Effects of a ciliary neurotrophic factor (CNTF) small-molecule peptide mimetic in an in vitro and in vivo model of CDKL5 deficiency disorder

Authors: Nicola Mottolese, Manuela Loi, Stefania Trazzi, Marianna Tassinari, Beatrice Uguagliati, Giulia Candini, Khalid Iqbal, Giorgio Medici, Elisabetta Ciani

Source: Journal of Neurodevelopmental Disorders, Vol 16, Iss 1, Pp 1-19 (2024)

Subject Terms: Cdkl5 KO mice, CNTF, Brain development, Dendritic pathology, Neuronal survival, Neuroinflammation, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://doaj.org/toc/1866-1955

Access URL: https://doaj.org/article/32c9a83d8a9f412dab4164af5108f5ca

Astragaloside IV promotes neuronal axon regeneration by inhibiting the PTEN/AKT pathway

Authors: Lin, Luning ^a, Zhao, Chenyang ^b, Lv, Huijuan ^c, Zhu, Liangrong ^d, Wang, Wangen ^a, Zheng, Xintian ^{a, ⁎, 1}

Source: In Brain Research 1 March 2025 1850

Melatonin enhances neurogenesis and neuroplasticity in long-term recovery following cerebral ischemia in mice

Authors: Beker, Merve ^a, Beker, Mustafa Caglar ^{b, c}, Elibol, Birsen ^d, Caglayan, Ahmet Burak ^e, Altug, Burcugul ^{f, g}, Kilic, Ertugrul ^{b, c}, Yilmaz, Bayram ^h, Celik, Ulkan ^{i, ⁎}

Source: In BBA - Molecular Basis of Disease April 2025 1871(4)

Transplantation of dorsal root ganglia overexpressing the NaChBac sodium channel improves locomotion after complete SCI

Authors: Hingorani, Sonia ¹, Paniagua Soriano, Guillem ¹, Sánchez Huertas, Carlos ², Villalba Riquelme, Eva María ³, López Mocholi, Eric ¹, Martínez Rojas, Beatriz ¹, Alastrué Agudo, Ana ¹, Dupraz, Sebastián ⁴, Ferrer Montiel, Antonio Vicente ³, Moreno Manzano, Victoria ^{1, ∗}

Source: In Molecular Therapy 5 June 2024 32(6):1739-1759

Mesenchymal stromal cell biotherapy for Parkinson’s disease premotor symptoms

Authors: Jinmei Sun, Wei Zhang, Zheng Zachory Wei, Xiaopeng Song, Liu Jian, Feng Jiang, Shuanglin Wang, Haibo Li, Yongbo Zhang, Houzhen Tuo, The CtrLyin Group

Source: Chinese Neurosurgical Journal, Vol 9, Iss 1, Pp 1-15 (2023)

Subject Terms: Cell therapy, Cognitive impairment, Depression, Neuronal survival and differentiation, Parkinson’ s disease, Surgery, RD1-811, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2057-4967

Access URL: https://doaj.org/article/62c6145fbd5140a09449eb1e339b0a38

Optic Neuropathies

Contributors: Tsai, Rongkung, Miller, Neil R.

