Clinical, histopathological and parasitological follow-up of dogs naturally infected by Leishmania infantum before and after miltefosine treatment and associated therapies.

Authors: Rosar, Amábilli de Souza¹ (AUTHOR), Martins, Carolina Leite¹ (AUTHOR), Menin, Álvaro² (AUTHOR), Reck, Carolina³ (AUTHOR), Grisard, Edmundo Carlos¹ (AUTHOR), Wagner, Glauber¹ (AUTHOR), Steindel, Mário¹ (AUTHOR), Stoco, Patricia Hermes¹ (AUTHOR), Quaresma, Patricia Flavia¹ (AUTHOR) patricia.quaresma@ufsc.br

Source: PLoS ONE. 1/9/2025, Vol. 20 Issue 1, p1-20. 20p.

Subject Terms: *VISCERAL leishmaniasis, *MILTEFOSINE, *DOGS, *LEISHMANIASIS, *INFLAMMATION, *LEISHMANIA infantum

In Vitro Evaluation of the Combinatorial Effect of Naringenin and Miltefosine against Leishmania amazonensis.

Authors: Lessa, Vinícius Lopes^1,2 (AUTHOR) ggustavogonsalves@gmail.com, Gonçalves, Gustavo¹ (AUTHOR) beatrizsantos.biobs@gmail.com, Santos, Beatriz¹ (AUTHOR) viccavalari97@gmail.com, Cavalari, Victoria Cruz¹ (AUTHOR) fabiano.figueiredo@fiocruz.br, da Costa Vieira, Rafael Felipe^3,4 (AUTHOR) rvieira@charlotte.edu, Figueiredo, Fabiano Borges¹ (AUTHOR)

Source: Pharmaceuticals (14248247). Aug2024, Vol. 17 Issue 8, p1014. 8p.

Subject Terms: *CUTANEOUS leishmaniasis, *MILTEFOSINE, *FOOD additives, *DRUG toxicity, *DOSAGE forms of drugs

Exploring hydrophilic 2,2-di(indol-3-yl)ethanamine derivatives against Leishmania infantum.

Authors: Centanni, Alessia¹ (AUTHOR), Diotallevi, Aurora² (AUTHOR), Buffi, Gloria² (AUTHOR), Olivieri, Diego² (AUTHOR), Santarém, Nuno^3,4 (AUTHOR), Lehtinen, Antti¹ (AUTHOR), Yli-Kauhaluoma, Jari¹ (AUTHOR), Cordeiro-da-Silva, Anabela^3,4 (AUTHOR), Kiuru, Paula¹ (AUTHOR) paula.kiuru@helsinki.fi, Lucarini, Simone² (AUTHOR) paula.kiuru@helsinki.fi, Galluzzi, Luca² (AUTHOR)

Source: PLoS ONE. 6/13/2024, Vol. 19 Issue 6, p1-18. 18p.

Subject Terms: *MILTEFOSINE, *CYTOTOXINS, *AMASTIGOTES, *IN vivo studies, *LEISHMANIA infantum, *LEISHMANIA mexicana

Chitosan nanoparticles improve the effectivity of miltefosine against Acanthamoeba.

Authors: Latifi, Alireza¹ (AUTHOR), Esmaeili, Fariba² (AUTHOR), Mohebali, Mehdi^1,3 (AUTHOR), Yasami-Khiabani, Setayesh⁴ (AUTHOR), Rezaeian, Mostafa¹ (AUTHOR), Soleimani, Mohammad⁵ (AUTHOR), Kazemirad, Elham¹ (AUTHOR) kazemirad@tums.ac.ir, Amani, Amir⁶ (AUTHOR) kazemirad@tums.ac.ir

Source: PLoS Neglected Tropical Diseases. 3/25/2024, Vol. 18 Issue 3, p1-21. 21p.

Subject Terms: *MILTEFOSINE, *CHITOSAN, *ACANTHAMOEBA, *ACANTHAMOEBA keratitis, *NANOPARTICLES

In Vitro Efficacy of Miltefosine Against Clinical Isolates of Acanthamoeba spp. from Patients with Keratitis.

Authors: Gowtham, Lakshminarayanan¹ (AUTHOR), Sharma, Savitri¹ (AUTHOR), Bagga, Bhupesh¹ (AUTHOR) bhupesh@lvpei.org

Source: Seminars in Ophthalmology. Feb2025, p1-8. 8p. 2 Illustrations.

