Orientin alleviates chondrocyte senescence and osteoarthritis by inhibiting PI3K/AKT pathway

Authors: Haitao Chen, Siyi Liu, Junwei Xing, Yinxian Wen, Liaobin Chen

Source: Bone & Joint Research, Vol 14, Iss 3, Pp 245-258 (2025)

Subject Terms: osteoarthritis, orientin, chondrocyte senescence, reactive oxygen species, pi3k/akt pathway, chondrocytes, osteoarthritis (oa), rat model, interleukin, osteophytes, cartilage, rna, radiograph, nuclear factor kappa b, anterior cruciate ligament transection (aclt), Diseases of the musculoskeletal system, RC925-935

File Description: electronic resource

Relation: https://doaj.org/toc/2046-3758

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Risk factors for non-responsiveness to 5-aminosalicylic acid in patients with ulcerative colitis identified using retrospective clinical study and Mendelian randomization

Authors: Zhi-Ning Ye, Xin-Tian Liu, Yue-Ming Gu, Shu-Xian Mao, Dan-Hong Liang, Kai Zhan, Hao-Qiang Lei, Shao-Gang Huang

Source: Scientific Reports, Vol 15, Iss 1, Pp 1-13 (2025)

Subject Terms: Ulcerative colitis, 5-Aminosalicylic acid, Responsiveness, Allergy, Aspartate aminotransferase-to-alanine aminotransferase ratio, Inhibitor of nuclear factor kappa-B kinase subunit alpha, Medicine, Science

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Relation: https://doaj.org/toc/2045-2322

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Targeting skeletal interoception: a novel mechanistic insight into intervertebral disc degeneration and pain management

Authors: Houcheng Zhu, JianHang Ren, Xiangjin Wang, Wenjing Qin, Yong Xie

Source: Journal of Orthopaedic Surgery and Research, Vol 20, Iss 1, Pp 1-19 (2025)

Subject Terms: Intervertebral disc degeneration, Interception, Skeletal interoception, Prostaglandin E2, Nuclear factor kappa B, Wnt/β-catenin, Orthopedic surgery, RD701-811, Diseases of the musculoskeletal system, RC925-935

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Relation: https://doaj.org/toc/1749-799X

Access URL: https://doaj.org/article/9e89359289644a658b16854b6c28c88f

Skullcapflavone II suppresses TGF-β-induced corneal epithelial mesenchymal transition in vitro

Authors: Meng-Xi Li, Zhen Zhang, Yue Zhang, Fan-Ru Zhao, Yu-Fan Li, Yu-Fei Dang, Yang-Yang Yue, Li Li

Source: International Journal of Ophthalmology, Vol 18, Iss 2, Pp 209-215 (2025)

Subject Terms: skullcapflavone ii, epithelial-mesenchymal transition, transforming growth factor, nuclear factor kappa-b, human corneal epithelial cells, Ophthalmology, RE1-994

File Description: electronic resource

Relation: http://ies.ijo.cn/en_publish/2025/2/20250202.pdf; https://doaj.org/toc/2222-3959; https://doaj.org/toc/2227-4898

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Gamma-glutamyl transferase 5 overexpression in cerebrovascular endothelial cells improves brain pathology, cognition, and behavior in APP/PS1 mice

Authors: Yanli Zhang, Tian Li, Jie Miao, Zhina Zhang, Mingxuan Yang, Zhuoran Wang, Bo Yang, Jiawei Zhang, Haiting Li, Qiang Su, Junhong Guo

Source: Neural Regeneration Research, Vol 20, Iss 2, Pp 533-547 (2025)

Subject Terms: alzheimer’s disease, amyloid-β, app/ps1 mice, cerebrovascular endothelial cells, cognitive deficits, gamma-glutamyl transferase 5, neurovascular unit, nuclear factor‐kappa b, synaptic plasticity, β-site app cleaving enzyme 1, Neurology. Diseases of the nervous system, RC346-429

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Relation: https://journals.lww.com/10.4103/NRR.NRR-D-23-01525; https://doaj.org/toc/1673-5374; https://doaj.org/toc/1876-7958

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Effects of Aerobic Exercise and Stem Cell Injection on the Expression of NF-κB and MMP1 Genes in the Knee Cartilage of Male Rat Models of Osteoarthritis

Authors: Hamidraza Sharifi, Zaher Etemad, Kamal Azizbeigi, Parvin Farzanegi

Source: مجله علوم پزشکی فیض (پیوسته), Vol 28, Iss 6, Pp 595-602 (2024)

Subject Terms: nuclear factor kappa b (nf-κb), matrix metalloproteinase-1 (mmp1), mesenchymal stem cells, osteoarthritis, aerobic exercise, Medicine

File Description: electronic resource

Relation: http://feyz.kaums.ac.ir/article-1-5124-en.pdf; https://doaj.org/toc/3060-5806; https://doaj.org/toc/3060-5814

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Structural Characterization of Polygonum divaricatum L. Polysaccharide and Its Inhibitory Effect on Lipopolysaccharide-Induced Inflammation in RAW264.7 Cells

