Toxicity Detection Methodology of Adverse Outcome Pathways using Physicochemical Properties and Machine Learning Approaches

Authors: Gupta, Vishan Kumar, Gupta, Avdhesh, Singh, Mukesh Kumar, Gupta, Ashutosh, Tomar, Ankit

Source: 2023 4th International Conference for Emerging Technology (INCET) Emerging Technology (INCET), 2023 4th International Conference for. :1-7 May, 2023

Relation: 2023 4th International Conference for Emerging Technology (INCET)

Conditional knockout of the NSD2 gene in mouse intestinal epithelial cells inhibits colorectal cancer progression

Authors: Mengyuan Li, Hanxue Chen, Xingjiu Yang, Wenlong Zhang, Chengyan Ma, Qinghong Wang, Xinpei Wang, Ran Gao

Source: Animal Models and Experimental Medicine, Vol 8, Iss 2, Pp 322-331 (2025)

Subject Terms: colorectal cancer, NSD2fl/fl‐Vil1‐Cre mice, nuclear receptor‐binding SET domain 2, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/2576-2095

Access URL: https://doaj.org/article/9c3984bf20e24840b88422c5706d80b6

Neutrophil extracellular traps (NETs) are increased in rheumatoid arthritis-associated interstitial lung disease

Authors: Jing Xue, Miaomiao Nian, Yangyang Liang, Zeqin Zhu, Zhenyu Hu, Yuanyuan Jia, Shuhong Chi, Juan Chen

Source: Respiratory Research, Vol 26, Iss 1, Pp 1-19 (2025)

Subject Terms: Nuclear receptor 4, Neutrophil extracellular traps, Rheumatoid arthritis, Interstitial lung disease, Diseases of the respiratory system, RC705-779

File Description: electronic resource

Relation: https://doaj.org/toc/1465-993X

Access URL: https://doaj.org/article/5bf3549bd3b840faba215d9d3d0b90df

Nuclear receptor profiling for subtype classification and as prognostic markers in 33 cancer types

Authors: Kazuya Nakamichi, Hironori Suzuki, Yusuke Yamamoto, Kentaro Semba, Jun Nakayama

Source: Discover Oncology, Vol 15, Iss 1, Pp 1-12 (2024)

Subject Terms: TCGA, Pan-cancer analysis, Hierarchical clustering, Classification, Nuclear receptor, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2730-6011

Access URL: https://doaj.org/article/1a0eb74a69bb4565bfa1774a56403c43

Intestinal epithelial cell NCoR deficiency ameliorates obesity and metabolic syndrome

Authors: Shaocong Hou, Hengcai Yu, Caihong Liu, Andrew M.F. Johnson, Xingfeng Liu, Qian Jiang, Qijin Zhao, Lijuan Kong, Yanjun Wan, Xiaowei Xing, Yibing Chen, Jingwen Chen, Qing Wu, Peng Zhang, Changtao Jiang, Bing Cui, Pingping Li

Source: Acta Pharmaceutica Sinica B, Vol 14, Iss 12, Pp 5267-5285 (2024)

Subject Terms: Nuclear receptor co-repressor 1, Intestinal epithelium, Metabolic syndrome, PPAR alpha, Liver X receptor, Thermogenesis, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211383524003848; https://doaj.org/toc/2211-3835

Access URL: https://doaj.org/article/fb18e1794a91426f81d665c0d8c9d2ac

Clinical spectrum and molecular basis in 19 Chinese patients with 46, XY disorder of sexual development caused by NR5A1 mutations

Authors: Yue Xu, Xuemeng Liu, Yang Liu, Hui Zhu, Jing Wu, Bing Han, Shiying Ling, Ren Cao, Haijun Yao, Yan Chen, Yu Liu, Yamin Rao, Xiaoyu Liu, Shuangxia Zhao, Huaidong Song, Jie Qiao

Source: Orphanet Journal of Rare Diseases, Vol 19, Iss 1, Pp 1-13 (2024)

Subject Terms: Nuclear receptor subfamily 5 group A member 1 (NR5A1) mutation, Disorder/differences of sexual development (DSD), Genotype–phenotype correlation, Leydig cell development, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1750-1172

Access URL: https://doaj.org/article/927eebfdc6894bac9cfa9eec0f353961

A novel heuristic of rigid docking scores positively correlates with full-length nuclear receptor LRH-1 regulation

