Natural Killer Cells Generated From Human Induced Pluripotent Stem Cells Mature to CD56brightCD16+NKp80+/-In-Vitro and Express KIR2DL2/DL3 and KIR3DL1

Authors: Johanna Euchner, Jasmin Sprissler, Toni Cathomen, Daniel Fürst, Hubert Schrezenmeier, Klaus-Michael Debatin, Klaus Schwarz, Kerstin Felgentreff

Source: Frontiers in Immunology, Vol 12 (2021)

Subject Terms: induced pluripotent stem cells (iPSC), natural killer (NK) cells, hematopoietic progenitor cells (HPC), NK cell differentiation, OP9-DL1, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.640672/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/0c91afd1d1fb47cc8e24f9f3fda9da84

In vitro OP9-DL1 co-culture and subsequent maturation in the presence of IL-21 generates tumor antigen-specific T cells with a favorable less-differentiated phenotype and enhanced functionality

Authors: Sarah Bonte, Stijn de Munter, Lore Billiet, Glenn Goetgeluk, Joline Ingels, Hanne Jansen, Melissa Pille, Laurenz de Cock, Karin Weening, Tom Taghon, Georges Leclercq, Bart Vandekerckhove, Tessa Kerre

Source: OncoImmunology, Vol 10, Iss 1 (2021)

Subject Terms: acute myeloid leukemia (aml), t cell immunotherapy, common gamma chain cytokines, hematopoietic stem cells, op9-dl1, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/b8d37350b35e4c9e9ca7c2af1a96b344

T-cells with a single tumor antigen-specific T-cell receptor can be generated in vitro from clinically relevant stem cell sources

Authors: Sarah Bonte, Stijn De Munter, Glenn Goetgeluk, Joline Ingels, Melissa Pille, Lore Billiet, Tom Taghon, Georges Leclercq, Bart Vandekerckhove, Tessa Kerre

Source: OncoImmunology, Vol 9, Iss 1 (2020)

Subject Terms: acute myeloid leukemia (aml), t-cell immunotherapy, hematopoietic stem cells, op9-dl1, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/8a9e6e8dd9154340bb2f53f8c0e0027b

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