The decrease in Rad51 and DNA ligase IV nuclear protein expression in Msh2 knockdown HC11 cells induced the low CRISPR/Cas9-mediated knock-in efficiency at the β-casein gene locus

Authors: Ga-Yeon Kim, Man-Jong Kang

Source: Animal Bioscience, Vol 38, Iss 3, Pp 560-567 (2025)

Subject Terms: clustered regularly interspaced short palindromic repeats/crispr-associated 9 (crispr/cas9), dna mismatch repair (mmr), homologous recombination (hr), non-homologous end joining (nhej), Zoology, QL1-991

File Description: electronic resource

Relation: http://www.animbiosci.org/upload/pdf/ab-24-0206.pdf; https://doaj.org/toc/2765-0189; https://doaj.org/toc/2765-0235

Access URL: https://doaj.org/article/2b42153382554a02bd569772edc126f3

Studying concatenation of the Cas9-cleaved transgenes using barcodes

Authors: A. V. Smirnov, A. N. Korablev, I. A. Serova, A. M. Yunusova, A. A. Muravyova, E. S. Valeev, N. R. Battulin

Source: Вавиловский журнал генетики и селекции, Vol 29, Iss 1, Pp 26-34 (2025)

Subject Terms: crispr/cas9, pronuclear microinjection, dna barcoding, transgenic animals, dsb repair, concatemer, homologous recombination (hr), non-homologous end-joining, nhej, mouse embryos, Genetics, QH426-470

File Description: electronic resource

Relation: https://vavilov.elpub.ru/jour/article/view/4473; https://doaj.org/toc/2500-3259

Access URL: https://doaj.org/article/423196588de040ae873243aa16f0b0e1

Tousled-like kinase loss confers PARP inhibitor resistance in BRCA1-mutated cancers by impeding non-homologous end joining repair

Authors: Min-ah Kim, Banseok Kim, Jihyeon Jeon, Jonghyun Lee, Hyeji Jang, Minjae Baek, Sang-Uk Seo, Dongkwan Shin, Anindya Dutta, Kyung Yong Lee

Source: Molecular Medicine, Vol 31, Iss 1, Pp 1-18 (2025)

Subject Terms: DNA damage repair, Double-stranded breaks (DSBs), Non-homologous end joining (NHEJ), Homologous recombination (HR), PARP inhibitor, Tousled-like kinase, Therapeutics. Pharmacology, RM1-950, Biochemistry, QD415-436

File Description: electronic resource

Relation: https://doaj.org/toc/1528-3658

Access URL: https://doaj.org/article/c7d8e3ee14534365a2f5f8d5b5316532

Negative feedback loop in the activation of non-homologous end joining DNA repair pathway in Helicobacter pylori infected patients with gastritis

Authors: Mohsen Amirnorouzi, Ahmadmoeen Karimi, Naser Ebrahimi Daryani, Amiratabak Rajaei, Mehrdad Hashemi, Masoud Alebouyeh

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)

Subject Terms: Helicobacter pylori, Chronic gastritis, Non-homologous end-joining, DNA repair system, DNA double-strand breaks, LncRNA in non-homologous end joining pathway 1, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/fb7f01585245439596647bd69f70ae25

Assessing spacer acquisition rates in E. coli type I-E CRISPR arrays

Authors: Luke J. Peach, Haoyun Zhang, Brian P. Weaver, James Q. Boedicker

Source: Frontiers in Microbiology, Vol 15 (2025)

Subject Terms: CRISPR adaptation, type I-E CRISPR, Cas1–Cas2, array expansion, spacer acquisition rates, non-homologous end joining, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmicb.2024.1498959/full; https://doaj.org/toc/1664-302X

Access URL: https://doaj.org/article/b5cff16dbf584f729e6e61785f7d704a

Artemis and its role in cancer

Authors: Armen Parsyan, Vasudeva Bhat, Harjot Athwal, Emily A. Goebel, Alison L Allan

Source: Translational Oncology, Vol 51, Iss , Pp 102165- (2025)

Subject Terms: DCLRE1C, Non-homologous end joining, Radiosensitization, Cancer treatment, Cancer biomarkers, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1936523324002912; https://doaj.org/toc/1936-5233

Access URL: https://doaj.org/article/8f66f5b523804291927e519f0d4b7c6e

NHEJ and HDR can occur simultaneously during gene integration into the genome of Aspergillus niger

