Serum and synovial fluid levels of CSF-1 and in knee osteoarthritis and its clinical significance.

Authors: Huang, Yuanchi¹ (AUTHOR), Pan, Wenjie¹ (AUTHOR), Bao, Huanli¹ (AUTHOR), Xu, Chao¹ (AUTHOR) 383697196@qq.com, Ma, Jianbing¹ (AUTHOR) JianbingMa2023@163.com

Source: BMC Musculoskeletal Disorders. 4/10/2025, Vol. 26 Issue 1, p1-9. 9p.

Subject Terms: *MACROPHAGE colony-stimulating factor, *SYNOVIAL fluid, *ENZYME-linked immunosorbent assay, *KNEE osteoarthritis, *MEDICAL sciences

CXCL2: a key player in the tumor microenvironment and inflammatory diseases.

Authors: Lv, Yuanhao^1,2 (AUTHOR), Chen, Caizheng¹ (AUTHOR), Han, Miaomiao¹ (AUTHOR), Tian, Chenfei¹ (AUTHOR), Song, Fuyang¹ (AUTHOR), Feng, Sijia³ (AUTHOR), Xu, Miaoming¹ (AUTHOR), Zhao, Ziyin¹ (AUTHOR), Zhou, Hongyan⁴ (AUTHOR), Su, Wei^2,5 (AUTHOR) hnswei@163.com, Zhong, Jiateng^1,2,4,5,6 (AUTHOR) jtzhong@xxmu.edu.cn

Source: Cancer Cell International. 4/7/2025, Vol. 25 Issue 1, p1-15. 15p.

Subject Terms: *MACROPHAGE inflammatory proteins, *CHEMOTACTIC factors, *TUMOR microenvironment, *LIFE sciences, *PNEUMONIA

Herbal extract fermented with inherent microbiota improves intestinal health by exerting antioxidant and anti-inflammatory effects in vitro and in vivo.

Authors: Heckmann, Mara¹ (AUTHOR), Sadova, Nadiia^1,2 (AUTHOR), Sandner, Georg² (AUTHOR), Neuhauser, Cathrina^1,2 (AUTHOR), Blank-Landeshammer, Bernhard^1,2 (AUTHOR), Schwarzinger, Bettina^1,2 (AUTHOR), König, Alice^1,2 (AUTHOR), Liang, Meizhen² (AUTHOR), Spitzer, Michael³ (AUTHOR), Weghuber, Julian^1,2 (AUTHOR) julian.weghuber@fh-wels.at, Stadlbauer, Verena^1,2 (AUTHOR) verena.stadlbauer@fh-wels.at

Source: Journal of Animal Science & Biotechnology. 4/6/2025, Vol. 16 Issue 1, p1-19. 19p.

Subject Terms: *MACROPHAGE inflammatory proteins, *NF-kappa B, *TUMOR necrosis factors, *MEDICAL sciences, *LIFE sciences, *T cells

T-ing up the storm: pathogenic cycling lymphocytes in the biology of macrophage activation syndrome.

Authors: Lam, Michael T.¹ (AUTHOR), Jiang, Connie L.^1,2 (AUTHOR), Lee, Pui Y.¹ (AUTHOR) pui.lee@childrens.harvard.edu

Source: Pediatric Rheumatology. 3/17/2025, Vol. 23 Issue 1, p1-10. 10p.

Subject Terms: *MACROPHAGE activation syndrome, *CYTOKINE release syndrome, *T cells, *MYELOID cells, *HEMOPHAGOCYTIC lymphohistiocytosis

Pharmacological Inhibition of Microglial Proliferation Supports Blood–Brain Barrier Integrity in Experimental Autoimmune Encephalomyelitis.

Authors: Borjini, Nozha^1,2,3,4 (AUTHOR) nborjini-ibis@us.es, Fernandez, Mercedes^2,5 (AUTHOR), Giardino, Luciana^3,5,6 (AUTHOR), Sorokin, Lydia^4,7,8 (AUTHOR), Calzà, Laura^5,9 (AUTHOR)

Source: Cells (2073-4409). Mar2025, Vol. 14 Issue 6, p414. 15p.

