Components of the Endosome-Lysosome Vesicular Machinery as Drivers of the Metastatic Cascade in Prostate Cancer.

Authors: Nturubika, Bukuru Dieu-Donne¹ (AUTHOR) bukuru.nturubika@mymail.unisa.edu.au, Logan, Jessica¹ (AUTHOR) courtney.moore@unisa.edu.au, Johnson, Ian R. D.¹ (AUTHOR) ka_lok.li@mymail.unisa.edu.au, Moore, Courtney¹ (AUTHOR) jingying.tang@unisa.edu.au, Li, Ka Lok¹ (AUTHOR) emma.parkinson-lawrence@unisa.edu.au, Tang, Jingying¹ (AUTHOR) des.williams@unisa.edu.au, Lam, Giang² (AUTHOR) giang.lam@unisa.edu.au, Parkinson-Lawrence, Emma¹ (AUTHOR) james.chakiris@mymail.unisa.edu.au, Williams, Desmond B.¹ (AUTHOR) madison.hindes@mymail.unisa.edu.au, Chakiris, James¹ (AUTHOR) rob.brooks@unisa.edu.au, Hindes, Madison¹ (AUTHOR), Brooks, Robert D.¹ (AUTHOR), Miles, Mark A.³ (AUTHOR) mark.miles@rmit.edu.au, Selemidis, Stavros³ (AUTHOR) stavros.selemidis@rmit.edu.au, Gregory, Philip² (AUTHOR) philip.gregory@unisa.edu.au, Weigert, Roberto⁴ (AUTHOR) weigertr@mail.nih.gov, Butler, Lisa^5,6 (AUTHOR) lisa.butler@adelaide.edu.au, Ward, Mark P.⁷ (AUTHOR) wardm6@tcd.ie, Waugh, David J. J.² (AUTHOR) david.waugh@unisa.edu.au, O'Leary, John J.⁸ (AUTHOR) olearyjj@tcd.ie

Source: Cancers. Jan2025, Vol. 17 Issue 1, p43. 31p.

Subject Terms: *LYSOSOMES, *CELL proliferation, *PROSTATE tumors, *EVALUATION of medical care, *TUMOR markers, *METASTASIS, *CYTOPLASM, *TUMOR classification, *INFLAMMATION, *DISEASE progression

New Advances in the Study of CMTM6, a Focus on Its Novel Non-Canonical Cellular Locations, and Functions beyond Its Role as a PD-L1 Stabilizer.

Authors: Urciaga-Gutierrez, Pedro Ivan¹ (AUTHOR) nadia.garcia2322@alumnos.udg.mx, Franco-Topete, Ramon Antonio² (AUTHOR), Bastidas-Ramirez, Blanca Estela¹ (AUTHOR), Solorzano-Ibarra, Fabiola¹ (AUTHOR), Rojas-Diaz, Jose Manuel¹ (AUTHOR), Garcia-Barrientos, Nadia Tatiana¹ (AUTHOR), Klimov-Kravtchenko, Ksenia¹ (AUTHOR), Tellez-Bañuelos, Martha Cecilia³ (AUTHOR), Ortiz-Lazareno, Pablo Cesar⁴ (AUTHOR), Peralta-Zaragoza, Oscar⁵ (AUTHOR), Meneses-Acosta, Angelica⁶ (AUTHOR), Alejandre-Gonzalez, Alan Guillermo¹ (AUTHOR), Bueno-Topete, Miriam Ruth¹ (AUTHOR), Haramati, Jesse³ (AUTHOR) jesse.haramati3727@academicos.udg.mx, del Toro-Arreola, Susana^1,7 (AUTHOR) jesse.haramati3727@academicos.udg.mx

Source: Cancers. Sep2024, Vol. 16 Issue 18, p3126. 16p.

Subject Terms: *FLOW cytometry, *LYSOSOMES, *RESEARCH funding, *PROGRAMMED death-ligand 1, *ENZYME-linked immunosorbent assay, *IMMUNOTHERAPY, *FLUORESCENT antibody technique, *PLASMAPHERESIS, *CANCER cell culture, *IMMUNE system, *CELL lines, *WESTERN immunoblotting, *BLOOD plasma, *COMPARATIVE studies, *MEMBRANE proteins, *EXOSOMES, *IMMUNITY, CERVIX uteri tumors

Geographic Terms: MEXICO

Bafilomycin 1A Affects p62/SQSTM1 Autophagy Marker Protein Level and Autophagosome Puncta Formation Oppositely under Various Inflammatory Conditions in Cultured Rat Microglial Cells.

Authors: Pesti, István^1,2 (AUTHOR) pesti.istvan@med.u-szeged.hu, Barczánfalvi, Gábor¹ (AUTHOR) barczanfalvi.gabor@med.u-szeged.hu, Dulka, Karolina¹ (AUTHOR) karolina.dulka@med.u-szeged.hu, Kata, Diana³ (AUTHOR) kata.diana@med.u-szeged.hu, Farkas, Eszter^1,2 (AUTHOR) farkas.eszter1@med.u-szeged.hu, Gulya, Karoly¹ (AUTHOR) gulyak@bio.u-szeged.hu

Source: International Journal of Molecular Sciences. Aug2024, Vol. 25 Issue 15, p8265. 17p.