Authors: Susanne Fritsche, Aline Reinfurt, Felix Fronek, Matthias G. Steiger

Source: Fungal Biology and Biotechnology, Vol 11, Iss 1, Pp 1-9 (2024)

Subject Terms: DNA repair, CRISPR/Cas9-mediated genome editing, DNA modification, Homology-directed repair, Non-homologous end joining, Self-replicating plasmid, Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: https://doaj.org/toc/2054-3085

Access URL: https://doaj.org/article/52347a8ee045481ba65569f2ffe7bf83

Loss of tet methyl cytosine dioxygenase 3 (TET3) enhances cardiac fibrosis via modulating the DNA damage repair response

Authors: Sandip Kumar Rath, Gunsmaa Nyamsuren, Björn Tampe, David Sung-wen Yu, Melanie S. Hulshoff, Denise Schlösser, Sabine Maamari, Michael Zeisberg, Elisabeth M. Zeisberg

Source: Clinical Epigenetics, Vol 16, Iss 1, Pp 1-20 (2024)

Subject Terms: TET3, Homologous recombination, Non-homologous end joining, TGF-ß, Fibrosis, Medicine, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1868-7083

Access URL: https://doaj.org/article/c9732583a636444882ccab2ad924f6f6

Focused ultrasound and microbubble-mediated delivery of CRISPR-Cas9 ribonucleoprotein to human induced pluripotent stem cells

Authors: Hazel, Kyle ¹, Singh, Davindra ¹, He, Stephanie ¹, Guertin, Zakary ¹, Husser, Mathieu C. ¹, Helfield, Brandon ^{1, 2, ∗}

Source: In Molecular Therapy 5 March 2025 33(3):986-996

In-silico analysis of XRCC5 non-synonymous single nucleotide polymorphisms (nsSNPs) in acute myeloid leukemia prognosis

Authors: Hossen, Md. Arif ^a, Hossain, Md. Arju ^b, Kamruzzaman, Mohammad ^a, Nobel, Fahim Alam ^a, Uddin, Md. Moin ^c, Hossain, Md. Tanvir ^c, Taz, Numan Bin ^a, Shahidullah ^a, Sarker, Tumpa Rani ^a, Farin, Rafia Tabassum ^a, Al Noman, Abdullah ^a, Uddin, Mohammad Nasir ^{a, ⁎, 1}, Islam, Mohammod Johirul ^{a, ⁎, 1}

Source: In Gene Reports March 2025 38

Saccharomyces cerevisiae Rev7 promotes non-homologous end-joining by blocking Mre11 nuclease and Rad50’s ATPase activities and homologous recombination

Authors: Sugith Badugu, Kshitiza Mohan Dhyani, Manoj Thakur, Kalappa Muniyappa

Source: eLife, Vol 13 (2024)

Subject Terms: homologous recombination, non-homologous end-joining, Rev7, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/96933; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/16079b0f341e4f83945b99eed8a613cf

Characterization of DNA damage repair pathway utilization in high-grade serous ovarian cancers yields rational therapeutic approaches

Authors: Erika Nakatsuka, Lijun Tan, Brianna Cunneen, Caroline Foster, Yu Leo Lei, Karen McLean

Source: Translational Oncology, Vol 50, Iss , Pp 102119- (2024)

Subject Terms: DNA damage repair, Homologous recombination, Non-homologous end-joining, ATM, PARP, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1936523324002468; https://doaj.org/toc/1936-5233

Access URL: https://doaj.org/article/e4134b89a1214d7b8343334fb3aae0c5

Guiqi Baizhu decoction enhances radiosensitivity in non-small cell lung cancer by inhibiting the HIF-1α/DNA-PKcs axis-mediated DNA repair

Authors: Li, Yangyang ^{a, 1}, Yang, Gengqiang ^{a, 1}, Li, Qiyang ^a, Zhang, Yiming ^b, Zhang, Shangzu ^c, Zhou, Ting ^a, Wang, Xin ^a, Liu, Fuxian ^a, Miao, Zhiming ^a, Qi, Yafeng ^a, Zhang, Liying ^{a, ⁎}, Liu, Yongqi ^{a, d, ⁎}, Su, Haixiang ^{e, ⁎⁎}