Subject Terms: *MILTEFOSINE, *ORPHAN drugs, *CELL anatomy, *EPITHELIAL cells, *KERATITIS

Disseminated Leishmaniasis, a Severe Form of Leishmania braziliensis Infection.

Authors: Machado, Paulo R. L.^1,2, 19pmachado@gmail.com, Lago, Alexsandro¹, Cardoso, Thiago M.¹, Magalhaes, Andréa¹, Carvalho, Lucas P.^1,2, Lago, Tainã¹, Carvalho, Augusto M.², Costa, Rúbia¹, Carvalho, Edgar M.^1,2

Source: Emerging Infectious Diseases; Aug2024, Vol. 30 Issue 8, p510-518, 9p

Evaluation of In Vitro Cytotoxic and Apoptotic Effects of Miltefosine on the Toxoplasma gondii RH Strain.

Authors: Khademvatan, Shahram^1,2, Yousefi, Elham^1,2, Asadi, Negar^1,2 asadi.n@umsu.ac.ir, Abasi, Esmaeil^1,3 e-abasi@razi.tums.ac.ir

Source: Iranian Journal of Parasitology. Jan-Mar2024, Vol. 19 Issue 1, p52-60. 9p.

Subject Terms: *MILTEFOSINE, *TOXOPLASMA gondii, *NITRIC-oxide synthases, *CYTOTOXINS, *DNA analysis, *FLOW cytometry

Geographic Terms: IRAN

Monitoring Cutaneous Leishmaniasis Lesions in Mice Undergoing Topical Miltefosine Treatment.

Authors: Neira, Laura Fernanda¹ (AUTHOR) laurafernandaneira@hotmail.com, Mantilla, Julio Cesar² (AUTHOR) jumantil@uis.edu.co, Escobar, Patricia¹ (AUTHOR) laurafernandaneira@hotmail.com

Source: Scientia Pharmaceutica. Dec2023, Vol. 91 Issue 4, p54. 16p.

Subject Terms: *CUTANEOUS leishmaniasis, *MILTEFOSINE, *VASCULAR endothelial growth factors, *INTERFERON gamma, *TRANSMISSION electron microscopy

Safety and efficacy of paromomycin/miltefosine/liposomal amphotericin B combinations for the treatment of post-kala-azar dermal leishmaniasis in Sudan: A phase II, open label, randomized, parallel arm study.

Authors: Younis, Brima Musa¹ (AUTHOR), Mudawi Musa, Ahmed¹ (AUTHOR), Monnerat, Séverine² (AUTHOR), Abdelrahim Saeed, Mohammed¹ (AUTHOR), Awad Gasim Khalil, Eltahir¹ (AUTHOR), Elbashir Ahmed, Anas¹ (AUTHOR), Ahmed Ali, Mujahid¹ (AUTHOR), Noureldin, Ali¹ (AUTHOR), Muthoni Ouattara, Gina³ (AUTHOR), Nyakaya, Godfrey M.³ (AUTHOR), Teshome, Samuel³ (AUTHOR), Omollo, Truphosa³ (AUTHOR), Ochieng, Michael³ (AUTHOR), Egondi, Thaddaeus³ (AUTHOR), Mmbone, Mildred³ (AUTHOR), Chu, Wan-Yu⁴ (AUTHOR), Dorlo, Thomas P. C.⁵ (AUTHOR), Zijlstra, Eduard E.² (AUTHOR), Wasunna, Monique³ (AUTHOR), Alvar, Jorge² (AUTHOR)

Source: PLoS Neglected Tropical Diseases. 11/21/2023, Vol. 17 Issue 11, p1-20. 20p.

Subject Terms: *AMPHOTERICIN B, *MILTEFOSINE, *DRUG side effects, *HEALTH facilities, *LEISHMANIASIS

Geographic Terms: SUDAN, EAST Africa

Thermodynamic behavior of breast cancer cell lines after miltefosine and cisplatin treatment.

Authors: Todinova, Svetla¹ (AUTHOR), Nikolova, Biliana¹ (AUTHOR), Iliev, Ivan^1,2 (AUTHOR), Semkova, Severina¹ (AUTHOR), Krumova, Sashka¹ (AUTHOR), Taneva, Stefka G.¹ (AUTHOR) sgtaneva@gmail.com

Source: Journal of Thermal Analysis & Calorimetry. Jul2022, Vol. 147 Issue 14, p7819-7828. 10p.