Authors: Zeinab Haratipour, David Foutch, Raymond D. Blind

Source: Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 3065-3080 (2024)

Subject Terms: Prioritize hit compounds, Nuclear receptor compound docking, Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2001037024002551; https://doaj.org/toc/2001-0370

Access URL: https://doaj.org/article/6b619a27ac964db4a2b22e334fb0ed34

Silencing LINC00663 inhibits inflammation and angiogenesis through downregulation of NR2F1 via EBF1 in bladder cancer

Authors: Xiulong Zhong, Lijiang Sun, Junxiang Liu, Xiaokun Yang, Minghui Hou, Xinning Wang, Huifeng Diao

Source: RNA Biology, Vol 21, Iss 1, Pp 673-686 (2024)

Subject Terms: LINC00663, EBF1, nuclear receptor subfamily 2 group F member 1, bladder cancer, inflammation, angiogenesis, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1547-6286; https://doaj.org/toc/1555-8584

Access URL: https://doaj.org/article/ea161a9f31ee454aad8d52b5d91e39ea

Study on the Inhibition of Esophageal Carcinoma Development in Mice by Salvia Chinensia Benth Induced Ferroptosis

Authors: LIN Xinrong, JIA Lei, LI Lifeng, HUANG Ming, WU Zhongbing, LI Jing

Source: Zhongguo quanke yixue, Vol 27, Iss 30, Pp 3784-3789 (2024)

Subject Terms: esophageal carcinoma, ferroptosis, salvia chinensia benth, induction of carcinoma in situ, glutathione peroxidase 4, nuclear receptor coactivator 4, Medicine

File Description: electronic resource

Relation: https://www.chinagp.net/fileup/1007-9572/PDF/20230342.pdf; https://doaj.org/toc/1007-9572

Access URL: https://doaj.org/article/4c5d0467973949abb219f937b5657fec

NCOA4 linked to endothelial cell ferritinophagy and ferroptosis:a key regulator aggravate aortic endothelial inflammation and atherosclerosis

Authors: Li Zhu, Zijian Liu, Jiahui Liu, Zhenglong Li, Youli Bao, Xin Sun, Wenchen Zhao, An Zhou, Hongfei Wu

Source: Redox Biology, Vol 79, Iss , Pp 103465- (2025)

Subject Terms: Nuclear receptor coactivator 4, Ferritinophagy, Ferroptosis, Endothelial injury, Atherosclerosis, “Gualou-Xiebai” herb pair, Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213231724004439; https://doaj.org/toc/2213-2317

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NR2F6 regulates stem cell hematopoiesis and myelopoiesis in mice

Authors: Johannes Woelk, Hamsa Narasimhan, Christa Pfeifhofer-Obermair, Barbara U. Schraml, Natascha Hermann-Kleiter

Source: Frontiers in Immunology, Vol 15 (2025)

Subject Terms: nuclear receptor NR2F6, bone marrow, hematopoiesis, HSC, GMP, MDP, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1404805/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/a21fb78c630b41c3b547db90d392a18a

Roles of NR1I3 and NR1H4 polymorphisms in the susceptibility to antituberculosis drug-induced liver injury in China: a case‒control study

Authors: Xiaoyan Xu, Ruina Chen, Lihuan Lu, Jingru Cheng, Xiaomin He, Hongqiu Pan, Meiling Zhang, Honggang Yi, Shaowen Tang

Source: Frontiers in Genetics, Vol 15 (2024)

Subject Terms: antituberculosis drug-induced liver injury, nuclear receptor subfamily 1 group I member 3, nuclear receptor subfamily 1 group H member 4, genetic polymorphisms, case-control study, Genetics, QH426-470

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fgene.2024.1428319/full; https://doaj.org/toc/1664-8021

Access URL: https://doaj.org/article/c23f2064b0ce49f5a07b7aa89d5290f6

Combining graph neural networks and transformers for few-shot nuclear receptor binding activity prediction

Authors: Luis H. M. Torres, Joel P. Arrais, Bernardete Ribeiro

Source: Journal of Cheminformatics, Vol 16, Iss 1, Pp 1-19 (2024)

Subject Terms: Graph Neural Network, Transformer, Few-shot Learning, Meta-Learning, Nuclear Receptor Binding Activity Prediction, Drug Discovery, Information technology, T58.5-58.64, Chemistry, QD1-999