Authors: CUI Yanyan, YUAN Yongxu, GUO Mingkun, HE Wenbing, LI Ming, PEI Shichun, LI Dajun

Source: Shipin Kexue, Vol 45, Iss 24, Pp 128-138 (2024)

Subject Terms: polygonum divaricatum l. polysaccharide, lipopolysaccharide, raw264.7 cells, inflammation, mitogen-activated protein kinases/nuclear factor kappa b signaling pathway, Food processing and manufacture, TP368-456

File Description: electronic resource

Relation: https://www.spkx.net.cn/fileup/1002-6630/PDF/2024-45-24-015.pdf; https://doaj.org/toc/1002-6630

Access URL: https://doaj.org/article/67ae35e7ef1d464e84fdc16390b8e2cf

High molecular weight hyaluronic acid alleviates ovariectomy-induced bone loss in mice

Authors: Khangarid Tenger, Keiichiro Komori, Ami Maehara, Kyosuke Miyazaki, Eriko Marukawa, Toshitaka Yoshii, Kunikazu Tsuji

Source: BMC Musculoskeletal Disorders, Vol 25, Iss 1, Pp 1-13 (2024)

Subject Terms: Hyaluronic acid, Osteoporosis, Ovariectomy, Receptor activator of nuclear factor kappa-B ligand, Diseases of the musculoskeletal system, RC925-935

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Relation: https://doaj.org/toc/1471-2474

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Fluoxetine inhibited RANKL-induced osteoclastic differentiation in vitro

Authors: Zhang Jing-wen, Zhao Fang-bing, Ma Bing’er, Shen Xiao-qing, Geng Yuan-ming

Source: Open Medicine, Vol 19, Iss 1, Pp 573-81 (2024)

Subject Terms: osteoclast, receptor activator of nuclear factor kappa-b ligand, selective serotonin reuptake inhibitor, fluoxetine, orthodontic tooth movement, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2391-5463

Access URL: https://doaj.org/article/c0bcd5517a41488daa160b78f7ac0f40

Melittin ameliorates schistosomiasis-induced liver fibrosis by suppressing signal transducer and activator of transcription 3 and nuclear factor kappa B

Authors: Ola I. Rozik, Manal M. Hussein, Ahmed S. El-elebiarie, Soad Nady

Source: Journal of the Arab Society for Medical Research, Vol 19, Iss 2, Pp 200-210 (2024)

Subject Terms: anti-inflammatory, liver fibrosis, melittin, nuclear factor kappa b, signal transducer and activator of transcription 3, Medicine

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Relation: https://journals.lww.com/10.4103/jasmr.jasmr_23_24; https://doaj.org/toc/1687-4293

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Differential expression of phosphoinositide 3-kinase/protein kinase B and Toll-like receptor/nuclear factor kappa B signaling pathways in experimental obesity Wistar rat model

Authors: Song Liya, Li Lihua

Source: Open Life Sciences, Vol 19, Iss 1, Pp 3898-918 (2024)

Subject Terms: obesity rat model, high-fat diet, phosphatidylinositol-3-kinase/protein kinase b, toll-like receptor/nuclear factor kappa b, differences, expression, Biology (General), QH301-705.5

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Relation: https://doaj.org/toc/2391-5412

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Evaluation of the effect of phellodendrin application on rats creating an experimental model of non-compression lumbar disc herniation on the NF-κB-related inflammatory signaling pathway

Authors: Panlin Tan, Jianbing Mei, Dong Wang

Source: Journal of Orthopaedic Surgery and Research, Vol 19, Iss 1, Pp 1-10 (2024)

Subject Terms: Non-compression lumbar disc herniation, Phellodendrine, Nuclear factor-kappa B, Tumor necrosis factor-alpha, Interleukin-1 beta, Orthopedic surgery, RD701-811, Diseases of the musculoskeletal system, RC925-935

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Relation: https://doaj.org/toc/1749-799X

Access URL: https://doaj.org/article/c15487372ef2449292c8171e373bd126

Resveratrol treats peri-implantitis in mice via inhibiting the MAPKs/NF-κB signaling pathway

Authors: LIU Senqing, ZHANG Hua, CHEN Yanyan, HE Haipeng, HUANG Jiamin, YUAN Jingyi, HU Tianyong, DU Ruitian

Source: 口腔疾病防治, Vol 32, Iss 11, Pp 845-852 (2024)

Subject Terms: peri-implantitis, resveratrol, animal model, p38 mitogen activated protein kinase, nuclear factor kappa-b, Medicine

File Description: electronic resource

Relation: https://www.kqjbfz.com/fileup/2096-1456/PDF/2096-1456（2024）11-0845-08.pdf; https://doaj.org/toc/2096-1456

Access URL: https://doaj.org/article/76807803bfde4e8c9272b70e8d6c7158

Homocysteine aggravates intestinal inflammation through promotion of 5-LOX and COX-2 in IBD

Authors: Jing Wang, Lin Li, Pingbo Chen, Chiyi He, Xiaoping Niu, Qiao Mei

Source: European Journal of Medical Research, Vol 29, Iss 1, Pp 1-12 (2024)