Subject Terms: neuroprotection, retinal ganglion cells, optic neuropathy, glaucoma, pattern electroretinogram, NMO, astrocytes, apoptosis, BID, inflammation, neuroimmunology, erythropoietin, retinal ganglion cell, optic nerve protection, neuromyelitis optica spectrum disease, aquaporin-4, myelin oligodendrocyte glycoprotein, ocular coherence tomography, complement, microcystic macular degeneration, Müller cell, astrocyte, oligodendrocyte, microglia, optic nerve head, lamina cribrosa, lamina cribrosa cells, scleral fibroblasts, glial cells, intraocular pressure, rat anterior ischemic optic neuropathy model, retinal ganglion cell death, TBP associated factor 9, TP53 regulated inhibitor of apoptosis 1, transcriptome, optic nerve, epigenetics, myelin, regeneration, oligodendrocytes, atypical optic neuritis treatment, typical optic neuritis, MOG, MS prevention, retina, transcription, CNS repair, oncomodulin, myeloid cells, glaucomatous optic neuropathy, fibrosis, miR-29, extracellular matrix, optic nerve crush, azithromycin, NAION, neural injury, neural ischemia, neural inflammation, Leber’s hereditary optic neuropathy, LHON, whole exome sequencing, nuclear modifier genes, leber’s hereditary optic neuropathy, mitochondrial disorder, mitochondrial optic neuropathy, hereditary optic neuropathy, neuro-ophthalmology, idebenone, nonarteritic anterior ischemic optic neuropathy, rodents, gene expression, models, diabetes, ischemic optic neuropathy, pioglitazone, HSF1, Klf4, Oct4, Sox2, Yamanaka factors, optic nerve regeneration, zebrafish, oligodendrocyte precursor cells, secondary degeneration, oxidative stress, DNA damage, proliferation, blood-brain barrier, CNS injury, optic nerve injury, synaptamide, A8, axonal degeneration, neuronal survival, visual evoked potential, Medicine and Nursing

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Access URL: https://directory.doabooks.org/handle/20.500.12854/100779
https://mdpi.com/books/pdfview/book/7241

Rare Monogenic Diseases: Molecular Pathophysiology and Novel Therapies

Contributors: Condò, Ivano

Subject Terms: mucopolysaccharidosis II, Hunter syndrome, adeno-associated viruses, genetic therapy, gene editing, review, CDKL5 deficiency disorder, GSK-3β, HDAC6, dual inhibitor, neuronal survival, hippocampal defects, synapse development, TMEM16A, ADPKD, polycystic kidneys, androgen, estrogen, CFTR, ARPKD, cyst, rare monogenic disease, nephrology, alpha-galactosidase A, Fabry disease, pharmacological chaperones, rare diseases, enzyme replacement therapy, purine metabolism, purinergic signaling, Huntington’s disease, multiple endocrine neoplasia type 1 (MEN1), MEN1 gene, loss of heterozygosity (LOH), microRNA (miRNAs), miR-24, hemophilia, advanced therapies, gene therapy, FVIII transgene, FIX transgene, adeno-associated virus, lentiviral vectors, FXTAS, FXPOI, FXAND, premutation, blood, biomarker, FMR1, FMRP, endocrine, mitochondria, miRNA, transcription, GABA, telomere, factor V deficiency, parahemophilia, Owren’s disease, mutation analysis, Bartter syndrome, Gitelman syndrome, genetics, genetic diagnosis, therapeutic targets, hyponatremia, hypokalemia, hypercalciuria, hypomagnesemia, β-thalassemia, fetal hemoglobin, γ-globin, HbF induction, K562 cells, Cinchona alkaloids, cinchonidine, quinidine, cinchonine, combined treatments, Medicine and Nursing

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Access URL: https://directory.doabooks.org/handle/20.500.12854/100126
https://mdpi.com/books/pdfview/book/7220

Editorial: Promoting nervous system regeneration by treatments targeting neuron-glia interactions

Authors: Silmara De Lima, Bruno Siqueira Mietto, Vinicius Toledo Ribas, Victor Tulio Ribeiro-Resende, Alexandre Leite Rodrigues Oliveira, Kevin K. Park

Source: Frontiers in Cellular Neuroscience, Vol 17 (2024)

Subject Terms: PNS, CNS, axon regeneration, glial cells, neuronal survival, neuron-glia crosstalk, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fncel.2023.1355469/full; https://doaj.org/toc/1662-5102

Access URL: https://doaj.org/article/a51dbe58e97a4cd1aaa9020209384662

Automated algorithm development to assess survival of human neurons using longitudinal single-cell tracking: Application to synucleinopathy