Subject Terms: *MACROPHAGE colony-stimulating factor, *MULTIPLE sclerosis, *DISEASE progression, *ENCEPHALOMYELITIS, *MICROGLIA

Chronic intermittent hypoxia disrupts protective microgliosis in ischemic proliferative retinopathy.

Authors: Yang, Tianxiang^1,2 (AUTHOR), Ronning, Kaitryn E.¹ (AUTHOR), Augustin, Sébastien¹ (AUTHOR), Blond, Frédéric¹ (AUTHOR), Nous, Caroline³ (AUTHOR), Argyriou, Foteini¹ (AUTHOR), Touhami, Sara⁴ (AUTHOR), Delarasse, Cécile¹ (AUTHOR), Guillonneau, Xavier¹ (AUTHOR), Sennlaub, Florian^1,3 (AUTHOR) florian.sennlaub@inserm.fr

Source: Journal of Neuroinflammation. 3/14/2025, Vol. 22 Issue 1, p1-14. 14p.

Subject Terms: *MACROPHAGE colony-stimulating factor, *MEDICAL sciences, *SLEEP apnea syndromes, *RETROLENTAL fibroplasia, *DIABETIC retinopathy

Centripetal migration and prolonged retention of microglia promotes spinal cord injury repair.

Authors: Ye, Jianan¹ (AUTHOR), Shan, Fangli¹ (AUTHOR), Xu, Xinzhong^1,2 (AUTHOR), Liang, Chao¹ (AUTHOR), Zhang, Ningyuan¹ (AUTHOR), Hu, Hao¹ (AUTHOR), Li, Jianjian¹ (AUTHOR), Ouyang, Fangru¹ (AUTHOR), Wang, Jingwen¹ (AUTHOR), Zhao, Yuanzhe¹ (AUTHOR), Ma, Zhida¹ (AUTHOR), Meng, Congpeng¹ (AUTHOR), Li, Ziyu^1,2 (AUTHOR), Yu, Shuisheng^1,2 (AUTHOR) ysspaper@sina.com, Jing, Juehua^1,2 (AUTHOR) jjhhu@sina.com, Zheng, Meige^1,2 (AUTHOR) zhengmg113@126.com

Source: Journal of Neuroinflammation. 3/12/2025, Vol. 22 Issue 1, p1-18. 18p.

Subject Terms: *MACROPHAGE colony-stimulating factor, *MEDICAL sciences, *CHEMOKINE receptors, *SPINAL cord injuries, *NERVOUS system regeneration

Macrophage colony-stimulating factor receptor/CD115⁺ non-classical monocytes are expanded in systemic lupus erythematosus and associated with lupus nephritis.

Authors: Zeisbrich, M¹ (AUTHOR) markus.zeisbrich@uniklinik-freiburg.de, Rzepka, R¹ (AUTHOR), Finzel, S¹ (AUTHOR), Venhoff, N¹ (AUTHOR), Voll, RE¹ (AUTHOR)

Source: Scandinavian Journal of Rheumatology. Mar2025, Vol. 54 Issue 2, p125-134. 10p.

Subject Terms: *CELL receptors, *MACROPHAGE colony-stimulating factor, *SYSTEMIC lupus erythematosus, *LUPUS nephritis, *CONNECTIVE tissue diseases

Tumor-Associated Macrophage (TAM)-Related Cytokines, sCD163, CCL2, and CCL4, as Novel Biomarkers for Overall Survival and Time to Treatment in Waldenstrom's Macroglobulinemia: Emphasis on Asymptomatic WM.

