Mesenchymal stem cell-derived extracellular vesicles alleviate autism by regulating microglial glucose metabolism reprogramming and neuroinflammation through PD-1/PD-L1 interaction.

Authors: Qin, Qian¹ (AUTHOR), Fan, Linlin¹ (AUTHOR), Zeng, Xin¹ (AUTHOR), Zheng, Danyang¹ (AUTHOR), Wang, Han¹ (AUTHOR), Li, Mengyue¹ (AUTHOR), Jiang, Yutong¹ (AUTHOR), Wang, Hui¹ (AUTHOR), Liu, Hao¹ (AUTHOR), Liang, Shengjun¹ (AUTHOR), Wu, Lijie¹ (AUTHOR) wulijiehyd@126.com, Liang, Shuang¹ (AUTHOR) liangyouyou2004@163.com

Source: Journal of Nanobiotechnology. 3/11/2025, Vol. 23 Issue 1, p1-25. 25p.

Subject Terms: *MATERNAL immune activation, *METABOLIC reprogramming, *IMMUNE checkpoint proteins, *AUTISM spectrum disorders, *INTRANASAL administration

A meta-analysis of sex differences in neonatal rodent ultrasonic vocalizations and the implication for the preclinical maternal immune activation model.

Authors: Randell, Alison M.¹ (AUTHOR), Salia, Stephanie¹ (AUTHOR), Fowler, Lucas F.^1,2 (AUTHOR), Aung, Toe³ (AUTHOR), Puts, David A.⁴ (AUTHOR), Swift-Gallant, Ashlyn¹ (AUTHOR) aswiftgallant@mun.ca

Source: Biology of Sex Differences. 1/25/2025, Vol. 16 Issue 1, p1-19. 19p.

Subject Terms: *MATERNAL immune activation, *SEX (Biology), *AUTISM spectrum disorders, *NUMBERS of species, *SOUNDS, *RATS

Transient CSF1R inhibition ameliorates behavioral deficits in Cntnap2 knockout and valproic acid-exposed mouse models of autism.

Authors: Meng, Jiao^1,2 (AUTHOR), Pan, Pengming^1,3 (AUTHOR), Guo, Gengshuo^1,2 (AUTHOR), Chen, Anqi^1,2 (AUTHOR), Meng, Xiangbao^1,3 (AUTHOR) xbmeng@hsc.pku.edu.cn, Liu, Heli^1,2,4 (AUTHOR) liuheli@hsc.pku.edu.cn

Source: Journal of Neuroinflammation. 10/18/2024, Vol. 21 Issue 1, p1-20. 20p.

Subject Terms: *MATERNAL immune activation, *AUTISM spectrum disorders, *SOMATOSENSORY cortex, *KNOCKOUT mice, *SOCIAL skills

Autophagy defects at weaning impair complement-dependent synaptic pruning and induce behavior deficits.

Authors: Su, Xi^1,2,3,4,5 (AUTHOR) suxi198919@163.com, Wang, Guanyu^1,3,4 (AUTHOR), Liu, Senqi^1,3,4 (AUTHOR), Li, Jinming^1,3,4 (AUTHOR), Shao, Minglong^1,2,3,4,5 (AUTHOR), Yang, Yongfeng^1,2,3,4,5 (AUTHOR), Song, Meng^1,2,3,4,5 (AUTHOR), Han, Yong^1,2,3,4,5 (AUTHOR), Li, Wenqiang^1,2,3,4,5 (AUTHOR), Lv, Luxian^1,3,4 (AUTHOR) lvx928@126.com

Source: Journal of Neuroinflammation. 9/27/2024, Vol. 21 Issue 1, p1-18. 18p.

Subject Terms: *MATERNAL immune activation, *LABORATORY rats, *SINGLE nucleotide polymorphisms, *DENDRITIC spines, *GENE expression

Sex-Specific Behavioral and Molecular Responses to Maternal Lipopolysaccharide-Induced Immune Activation in a Murine Model: Implications for Neurodevelopmental Disorders.