Subject Terms: *CELL lines, *MILTEFOSINE, *BREAST, *CANCER cells, *BREAST cancer, *CELL morphology

Skin pharmacokinetics of miltefosine in the treatment of post-kala-azar dermal leishmaniasis in South Asia.

Authors: Palić, Semra¹ (AUTHOR), Chu, Wan-Yu^1,2 (AUTHOR), Sundar, Shyam³ (AUTHOR), Mondal, Dinesh⁴ (AUTHOR), Das, Pradeep⁵ (AUTHOR), Pandey, Krishna⁵ (AUTHOR), Raja, Sheeraz⁶ (AUTHOR), Rijal, Suman⁶ (AUTHOR), Roseboom, Ignace C¹ (AUTHOR), Hamadeh, Abdullah⁷ (AUTHOR), Malik, Paul R V⁷ (AUTHOR), Beijnen, Jos H¹ (AUTHOR), Huitema, Alwin D R^1,8,9 (AUTHOR), Sjögren, Erik^10,11 (AUTHOR), Alves, Fabiana¹² (AUTHOR), Dorlo, Thomas P C^1,2 (AUTHOR) thomas.dorlo@farmaci.uu.se

Source: Journal of Antimicrobial Chemotherapy (JAC). Jul2024, Vol. 79 Issue 7, p1547-1554. 8p.

Subject Terms: *LEISHMANIASIS, *MILTEFOSINE, *VISCERAL leishmaniasis, *CUTANEOUS leishmaniasis, *PHARMACOKINETICS, *AMPHOTERICIN B

Geographic Terms: SOUTH Asia

A phase II multicenter randomized study to evaluate the safety and efficacy of combining thermotherapy and a short course of miltefosine for the treatment of uncomplicated cutaneous leishmaniasis in the New World.

Authors: López, Liliana¹ (AUTHOR) liliana.lopez@pecet-colombia.org, Alvarez, Fiorela² (AUTHOR), Ramos, Ana Pilar² (AUTHOR), Llanos-Cuentas, Alejandro² (AUTHOR), Echevarria, Juan² (AUTHOR), Vélez, Iván¹ (AUTHOR), Boni, Marina³ (AUTHOR), Rode, Joelle³ (AUTHOR), Quintero, Juliana¹ (AUTHOR), Jiménez, Alejandra¹ (AUTHOR), Tabares, Yulied¹ (AUTHOR), Méndez, Claudia⁴ (AUTHOR), Arana, Byron⁵ (AUTHOR)

Source: PLoS Neglected Tropical Diseases. 3/7/2022, Vol. 16 Issue 3, p1-15. 15p.

Subject Terms: *CUTANEOUS leishmaniasis, *MILTEFOSINE, *THERMOTHERAPY, *LIVER enzymes, *NEGLECTED diseases

Antiviral Activity of Nitazoxanide and Miltefosine Against FeHV‐1 In Vitro.

Authors: Longobardi, Consiglia¹ (AUTHOR), Ferrara, Gianmarco¹ (AUTHOR) gianmarco.ferrara@unina.it, Damiano, Sara¹ (AUTHOR), Florio, Salvatore¹ (AUTHOR), Iovane, Giuseppe¹ (AUTHOR), Pagnini, Ugo¹ (AUTHOR), Montagnaro, Serena¹ (AUTHOR), Ciarcia, Roberto¹ (AUTHOR), Rabbani, Imtiaz¹ (AUTHOR)

Source: Veterinary Medicine International. 10/18/2024, Vol. 2024, p1-10. 10p.

Subject Terms: *PI3K/AKT pathway, *ANTIVIRAL agents, *MILTEFOSINE, *WESTERN immunoblotting, *VIRAL replication

Neosporosis and Visceral Leishmaniosis in a Dog in Central–West Brazil

Authors: Sena Bianca Ribas, Freitas Maria Sabrina de, Freitas Maria Natália de, Almeida Arleana do Bom Parto Ferreira de, Sousa Valéria Régia Franco

Source: Acta Veterinaria, Vol 74, Iss 4, Pp 573-581 (2024)

Subject Terms: neospora caninum, leishmania infantum, co-infection, miltefosine, Veterinary medicine, SF600-1100

File Description: electronic resource

Relation: https://doaj.org/toc/1820-7448

Access URL: https://doaj.org/article/c41c64875d6f42d08a38f926a9f6f33c

Neuro-leishmaniasis with cauda equina syndrome and cranial nerve palsy: a rare manifestation of recurrent atypical visceral leishmaniasis