Authors: Gkiokas, Alexandros¹ (AUTHOR) alexander.gkiokas12@gmail.com, Papadatou-Gigante, Mavra¹ (AUTHOR) anni.iwan.gk@gmail.com, Gkioka, Annita Ioanna¹ (AUTHOR) aspakoud@hotmail.gr, Koudouna, Aspasia¹ (AUTHOR) thommais@hotmail.com, Tryfou, Thomai M.¹ (AUTHOR) al.alexandropoulos@gmail.com, Alexandropoulos, Alexandros¹ (AUTHOR) vbartzi@yahoo.com, Bartzi, Vassiliki¹ (AUTHOR) mckyrtsonis@gmail.com, Kafasi, Nikolitsa² (AUTHOR) nkafassi@hotmail.com, Kyrtsonis, Marie-Christine¹ (AUTHOR)

Source: Cells (2073-4409). Feb2025, Vol. 14 Issue 4, p275. 12p.

Subject Terms: *WALDENSTROM'S macroglobulinemia, *MACROPHAGE inflammatory proteins, *ENZYME-linked immunosorbent assay, *OVERALL survival, *PROGNOSIS

Development of Serum-Free Culture Systems for an Immortalized Porcine Kidney-Derived Macrophage Cell Line.

Authors: Haraguchi, Seiki¹ (AUTHOR) sharaguchi@affrc.go.jp, Takenouchi, Takato¹ (AUTHOR) shunsuzu@affrc.go.jp, Masujin, Kentaro² (AUTHOR) masujin@affrc.go.jp, Suzuki, Shunichi¹ (AUTHOR) huenishi@affrc.go.jp, Kokuho, Takehiro² (AUTHOR) takehiro@affrc.go.jp, Uenishi, Hirohide¹ (AUTHOR)

Source: Animals (2076-2615). Feb2025, Vol. 15 Issue 4, p558. 15p.

Subject Terms: *MACROPHAGE colony-stimulating factor, *AFRICAN swine fever virus, *SERUM-free culture media, *CELL lines, *CELL adhesion, *CELL culture

NOTCH1 promotes the elevation of GM-CSF and IL-6 through the EZH2/STAT3 pathway to facilitate the fibrotic state of the myocardium in DLBCL.

Authors: Zhang, Huimin¹ (AUTHOR) 57703313@hebmu.edu.cn, Dong, Wen¹ (AUTHOR), Zhang, Lihong¹ (AUTHOR), Ma, Bing¹ (AUTHOR), Wang, Jianying¹ (AUTHOR), Shen, Yang¹ (AUTHOR), Zhao, Dan¹ (AUTHOR), Yin, Wanyi¹ (AUTHOR), Li, Yuexian¹ (AUTHOR), Liu, Qingchi¹ (AUTHOR)

Source: PLoS ONE. 2/14/2025, Vol. 20 Issue 2, p1-19. 19p.

Subject Terms: *DIFFUSE large B-cell lymphomas, *GRANULOCYTE-macrophage colony-stimulating factor, *NOTCH proteins, *MYOCARDIAL infarction, *HEART fibrosis, *NOTCH genes

Lack of HLH in FMF.

Authors: Basaran, Ozge¹ (AUTHOR), Sag, Erdal^1,2 (AUTHOR), Aydın, Elif Arslanoglu³ (AUTHOR), Aydın, Busra² (AUTHOR), Tasdemir, Nur Kübra² (AUTHOR), Celikel, Elif⁴ (AUTHOR), Bayındır, Yagmur¹ (AUTHOR), Özdel, Semanur³ (AUTHOR), Bilginer, Yelda¹ (AUTHOR), Grom, Alexei A⁵ (AUTHOR), Ozen, Seza^1,2 (AUTHOR) sezaozen@gmail.com

Source: Pediatric Rheumatology. 2/8/2025, Vol. 23 Issue 1, p1-6. 6p.

Subject Terms: *MACROPHAGE activation syndrome, *MONONUCLEAR leukocytes, *JUVENILE idiopathic arthritis, *FAMILIAL Mediterranean fever, *CYTOKINE release syndrome

Emapalumab in Patients With Macrophage Activation Syndrome Associated With Still's Disease: A Population Pharmacokinetic/Pharmacodynamic Analysis.

Authors: Brossard, Patrick¹ (AUTHOR) patrick.brossard@sobi.com

Source: CTS: Clinical & Translational Science. Feb2025, Vol. 18 Issue 2, p1-8. 8p.

