Monogenic lupus – from gene to targeted therapy

Authors: Katharina Menzel, Kateryna Novotna, Nivya Jeyakumar, Christine Wolf, Min Ae Lee-Kirsch

Source: Molecular and Cellular Pediatrics, Vol 11, Iss 1, Pp 1-7 (2024)

Subject Terms: SLE, Systemic lupus erythematosus, Cutaneous lupus erythematosus, Nucleic acid immunity, Nucleic acid metabolism, Nucleic acid sensing, Pediatrics, RJ1-570

File Description: electronic resource

Relation: https://doaj.org/toc/2194-7791

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Nucleic-acid-induced ZCCHC3 condensation promotes broad innate immune responses

Authors: Shi, Miao ^{1, 2, 4}, Jiang, Tao ^{2, 4}, Zhang, Mengfan ^{2, 3, 4}, Li, Quanjin ^{2, 3}, Liu, Kexin ^{2, 3}, Lin, Ni ^{1, 2}, Wang, Xinlu ², Jiang, Amin ², Gao, Yina ², Wang, Yong ², Liu, Songqing ², Zhang, Liguo ^{2, 3, ∗}, Li, Dong ^{2, 3, ∗∗}, Gao, Pu ^{2, 3, 5, ∗∗∗}

Source: In Molecular Cell 6 March 2025 85(5):962-975

Rapid fluorescent nucleic acid sensing with ultra-thin gold nanosheets

Authors: Li, Peiyin ^a, Zhang, Huiyang ^a, Yang, Zhenyu ^b, Li, Yiling ^a, Huang, Manli ^a, Yang, Lingzhi ^{a, ⁎}, Zhang, Xueji ^b

Source: In Analytica Chimica Acta 15 August 2024 1317

Nucleic acid-sensing-related gene signature in predicting prognosis and treatment efficiency of small cell lung cancer patients

Authors: Qianshi Liu, Zhaoshen Li, Na Li, Junjie Liu, Hong Wu, Jie Chen

Source: Frontiers in Oncology, Vol 14 (2024)

Subject Terms: small cell lung cancer, nucleic acid sensing-related genes, prognostic signature, tumor microenvironment, multiplex immunohistochemistry, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2024.1394286/full; https://doaj.org/toc/2234-943X

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Editorial: Broadening our view on nucleic acid sensing: novel sensors, signaling pathways, and involvement in non-infectious diseases

Authors: Lise Chauveau, Nadine Laguette, Natalia G. Sampaio

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: nucleic acid sensing, pattern recognition receptor (PRR), PAMPs and DAMPs, self/nonself recognition, sterile inflammation, non-infectious disease, Immunologic diseases. Allergy, RC581-607

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Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1266732/full; https://doaj.org/toc/1664-3224

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Increased IKKϵ protein stability ensures efficient type I interferon responses in conditions of TBK1 deficiency

Authors: Julia Wegner, Charlotte Hunkler, Katrin Ciupka, Gunther Hartmann, Martin Schlee

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: innate immunity, pathogens, virus infection, nucleic acid sensing, cGAS, TBK1, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1073608/full; https://doaj.org/toc/1664-3224

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Nucleic Acid-Sensing Pathways During SARS-CoV-2 Infection: Expectations versus Reality

Authors: Mdkhana B, Saheb-Sharif Askari N, Ramakrishnan RK, Goel S, Hamid Q, Halwani R

Source: Journal of Inflammation Research, Vol Volume 14, Pp 199-216 (2021)

Subject Terms: covid-19, sars-cov-2, innate immune system, nucleic acid sensing, immune evasion, nlrp3, cgas-sting, coronavirus, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.dovepress.com/nucleic-acid-sensing-pathways-during-sars-cov-2-infection-expectations-peer-reviewed-article-JIR; https://doaj.org/toc/1178-7031

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Pathophysiological Role of Nucleic Acid-Sensing Pattern Recognition Receptors in Inflammatory Diseases

