Pharmacology and Mechanism of Action of Suzetrigine, a Potent and Selective NaV1.8 Pain Signal Inhibitor for the Treatment of Moderate to Severe Pain

Authors: Jeremiah D. Osteen, Swapna Immani, Tim L. Tapley, Tim Indersmitten, Nicole W. Hurst, Tiffany Healey, Kathleen Aertgeerts, Paul A. Negulescu, Sandra M. Lechner

Source: Pain and Therapy, Vol 14, Iss 2, Pp 655-674 (2025)

Subject Terms: Moderate to severe pain, NaV1.8, Non-opioid analgesic, Selective pain signal inhibitor, Suzetrigine, VX-548, Anesthesiology, RD78.3-87.3

File Description: electronic resource

Relation: https://doaj.org/toc/2193-8237; https://doaj.org/toc/2193-651X

Access URL: https://doaj.org/article/6437cb03b68f4f51bbaaa93ce6386946

Outcomes of an Emergency Department opioid alternatives Program implemented within a safety-net hospital system

Authors: Magda Montague, Charlotte Hopson, Claire Layton, Jennifer Fishe, Ashley Norse, L. Kendall Webb, Petra Duran-Gehring, Andrew Bertrand, Jennifer Brailsford, Taylor Munson, Rui Wang, Nolan Menze, Katelyn Perl, Phyllis Hendry, Sophia Sheikh

Source: BMC Emergency Medicine, Vol 25, Iss 1, Pp 1-10 (2025)

Subject Terms: Opioid alternative, Pain management, EMR order panels, Non-opioid analgesic, Special situations and conditions, RC952-1245, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9

File Description: electronic resource

Relation: https://doaj.org/toc/1471-227X

Access URL: https://doaj.org/article/e88d7451ff0847f7a6ef4ca8059bae68

A synthetic peptide, derived from neurotoxin GsMTx4, acts as a non-opioid analgesic to alleviate mechanical and neuropathic pain through the TRPV4 channel

Authors: Ke, ShaoXi ^{a, b, †}, Dong, Ping ^{a, c, †}, Mei, Yi ^{a, †}, Wang, JiaQi ^{a, †}, Tang, Mingxi ^{d, e, †}, Su, Wanxin ^{a, †}, Wang, JingJing ^{a, †}, Chen, Chen ^a, Wang, Xiaohui ^a, Ji, JunWei ^a, Zhuang, XinRan ^a, Yang, ShuangShuang ^a, Zhang, Yun ^a, Boland, Linda M. ^f, Cui, Meng ^g, Sokabe, Masahiro ^{h, i}, Zhang, Zhe ^{a, j, ⁎}, Tang, QiongYao ^{a, j, ⁎}

Source: In Acta Pharmaceutica Sinica B November 2024

Effect of S-Ketamine on Postoperative Nausea and Vomiting in Patients Undergoing Video-Assisted Thoracic Surgery: A Randomized Controlled Trial

Authors: Qi Y, Zhou M, Zheng W, Dong Y, Li W, Wang L, Xu H, Zhang M, Yang D, Zhou H

Source: Drug Design, Development and Therapy, Vol Volume 18, Pp 1189-1198 (2024)

Subject Terms: s-ketamine, postoperative nausea and vomiting, hemodynamics, non-opioid analgesic, postoperative pain, video-assisted thoracoscopic surgery lobectomy, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.dovepress.com/effect-of-s-ketamine-on-postoperative-nausea-and-vomiting-in-patients--peer-reviewed-fulltext-article-DDDT; https://doaj.org/toc/1177-8881

Access URL: https://doaj.org/article/2ffa2a5a6e2f4770b400c3155cce1a99

Efficacy of flupirtine for postoperative pain: A systematic review and meta-analysis

Authors: Samarjit Dey, Indubala Maurya, Ayush Lohiya, Prateek Arora, Rizwan Suliankatchi Abdulkader, Sairem Mangolnganbi Chanu

Source: Indian Journal of Anaesthesia, Vol 67, Iss 3, Pp 247-255 (2023)

Subject Terms: acute pain, flupirtine, non-opioid analgesic, post-operative pain, Anesthesiology, RD78.3-87.3

File Description: electronic resource

Relation: http://www.ijaweb.org/article.asp?issn=0019-5049;year=2023;volume=67;issue=3;spage=247;epage=255;aulast=Dey; https://doaj.org/toc/0019-5049; https://doaj.org/toc/0976-2817

Access URL: https://doaj.org/article/361a7b43ab344c91b97bee4b366dad3f

Parenteral Ready-to-Use Fixed-Dose Combinations Including NSAIDs with Paracetamol or Metamizole for Multimodal Analgesia—Approved Products and Challenges

Authors: Fernando Silva, Gustavo Costa, Francisco Veiga, Catarina Cardoso, Ana Cláudia Paiva-Santos

Source: Pharmaceuticals, Vol 16, Iss 8, p 1084 (2023)

Subject Terms: fixed-dose combination, NSAID, non-opioid analgesic, ready-to-use, parenteral, multimodal analgesia, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/16/8/1084; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/93b3f1b0b344491497f51b105e14684e

Pharmaceutical Effects of Inhibiting the Soluble Epoxide Hydrolase in Canine Osteoarthritis

Authors: Cindy B. McReynolds, Sung Hee Hwang, Jun Yang, Debin Wan, Karen Wagner, Christophe Morisseau, Dongyang Li, William K. Schmidt, Bruce D. Hammock

Source: Frontiers in Pharmacology, Vol 10 (2019)

Subject Terms: soluble epoxide hydrolase, osteoarthritis, epoxyeicostrienoic acids, analgesic, non-opioid analgesic, non-NSAID analgesic, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fphar.2019.00533/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/dac2eddca3cf4d3aa41cd147550a0d8f

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Advances in chemical synthesis reveal rare natural product with potent pain-killing properties

Source: domain-B (India), June 3, 2011 News, 4pp

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