Subject Terms: *MACROPHAGE activation syndrome, *STILL'S disease, *PHARMACODYNAMICS, *CLINICAL trials, *INFLAMMATION, *PHARMACOKINETICS, *BIOTHERAPY, *INTERFERON gamma

Synergistic effects of cryoablation and GM-CSF in colorectal liver metastases management in tumor-bearing mice.

Authors: Junfeng Wang^1,2,3,4, Dalu Kong^1,2,3,4 zlyyjzck@163.com

Source: Iranian Journal of Basic Medical Sciences. May2025, Vol. 28 Issue 5, p584-591. 8p.

Subject Terms: *GRANULOCYTE-macrophage colony-stimulating factor, *COLORECTAL liver metastasis, *SURVIVAL rate, *CRYOSURGERY, *DENDRITIC cells

Myeloid cell-derived apCAFs promote HNSCC progression by regulating proportion of CD4⁺ and CD8⁺ T cells.

Authors: Ren, Feilong^1,2 (AUTHOR), Meng, Lin¹ (AUTHOR), Zheng, Shize^1,2 (AUTHOR), Cui, Jiasen³ (AUTHOR), Song, Shaoyi^1,2 (AUTHOR), Li, Xing^1,2 (AUTHOR), Wang, Dandan^1,2 (AUTHOR), Liu, Qilin^1,4 (AUTHOR) qlliu@jlu.edu.cn, Bu, Wenhuan^1,5 (AUTHOR) whbu@jlu.edu.cn, Sun, Hongchen^1,2 (AUTHOR) hcsun@mail.jlu.edu.cn

Source: Journal of Experimental & Clinical Cancer Research (17569966). 1/31/2025, Vol. 44 Issue 1, p1-24. 24p.

Subject Terms: *MACROPHAGE migration inhibitory factor, *MYELOID cells, *JAK-STAT pathway, *MEDICAL sciences, *T cells

Rescue of in vitro models of CSF1R-related adult-onset leukodystrophy by iluzanebart: mechanisms and therapeutic implications of TREM2 agonism.

Authors: Larson, Kelley C.¹ (AUTHOR) klarson@vigilneuro.com, Gergits, Frederick W.¹ (AUTHOR), Renoux, Abigail J.¹ (AUTHOR), Weisman, Elizabeth J.¹ (AUTHOR), Dejanovic, Borislav¹ (AUTHOR), Huang, Liyue¹ (AUTHOR), Pandya, Bhaumik¹ (AUTHOR), McLaren, Donald G.¹ (AUTHOR), Lynch, Berkley A.² (AUTHOR), Fisher, Richard³ (AUTHOR), Thackaberry, Evan¹ (AUTHOR), Gray, David¹ (AUTHOR), Gaudreault, Francois¹ (AUTHOR), Mirescu, Christian¹ (AUTHOR)

Source: Journal of Neuroinflammation. 1/31/2025, Vol. 22 Issue 1, p1-21. 21p.

Subject Terms: *MACROPHAGE colony-stimulating factor, *MYELOID cells, *INDUCED pluripotent stem cells, *PROTEIN-tyrosine kinases, *GENE expression

Wild-type bone marrow cells repopulate tissue resident macrophages and reverse the impacts of homozygous CSF1R mutation.

Authors: Carter-Cusack, Dylan¹ (AUTHOR) david.hume@uq.edu.au, Huang, Stephen¹ (AUTHOR), Keshvari, Sahar¹ (AUTHOR), Patkar, Omkar¹ (AUTHOR), Sehgal, Anuj¹ (AUTHOR), Allavena, Rachel² (AUTHOR), Byrne, Robert A. J.³ (AUTHOR), Morgan, B. Paul³ (AUTHOR), Bush, Stephen J.⁴ (AUTHOR), Summers, Kim M.¹ (AUTHOR), Irvine, Katharine M.¹ (AUTHOR), Hume, David A.¹ (AUTHOR) d.cartercusack@student.uq.edu.au

Source: PLoS Genetics. 1/27/2025, Vol. 21 Issue 1, p1-39. 39p.