Authors: Norisuke Kano, Guang Han Ong, Daisuke Ori, Taro Kawai

Source: Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)

Subject Terms: PRR, inflammation, nucleic acid sensing, autoimmune disease, autoinflammatory disease, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcimb.2022.910654/full; https://doaj.org/toc/2235-2988

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Monocytes are the main source of STING-mediated IFN-α production

Authors: Nicolas Congy-Jolivet, Claire Cenac, Jérôme Dellacasagrande, Bénédicte Puissant-Lubrano, Pol André Apoil, Kevin Guedj, Flora Abbas, Sophie Laffont, Sandrine Sourdet, Sophie Guyonnet, Fati Nourhashemi, Jean-Charles Guéry, Antoine Blancher

Source: EBioMedicine, Vol 80, Iss , Pp 104047- (2022)

Subject Terms: Age, Sex, Nucleic acid sensing, Type I interferons, TLR7, TLR9, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396422002286; https://doaj.org/toc/2352-3964

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Disrupting Mechanisms that Regulate Genomic Repeat Elements to Combat Cancer and Drug Resistance

Authors: Chames Kermi, Lena Lau, Azar Asadi Shahmirzadi, Marie Classon

Source: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

Subject Terms: transposable elements, drug resistance, epigenetic regulation, restriction factors, R-loops, nucleic acid sensing, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2022.826461/full; https://doaj.org/toc/2296-634X

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Nucleic Acid Sensing Pathways in DNA Repair Targeted Cancer Therapy

Authors: Bingteng Xie, Aiqin Luo

Source: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

Subject Terms: DNA damage and repair, DDR inhibitors, nucleic acid-sensing pathways, innate immunity, immunotherapy, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2022.903781/full; https://doaj.org/toc/2296-634X

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Modulation of Type I Interferon Responses to Influence Tumor-Immune Cross Talk in PDAC

Authors: Carlotta Cattolico, Peter Bailey, Simon T. Barry

Source: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

Subject Terms: innate immunity, PDAC, IFN-I, nucleic acid sensing, immunotherapy, tumor microenvironment, Biology (General), QH301-705.5

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Relation: https://www.frontiersin.org/articles/10.3389/fcell.2022.816517/full; https://doaj.org/toc/2296-634X

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Editorial: Nucleic Acid-Associated Inflammation

Authors: Nadine Laguette, Christelle Langevin, David Olagnier, Vincenzo Torraca, Claire Vanpouille-Box, Eloi R. Verrier

Source: Frontiers in Immunology, Vol 12 (2021)

Subject Terms: inflammation, nucleic acid sensing, DNA, RNA, type I interferon, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.791580/full; https://doaj.org/toc/1664-3224

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ADA2 is a lysosomal deoxyadenosine deaminase acting on DNA involved in regulating TLR9-mediated immune sensing of DNA

Authors: Greiner-Tollersrud, Ole Kristian ^{1, 23}, Krausz, Máté ^{2, 23}, Boehler, Vincent ³, Polyzou, Aikaterini ^{4, 5}, Seidl, Maximilian ⁶, Spahiu, Ambra ², Abdullah, Zeinab ⁷, Andryka-Cegielski, Katarzyna ⁸, Dominick, Felix Immunuel ⁸, Huebscher, Katrin ^{2, 9}, Goschin, Andreas ², Smulski, Cristian R. ¹⁰, Trompouki, Eirini ^{4, 5}, Link, Regina ³, Ebersbach, Hilmar ^{3, 22}, Srinivas, Honnappa ³, Marchant, Martine ³, Sogkas, Georgios ^{11, 12}, Staab, Dieter ³, Vågbø, Cathrine ¹³, Guerini, Danilo ³, Baasch, Sebastian ^{2, 14, 15}, Latz, Eicke ¹⁶, Hartmann, Gunther ⁸, Henneke, Philippe ^{2, 14}, Geiger, Roger ^{17, 18}, Peng, Xiao P. ¹⁹, Grimbacher, Bodo ^{2, 20}, Bartok, Eva ^{8, 23}, Alseth, Ingrun ^{21, 23}, Warncke, Max ^{3, 23}, Proietti, Michele ^{2, 11, 12, 23, 24, ∗}