Authors: Xu, Jing¹ (AUTHOR) xuj391@nenu.edu.cn, Zhao, Rujuan² (AUTHOR) zhaorj046@nenu.edu.cn, Yan, Mingyang² (AUTHOR) mingyangyan@nenu.edu.cn, Zhou, Meng² (AUTHOR) zhoum747@nenu.edu.cn, Liu, Huanhuan² (AUTHOR) huanhuanliu211@163.com, Wang, Xueying² (AUTHOR) wangxy045@nenu.edu.cn, Lu, Chang² (AUTHOR) luc816@nenu.edu.cn, Li, Qiang² (AUTHOR) liq245@nenu.edu.cn, Mo, Yan¹ (AUTHOR) moy335@nenu.edu.cn, Zhang, Paihao² (AUTHOR) zhangph807@nenu.edu.cn, Ju, Xingda² (AUTHOR) juxd513@nenu.edu.cn, Zeng, Xianlu¹ (AUTHOR) juxd513@nenu.edu.cn

Source: International Journal of Molecular Sciences. Sep2024, Vol. 25 Issue 18, p9885. 15p.

Subject Terms: *MATERNAL immune activation, *GENE expression, *NEURAL development, *LIPOPOLYSACCHARIDES, *ANXIETY

A Novel Non-Invasive Murine Model of Neonatal Hypoxic-Ischemic Encephalopathy Demonstrates Developmental Delay and Motor Deficits with Activation of Inflammatory Pathways in Monocytes.

Authors: Lemanski, Elise A.^1,2 (AUTHOR) elise.lemanski@nemours.org, Collins, Bailey A.^1,2 (AUTHOR) bailey.collins@nemours.org, Ebenezer, Andrew T.¹ (AUTHOR) andrew.ebenezer@nemours.org, Anilkumar, Sudha^1,2 (AUTHOR) sudha.anilkumar@nemours.org, Langdon, Victoria A.¹ (AUTHOR) victoria.langdon@nemours.org, Zheng, Qi¹ (AUTHOR) qi.zheng@nemours.org, Ding, Shanshan³ (AUTHOR) sding@udel.edu, Franke, Karl Royden¹ (AUTHOR) karl.franke@nemours.org, Schwarz, Jaclyn M.² (AUTHOR), Wright-Jin, Elizabeth C.^1,2,4,5 (AUTHOR) elizabeth.wright-jin@nemours.org

Source: Cells (2073-4409). Sep2024, Vol. 13 Issue 18, p1551. 21p.

Subject Terms: *MATERNAL immune activation, *CEREBRAL anoxia-ischemia, *SIZE of brain, *MOTOR ability, *GENE expression

PolyI:C Maternal Immune Activation on E9.5 Causes the Deregulation of Microglia and the Complement System in Mice, Leading to Decreased Synaptic Spine Density.

Authors: Yan, Shuxin¹ (AUTHOR) shuxin.yan@camh.ca, Wang, Le^1,2 (AUTHOR) wangle@ojlab.ac.cn, Samsom, James Nicholas¹ (AUTHOR) james.samsom@camh.ca, Ujic, Daniel^1,3 (AUTHOR) daniel.ujic@mail.utoronto.ca, Liu, Fang^1,3,4,5 (AUTHOR) fang.liu@camh.ca

Source: International Journal of Molecular Sciences. May2024, Vol. 25 Issue 10, p5480. 14p.

Subject Terms: *MATERNAL immune activation, *DENDRITIC spines, *COMPLEMENT activation, *MICROGLIA, *SPINE, *SOMATOSENSORY cortex, *COMPLEMENT receptors

Impact of maternal immune activation and sex on placental and fetal brain cytokine and gene expression profiles in a preclinical model of neurodevelopmental disorders.

Authors: Osman, Hadley C.^1,2 (AUTHOR), Moreno, Rachel^1,2 (AUTHOR), Rose, Destanie^1,2 (AUTHOR), Rowland, Megan E.^3,4 (AUTHOR), Ciernia, Annie Vogel^3,4 (AUTHOR), Ashwood, Paul^1,2 (AUTHOR) pashwood@ucdavis.edu

Source: Journal of Neuroinflammation. 5/7/2024, Vol. 21, p1-14. 14p.

Subject Terms: *MATERNAL immune activation, *FETAL brain, *GENE expression profiling, *PLACENTA, *AUTISM spectrum disorders, *POLYHYDRAMNIOS

Exploration of cell type–specific somatic mutations in schizophrenia and the impact of maternal immune activation on the somatic mutation profile in the brain.