Authors: Karthick Kumar Vaitheeswaran, Baidhnath Kumar Gupta, Rahul Krishnan G, Manish Soneja, Naval K. Vikram, Upendra Baitha, Amandeep Singh, Naveet Wig, Mudsser Azam, Ruchi Singh, Ajay Garg, Nishikant Damle, Yamini Dharmashaktu

Source: BMC Infectious Diseases, Vol 24, Iss 1, Pp 1-8 (2024)

Subject Terms: Neuro-leishmaniasis, Atypical visceral leishmaniasis, Relapse, Liposomal Amphotericin B (L-AmB), Miltefosine, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2334

Access URL: https://doaj.org/article/aac306a163364a24a0054ebe2b0d5757

Progress in antileishmanial drugs: Mechanisms, challenges, and prospects.

Authors: Zhang, Haoran, Yan, Ruixi, Liu, Yahui, Yu, Mengtao, He, Ziyi, Xiao, Junfeng, Li, Kaijie, Liu, Gang, Ning, Qin, Li, Yan

Source: PLoS Neglected Tropical Diseases; 1/3/2025, Vol. 19 Issue 1, p1-28, 28p

Subject Terms: AMPHOTERICIN B, NEGLECTED diseases, DRUG delivery systems, LEISHMANIASIS, MILTEFOSINE

Promoting safe and appropriate use of miltefosine to treat tegumentary leishmaniasis in Brazil: a best practice implementation project.

Authors: Silva, Sarah Nascimento, Ribeiro, Laís Raquel, Borges dos Santos, Kelli, Cota, Gláucia

Source: JBI Evidence Implementation; Jan2025, Vol. 23 Issue 1, p14-23, 10p

Subject Terms: PREVENTION of drug side effects, AUDITING, MEDICAL protocols, MILTEFOSINE, PATIENT safety, HUMAN services programs, RESEARCH funding, MEDICAL care, DRUG monitoring, PROFESSIONS, EVIDENCE-based medicine, HOSPITAL health promotion programs, QUALITY assurance, LEISHMANIASIS, LEGAL compliance

Geographic Terms: BRAZIL

Disease-Specific Differences in Pharmacokinetics of Paromomycin and Miltefosine Between Post-Kala-Azar Dermal Leishmaniasis and Visceral Leishmaniasis Patients in Eastern Africa.

Authors: Chu, Wan-Yu, Verrest, Luka, Younis, Brima M, Musa, Ahmed M, Mbui, Jane, Mohammed, Rezika, Olobo, Joseph, Ritmeijer, Koert, Monnerat, Séverine, Wasunna, Monique, Roseboom, Ignace C, Solomos, Alexandra, Huitema, Alwin D R, Alves, Fabiana, Dorlo, Thomas P C

Source: Journal of Infectious Diseases; 12/15/2024, Vol. 230 Issue 6, pe1375-e1384, 10p

Subject Terms: VISCERAL leishmaniasis, KIDNEY tubules, END of treatment, GLOMERULAR filtration rate, MILTEFOSINE

Safety profile of miltefosine in the treatment of cutaneous leishmaniasis.

Authors: Ribeiro, Laís Raquel, Silva, Sarah Nascimento, Saliba, Mell Ferreira, de Pina Carvalho, Janaína, Cota, Gláucia

Source: PLoS ONE; 12/13/2024, Vol. 19 Issue 12, p1-15, 15p

Subject Terms: CUTANEOUS leishmaniasis, NEGLECTED diseases, TERMINATION of treatment, MILTEFOSINE, LEISHMANIASIS

In vitro susceptibility to miltefosine of amphotericin B-resistant Leishmania (Mundinia) martiniquensis.

Authors: Mano, Chonlada¹ (AUTHOR), Kongkaew, Aphisek² (AUTHOR), Tippawangkosol, Pongsri³ (AUTHOR), Junkum, Anuluck³ (AUTHOR), Siriyasatien, Padet⁴ (AUTHOR), Jariyapan, Narissara⁴ (AUTHOR) narissara.j@chula.ac.th

Source: Parasitology Research. Dec2023, Vol. 122 Issue 12, p3027-3035. 9p.

Subject Terms: *MILTEFOSINE, *AMPHOTERICIN B, *LEISHMANIASIS, *LEISHMANIA, *AMASTIGOTES, *PATIENT surveys

Geographic Terms: THAILAND