Source: In Cell Reports 26 November 2024 43(11)

Defective Interfering Genomes and the Full-Length Viral Genome Trigger RIG-I After Infection With Vesicular Stomatitis Virus in a Replication Dependent Manner

Authors: Andreas Linder, Viktoria Bothe, Nicolas Linder, Paul Schwarzlmueller, Frank Dahlström, Christoph Bartenhagen, Martin Dugas, Dharmendra Pandey, Julia Thorn-Seshold, Daniel F. R. Boehmer, Lars M. Koenig, Sebastian Kobold, Max Schnurr, Johannes Raedler, Giulia Spielmann, Hadi Karimzadeh, Andreas Schmidt, Stefan Endres, Simon Rothenfusser

Source: Frontiers in Immunology, Vol 12 (2021)

Subject Terms: vesicular stomatitis virus (VSV), retinoid acid inducible gene I (RIG-I), pattern recognition receptor (PRR), pathogen associated molecular pattern (PAMP), nucleic acid sensing, defective interfering genome, Immunologic diseases. Allergy, RC581-607

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Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.595390/full; https://doaj.org/toc/1664-3224

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Cell Surface Expression of Endosomal Toll-Like Receptors—A Necessity or a Superfluous Duplication?

Authors: Matylda Barbara Mielcarska, Magdalena Bossowska-Nowicka, Felix Ngosa Toka

Source: Frontiers in Immunology, Vol 11 (2021)

Subject Terms: TLR3, cell surface expression, nucleic acid-sensing receptors, TLR signaling, innate immune function, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2020.620972/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/a0e618a8c86346b48f8ba15c6ba79b96

Signaling Through Nucleic Acid Sensors and Their Roles in Inflammatory Diseases

Authors: Haruna Okude, Daisuke Ori, Taro Kawai

Source: Frontiers in Immunology, Vol 11 (2021)

Subject Terms: Toll-like receptor, RIG-I-like receptor, cGAMP synthase, nucleic acid sensing, autoimmune disease, autoinflammatory disease, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2020.625833/full; https://doaj.org/toc/1664-3224

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Immunostimulatory Endogenous Nucleic Acids Perpetuate Interface Dermatitis—Translation of Pathogenic Fundamentals Into an In Vitro Model

Authors: Christine Braegelmann, Tanja Fetter, Dennis Niebel, Lara Dietz, Thomas Bieber, Joerg Wenzel

Source: Frontiers in Immunology, Vol 11 (2021)

Subject Terms: interface dermatitis/lichenoid tissue reaction, nucleic acid sensing, damage associated molecular patterns (DAMPs), type I immunity, lupus erythematosus, lichen planus, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2020.622511/full; https://doaj.org/toc/1664-3224

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Self-Nucleic Acid Sensing: A Novel Crucial Pathway Involved in Obesity-Mediated Metaflammation and Metabolic Syndrome

Authors: Amandine Ferriere, Pauline Santa, Anne Garreau, Purbita Bandopadhyay, Patrick Blanco, Dipyaman Ganguly, Vanja Sisirak

Source: Frontiers in Immunology, Vol 11 (2021)

Subject Terms: nucleic acids, obesity, metabolic syndrome, metainflammation, inflammation, nucleic acid sensing, Immunologic diseases. Allergy, RC581-607

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Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2020.624256/full; https://doaj.org/toc/1664-3224

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The Hippo Pathway in Innate Anti-microbial Immunity and Anti-tumor Immunity

Authors: Qian Zhang, Ruyuan Zhou, Pinglong Xu

Source: Frontiers in Immunology, Vol 11 (2020)

Subject Terms: Hippo-YAP signaling, innate immunity, anti-tumor immunity, anti-microbial, nucleic acid sensing, antiviral immunity, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2020.01473/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/cc998bc5cb564be09d0f1879210ed707