Subject Terms: *MACROPHAGE colony-stimulating factor, *BONE marrow cells, *COMPLEMENT (Immunology), *HUMAN abnormalities, *ORGANS (Anatomy)

Decreased PD-L1 contributes to preeclampsia by suppressing GM-CSF via the JAK2/STAT5 signal pathway.

Authors: Tian, Yingying¹ (AUTHOR), Peng, Xu¹ (AUTHOR), Yang, Xiuhua¹ (AUTHOR) xhyang@cmu.edu.cn, Street, Nanjing North¹ (AUTHOR)

Source: Scientific Reports. 1/24/2025, Vol. 15 Issue 1, p1-18. 18p.

Subject Terms: *MACROPHAGE colony-stimulating factor, *GRANULOCYTE-colony stimulating factor, *APOPTOSIS, *PROGRAMMED cell death 1 receptors, *PROGRAMMED death-ligand 1, *PREECLAMPSIA, *TROPHOBLAST

Single-Cell RNA Sequencing Reveals Macrophage Dynamics During MASH in Leptin -Deficient Rats.

Authors: Xin, Xiaoming¹ (AUTHOR) xmxin1687@163.com, Ni, Yaohua¹ (AUTHOR) ericani16@outlook.com, Wang, Jing¹ (AUTHOR) wangjing02212024@126.com, Wu, Fenglin² (AUTHOR) wfl050123@126.com, Liu, Meichen¹ (AUTHOR) 13140728648@163.com, Wu, Lingjuan¹ (AUTHOR) lingjuanwu1@163.com, Dai, Jiaxing¹ (AUTHOR) 17873421679@163.com, Wu, Chenglin¹ (AUTHOR) wucl@sumhs.edu.cn, Song, Xiaolei¹ (AUTHOR) songxl@sumhs.edu.cn, Zhang, Wang³ (AUTHOR) zhangwang@shanghaitech.edu.cn, Yang, Guangrui² (AUTHOR) yanggr@sumhs.edu.cn, Shen, Ruling⁴ (AUTHOR) shenruling@slarc.org.cn, Zhu, Xianmin^3,4 (AUTHOR) shenruling@slarc.org.cn

Source: Cells (2073-4409). Jan2025, Vol. 14 Issue 2, p96. 16p.

Subject Terms: *MACROPHAGE migration inhibitory factor, *KILLER cells, *LABORATORY rats, *RNA sequencing, *LIVER cells

Synthetic GPR84 Agonists in Colorectal Cancer: Effective in THP-1 Cells but Ineffective in BMDMs and MC38 Mouse Tumor Models.

Authors: Schwarzfischer, Marlene¹ (AUTHOR) marlene.schwarzfischer@usz.ch, Walker, Maria Rae¹ (AUTHOR) maria.walker@usz.ch, Curcio, Michele^2,3 (AUTHOR) michele.curcio@cistim.be, Boshta, Nader M.^2,3 (AUTHOR) nader.boshta@cistim.be, Marchand, Arnaud^2,3 (AUTHOR) arnaud.marchand@cistim.be, Soons, Erik^2,3 (AUTHOR) erik.soons@cistim.be, Pöhlmann, Doris¹ (AUTHOR) doris.poehlmann@usz.ch, Wawrzyniak, Marcin¹ (AUTHOR) marcin.wawrzyniak@usz.ch, Morsy, Yasser¹ (AUTHOR) yasser.morsy@usz.ch, Lang, Silvia¹ (AUTHOR) silvia.lang@usz.ch, Spalinger, Marianne Rebecca¹ (AUTHOR) marianne.spalinger@usz.ch, Versele, Matthias^2,3 (AUTHOR) matthias.versele@cistim.be, Scharl, Michael¹ (AUTHOR) michael.scharl@usz.ch

Source: International Journal of Molecular Sciences. Jan2025, Vol. 26 Issue 2, p490. 22p.

Subject Terms: *MACROPHAGE activation, *REACTIVE oxygen species, *PHAGOCYTOSIS, *ANTINEOPLASTIC agents, *COLORECTAL cancer