Authors: Jeonghoon Choi, Hiroaki Kii, Justin Nelson, Yoichi Yamazaki, Fumiki Yanagawa, Atsushi Kitajima, Takayuki Uozumi, Yasujiro Kiyota, Dimple Doshi, Kenneth Rhodes, Robert Scannevin, Heather Sadlish, Chee Yeun Chung

Source: SLAS Technology, Vol 28, Iss 2, Pp 63-69 (2023)

Subject Terms: Neuronal survival assay, Single cell tracking, Automated analysis, CL-Quant, Alpha-synuclein, Parkinson's disease, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S247263032205186X; https://doaj.org/toc/2472-6303

Access URL: https://doaj.org/article/718216d2882f4578a15d3fa8eb3f2afb

NOD-like receptor NLRC5 promotes neuroinflammation and inhibits neuronal survival in Parkinson’s disease models

Authors: Zhaolin Liu, Chenye Shen, Heng Li, Jiabin Tong, Yufei Wu, Yuanyuan Ma, Jinghui Wang, Zishan Wang, Qing Li, Xiaoshuang Zhang, Hongtian Dong, Yufang Yang, Mei Yu, Jian Wang, Renyuan Zhou, Jian Fei, Fang Huang

Source: Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-21 (2023)

Subject Terms: Parkinson’s disease, NLRC5, Neuroinflammation, Microglia, Neuronal survival, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1742-2094

Access URL: https://doaj.org/article/d737bffdd402413a88282475ecf69a39

Neuroprotective effects of Neurotrophin-3 in MPTP-induced zebrafish Parkinson’s disease model

Authors: Noor Azzizah Omar, Jaya Kumar, Seong Lin Teoh

Source: Frontiers in Pharmacology, Vol 14 (2023)

Subject Terms: neurodegenerative disease, neurotrophin-3, danio rerio, neuronal survival, neurotoxin, dopaminergic neuron, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2023.1307447/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/0edfdc6891364135af46fbb6e8fedf78

The alternative 3′ splice site of GPNMB may promote neuronal survival after neonatal hypoxic–ischemic encephalopathy injury

Authors: Guo‐Jiao Chen, Shan‐Shan Yan, Jing‐Han Zhang, Ji Zhang, Isaac Bul Deng, Rong He

Source: Ibrain, Vol 8, Iss 3, Pp 302-313 (2022)

Subject Terms: alternative splicing, gene sequencing, GPNMB, neonatal hypoxic–ischemic encephalopathy, neuronal survival, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://doaj.org/toc/2769-2795

Access URL: https://doaj.org/article/d8cae1c4268747c7bab93cedb4bb7bdc

Development of Pleiotropic TrkB and 5-HT4 Receptor Ligands as Neuroprotective Agents

Authors: Mirjana Antonijevic, Despoina Charou, Audrey Davis, Thomas Curel, Maria Valcarcel, Isbaal Ramos, Patricia Villacé, Sylvie Claeysen, Patrick Dallemagne, Achille Gravanis, Ioannis Charalampopoulos, Christophe Rochais

Source: Molecules, Vol 29, Iss 2, p 515 (2024)

Subject Terms: neurodegeneration, TrkB receptor, 5-HT4 receptor, neuronal survival, neurite differentiation, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/29/2/515; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/0068818731ab4fbd88ebde7ede7d77ef

Early-onset brain alterations during postnatal development in a mouse model of CDKL5 deficiency disorder

Authors: Marianna Tassinari, Beatrice Uguagliati, Stefania Trazzi, Camilla Bruna Cerchier, Ottavia Vera Cavina, Nicola Mottolese, Manuela Loi, Giulia Candini, Giorgio Medici, Elisabetta Ciani

Source: Neurobiology of Disease, Vol 182, Iss , Pp 106146- (2023)

