Development of a multi-targeted chemotherapeutic approach based on G-quadruplex stabilisation and carbonic anhydrase inhibition

Authors: Alessio Nocentini, Anna Di Porzio, Alessandro Bonardi, Carla Bazzicalupi, Andrea Petreni, Tarita Biver, Silvia Bua, Simona Marzano, Jussara Amato, Bruno Pagano, Nunzia Iaccarino, Stefano De Tito, Stefano Amente, Claudiu T. Supuran, Antonio Randazzo, Paola Gratteri

Source: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)

Subject Terms: G-Quadruplex, carbonic anhydrase, multitarget-directed ligands, tumours, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

Access URL: https://doaj.org/article/72c74b1aaac342a2836205f0ff910408

Discovery of Effective Inhibitors Against Phosphodiesterase 9, a Potential Therapeutic Target of Alzheimer’s Disease with Antioxidant Capacities

Authors: Qian Zhou, Xu-Nian Wu, Wei-Hao Luo, Qing-Hua Huang, Ling-Ling Feng, Yinuo Wu, Chen Zhang

Source: Antioxidants, Vol 14, Iss 2, p 123 (2025)

Subject Terms: phosphodiesterase 9 (PDE9), antioxidant capacity, multitarget-directed ligands (MTDLs), Alzheimer’s disease (AD), Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.mdpi.com/2076-3921/14/2/123; https://doaj.org/toc/2076-3921

Access URL: https://doaj.org/article/90756fe19790497f947d7cf75306e823

Virtual Screening Approaches to Identify Promising Multitarget-Directed Ligands for the Treatment of Autism Spectrum Disorder

Authors: Jakub Jończyk, Klaudia Przybylska, Marek Staszewski, Justyna Godyń, Tobias Werner, Monika Stefaniak-Napieralska, Holger Stark, Krzysztof Walczyński, Marek Bajda

Source: Molecules, Vol 29, Iss 22, p 5271 (2024)

Subject Terms: autism spectrum disorder, virtual screening, histamine H3 receptor, multitarget-directed ligands, dopamine receptors, cholinesterases, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/29/22/5271; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/d7f9d3125f3f4764b73b77f3027329fb

Chromone-based monoamine oxidase B inhibitor with potential iron-chelating activity for the treatment of Alzheimer’s disease

Authors: Changjun Zhang, Yujia Zhang, Yangjing Lv, Jianan Guo, Bianbian Gao, Yi Lu, Anjie Zang, Xi Zhu, Tao Zhou, Yuanyuan Xie

Source: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1, Pp 100-117 (2023)

Subject Terms: Alzheimer’s disease, multitarget-directed ligands, MAO-B inhibitor, iron-chelating, hydroxypyridinones, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

Access URL: https://doaj.org/article/474848c2851c400e9f7f9cec71ca3915

Multitarget-Directed Ligands Hitting Serotonin Receptors: A Medicinal Chemistry Survey

Authors: Imane Ghafir El Idrissi, Angela Santo, Enza Lacivita, Marcello Leopoldo

Source: Pharmaceuticals, Vol 17, Iss 9, p 1238 (2024)

Subject Terms: serotonin, acetyl cholinesterases, butyryl cholinesterases, sigma receptors, multitarget-directed ligands, schizophrenia, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/17/9/1238; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/4111d15bed8547cabd7a758ceca6537e

Development of Novel ROCK Inhibitors via 3D-QSAR and Molecular Docking Studies: A Framework for Multi-Target Drug Design

Authors: Milan Beljkas, Milos Petkovic, Ana Vuletic, Ana Djuric, Juan Francisco Santibanez, Tatjana Srdic-Rajic, Katarina Nikolic, Slavica Oljacic

Source: Pharmaceutics, Vol 16, Iss 10, p 1250 (2024)

Subject Terms: Rho-associated protein kinases, multitarget-directed ligands, rational drug design, molecular modeling, 3D-QSAR, antineoplastic agents, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/16/10/1250; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/bd8868677c294249b17ff5df1ce6bb25

Novel benzothiazole derivatives as multitargeted-directed ligands for the treatment of Alzheimer’s disease

Authors: Donia E. Hafez, Mariam Dubiel, Gabriella La Spada, Marco Catto, David Reiner-Link, Yu-Ting Syu, Mohammad Abdel-Halim, Tsong-Long Hwang, Holger Stark, Ashraf H. Abadi

Source: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)

Subject Terms: Multitarget-directed ligands, Alzheimer’s disease, cholinesterase inhibitors, histamine H3 receptor ligands, monoamine oxidase inhibitors, benzothiazole derivatives, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

