Mesothelin-targeted CAR-T cells secreting NKG2D-BiTEs exhibit potent efficacy against triple-negative breast cancer

Authors: Muhammad Auwal Saliu, Qi Wang, Mansur Dabai Salisu, Yuanfeng Ren, Pengchao Zhang, Rabiatu Bako Suleiman, Bingbing Cao, Yiqiao Xu, Xudong Liu, Frederic Lluis, Maoxuan Liu, Xiaochun Wan

Source: Experimental Hematology & Oncology, Vol 14, Iss 1, Pp 1-4 (2025)

Subject Terms: CAR-T therapy, BiTEs, Triple-negative breast cancer, Mesothelin, NKG2D ligands, Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-3619

Access URL: https://doaj.org/article/56f3aa032b884baa8110d74696f2007b

CAR-NK cells with dual targeting of PD-L1 and MICA/B in lung cancer tumor models

Authors: Lingtong Zhi, Zikang Zhang, Qing Gao, Chongye Shang, Wenhui He, Yuqing Wang, Changjiang Guo, Zhiyuan Niu, Wuling Zhu

Source: BMC Cancer, Vol 25, Iss 1, Pp 1-11 (2025)

Subject Terms: NK cells, PD-L1 nanoantibody, NKG2D, Pyroptosis, NK-tailored CAR, Human lung cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/0d7555a648b8445081c4e86344322354

Arachidonic acid impairs natural killer cell functions by disrupting signaling pathways driven by activating receptors and reactive oxygen species

Authors: Mohamad K. Hammoud, Celina Meena, Raimund Dietze, Nathalie Hoffmann, Witold Szymanski, Florian Finkernagel, Andrea Nist, Thorsten Stiewe, Johannes Graumann, Elke Pogge von Strandmann, Rolf Müller

Source: Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-23 (2024)

Subject Terms: Arachidonic acid, Cytotoxicity receptors, Interleukin 2, Natural killer (NK) cells, NKG2D, Ovarian carcinoma, Medicine, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1478-811X

Access URL: https://doaj.org/article/b5b59f79e7714241a2f9d27ed2f57ac0

Heterogeneity of γδ T-cell subsets and their clinical correlation in patients with AML

Authors: Siyuan Jiang, Shiyu Zheng, Chao Yao, Dengchong Ning, Shaoyun Zou, Jiannan Zhan, Tianbi Lan, Tingzhuang Yi, Zhenyi Jin, Xiuli Wu

Source: Frontiers in Immunology, Vol 16 (2025)

Subject Terms: acute myeloid leukemia, NKG2D, TIGIT, Foxp3, γδ T cells, prognosis, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2025.1552235/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/e0a844af82a941acaf22e49494c2c143

Impaired immune reconstitution in HIV infection: the role of CD4+ T-cell-associated NKG2D ligands, CD4+ T-cell subsets imbalance, and immune function deficiency

Authors: Qianqian Xu, Qiuyue Zhang, Peng Xu, Tong Zhang, Hao Wu, Xin Zhang, Christiane Moog, Bin Su

Source: Frontiers in Immunology, Vol 16 (2025)

Subject Terms: immunological non-responders, NK cell ligands, CD4+T cell subsets, HIV, aids, NKG2D, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2025.1541574/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/f1a77396d516461bbc0a3a7e1ffde156

Diethyldithiocarbamate-copper complex ignites the tumor microenvironment through NKG2D-NKG2DL axis

Authors: Daciana C. Dumut, Marian Hajduch, Amanda M. Zacharias, Qingling Duan, Ivo Frydrych, Zuzana Rozankova, Miroslav Popper, Dusan Garic, Radu Alexandru Paun, Amanda Centorame, Juhi Shah, Martin Mistrik, Petr Dzubak, Juan B. De Sanctis, Danuta Radzioch

Source: Frontiers in Immunology, Vol 16 (2025)

Subject Terms: copper bis-diethyldithiocarbamate, disulfiram, colorectal cancer, NK cells, NKG2D, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2025.1491450/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/63374aafeb1d4b008a513ba94caf46c0

The molecular receptor NKBB enhances the persistence and anti-hepatocellular carcinoma activity of GPC3 CAR-T cells

Authors: Minghao Sui, Tiantian Liu, Xuanli Song, Ji Li, Han Ding, Yuqian Liu, Xinyu Wang, Huimin Liu, Yuchan Xue, Jianni Qi, Miao Zhang, Songbo Zhao, Qiang Zhu

Source: Pharmacological Research, Vol 212, Iss , Pp 107619- (2025)

