AC-73 and Syrosingopine Inhibit SARS-CoV-2 Entry into Megakaryocytes by Targeting CD147 and MCT4.

Authors: Spinello, Isabella¹ (AUTHOR) isabella.spinello@iss.it, Saulle, Ernestina¹ (AUTHOR) ernestina.saulle@iss.it, Quaranta, Maria Teresa¹ (AUTHOR) mariateresa.quaranta@iss.it, Pelosi, Elvira² (AUTHOR) elvira.pelosi@iss.it, Castelli, Germana² (AUTHOR) germana.castelli@iss.it, Cerio, Annamaria² (AUTHOR) annamaria.cerio@iss.it, Pasquini, Luca³ (AUTHOR) luca.pasquini@iss.it, Morsilli, Ornella⁴ (AUTHOR) ornella.morsilli@iss.it, Dupuis, Maria Luisa¹ (AUTHOR) marialuisa.dupuis@iss.it, Labbaye, Catherine¹ (AUTHOR) catherine.labbaye@iss.it

Source: Viruses (1999-4915). Jan2024, Vol. 16 Issue 1, p82. 20p.

Subject Terms: *MEGAKARYOCYTES, *SARS-CoV-2, *POST-acute COVID-19 syndrome, *VIRUS diseases, *PROGENITOR cells, *BLOOD coagulation factors, *GLYCOLYSIS

Reprogramming Megakaryocytes for Controlled Release of Platelet-like Particles Carrying a Single-Chain Thromboxane A 2 Receptor-G-Protein Complex with Therapeutic Potential.

Authors: Lu, Renzhong¹ (AUTHOR), Li, Yan¹ (AUTHOR), Xu, Anna¹ (AUTHOR) rlu12@cougarnet.uh.edu, King, Bridgette¹ (AUTHOR), Ruan, Ke-He¹ (AUTHOR) kruan@central.uh.edu

Source: Cells (2073-4409). Dec2023, Vol. 12 Issue 24, p2775. 14p.

Subject Terms: *MEGAKARYOCYTES, *LIGAND binding (Biochemistry), *WESTERN immunoblotting, *CELL fusion, *CHIMERIC proteins, *G protein coupled receptors, *STRUCTURAL models, *CELL lines, *BLOOD platelet aggregation

Rapid isolation of mature murine primary megakaryocytes by size exclusion via filtration.

Authors: Spindler, Markus¹, Mott, Kristina¹, Schulze, Harald¹ harald.schulze@uni-wuerzburg.de, Bender, Markus¹ Bender_M1@ukw.de

Source: Platelets. Dec2023, Vol. 34 Issue 1, p1-8. 8p.

Subject Terms: *MEGAKARYOCYTES, *BLOOD platelets, *HEMATOPOIETIC system, *BLOOD circulation, *BONE marrow

The role of platelets and megakaryocytes in sepsis and ARDS.

Authors: Leung, Gabriel¹, Middleton, Elizabeth A.^1,2 Elizabeth.Middleton@hsc.utah.edu

Source: Journal of Physiology. Nov2024, Vol. 602 Issue 22, p6047-6063. 17p.

Subject Terms: *BLOOD platelets, *MEGAKARYOCYTES, *COVID-19 pandemic, *LUNG injuries, *SYSTEMIC inflammatory response syndrome

Long-lived lung megakaryocytes contribute to platelet recovery in thrombocytopenia models.

Authors: Livada, Alison C.^1,2, McGrath, Kathleen E.³, Malloy, Michael W.¹, Chen Li¹, Ture, Sara K.¹, Kingsley, Paul D.³, Koniski, Anne D.³, Vit, Leah A.³, Nolan, Katherine E.⁴, Mickelsen, Deanne¹, Monette, Grace E.¹, Maurya, Preeti¹, Palis, James^2,3 James_Palis@urmc.rochester.edu, Morrell, Craig N.^1,2,5,6 Craig_Morrell@urmc.rochester.edu

Source: Journal of Clinical Investigation. 11/15/2024, Vol. 134 Issue 22, p1-15. 15p.

Subject Terms: *LUNGS, *MEGAKARYOCYTES, *HEMATOPOIETIC stem cells, *THROMBOCYTOPENIA, *BLOOD platelets

Lectin-based carbohydrate profile of megakaryocytes in murine fetal liver during development.

Authors: Bomfim, Barbara Cristina Marcollino¹ (AUTHOR), Azevedo-Silva, Jessyca¹ (AUTHOR), Caminha, Giulia¹ (AUTHOR), Santos, João Paulo Rodrigues¹ (AUTHOR), Pelajo-Machado, Marcelo^1,2 (AUTHOR), de Paula Ayres-Silva, Jackline¹ (AUTHOR) jayres@ioc.fiocruz.br

Source: Scientific Reports. 4/25/2023, Vol. 13 Issue 1, p1-13. 13p.