Subject Terms: *AUTOPHAGY, *LYSOSOMES, *MICROGLIA, *WESTERN immunoblotting, *IMMUNOCYTOCHEMISTRY

Phenotypic and Functional Outcomes in Macrophages Exposed to an Environmentally Relevant Mixture of Organophosphate Esters in Vitro.

Authors: Giles, Braeden H.^1,2, Kukolj, Nikola^1,2, Mann, Koren K.^1,2, Robaire, Bernard^1,3, bernard.robaire@mcgill.ca

Source: Environmental Health Perspectives; Aug2024, Vol. 132 Issue 8, p087002-1-087002-13, 13p

T-cell metabolism in rheumatoid arthritis: focus on mitochondrial and lysosomal dysfunction.

Authors: Parab, Asmita¹ (AUTHOR), Bhatt, Lokesh Kumar¹ (AUTHOR) lokesh.bhatt@bncp.ac.in

Source: Immunopharmacology & Immunotoxicology. Jun2024, Vol. 46 Issue 3, p378-384. 7p.

Subject Terms: *LYSOSOMES, *RHEUMATOID arthritis, *T cells, *METABOLISM, *PENTOSE phosphate pathway, *MITOCHONDRIA

Copper Chelation Therapy Attenuates Periodontitis Inflammation through the Cuproptosis/Autophagy/Lysosome Axis.

Authors: Zhang, Lujin¹ (AUTHOR), Tsai, I-Chen¹ (AUTHOR), Ni, Zihan¹ (AUTHOR) zlujin@163.com, Chen, Beichen¹ (AUTHOR), Zhang, Shuaiyuan¹ (AUTHOR), Cai, Luhui¹ (AUTHOR), Xu, Qiong¹ (AUTHOR) xqiong@mail.sysu.edu.cn

Source: International Journal of Molecular Sciences. Jun2024, Vol. 25 Issue 11, p5890. 20p.

Subject Terms: *LYSOSOMES, *CHELATION therapy, *PERIODONTITIS, *CATHEPSIN B, *AUTOPHAGY, *MEMBRANE permeability (Biology), *CHELATING agents

Amphiphilic Chlorin‐β‐cyclodextrin Conjugates in Photo‐Triggered Drug Delivery: The Role of Aggregation.

Authors: Panagiotakis, Stylianos¹ (AUTHOR), Mavroidi, Barbara² (AUTHOR), Athanasopoulos, Alexandros² (AUTHOR), Charalambidis, Georgios^3,4 (AUTHOR), Coutsolelos, Athanassios G.³ (AUTHOR), Pelecanou, Maria² (AUTHOR), Yannakopoulou, Konstantina¹ (AUTHOR) k.yannakopoulou@inn.demokritos.gr

Source: ChemPlusChem. Jun2024, Vol. 89 Issue 6, p1-9. 9p.

Subject Terms: *REACTIVE oxygen species, *LYSOSOMES, *LIGHT scattering, *CYCLODEXTRINS, *CHLORINS, *PHOTOPLETHYSMOGRAPHY, *CELL survival

Regulation of TSC2 lysosome translocation and mitochondrial turnover by TSC2 acetylation status.

Authors: Marqués, Patricia¹ (AUTHOR), Burillo, Jesús² (AUTHOR), González-Blanco, Carlos^1,2,3,4 (AUTHOR), Jiménez, Beatriz^1,2,3 (AUTHOR), García, Gema^2,3 (AUTHOR), García-Aguilar, Ana^2,3,5 (AUTHOR), Iglesias-Fortes, Sarai¹ (AUTHOR), Lockwood, Ángela^1,2,3,4 (AUTHOR), Guillén, Carlos^1,2,3,4 (AUTHOR) cguillen@ucm.es

Source: Scientific Reports. 5/31/2024, Vol. 14 Issue 1, p1-13. 13p.

Subject Terms: *LYSOSOMES, *ACETYLATION, *PANCREATIC beta cells, *MITOCHONDRIA, *TUBEROUS sclerosis, *TYPE 2 diabetes

TASL mediates keratinocyte differentiation by regulating intracellular calcium levels and lysosomal function.

Authors: Park, Ji Yeong¹ (AUTHOR), Kim, Hyeng-Soo² (AUTHOR) grayciel@knu.ac.kr, Hyung, Hyejin¹ (AUTHOR), Jang, Soyeon² (AUTHOR), Ko, Jiwon² (AUTHOR), Lee, Jin Hong¹ (AUTHOR), Kim, Si-Yong¹ (AUTHOR), Park, Song^3,4 (AUTHOR), Yi, Junkoo⁵ (AUTHOR), Park, Sijun² (AUTHOR), Lim, Su-Geun² (AUTHOR), Kim, Seonggon⁶ (AUTHOR), Lee, Sanggyu¹ (AUTHOR), Kim, Myoung Ok⁷ (AUTHOR), Jang, Soyoung¹ (AUTHOR) wkdthdud21@naver.com, Ryoo, Zae Young¹ (AUTHOR) jaewoong64@knu.ac.kr

Source: Scientific Reports. 5/14/2024, Vol. 14 Issue 1, p1-12. 12p.