File Description: electronic resource

Relation: https://doaj.org/toc/1758-2946

Access URL: https://doaj.org/article/c22421c89d3a4596ba148a105dceb718

SUMOylation of nuclear receptor Nor1/NR4A3 coordinates microtubule cytoskeletal dynamics and stability in neuronal cells

Authors: Jonathan Gagnon, Véronique Caron, André Tremblay

Source: Cell & Bioscience, Vol 14, Iss 1, Pp 1-15 (2024)

Subject Terms: Nuclear receptor, NR4A3, Nor-1, Neuronal protection, SUMO1, Microtubules, Biotechnology, TP248.13-248.65, Biology (General), QH301-705.5, Biochemistry, QD415-436

File Description: electronic resource

Relation: https://doaj.org/toc/2045-3701

Access URL: https://doaj.org/article/037b99fc5fa344cebc5549d31f16977a

Free-Radical Scavenging and Antioxidant Properties of Melatonin

Contributors: Garcia-Macia, Marina, Santos-Ledo, Adrián

Subject Terms: archaea, Ard1, N-acetylserotonin, N-acetyltyramine, synthetic genes, melatonin, rice seed size, monochromatic light combination, oxidative stress, nuclear receptor, B lymphocyte, apoptosis, chick, reactive oxygen species, mitochondria, cancer, dose-response, BAT, thermogenesis, UCP1, obesity, ZDF rat, metallodrugs, platinum(II) complex, thiazoline, breast cancer, sulfur and nitrogen mustard, melatonin metabolites, NLRP3 inflammasome, DNA damage, agomelatine, p53, circadian clock, colorectal cancer, SIRT1, sepsis-associated encephalopathy, sepsis, antioxidant, neuroinflammation, neurodevelopmental disorders, brain development, circadian rhythms, sleep–wake rhythms, sleep disturbance, autism, schizophrenia, regeneration, ROS, zebrafish, visual system, Theatre studies

File Description: application/octet-stream

Access URL: https://directory.doabooks.org/handle/20.500.12854/152772
https://mdpi.com/books/pdfview/book/9940

Design, synthesis, and biological evaluation of imidazolidinone derivatives as potent PPARα/δ agonists for the treatment of cholestatic liver diseases

Authors: Fu, Zhuoxin ¹, Liu, Xin ¹, Yu, Wenhui ¹, Kuang, Yufan, Wang, Fengqin, Qian, Zhiqiang, Xu, Qinglong ^⁎⁎, Dai, Liang ^⁎, Feng, Zhiqi ^⁎⁎⁎

Source: In European Journal of Medicinal Chemistry 15 March 2025 286

Surveying helix 12 dynamics within constitutively active estrogen receptors using bipartite tetracysteine display

Authors: Sendanayake, Lasantha R. ¹, Pokhrel, Ranju ¹, Holub, Justin M. ^{1, 2, 3, ∗}

Source: In Journal of Biological Chemistry March 2025 301(3)

Lycium barbarum L.-Derived miR162a Functions on Osteoporosis Through Directly Promoting Osteoblast Formation

Authors: Gu, Chunyan ^{a, b, e, #}, Yu, Xichao ^{b, #}, Tang, Xiaozhu ^{b, #}, Gong, Leilei ^{c, #}, Tan, Jingquan ^{d, #}, Zhang, Yuanjiao ^b, Zheng, Huili ^e, Wang, Ze ^b, Zhang, Chenqian ^b, Zhu, Yejin ^b, Zhou, Zuojian ^f, Yu, Heming ^a, Xu, Kai ^{d, ⁎}, Duan, Jinao ^{e, ⁎}, Gu, Xiaosong ^{a, c, ⁎}, Yang, Ye ^{b, ⁎}

Source: In Engineering March 2025 46:162-171

Comparative study on gene expression profiles in the liver of male neonatal mice prenatally exposed to PFOA and its alternative HFPO-DA

Authors: Murase, Wataru ^a, Kubota, Atsuhito ^a, Hakota, Ryo ^a, Yasuda, Ayaka ^a, Ikeda, Atsuko ^{b, c}, Nakagawa, Koji ^{a, d}, Shizu, Ryota ^e, Yoshinari, Kouichi ^e, Kojima, Hiroyuki ^{a, d, ⁎}

Source: In Toxicology February 2025 511

Allosteric communications between domains of nuclear receptors

Authors: Rastinejad, Fraydoon ^⁎

Source: In Steroids February 2025 214