Subject Terms: *PLANT lectins, *MEGAKARYOCYTES, *FETAL liver cells, *LECTINS, *LIVER, *CARBOHYDRATES, *OLIGOSACCHARIDES, *EMBRYOLOGY, *GALACTOSE

Identification of Myeloproliferative Neoplasms using Deep Learning

Authors: Abraham, Soby, Penchalareddy, Bhumireddy, S., Sumam David, Vijayasenan, Deepu, H B, Sridevi

Source: 2024 Seventh International Women in Data Science Conference at Prince Sultan University (WiDS PSU) WIDS-PSU Women in Data Science Conference at Prince Sultan University (WiDS PSU), 2024 Seventh International. :62-66 Mar, 2024

Relation: 2024 Seventh International Women in Data Science Conference at Prince Sultan University (WiDS PSU)

Mechanical confinement prevents ectopic platelet release.

Authors: Guinard, Ines¹, Brassard-Jollive, Noémie¹, Ruch, Laurie¹, Weber, Josiane¹, Eckly, Anita¹, Boscher, Julie¹, Léon, Catherine¹, catherine.leon@efs.sante.fr

Source: Proceedings of the National Academy of Sciences of the United States of America; 9/17/2024, Vol. 121 Issue 38, p1-11, 33p

In vitro Generated Megakaryocytes for the Detection of Human Platelet Antigen-Specific Alloantibodies.

Authors: Uzun, Günalp^1,2 (AUTHOR), Lucic, Josip³ (AUTHOR), Marini, Irene^1,2 (AUTHOR), Rigoni, Flavianna² (AUTHOR), Lyshy, Franziska¹ (AUTHOR), Haghighi, Omid² (AUTHOR), Wolska, Nina² (AUTHOR), Nowak-Harnau, Stefanie¹ (AUTHOR), Althaus, Karina^1,2 (AUTHOR), Sachs, Ulrich J.^4,5 (AUTHOR), Bakchoul, Tamam^1,2 (AUTHOR) tamam.bakchoul@med.uni-tuebingen.de

Source: Transfusion Medicine & Hemotherapy. Jul2024, p1-10. 10p. 6 Illustrations.

Subject Terms: *MEGAKARYOCYTES, *BLOOD platelets, *OPACITY (Optics), *ANTIBODY titer, *CD34 antigen

A New Role of NAP1L1 in Megakaryocytes and Human Platelets.

Authors: Freitag, Martin¹ (AUTHOR), Schwertz, Hansjörg^2,3,4 (AUTHOR) hansjorg.schwertz@u2m2.utah.edu

Source: International Journal of Molecular Sciences. Dec2022, Vol. 23 Issue 23, p14694. 22p.

Subject Terms: *MEGAKARYOCYTES, *NUCLEAR proteins, *BLOOD platelets, *MULTIENZYME complexes, *MITOCHONDRIAL proteins, *CELL respiration, *BLOOD platelet aggregation, *RESPIRATION, *HISTONES

Cardiac megakaryocytes in SARS-CoV-2-positive autopsies.

Authors: Gawelek, Kara L.¹, Padera, Robert¹, Connors, Jean², Pinkus, Geraldine S.¹, Podznyakova, Olga¹, Battinelli, Elisabeth M.² embattinelli@bwh.harvard.edu

Source: Histopathology. Nov2022, Vol. 81 Issue 5, p600-624. 25p.

Subject Terms: *MEGAKARYOCYTES, *AUTOPSY, *COVID-19, *VIRUS diseases, *PLATELET count, *DISEASE complications

Developmental differences of in vitro cultured murine bone marrow- and fetal liver-derived megakaryocytes.

Authors: Bertović, Ivana¹ (AUTHOR), Bura, Ana¹ (AUTHOR), Jurak Begonja, Antonija¹ (AUTHOR) ajbegonja@biotech.uniri.hr

Source: Platelets. 2022, Vol. 33 Issue 6, p887-899. 13p.

Subject Terms: *MEGAKARYOCYTES, *CYTOSKELETAL proteins, *BONE marrow, *INDUSTRIAL capacity, *F-actin

Carboplatin-Induced Thrombocytopenia through JAK2 Downregulation, S-Phase Cell Cycle Arrest and Apoptosis in Megakaryocytes.

Authors: Wu, Yi-Hong^1,2 (AUTHOR) mzpjih@adm.cgmh.org.tw, Chen, Hsing-Yu^1,2,3 (AUTHOR) b8705016@gmail.com, Hong, Wei-Chin¹ (AUTHOR) cute09272006@gmail.com, Wei, Chen-Ying¹ (AUTHOR) hedywei@cgmh.org.tw, Pang, Jong-Hwei Su^3,4 (AUTHOR) jonghwei@mail.cgu.edu.tw

Source: International Journal of Molecular Sciences. Jun2022, Vol. 23 Issue 11, p6290-6290. 15p.

Subject Terms: *JAK-STAT pathway, *MEGAKARYOCYTES, *DOWNREGULATION, *THROMBOCYTOPENIA, *THROMBOPOIETIN, *CELL cycle

Megakaryocytes form linear podosomes devoid of digestive properties to remodel medullar matrix.