Access URL: https://doaj.org/article/524cab4f650e41a28fe24ba5d6089fe3

Design, synthesis, and evaluation of chalcone-Vitamin E-donepezil hybrids as multi-target-directed ligands for the treatment of Alzheimer’s disease

Authors: Zhipei Sang, Qing Song, Zhongcheng Cao, Yong Deng, Li Zhang

Source: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 69-85 (2022)

Subject Terms: alzheimer’s disease, chalcone-vitamin e-donepezil hybrids, multitarget-directed ligands, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

Access URL: https://doaj.org/article/3e3089f1b6be45ab99641b37a3981463

A review on coumarin backbone: An attractive scaffold for promising bioactive compounds

Authors: Sara Jasim, Yasser Mustafa

Source: المجلة العراقية للصيدلة, Vol 18, Iss 2, Pp 104-125 (2022)

Subject Terms: coumarin, multitarget-directed ligands, monoamine oxidase inhibitors, cholinesterase inhibitors, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://iphr.mosuljournals.com/article_170402_3009fbd5acbc89832a99124db88dd416.pdf; https://doaj.org/toc/1680-2594; https://doaj.org/toc/2664-2522

Access URL: https://doaj.org/article/96d099fffb2b4e1386dfe24305a4a81b

Gains from no real PAINS: Where ‘Fair Trial Strategy’ stands in the development of multi-target ligands

Authors: Jianbo Sun, Hui Zhong, Kun Wang, Na Li, Li Chen

Source: Acta Pharmaceutica Sinica B, Vol 11, Iss 11, Pp 3417-3432 (2021)

Subject Terms: Multitarget-directed ligands, PAINS suspects, In silico filtering, Biochemical experiment, Fair trial strategy, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S221138352100071X; https://doaj.org/toc/2211-3835

Access URL: https://doaj.org/article/f560e80bb16a4f2e99ee310b9fb009cf

Flavonoids as Promising Multitarget Agents in Alzheimer’s Disease Therapy

Authors: Elisabete Lima, Amélia P. Rauter, Jorge Medeiros

Source: Applied Sciences, Vol 13, Iss 8, p 4651 (2023)

Subject Terms: Alzheimer’s disease, plant natural products, flavonoids, multitarget-directed ligands (MTDLs) approach, Technology, Engineering (General). Civil engineering (General), TA1-2040, Biology (General), QH301-705.5, Physics, QC1-999, Chemistry, QD1-999

File Description: electronic resource

Relation: https://www.mdpi.com/2076-3417/13/8/4651; https://doaj.org/toc/2076-3417

Access URL: https://doaj.org/article/450c05c992324edb8f3077d0bc0dce0b

An Artificial Peptide-Based Bifunctional HIV-1 Entry Inhibitor That Interferes with Viral Glycoprotein-41 Six-Helix Bundle Formation and Antagonizes CCR5 on the Host Cell Membrane

Authors: Chao Wang, Qing Li, Lujia Sun, Xinling Wang, Huan Wang, Wenpeng Zhang, Jiahui Li, Yang Liu, Lu Lu, Shibo Jiang

Source: Viruses, Vol 15, Iss 5, p 1038 (2023)

Subject Terms: HIV-1, gp41, CCR5, entry inhibitors, multitarget-directed ligands, coiled coil, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4915/15/5/1038; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/1981d0a939a446fcaadeed1571df4444

Benzophenone Derivatives with Histamine H3 Receptor Affinity and Cholinesterase Inhibitory Potency as Multitarget-Directed Ligands for Possible Therapy of Alzheimer’s Disease

Authors: Justyna Godyń, Paula Zaręba, Dorota Stary, Maria Kaleta, Kamil J. Kuder, Gniewomir Latacz, Szczepan Mogilski, David Reiner-Link, Annika Frank, Agata Doroz-Płonka, Agnieszka Olejarz-Maciej, Sylwia Sudoł-Tałaj, Tobias Nolte, Jadwiga Handzlik, Holger Stark, Anna Więckowska, Barbara Malawska, Katarzyna Kieć-Kononowicz, Dorota Łażewska, Marek Bajda

Source: Molecules, Vol 28, Iss 1, p 238 (2022)

Subject Terms: multitarget-directed ligands, benzophenone derivatives, Alzheimer’s disease, cholinesterase inhibitors, histamine H3 receptor ligands, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/28/1/238; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/2481fe283dea45f89bc7efb49683033f

Biginelli Reaction Synthesis of Novel Multitarget-Directed Ligands with Ca2+ Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 Activation