Subject Terms: CAR-T, Hepatocellular carcinoma, GPC3, NKG2D, CTSL, IL-17, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1043661825000441; https://doaj.org/toc/1096-1186

Access URL: https://doaj.org/article/b1b929dc43cc4de28d67375823281ca2

Local treatment of HVJ-E with T cell costimulatory molecule stimulation elicits systemic anti-tumor effects

Authors: Airi Ishibashi, Yue Li, Yuuta Hisatomi, Noriko Ohta, Yuko Uegaki, Atsushi Tanemura, Riuko Ohashi, Koji Kitamura, Kotaro Saga, Yasuhide Yoshimura, Satoko Inubushi, Kyoso Ishida, Sadahiro Iwabuchi, Shinichi Hashimoto, Eiji Kiyohara, Hideo Yagita, Yasufumi Kaneda, Keisuke Nimura

Source: Molecular Therapy: Oncology, Vol 32, Iss 4, Pp 200893- (2024)

Subject Terms: Sendai virus, HVJ, HVJ-E, OX40, Nkg2d, Nkg2d ligand, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2950329924001358; https://doaj.org/toc/2950-3299

Access URL: https://doaj.org/article/951e81fafd1f410bb0dbccb39e7651a0

MHC class I polypeptide-related sequence B shedding modulates pancreatic tumor immunity via the activation of NKG2DLow T cells

Authors: Hitoshi Toyoda, Atsuo Kuramasu, Masahiro Hosonuma, Masakazu Murayama, Yoichiro Narikawa, Junya Isobe, Yuta Baba, Kohei Tajima, Eiji Funayama, Midori Shida, Yuki Maruyama, Aya Sasaki, Yuya Hirasawa, Toshiaki Tsurui, Hirotsugu Ariizumi, Tomoyuki Ishiguro, Risako Suzuki, Sei Kobayashi, Atsushi Horiike, Noriko Hida, Takehiko Sambe, Koji Nobe, Satoshi Wada, Hitome Kobayashi, Mayumi Tsuji, Shinichi Kobayashi, Takuya Tsunoda, Yoshifumi Kudo, Yuji Kiuchi, Kiyoshi Yoshimura

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)

Subject Terms: NKG2DL, NKG2D, T cell, MICB, ADAM, Pancreatic tumor, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/9cc18d13b98e4eae855bec63d4c5642c

Efficacy of NKG2D CAR-T cells with IL-15/IL-15Rα signaling for treating Epstein-Barr virus-associated lymphoproliferative disorder

Authors: Qiusui Mai, Bailin He, Shikai Deng, Qing Zeng, Yanwen Xu, Cong Wang, Yunyi Pang, Sheng Zhang, Jinfeng Li, Jinfeng Zeng, Liqin Huang, Yongshui Fu, Chengyao Li, Tingting Li, Xiaojun Xu, Ling Zhang

Source: Experimental Hematology & Oncology, Vol 13, Iss 1, Pp 1-18 (2024)

Subject Terms: NKG2D, IL-15/IL-15Rα, CAR-T cells, EBV infection, Post-transplantation, Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-3619

Access URL: https://doaj.org/article/4f77cc45aa3f49358bfb6eacd3798041

A Concise Review of the Role of the NKG2D Receptor and Its Ligands in Cancer

Authors: Elitsa Boneva, Velizar Shivarov, Milena Ivanova

Source: Immuno, Vol 5, Iss 1, p 9 (2025)

Subject Terms: NKG2D, NKG2D ligands, MICA, MICB, cancer, therapy, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2673-5601/5/1/9; https://doaj.org/toc/2673-5601

Access URL: https://doaj.org/article/4818392afc72456488730b577f3ea768

Natural killer cell engagers for cancer immunotherapy

Authors: Shahryar Khoshtinat Nikkhoi, Geng Li, Arash Hatefi

Source: Frontiers in Oncology, Vol 14 (2025)

Subject Terms: NKCE platform technologies, NK activating receptors, bispecific trispecific multispecific antibodies, CD16a NKG2D NKG2C NKp30 NKp46, cancer immunotherapy, natural killer cells (NK cells), Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2024.1483884/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/e81c3652217642b99ad0cb9319d5538d

Sodium valproate enhances efficacy of NKG2D CAR-T cells against glioblastoma

Authors: Junchen Liu, Kun Dai, Muhammad Auwal Saliu, Mansur Dabai Salisu, Jiangyu Gan, Lukman Olalekan Afolabi, Dehong Yan, Guizhong Zhang, Maoxuan Liu, Xiaochun Wan

Source: Frontiers in Immunology, Vol 15 (2025)

