Spinal Teratoma with Recurrent Epileptic Episodes in Adults: A Case Report

Authors: Jinlong Wang, Bo Cao

Source: Case Reports in Neurology, Vol 16, Iss 1, Pp 249-255 (2024)

Subject Terms: epilepsy, mglur5, spinal teratomas, conus medullaris teratoma, case report, Neurology. Diseases of the nervous system, RC346-429

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Relation: https://beta.karger.com/Article/FullText/541522; https://doaj.org/toc/1662-680X

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Past, Present, and Future of Radiochemical Synthesis

Contributors: Borup Jensen, Svend

Subject Terms: fluorine-18, fluorination on Sep-Pak, [18F]FFNP, [18F]FDHT, mass spectrometry, molar activity, radiolabeling, bioorthogonal reaction, click chemistry, site-specific reaction, radiopharmaceuticals, radioisotopes, molecular imaging, radiochemistry, late-stage radiofluorination, drug development, copper-catalyzed, boronic pinacol ester, Huntington’s disease, mutant huntingtin, Positron Emission Tomography, carbon-11, [11C]raclopride, [18F]MNI-659, peptide transporters, positron emission tomography, radiotracer, fluorination, ProTides, radiolabelling, PET imaging, [18F]FPEB, mGluR5, positron emission tomography (PET), iodonium-ylide, Alzheimer’s Disease (AD), titanium-45, PSMA, PET, gastrin-releasing peptide receptor targeting, [99mTc]Tc-radiotracer, tumor targeting, [99mTc]Tc-DB1 mimic, PEGx-spacer, neprilysin-inhibition, phosphoramidon, radiolabeled somatostatin analogs, SST2, SST5, Lu-177, targeted radionuclide therapy, neuroendocrine tumors, dual-tumor mouse model, osteomyelitis, animal experimentation, pigs, PET/CT, [18F]FDG, [18F]NaF, [68Ga]Ga-DOTA-K-A9, [68Ga]Ga-DOTA-GSGK-A11 [68Ga]Ga-DOTA-Siglec-9, [68Ga]Ga-ubiquicidin, Inorganic chemistry

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Access URL: https://directory.doabooks.org/handle/20.500.12854/137477
https://mdpi.com/books/pdfview/book/8634

Non-ionotropic signaling through the NMDA receptor GluN2B carboxy-terminal domain drives dendritic spine plasticity and reverses fragile X phenotypes

Authors: Barnes, Stephanie A. ^{1, 2}, Thomazeau, Aurore ¹, Finnie, Peter S.B. ¹, Heinrich, Maxwell J. ¹, Heynen, Arnold J. ¹, Komiyama, Noburu H. ^{3, 4, 5}, Grant, Seth G.N. ^{3, 4}, Menniti, Frank S. ⁶, Osterweil, Emily K. ^{2, 7}, Bear, Mark F. ^{1, 8, ∗}

Source: In Cell Reports 25 March 2025 44(3)

Intracellular metabotropic glutamate receptor 5 in spinal dorsal horn neurons contributes to pain in a mouse model of vincristine-induced neuropathic pain

Authors: Li, Xiao ^{a, 1}, Yang, Hui ^{b, 1}, Qian, Ming ^b, Liu, Hang ^b, Zuo, Shuang ^a, Liu, Jin-Chun ^{b, ⁎}, Ge, Wei-Hong ^{a, b, ⁎}, Zhou, Lin ^{b, ⁎}

Source: In Neuroscience Letters 15 March 2025 852

Astrocytic G Protein-Coupled Receptors in Drug Addiction

Authors: Zinsmaier, Alexander K. ^a, Nestler, Eric J. ^b, Dong, Yan ^{a, ⁎}

Source: In Engineering January 2025 44:256-265

Exploring novel ligands for mGluR5: Design, computational analysis, and protein-ligand interaction studies

Authors: Chandraprakash Gond, Nikhil Kumar, Vijay Kumar Singh, Anupama Datta, Anjani Kumar Tiwari

Source: Chemical Physics Impact, Vol 9, Iss , Pp 100691- (2024)

Subject Terms: mGluR5, Docking, MD Simulation, CADD, Physics, QC1-999, Chemistry, QD1-999

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2667022424002354; https://doaj.org/toc/2667-0224

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Long-Term Regulation of IL-17 Expression in Pacific Oyster Hemocytes by mGluR5 Through the Phosphoinositide Pathway

Authors: Yiran Si, Deliang Li, Wenjing Ren, Xueshu Zhang, Lingling Wang, Linsheng Song

Source: Cells, Vol 14, Iss 6, p 438 (2025)

Subject Terms: glutamate, mGluR5, Crassostrea gigas, hemocyte, IL-17 expression, Cytology, QH573-671