Authors: Du, Jianbin¹ (AUTHOR), Nakachi, Yutaka¹ (AUTHOR), Murata, Yui^1,2 (AUTHOR), Kiyota, Emi¹ (AUTHOR), Kato, Tadafumi^2,3 (AUTHOR), Bundo, Miki^1,2 (AUTHOR) bundo@kumamoto-u.ac.jp, Iwamoto, Kazuya^1,2 (AUTHOR) iwamotok@kumamoto-u.ac.jp

Source: Psychiatry & Clinical Neurosciences. Apr2024, Vol. 78 Issue 4, p237-247. 11p.

Subject Terms: *SOMATIC mutation, *MATERNAL immune activation, *SOMATIC cells, *PREFRONTAL cortex, *CELL differentiation

Increased NLRP1 mRNA and Protein Expression Suggests Inflammasome Activation in the Dorsolateral Prefrontal and Medial Orbitofrontal Cortex in Schizophrenia.

Authors: Španić Popovački, Ena¹ (AUTHOR) llanger@hiim.hr, Vogrinc, Dora¹ (AUTHOR), Fuller, Heidi R.^2,3 (AUTHOR) h.r.fuller@keele.ac.uk, Langer Horvat, Lea¹ (AUTHOR), Mayer, Davor⁴ (AUTHOR), Kopić, Janja¹ (AUTHOR), Pintarić, Klara¹ (AUTHOR), Babić Leko, Mirjana¹ (AUTHOR), Pravica, Mihaela¹ (AUTHOR), Krsnik, Željka¹ (AUTHOR), Marčinko, Darko^5,6 (AUTHOR) predstojnik.psi@kbc-zagreb.hr, Šagud, Marina^5,6 (AUTHOR), Hof, Patrick R.⁷ (AUTHOR) patrick.hof@mssm.edu, Mladinov, Mihovil⁸ (AUTHOR), Šimić, Goran¹ (AUTHOR) gsimic@hiim.hr

Source: Biomolecules (2218-273X). Mar2024, Vol. 14 Issue 3, p302. 22p.

Subject Terms: *MATERNAL immune activation, *GENE expression, *PROTEIN expression, *INFLAMMASOMES, *PYRAMIDAL neurons, *POSTMORTEM changes, *SCHIZOPHRENIA, *PREFRONTAL cortex

Maternal immune activation alters the GABAergic system in the prefrontal cortex of female rat offspring: Role of interleukin-6.

Authors: Harbi, Retaj Al¹ (AUTHOR), Mouihate, Abdeslam¹ (AUTHOR) a.mouihate@ku.edu.kw

Source: Neuroscience. Mar2025, Vol. 568, p399-407. 9p.

Subject Terms: *MATERNAL immune activation, *PREFRONTAL cortex, *GABA, *INTRAPERITONEAL injections, *SALINE solutions

Maternal immune activation followed by peripubertal stress combinedly produce reactive microglia and confine cerebellar cognition.

Authors: Hikosaka, Momoka¹ (AUTHOR), Parvez, Md Sorwer Alam^1,2 (AUTHOR), Yamawaki, Yuki¹ (AUTHOR), Oe, Souichi³ (AUTHOR), Liang, Yuan^1,4 (AUTHOR), Wada, Yayoi¹ (AUTHOR), Hirahara, Yukie³ (AUTHOR), Koike, Taro³ (AUTHOR), Imai, Hirohiko^5,6 (AUTHOR), Oishi, Naoya^7,8 (AUTHOR), Schalbetter, Sina M.⁹ (AUTHOR), Kumagai, Asuka¹⁰ (AUTHOR), Yoshida, Mari¹¹ (AUTHOR), Sakurai, Takeshi¹ (AUTHOR), Kitada, Masaaki³ (AUTHOR), Meyer, Urs⁹ (AUTHOR), Narumiya, Shuh¹ (AUTHOR), Ohtsuki, Gen¹ (AUTHOR) ohtsuki.gen.7w@kyoto-u.ac.jp

Source: Communications Biology. 3/3/2025, Vol. 8 Issue 1, p1-26. 26p.

