Subject Terms: HOG pathway, human health, osmotic stress, MAPK, p38, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2025.1522294/full; https://doaj.org/toc/2296-634X

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Natural products modulating MAPK for CRC treatment: a promising strategy

Authors: Lin Zhou, Jinlong Zhang, Kangning Zhao, Bo Chen, Zhen Sun

Source: Frontiers in Pharmacology, Vol 16 (2025)

Subject Terms: colorectal cancer, natural products, MAPK pathway, ERK, p38, JNK, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2025.1514486/full; https://doaj.org/toc/1663-9812

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C-reactive protein-induced injury in Mycoplasma pneumoniae-infected lung epithelial cells is mediated by the P38 MAPK/mitochondrial apoptosis pathway

Authors: Lianjia Li, Yang Zhang, Lin Zhao, Yalin Shi

Source: Microbiology Spectrum, Vol 13, Iss 3 (2025)

Subject Terms: Mycoplasma pneumoniae, p38 MAPK/mitochondrial apoptosis pathway, apoptosis, C-reactive protein, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2165-0497

Access URL: https://doaj.org/article/f5ad65a0a23649a082ef81835cf4a15c

AFB1 exposure promotes SIV replication and lung damage via RIG-I- and p38-mediated RETREG1/FAM134B-dependent endoplasmic reticulum autophagy

Authors: Wenshuo Zhao, Siyao Pang, Jinlong Zhang, Zhaoran Yao, Yuqi Song, Yuhang Sun

Source: Ecotoxicology and Environmental Safety, Vol 292, Iss , Pp 117970- (2025)

Subject Terms: Aflatoxin B1, Swine influenza virus, Endoplasmic reticulum autophagy, RIG-I, P38 MAPK, Environmental pollution, TD172-193.5, Environmental sciences, GE1-350

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0147651325003069; https://doaj.org/toc/0147-6513

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Effects of alpha-ketoisocaproate in oxidative stress-induced C2C12 myotubes via inhibition of p38 MAPK and ERK1/2

Authors: Pooreum Lim, Sang Woo Woo, Jihye Han, Young Lim Lee, Jae Ho Shim, Hyeon Soo Kim

Source: Biochemistry and Biophysics Reports, Vol 41, Iss , Pp 101955- (2025)

Subject Terms: α-ketoisocaproate, C2C12, ERK1/2, Muscle atrophy, Sarcopenia, p38 MAPK, Biology (General), QH301-705.5, Biochemistry, QD415-436

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405580825000421; https://doaj.org/toc/2405-5808

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Berberine hydrochloride enhances innate immunity to protect against pathogen infection via p38 MAPK pathway

Authors: Yi Xiao, Yingwen Cui, Yan Zhang, Wenqiao Fu, Yun Liu, Fang Liu

Source: Frontiers in Immunology, Vol 16 (2025)

Subject Terms: Berberine hydrochloride, innate immunity, p38 MAPK pathway, Caenorhabditis elegans, mouse, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2025.1536143/full; https://doaj.org/toc/1664-3224

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Revealing the core suppression effects of various Di (2-ethylhexyl) phthalate exposure on early meiosis progression in postnatal male mice via single-cell RNA sequencing

Authors: Baoquan Han, Lei Hua, Shuai Yu, Wei Ge, Cong Huang, Yu Tian, Chunxiao Li, Jiamao Yan, Tian Qiao, Jiachen Guo, Dongliang Lu, Bin Wang, Diya Cai, Yunqi Zhang, Shaolin Liang, Jianjuan Zhao, Qi Hou, Wei Shen, Zhongyi Sun

Source: Ecotoxicology and Environmental Safety, Vol 291, Iss , Pp 117866- (2025)

Subject Terms: Di (2-ethylhexyl) phthalate, Early meiosis, Single-cell RNA sequencing, P38 mitogen-activated protein kinase pathway, Trp53, Reproductive toxicity, Environmental pollution, TD172-193.5, Environmental sciences, GE1-350

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0147651325002027; https://doaj.org/toc/0147-6513

Access URL: https://doaj.org/article/39920737447d4ec0a3a777294e381df7