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Relation: https://www.mdpi.com/2073-4409/14/6/438; https://doaj.org/toc/2073-4409

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Negative allosteric modulator of Group Ⅰ mGluRs: Recent advances and therapeutic perspective for neuropathic pain

Authors: Li, Jia-Ling ^{a, 1}, Zhu, Chun-Hao ^{a, 1}, Tian, Miao-Miao ^a, Liu, Yue ^a, Ma, Lin ^a, Tao, Li-Jun ^b, Zheng, Ping ^{a, ⁎}, Yu, Jian-Qiang ^{a, ⁎, 2}, Liu, Ning ^{a, c, ⁎}

Source: In Neuroscience 12 November 2024 560:406-421

In vitro modulation of mTOR and mGlur5 influence α-synuclein accumulation

Authors: Viktoria Xing, Kyle Biggar, Stephen S. G. Ferguson, Shawn Hayley

Source: Molecular Brain, Vol 17, Iss 1, Pp 1-10 (2024)

Subject Terms: α-synuclein, mGluR5, Parkinson’s disease, mTOR, In vitro, Neurology. Diseases of the nervous system, RC346-429

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Relation: https://doaj.org/toc/1756-6606

Access URL: https://doaj.org/article/e5a200be4ccc46d083476d4ce66f614b

The protective effects of methylene blue on astrocytic swelling after cerebral ischemia-reperfusion injuries are mediated by Aquaporin-4 and metabotropic glutamate receptor 5 activation

Authors: Lai, Yu ^{a, ⁎, 1}, Han, Jie ^{a, 1}, Qiu, Dongxian ^b, Liu, Xinyan ^c, Sun, Kan ^a, Fan, Yuzhu ^d, Wang, Chunliang ^a, Zhang, Song ^a

Source: In Heliyon 30 April 2024 10(8)

Female-specific dysfunction of sensory neocortical circuits in a mouse model of autism mediated by mGluR5 and estrogen receptor α

Authors: Molinaro, Gemma ¹, Bowles, Jacob E. ¹, Croom, Katilynne ³, Gonzalez, Darya ¹, Mirjafary, Saba ¹, Birnbaum, Shari G. ², Razak, Khaleel A. ^{3, 4}, Gibson, Jay R. ¹, Huber, Kimberly M. ^{1, 5, ∗}

Source: In Cell Reports 23 April 2024 43(4)

Analysis of single nucleotide polymorphisms of the metabotropic glutamate receptors in a transgender population

Authors: Rosa Fernández, Karla Ramírez, Roberto Lorente-Bermúdez, Esther Gómez-Gil, Mireia Mora, Antonio Guillamon, Eduardo Pásaro

Source: Frontiers in Endocrinology, Vol 15 (2024)

Subject Terms: gender dysphoria (GD), gender incongruence, membrane-bound estrogen receptors, mERs, metabotropic glutamate receptors (mGluR), mGluR5, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

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Relation: https://www.frontiersin.org/articles/10.3389/fendo.2024.1382861/full; https://doaj.org/toc/1664-2392

Access URL: https://doaj.org/article/846245694a8844f39a9d1fd164972431

Therapeutic Potential for Cannabis and Cannabinoids

Contributors: Raup-Konsavage, Wesley M.

Subject Terms: anti-microbial activity, anti-biofilm activity, Cannabis sativa L., endocannabinoids, gut microbiota, pathogens, phytocannabinoids, synovial fibroblast, rheumatoid arthritis, cannabis, tetrahydrocannabinol, cytokines, calcium, PBMC, cannabinoid receptors, TRPA1, 2-hydroxy oleic acid, anandamide, anti Bcl2, endocannabinoid system, membrane lipid therapy, neuroblastoma, N-arachidonoylethanolamine, cortisol, chronic pain, injury, autism spectrum disorder, cannabinoids, cannabidiol, clinical trials, randomized controlled, sleep, child psychiatry, developmental disorders, rat, post-traumatic stress disorder (PTSD), URB597, mGluR5, CB1 receptor, fatty acid amide hydrolase (FAAH), β-catenin, cannabinoid, immune, macrophage, elderly, inflammatory bowel disease, D9 tetrahydrocannabinol, nitric oxide, epilepsy, animal model, cognitive dysfunction, zebrafish, ∆9-tetrahydrocannabinol, THC, CBD, prefrontal cortex, striatum, BDNF, aging, age-related diseases, neuropathic pain, anxiety, inhalation, HRQoL, phytochemistry, terpenes, synergy, entourage effect, biosynthesis, HIV, cannabidiol (CBD), tetrahydrocannabinol (THC), chronic liver diseases, quality of life, pilot clinical trial, MMP-2, MMP-9, VSMC, H9c2 cells, glucose, cell proliferation, apoptosis, cardiovascular disease, FAAH inhibitors, MGL inhibitors, neonatal brain injury, hypoxia–ischemia, neuroprotection, neurogenesis, inflammation, bile acids, transcriptomics, estrogen deficiency, ovariectomized mice, postmenopause, gut organoids, ghrelin, GHSR signaling, late adolescence, medical cannabis, polypharmacy, Medicine and Nursing