Subject Terms: *SOCIAL defeat, *MATERNAL immune activation, *PURKINJE cells, *SCHIZOPHRENIA, *DISEASE risk factors, *CEREBELLAR cortex

ATP8A2 expression is reduced in the mPFC of offspring mice exposed to maternal immune activation and its upregulation ameliorates synapse-associated protein loss and behavioral abnormalities.

Authors: Liu, Wenhui¹ (AUTHOR), Yan, Kai¹ (AUTHOR), Xu, Siqi¹ (AUTHOR), Li, Lifang¹ (AUTHOR), Zhong, Mengdan² (AUTHOR), Liu, Jing¹ (AUTHOR), Li, Guoying^1,3 (AUTHOR) gzlgying820@163.com, Yang, Junhua^1,4 (AUTHOR) jhyang2018@gdpu.edu.cn

Source: Brain, Behavior & Immunity. Feb2025, Vol. 124, p409-430. 22p.

Subject Terms: *MATERNAL immune activation, *NEUROBEHAVIORAL disorders, *PHOSPHATIDYLSERINES, *NEURAL development, *NEUROPLASTICITY

Morphological and Molecular Biological Changes in the Hippocampus and Prefrontal Cortex of the Brain of Newborn Male and Female Wistar Rats after LPS-Induced Activation of the Maternal Immune Response.

Authors: Lyamtsev, A. S.¹ (AUTHOR), Sentyabreva, A. V.^1,2 (AUTHOR) alexandraasentyabreva@gmail.com, Tsvetkov, I. S.¹ (AUTHOR), Miroshnichenko, E. A.^1,2 (AUTHOR), Kosyreva, A. M.^1,2 (AUTHOR)

Source: Bulletin of Experimental Biology & Medicine. Jan2025, Vol. 178 Issue 3, p381-386. 6p.

Subject Terms: *MATERNAL immune activation, *LIFE sciences, *PREFRONTAL cortex, *MATERNALLY acquired immunity, *LABORATORY rats

The association of maternal COVID-19-infection during pregnancy on the neonatal immune profile and associations with later diagnosis of neurodevelopmental disorders.

Authors: Kim, Danielle HJ^1,2 (AUTHOR), Croen, Lisa A³ (AUTHOR), Iosif, Ana-Maria⁴ (AUTHOR), Ames, Jennifer L³ (AUTHOR), Alexeeff, Stacey³ (AUTHOR), Qian, Yinge³ (AUTHOR), Yolken, Robert H⁵ (AUTHOR), Ashwood, Paul^6,7 (AUTHOR), Van de Water, Judy^1,6,7 (AUTHOR) javandewater@ucdavis.edu

Source: Brain, Behavior & Immunity. Jan2025, Vol. 123, p1071-1080. 10p.

Subject Terms: *COVID-19 pandemic, *MATERNAL immune activation, *COVID-19, *MATERNALLY acquired immunity, *PRENATAL exposure, *TEENAGE pregnancy

Sex-specific associations between maternal prenatal inflammation and offspring cortical morphology in youth: A harmonised study across four birth cohorts.

Authors: Niskanen, Anni^1,2,3 (AUTHOR), Barron, Aaron^1,4,5,6 (AUTHOR), Azaryah, Hatim^7,8,9 (AUTHOR), Kerkelä, Martta^1,2 (AUTHOR), Pulli, Elmo^4,10 (AUTHOR), Tuulari, Jetro J.^4,5,10,11 (AUTHOR), Lukkarinen, Minna^4,10,12 (AUTHOR), Karlsson, Linnea^4,10,13,14 (AUTHOR), Muetzel, Ryan L.^15,16 (AUTHOR), Campoy, Cristina^7,8,9,17 (AUTHOR), Catena, Andrés^18,19 (AUTHOR), Tiemeier, Henning^15,20 (AUTHOR), Khandaker, Golam M.^21,22,23,24 (AUTHOR), Karlsson, Hasse^4,5,10 (AUTHOR), Veijola, Juha^1,2,3 (AUTHOR), Björnholm, Lassi^1,2,3 (AUTHOR) lassi.bjornholm@oulu.fi

Source: Brain, Behavior & Immunity. Jan2025, Vol. 123, p1081-1090. 10p.

Subject Terms: *MATERNAL immune activation, *REGIONAL development, *PRENATAL exposure, *C-reactive protein, *STATISTICAL association

A microglia-containing cerebral organoid model to study early life immune challenges.