Subject Terms: Cysteinyl leukotrienes, Prostaglandin E2, Nuclear factor kappa B, Inflammatory bowel disease, Homocysteine, 5-Lipoxygenase, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2047-783X

Access URL: https://doaj.org/article/2741bffc8940412a848a8f360df6b776

Repurposing of sericin combined with dactolisib or vitamin D to combat non-small lung cancer cells through computational and biological investigations

Authors: Maged W. Helmy, Mariam H. Youssef, Imane Yamari, Alaa Amr, Farouzia I. Moussa, Abeer El Wakil, Samir Chtita, Lamia M. El-Samad, Mohamed A. Hassan

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-24 (2024)

Subject Terms: Sericin, Dactolisib, Vitamin D, Lung cancer, Non-small lung cancer cells, Nuclear factor Kappa B (NF-κB), Medicine, Science

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Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/222de78aca1644d8ba512904c839c345

Medicinal Herbal Extracts: Therapeutic Potential in Acute Lung Injury

Authors: Jae-Won Lee, Hee Jae Lee, Seok Han Yun, Juhyun Lee, Hyueyun Kim, Ha Yeong Kang, Kyung-Seop Ahn, Wanjoo Chun

Source: Future Pharmacology, Vol 4, Iss 4, Pp 700-715 (2024)

Subject Terms: acute lung injury, medicinal herbal extract, macrophages, cytokines, nuclear factor kappa B, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.mdpi.com/2673-9879/4/4/37; https://doaj.org/toc/2673-9879

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The modulatory effects of Lonicera caerulea L. extract and omega-3 on sarcopenia via regulating PI3K and FOXO signaling pathways in rats

Authors: Radwa Wahid Mohamed, Nourhan Gamal El-Rahmany

Source: Journal of HerbMed Pharmacology, Vol 13, Iss 4, Pp 651-658 (2024)

Subject Terms: cathepsin, dexamethasone, muscle atrophy, atrogin-1, haskap berry, nuclear factor kappa b, oxidative damage, Medicine (General), R5-920, Therapeutics. Pharmacology, RM1-950

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Relation: https://herbmedpharmacol.com/PDF/jhp-13-651.pdf; https://doaj.org/toc/2345-5004

Access URL: https://doaj.org/article/dc136b9c1afc4da4b9cb1b106c7ea313

Activating Transcription Factor 6 Mediates Inflammation in Experimental Varicocele-Induced Epididymal Epithelial Cells

Authors: Jin YS, Cui YQ, Xu YP, Chen J, Zhang XB, Wang X

Source: Journal of Inflammation Research, Vol Volume 17, Pp 7261-7274 (2024)

Subject Terms: epididymal neutral α-glucosidase, hypoxia, left varicocele, nuclear factor-kappa b p65, nf-κb p65, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.dovepress.com/activating-transcription-factor-6-mediates-inflammation-in-experimenta-peer-reviewed-fulltext-article-JIR; https://doaj.org/toc/1178-7031

Access URL: https://doaj.org/article/2950e1557f5048e0b52667358fcee442

Ginsenoside Rb1 Alleviates DSS-Induced Ulcerative Colitis by Protecting the Intestinal Barrier Through the Signal Network of VDR, PPARγ and NF-κB

Authors: Zhou Y, Xiong X, Cheng Z, Chen Z, Wu S, Yu Y, Liu Y, Chen G, Li L

Source: Drug Design, Development and Therapy, Vol Volume 18, Pp 4825-4838 (2024)

Subject Terms: ginsenoside rb1, ulcerative colitis, intestinal barrier, vitamin d receptor, nuclear factor-kappa b, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.dovepress.com/ginsenoside-rb1-alleviates-dss-induced-ulcerative-colitis-by-protectin-peer-reviewed-fulltext-article-DDDT; https://doaj.org/toc/1177-8881

Access URL: https://doaj.org/article/df6992f2b4bc46e98a6b69b9227e1c1a

In Vivo Evidence for the Preventive Role of Vaccinium macrocarpon Aiton in Indomethacin‐Induced Gastric Ulcer: Focusing on Antioxidant, Anti‐Inflammatory and Anti‐Apoptotic Mechanisms

Authors: Ismail Cagri Aydin, Irmak Ferah Okkay, Ufuk Okkay, Mustafa Ozkaraca, Fatma Yesilyurt, Aysegul Yilmaz, Betul Cicek, Ozhan Karatas, Hilal Kadioglu Kalkandelen, Bilge Aydin, Ahmet Hacimuftuoglu, Songul Karakaya, Zuhal Güvenalp, A. M. Abd El‐Aty

Source: Veterinary Medicine and Science, Vol 11, Iss 1, Pp n/a-n/a (2025)

Subject Terms: cyclooxygenase (COX), nuclear factor kappa B (NF‐κB)/inhibitor kappa B (IκB), oxidative stress, ulcer, vaccinium macrocarpon, Veterinary medicine, SF600-1100

File Description: electronic resource

Relation: https://doaj.org/toc/2053-1095

Access URL: https://doaj.org/article/c25930aea1f348ae932a35fbbb8a43a4