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https://mdpi.com/books/pdfview/book/7420

A molecular perspective on mGluR5 regulation in the antidepressant effect of ketamine

Authors: Ola Sobhy A. Elmeseiny, Heidi Kaastrup Müller

Source: Pharmacological Research, Vol 200, Iss , Pp 107081- (2024)

Subject Terms: mGluR5, Ketamine, Homer1a, Antidepressant, Molecular mechanism, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1043661824000252; https://doaj.org/toc/1096-1186

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Impact of framing scheme optimization and smoking status on binding potential analysis in dynamic PET with [11C]ABP688

Authors: Cláudia Régio Brambilla, Jürgen Scheins, Lutz Tellmann, Ahlam Issa, Hans Herzog, N. Jon Shah, Irene Neuner, Christoph W. Lerche

Source: EJNMMI Research, Vol 13, Iss 1, Pp 1-11 (2023)

Subject Terms: PET, Quantification bias, Non-displaceable binding potential, Framing scheme, mGluR5, Smoking status, Medical physics. Medical radiology. Nuclear medicine, R895-920

File Description: electronic resource

Relation: https://doaj.org/toc/2191-219X

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Blockade of mGluR5 in astrocytes derived from human iPSCs modulates astrocytic function and increases phagocytosis

Authors: Izabella B. Q. de Lima, Pablo L. Cardozo, Julia S. Fahel, Juliana P. S. Lacerda, Aline S. Miranda, Antônio L. Teixeira, Fabiola M. Ribeiro

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: mGluR5, astrocyte, hiPSC, phagocytosis, TNFα, Immunologic diseases. Allergy, RC581-607

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Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1283331/full; https://doaj.org/toc/1664-3224

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Case report: Orthostatic leg tremor as the initial manifestation in a patient with metabotropic glutamate receptor-5 encephalitis without cortical dysfunction: complexities in identification and treatment

Authors: Xia Yang, Qiong Liu, Ming-feng Lai, Xiao-hong Ma, Xiao-ting Hao, Jia-jun Xu, Wan-jun Guo

Source: Frontiers in Neurology, Vol 14 (2023)

Subject Terms: mGluR5, autoimmune encephalitis, orthostatic leg tremor, prednisone, motor disorder, Neurology. Diseases of the nervous system, RC346-429

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Relation: https://www.frontiersin.org/articles/10.3389/fneur.2023.1288075/full; https://doaj.org/toc/1664-2295

Access URL: https://doaj.org/article/e0770a966ad84ad8acd1c543c906d57e

Social withdrawal and anxiety-like behavior have an impact on zebrafish adult neurogenesis

Authors: Panagiotis Perdikaris, Paulina Prouska, Catherine R. Dermon

Source: Frontiers in Behavioral Neuroscience, Vol 17 (2023)

Subject Terms: social deficits, NMDAR hypofunction, MK-801, cell proliferation, neurogenesis, mGLuR5, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnbeh.2023.1244075/full; https://doaj.org/toc/1662-5153

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Binding of a positive allosteric modulator CDPPB to metabotropic glutamate receptor type 5 (mGluR5) probed by all-atom molecular dynamics simulations

Authors: Uba, Abdullahi Ibrahim ^a, Chea, John ^b, Hoag, Hannah ^a, Hryb, Mariya ^a, Bui-Linh, Candice ^a, Wu, Chun ^{a, ⁎}

Source: In Life Sciences 15 November 2022 309

mGluR-dependent plasticity in rodent models of Alzheimer’s disease

Authors: Gonzalo Valdivia, Alvaro O. Ardiles, Abimbola Idowu, Claudia Salazar, Hey-Kyoung Lee, Michela Gallagher, Adrian G. Palacios, Alfredo Kirkwood

Source: Frontiers in Synaptic Neuroscience, Vol 15 (2023)

Subject Terms: LTP (long term potentiation), LTD (long term pepression), mGluR5, Alzheimer’s disease, aging, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

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Relation: https://www.frontiersin.org/articles/10.3389/fnsyn.2023.1123294/full; https://doaj.org/toc/1663-3563

Access URL: https://doaj.org/article/468561cadf704e42872711578eef54fc