Authors: Buonfiglioli, Alice¹ (AUTHOR) alice.buonfiglioli@mssm.edu, Kübler, Raphael^2,3,4 (AUTHOR), Missall, Roy¹ (AUTHOR), De Jong, Renske¹ (AUTHOR), Chan, Stephanie¹ (AUTHOR), Haage, Verena⁵ (AUTHOR), Wendt, Stefan⁶ (AUTHOR), Lin, Ada J.⁷ (AUTHOR), Mattei, Daniele² (AUTHOR), Graziani, Mara^1,4,8 (AUTHOR), Latour, Brooke^4,8 (AUTHOR), Gigase, Frederieke¹ (AUTHOR), Chiu, Rebecca⁵ (AUTHOR), Zhang, Ya⁵ (AUTHOR), Nygaard, Haakon B.⁷ (AUTHOR), De Jager, Philip L.⁵ (AUTHOR), De Witte, Lot D.^1,4,8,9 (AUTHOR)

Source: Brain, Behavior & Immunity. Jan2025, Vol. 123, p1127-1146. 20p.

Subject Terms: *MATERNAL immune activation, *BRAIN abnormalities, *MICROGLIA, *IMMUNE system, *PRENATAL exposure

Gut microbiota transfer from the preclinical maternal immune activation model of autism is sufficient to induce sex-specific alterations in immune response and behavioural outcomes.

Authors: Salia, Stephanie¹ (AUTHOR) ssalia@mun.ca, Burke, Francine F.¹ (AUTHOR), Hinks, Meagan E.¹ (AUTHOR), Randell, Alison M.¹ (AUTHOR), Matheson, Mairead Anna¹ (AUTHOR), Walling, Susan G.¹ (AUTHOR), Swift-Gallant, Ashlyn¹ (AUTHOR) aswiftgallant@mun.ca

Source: Brain, Behavior & Immunity. Jan2025, Vol. 123, p813-823. 11p.

Subject Terms: *MATERNAL immune activation, *GUT microbiome, *SEX (Biology), *AUTISM spectrum disorders, *LABORATORY mice, *SOCIABILITY

Maternal immune activation alters temporal Precision of spike generation of CA1 pyramidal neurons by Unbalancing GABAergic inhibition in the Offspring.

Authors: Griego, Ernesto^1,2 (AUTHOR), Cerna, Camila^3,4 (AUTHOR), Sollozo-Dupont, Isabel⁵ (AUTHOR), Fuenzalida, Marco^3,4 (AUTHOR), Galván, Emilio J.^1,6 (AUTHOR) ejgalvan@cinvestav.mx

Source: Brain, Behavior & Immunity. Jan2025, Vol. 123, p211-228. 18p.

Subject Terms: *MATERNAL immune activation, *PYRAMIDAL neurons, *AUTISM spectrum disorders, *ACTION potentials, *MENTAL illness

High level of immunoglobulin G targeting mycoplasma or cytomegalovirus in the newborn increases risk of ADHD.

Authors: Borbye-Lorenzen, Nis¹ (AUTHOR), Holmgaard, Solveig¹ (AUTHOR), Ottosson, Filip¹ (AUTHOR), Nudel, Ron^2,3,4 (AUTHOR), Appadurai, Vivek⁵ (AUTHOR), Laursen, Thomas Munk⁶ (AUTHOR), Bækvad-Hansen, Marie¹ (AUTHOR), Bybjerg-Grauholm, Jonas¹ (AUTHOR), Nordentoft, Merete^3,4,7 (AUTHOR), Børglum, Anders D^4,8,9 (AUTHOR), Mortensen, Preben Bo^4,6 (AUTHOR), Werge, Thomas^5,7 (AUTHOR), Benros, Michael E^2,7 (AUTHOR), Hougaard, David Michael¹ (AUTHOR), Skogstrand, Kristin¹ (AUTHOR) ksk@ssi.dk

Source: Brain, Behavior & Immunity. Jan2025, Vol. 123, p99-107. 9p.

Subject Terms: *GENETIC risk score, *MATERNAL immune activation, *ATTENTION-deficit hyperactivity disorder, *MYCOPLASMA pneumoniae, *IMMUNOGLOBULIN G