Authors: Rim Malek, Alexey Simakov, Audrey Davis, Maciej Maj, Paul J. Bernard, Artur Wnorowski, Helene Martin, José Marco-Contelles, Fakher Chabchoub, Patrick Dallemagne, Christophe Rochais, Krzysztof Jozwiak, Lhassane Ismaili

Source: Molecules, Vol 28, Iss 1, p 71 (2022)

Subject Terms: Biginelli reaction, multitarget-directed ligands, calcium channel antagonism, Nrf2, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/28/1/71; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/c1008cfa0311472f9605360beca986c5

New Drug Design Avenues Targeting Alzheimer’s Disease by Pharmacoinformatics-Aided Tools

Authors: Lily Arrué, Alexandra Cigna-Méndez, Tábata Barbosa, Paola Borrego-Muñoz, Silvia Struve-Villalobos, Victoria Oviedo, Claudia Martínez-García, Alexis Sepúlveda-Lara, Natalia Millán, José C. E. Márquez Montesinos, Juana Muñoz, Paula A. Santana, Carlos Peña-Varas, George E. Barreto, Janneth González, David Ramírez

Source: Pharmaceutics, Vol 14, Iss 9, p 1914 (2022)

Subject Terms: Alzheimer’s disease, drug design, computational polypharmacology, bioinformatics, pharmacoinformatics, multitarget directed ligands, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/14/9/1914; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/554e475601bd4b3e8b4830c852e29781

Multitarget therapeutic strategies for Alzheimer’s disease

Authors: Mostafa M. Ibrahim, Moustafa T. Gabr

Source: Neural Regeneration Research, Vol 14, Iss 3, Pp 437-440 (2019)

Subject Terms: multitarget-directed ligands, acetylcholinesterase, β-secretase, Alzheimer′s disease, hybridization, neurodegenerative diseases, tacrine, brain permeability, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=3;spage=437;epage=440;aulast=Ibrahim; https://doaj.org/toc/1673-5374

Access URL: https://doaj.org/article/ec2073516640454f9376105bf5d0c472

Journey on Naphthoquinone and Anthraquinone Derivatives: New Insights in Alzheimer’s Disease

Authors: Marta Campora, Valeria Francesconi, Silvia Schenone, Bruno Tasso, Michele Tonelli

Source: Pharmaceuticals, Vol 14, Iss 1, p 33 (2021)

Subject Terms: naphthoquinone/anthraquinone derivatives, Alzheimer’s disease (AD), Aβ aggregation inhibition, AChE and BChE inhibition, Tau inhibition, multitarget directed ligands, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/14/1/33; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/d0affbd0bcc345b0ab94941d4b802344

Pharmacophore Modeling and 3D-QSAR Study of Indole and Isatin Derivatives as Antiamyloidogenic Agents Targeting Alzheimer’s Disease

Authors: Rosa Purgatorio, Nicola Gambacorta, Marco Catto, Modesto de Candia, Leonardo Pisani, Alba Espargaró, Raimon Sabaté, Saverio Cellamare, Orazio Nicolotti, Cosimo D. Altomare

Source: Molecules, Vol 25, Iss 23, p 5773 (2020)

Subject Terms: isatin hydrazones, indole derivatives, antiamyloid agents, multitarget-directed ligands, 3D-QSAR, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/25/23/5773; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/ac0b4598acf445d5b30db80cd238b0e3

Hydrogen Sulfide: A Worthwhile Tool in the Design of New Multitarget Drugs

Authors: Simona Sestito, Giulia Nesi, Rongbiao Pi, Marco Macchia, Simona Rapposelli

Source: Frontiers in Chemistry, Vol 5 (2017)

Subject Terms: hydrogen sulfide, multitarget-directed ligands, bone disease, hybrid molecules, H2S-donors, multifunctional compounds, Chemistry, QD1-999

File Description: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fchem.2017.00072/full; https://doaj.org/toc/2296-2646

Access URL: https://doaj.org/article/455716f7ee804caf80c1563f57de1b6e

Design, Synthesis and Biological Evaluation of New Antioxidant and Neuroprotective Multitarget Directed Ligands Able to Block Calcium Channels

Authors: Irene Pachòn Angona, Solene Daniel, Helene Martin, Alexandre Bonet, Artur Wnorowski, Maciej Maj, Krzysztof Jóźwiak, Tiago Barros Silva, Bernard Refouvelet, Fernanda Borges, José Marco-Contelles, Lhassane Ismaili

Source: Molecules, Vol 25, Iss 6, p 1329 (2020)

Subject Terms: alzheimer’s disease, ca2+ channel antagonists, hantzsch reaction, multitarget directed ligands, neuroprotection, oxidative stress, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/25/6/1329; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/5b1ff1d189734033aeb82bc9f2efc13b