Subject Terms: Cdkl5 KO mice, Brain development, Dendritic pathology, Neuronal survival, Neuroinflammation, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996123001602; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/e4716d25c1e3418cbbfe63ef6ef10df1

The role of protein glycosylation in the occurrence and outcome of acute ischemic stroke

Authors: Jianzhuang Li, Yanmei Qiu, Chunlin Zhang, Hailing Wang, Rentang Bi, Yanhao Wei, Yanan Li, Bo Hu

Source: Pharmacological Research, Vol 191, Iss , Pp 106726- (2023)

Subject Terms: Protein glycosylation, Acute ischemic stroke, Atherosclerosis, Atrial fibrillation, Neuronal survival, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1043661823000828; https://doaj.org/toc/1096-1186

Access URL: https://doaj.org/article/3d8ca74e88384a43afa6757ffd4963f2

Inhibition of LncRNA Vof-16 expression promotes nerve regeneration and functional recovery after spinal cord injury

Authors: Xiao-Min Zhang, Li-Ni Zeng, Wan-Yong Yang, Lu Ding, Kang-Zhen Chen, Wen-Jin Fu, Si-Quan Zeng, Yin-Ru Liang, Gan-Hai Chen, Hong-Fu Wu

Source: Neural Regeneration Research, Vol 17, Iss 1, Pp 217-227 (2022)

Subject Terms: apoptosis, functional recovery, inflammation, long non-coding rna ischemia related factor vof-16, nerve regeneration, nerve repair, neurite extension, neuronal survival, proliferation, spinal cord injury, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=1;spage=217;epage=227;aulast=Zhang; https://doaj.org/toc/1673-5374

Access URL: https://doaj.org/article/2b8377478919498e8b694641b22b8eda

Rb deficiency, neuronal survival and neurodegeneration: In search of the perfect mouse model

Authors: Saad Omais, Yara E. El Atie, Noël Ghanem

Source: Current Research in Neurobiology, Vol 4, Iss , Pp 100074- (2023)

Subject Terms: The Retinoblastoma Protein pRb, Knock-out, Mouse models, Neuronal survival, Cell cycle Re-Entry, Neurodegeneration, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2665945X23000025; https://doaj.org/toc/2665-945X

Access URL: https://doaj.org/article/9b8aa468a4ef441284c63261d8cdbc9c

GPR3 expression in retinal ganglion cells contributes to neuron survival and accelerates axonal regeneration after optic nerve crush in mice

Authors: Shun Masuda, Shigeru Tanaka, Hiroko Shiraki, Yusuke Sotomaru, Kana Harada, Izumi Hide, Yoshiaki Kiuchi, Norio Sakai

Source: Neurobiology of Disease, Vol 172, Iss , Pp 105811- (2022)

Subject Terms: GPR3, cAMP, Axonal regeneration, Retinal granular cells, Neuronal survival, Optic nerve injury, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

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Relation: http://www.sciencedirect.com/science/article/pii/S0969996122002030; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/cbcc8843261b4ff890e0fed40f1d323c

Inhibition of microglia overactivation restores neuronal survival in a mouse model of CDKL5 deficiency disorder

Authors: Giuseppe Galvani, Nicola Mottolese, Laura Gennaccaro, Manuela Loi, Giorgio Medici, Marianna Tassinari, Claudia Fuchs, Elisabetta Ciani, Stefania Trazzi

Source: Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-21 (2021)

Subject Terms: CDKL5, Neuroinflammation, Neuronal survival, Luteolin, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1742-2094

Access URL: https://doaj.org/article/3c91c0c420e84054b26876a55fdb9ad0

Repressor element 1 silencing transcription factor /neuron-restrictive silencing factor (REST/NRSF) in social stress and depression

Authors: Soga, Tomoko ^a, Nakajima, Shingo ^a, Kawaguchi, Maiko ^b, Parhar, Ishwar S. ^{a, ⁎}

Source: In Progress in Neuropsychopharmacology & Biological Psychiatry 10 January 2021 104