Source: In Phytomedicine May 2025 140

Prime Editing: Mechanistic Insights and DNA Repair Modulation

Authors: Astrid Mentani, Marcello Maresca, Anna Shiriaeva

Source: Cells, Vol 14, Iss 4, p 277 (2025)

Subject Terms: Cas9, prime editing, DNA repair mechanisms, DNA repair modulation, homologous recombination, non-homologous end joining, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/14/4/277; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/0bf97c4d81d54c9bbded75e3ea5d1ee9

Assessment of DNA Double Strand Break Repair Activity Using High-throughput and Quantitative Luminescence-Based Reporter Assays

Authors: Diego Grande, author¹, Eeson Rajendra, author¹, Bethany Mason, author¹, Alessandro Galbiati, author¹, Simon J. Boulton, author^{1, 2}, Graeme C. M. Smith, author¹, Helen M. R. Robinson, author¹

Source: Journal of Visualized Experiments. (208)

Availability: http://www.jove.com/video/66969

DNA contamination within recombinant adeno-associated virus preparations correlates with decreased CD34+ cell clonogenic potential

Authors: Luthers, Christopher R. ^{1, 2}, Ha, Sung-Min ³, Mittelhauser, Annika ², Morselli, Marco ⁴, Long, Joseph D. ², Kuo, Caroline Y. ², Romero, Zulema ², Kohn, Donald B. ^{2, ∗}

Source: In Molecular Therapy - Methods & Clinical Development 12 December 2024 32(4)

Genome-scale transcriptional activation by non-homologous end joining-mediated integration in Yarrowia lipolytica

Authors: Xiaoqin Liu, Jingyu Deng, Jinhong Zhang, Zhiyong Cui, Qingsheng Qi, Jin Hou

Source: Biotechnology for Biofuels and Bioproducts, Vol 17, Iss 1, Pp 1-11 (2024)

Subject Terms: Gene regulatory library, Non-homologous end joining, Targets identification, Yarrowia lipolytica, Biotechnology, TP248.13-248.65, Fuel, TP315-360

File Description: electronic resource

Relation: https://doaj.org/toc/2731-3654

Access URL: https://doaj.org/article/ddd698e7aae44bfbbade402ca7afc93a

Genomic characterization of IDH-mutant astrocytoma progression to grade 4 in the treatment setting

Authors: Kirsi J. Rautajoki, Serafiina Jaatinen, Anja Hartewig, Aliisa M. Tiihonen, Matti Annala, Iida Salonen, Masi Valkonen, Vili Simola, Elisa M. Vuorinen, Anni Kivinen, Minna J. Rauhala, Riikka Nurminen, Kendra K. Maass, Sirpa-Liisa Lahtela, Arja Jukkola, Olli Yli-Harja, Pauli Helén, Kristian W. Pajtler, Pekka Ruusuvuori, Joonas Haapasalo, Wei Zhang, Hannu Haapasalo, Matti Nykter

Source: Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-20 (2023)

Subject Terms: Diffuse glioma, Secondary glioblastoma, Non-homologous end-joining, Microhomology-mediated end-joining, Homologous recombination repair, Longitudinal analysis, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2051-5960

Access URL: https://doaj.org/article/93bb5201f4a448cca5fb328e55e9e60a

Extracellular vesicle-packaged circBIRC6 from cancer-associated fibroblasts induce platinum resistance via SUMOylation modulation in pancreatic cancer

Authors: Shangyou Zheng, Qing Tian, Yuan Yuan, Shuxin Sun, Tingting Li, Renpeng Xia, Rihua He, Yuming Luo, Qing Lin, Zhiqiang Fu, Yu Zhou, Rufu Chen, Chonghui Hu

Source: Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-20 (2023)

Subject Terms: Extracellular vesicles, Cancer-associated fibroblasts, Circular RNAs, Non-homologous end joining, SUMOylation, Oxaliplatin resistance., Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/03abc8fc8c0442eda06dfb68c7178cbc

Discrepant involvement of homologous repair and non-homologous end joining pathways in maize development and growth

Authors: Zhao, Shuanghui ^a, Zheng, Leiming ^a, Zheng, Minghui ^a, Li, Menghan ^a, Li, Shuyue ^a, Wu, Nan ^a, He, Yan ^{a, b, ⁎}, Liu, Jinghan ^{a, ⁎}

Source: In The Crop Journal November 2024