Authors: Oprescu, Antoine¹ (AUTHOR), Michel, Déborah¹ (AUTHOR), Antkowiak, Adrien¹ (AUTHOR), Vega, Elodie¹ (AUTHOR), Viaud, Julien¹ (AUTHOR), Courtneidge, Sara A.² (AUTHOR), Eckly, Anita³ (AUTHOR), de la Salle, Henri³ (AUTHOR), Chicanne, Gaëtan¹ (AUTHOR), Léon, Catherine³ (AUTHOR), Payrastre, Bernard^1,4 (AUTHOR), Gaits-Iacovoni, Frédérique^1,5 (AUTHOR) frgaits@gmail.com

Source: Scientific Reports. 4/15/2022, Vol. 12 Issue 1, p1-17. 17p.

Subject Terms: *MEGAKARYOCYTES, *INVERSE relationships (Mathematics), *CELL differentiation, *COLLAGEN

OneSC: a computational platform for recapitulating cell state transitions.

Authors: Peng, Da¹, Cahan, Patrick^1,2,3

Source: Bioinformatics; Dec2024, Vol. 40 Issue 12, p1-13, 13p

A subset of megakaryocytes regulates development of hematopoietic stem cell precursors.

Authors: Lan, Wenlang¹ (AUTHOR), Li, Jinping¹ (AUTHOR), Ye, Zehua¹ (AUTHOR), Liu, Yumin¹ (AUTHOR), Luo, Sifan¹ (AUTHOR), Lu, Xun¹ (AUTHOR), Cao, Zhan¹ (AUTHOR), Chen, Yifan¹ (AUTHOR), Chen, Hongtian¹ (AUTHOR), Li, Zhuan¹ (AUTHOR) zhuanli2018@smu.edu.cn

Source: EMBO Journal. May2024, Vol. 43 Issue 9, p1722-1739. 18p.

Subject Terms: *HEMATOPOIETIC stem cells, *MEGAKARYOCYTES, *EMBRYOLOGY, *YOLK sac, *CELL differentiation, *ANIMAL rescue, *SOMATIC embryogenesis

Isolation of megakaryocytes using magnetic cell separation and adverse effects induced by diclofenac toxicity in an experiment.

Authors: Bagmut, Irina Yuriivna¹ irina.bagmut@ukr.net, Ivanov, Olexiy Sergiyovych¹, Sheremet, Michael Ivanovich² mihayl71@gmail.com, Smirnov, Sergiy Mykolayovych³, Kolisnyk, Igor Leonidovich¹, Ivanova, Julia Viktorivna⁴, Tymchenko, Mykhailo Yevgenievich⁵, Lazirskiy, Vyacheslav Oleksievich⁶

Source: Journal of Medicine & Life. Jan2022, Vol. 15 Issue 1, p65-70. 6p.

Subject Terms: *CELL separation, *MEGAKARYOCYTES, *MAGNETIC separation, *BONE marrow cells, *DICLOFENAC

Nucleoside reverse transcriptase inhibition enhances platelet production and megakaryocyte maturation in patients with COVID‐19.

Authors: Li, Yubin, Wang, Juan, Huang, Bingqian, Wang, Ruixue, Xu, Yitong, Zhang, Ping, Wang, Ruting, Wang, Wanru, Cao, Junying, Hou, Ming, Hou, Yu

Source: British Journal of Haematology; Mar2025, Vol. 206 Issue 3, p846-857, 12p

Subject Terms: COVID-19, NUCLEOSIDE reverse transcriptase inhibitors, THROMBOCYTOPENIA, MEGAKARYOCYTES, ANTIVIRAL agents, SARS-CoV-2, BLOOD platelet activation, HEMATOPOIETIC system

Defining and Harnessing the Megakaryocyte/Platelet Checkpoint.

Authors: Mazharian, Alexandra, Senis, Yotis A.

Source: Molecular & Cellular Biology; 2025, Vol. 45 Issue 3, p116-128, 13p

Subject Terms: HEPARAN sulfate proteoglycans, BRAKE systems, BLOOD platelets, MEGAKARYOCYTES, PHOSPHATASES

D-dencichine Regulates Thrombopoiesis by Promoting Megakaryocyte Adhesion, Migration and Proplatelet Formation.

Authors: Ding, Shilan, Wang, Min, Fang, Song, Xu, Huibo, Fan, Huiting, Tian, Yu, Zhai, Yadong, Lu, Shan, Qi, Xin, Wei, Fei, Sun, Guibo, Sun, Xiaobo

Source: Frontiers in Pharmacology; 2025, p1-16, 16p

Subject Terms: THROMBOPOIETIN, TREATMENT delay (Medicine), BLOOD platelets, THROMBOCYTOPENIA, MEGAKARYOCYTES, PLATELET count, THROMBOPOIETIN receptors