Subject Terms: CAR-T, glioblastoma, NKG2D, sodium valproate, combination therapy, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1519777/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/f575429b49e240a9b5802677f1b75d9b

The current state of knowledge on the role of NKG2D ligands in multiple sclerosis and other autoimmune diseases

Authors: Aleksandra Pogoda-Wesołowska, Nina Sługocka, Agnieszka Synowiec, Klaudia Brodaczewska, Marcin Mejer-Zahorowski, Maciej Ziękiewicz, Wojciech Szypowski, Piotr Szymański, Adam Stępień

Source: Frontiers in Molecular Neuroscience, Vol 17 (2025)

Subject Terms: multiple sclerosis, NKG2D ligands, review, biomarkers, astrocytes, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnmol.2024.1493308/full; https://doaj.org/toc/1662-5099

Access URL: https://doaj.org/article/df7192c6b8694b2095942455514bde43

Agonistic anti-NKG2D antibody structure reveals unique stoichiometry and epitope compared to natural ligands

Authors: Daniel Fallon, Ching-Shin Huang, Jingya Ma, Christopher Morgan, Zhaohui Sunny Zhou

Source: mAbs, Vol 16, Iss 1 (2024)

Subject Terms: NKG2D, antibody agonist, natural killer cells, SPR, X-ray crystallography, Therapeutics. Pharmacology, RM1-950, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://doaj.org/toc/1942-0862; https://doaj.org/toc/1942-0870

Access URL: https://doaj.org/article/226c08477f9a4a3aac1f4727a2361136

MICA and NKG2D gene polymorphisms influence graft survival, and response to therapy in kidney transplantation

Authors: Roberto Littera, Stefano Mocci, Davide Argiolas, Letizia Littarru, Sara Lai, Maurizio Melis, Celeste Sanna, Caterina Mereu, Michela Lorrai, Alessia Mascia, Andrea Angioi, Giacomo Mascia, Valeria Matta, Nicola Lepori, Matteo Floris, Cristina Manieli, Paola Bianco, Daniela Onnis, Stefania Rassu, Silvia Deidda, Mauro Giovanni Carta, Erika Giuressi, Andrea Perra, Luchino Chessa, Sabrina Giglio, Antonello Pani

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: kidney transplant, antibody-mediated rejection, MICA, NKG2D, DSA, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1440887/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/6ed1fe38c60c43d99e3e2af024d4866c

Cruciferae-based oral selenium delivery system reprograms antitumor response and enhances the anti-tumor potency of natural killer cells

Authors: Li, Shuoshan, Li, Guizhen, Guo, Kexin, Zhou, Lin, Zhang, Haimei, Lai, Haoqiang ^⁎, Chen, Tianfeng ^⁎

Source: In Nano Today June 2025 62

Enrichment of CD7+CXCR3+ CAR T cells in infusion products is associated with durable remission in relapsed or refractory diffuse large B-cell lymphoma

Authors: Bartolini, R. ^{1, †}, Trueb, L. ^{2, †}, Daoudlarian, D. ^{1, †}, Joo, V. ¹, Noto, A. ¹, Stadelmann, R. ^{3, 4}, Gentner, B. ^{2, 5, 6, 7}, Fenwick, C. ¹, Perreau, M. ¹, Coukos, G. ^{2, 5, 6, 7}, Pantaleo, G. ¹, Arber, C. ^{2, 3, 5, 6, 7}, Obeid, M. ^{1, ∗}

Source: In Annals of Oncology

A mechanism of human cytomegalovirus for establishing latency through inhibition of HCMV UL16 expression by hcmv-miR-US33-5p

Authors: Chang, Xiaocen ^a, Shao, Yaozhong ^b, Wang, Xinyi ^c, Guo, Xin ^{d, ⁎}

Source: In International Journal of Biological Macromolecules December 2024 283 Part 3

Solid tumor immunotherapy using NKG2D-based adaptor CAR T cells

Authors: Obajdin, Jana ^{1, 10}, Larcombe-Young, Daniel ^{1, 10}, Glover, Maya ², Kausar, Fahima ², Hull, Caroline M. ², Flaherty, Katie R. ³, Tan, Ge ¹, Beatson, Richard E. ⁴, Dunbar, Phoebe ², Mazza, Roberta ², Bove, Camilla ², Taylor, Chelsea ², Bille, Andrea ⁵, Spillane, Katelyn M. ⁶, Cozzetto, Domenico ⁷, Vigilante, Alessandra ⁸, Schurich, Anna ³, Davies, David M. ^{2, 10}, Maher, John ^{1, 2, 9, 10, 11, ∗}

Source: In Cell Reports Medicine 19 November 2024 5(11)