Subject Terms: *LYSOSOMES, *INTRACELLULAR calcium, *CELL cycle, *KERATINOCYTES, *BIOLOGY, *CELL lines, KERATINOCYTE differentiation

iTRAQ-based proteomic study on monocyte cell model discovered an association of LAMP2 downregulation with HIV-1 latency.

Authors: Yin, Lin¹ (AUTHOR), Wang, Qimin¹ (AUTHOR), Liu, Siyuan² (AUTHOR), Chen, Jun¹ (AUTHOR), Zhang, Yujiao¹ (AUTHOR), Lu, Lingqing¹ (AUTHOR), Lu, Hongzhou^1,3 (AUTHOR), Song, Zhigang¹ (AUTHOR) ys02261059@163.com, Zhang, Lijun¹ (AUTHOR) zhanglijun1221@163.com

Source: Proteome Science. 5/15/2024, Vol. 22 Issue 1, p1-14. 14p.

Subject Terms: *HIV, *LYSOSOMES, *CD47 antigen, *LATENT infection, *CELL surface antigens, *PROTEOMICS, *DOWNREGULATION

Legionella pneumophila exploits the endo-lysosomal network for phagosome biogenesis by co-opting SUMOylated Rab7.

Authors: Li, Chuang¹ (AUTHOR), Fu, Jiaqi¹ (AUTHOR), Shao, Shuai^2,3 (AUTHOR), Luo, Zhao-Qing¹ (AUTHOR) luoz@purdue.edu

Source: PLoS Pathogens. 5/13/2024, Vol. 20 Issue 5, p1-29. 29p.

Subject Terms: *LEGIONELLA pneumophila, *LYSOSOMES, *GOLGI apparatus, *CELL death, *ENDOPLASMIC reticulum, *GUANOSINE triphosphatase, *CRISPRS

Mycobacterium tuberculosis resides in lysosome-poor monocyte-derived lung cells during chronic infection.

Authors: Zheng, Weihao¹ (AUTHOR), Chang, I-Chang¹ (AUTHOR), Limberis, Jason¹ (AUTHOR), Budzik, Jonathan M.² (AUTHOR), Zha, Beth Shoshana^1,2 (AUTHOR), Howard, Zachary¹ (AUTHOR), Chen, Lucas¹ (AUTHOR), Ernst, Joel D.¹ (AUTHOR) joel.ernst@ucsf.edu

Source: PLoS Pathogens. 5/3/2024, Vol. 20 Issue 5, p1-32. 32p.

Subject Terms: *LYSOSOMES, *MYCOBACTERIUM tuberculosis, *MACROPHAGES, *LUNGS, *MYELOID cells, *ALVEOLAR macrophages, *TUBERCULOSIS in cattle

Swelling, Rupture and Endosomal Escape of Biological Nanoparticles Per Se and Those Fused with Liposomes in Acidic Environment.

Authors: Ponomareva, Natalia^1,2,3 (AUTHOR) gegechkori_v_i@staff.sechenov.ru, Brezgin, Sergey^1,2 (AUTHOR) frolanasta@gmail.com, Karandashov, Ivan¹ (AUTHOR) vladimir@chulanov.ru, Kostyusheva, Anastasiya¹ (AUTHOR) dkostushev@gmail.com, Demina, Polina^4,5 (AUTHOR) polidemina1207@yandex.ru, Slatinskaya, Olga⁶ (AUTHOR) slatolya@mail.ru, Bayurova, Ekaterina⁷ (AUTHOR) bayurova_eo@chumakovs.su, Silachev, Denis^8,9 (AUTHOR) silachevdn@belozersky.msu.ru, Pokrovsky, Vadim S.^2,10,11 (AUTHOR) zamyat@belozersky.msu.ru, Gegechkori, Vladimir³ (AUTHOR), Khaydukov, Evgeny^4,5 (AUTHOR) khaydukov@mail.ru, Maksimov, Georgy⁶ (AUTHOR) gmaksimov@mail.ru, Frolova, Anastasia^2,12 (AUTHOR) aparodi.sechenovuniversity@gmail.com, Gordeychuk, Ilya⁷ (AUTHOR) gordeychuk_iv@chumakovs.su, Zamyatnin Jr., Andrey A.^2,9,13 (AUTHOR), Chulanov, Vladimir^1,14 (AUTHOR), Parodi, Alessandro² (AUTHOR), Kostyushev, Dmitry^1,2,13 (AUTHOR)

Source: Pharmaceutics. May2024, Vol. 16 Issue 5, p667. 17p.

Subject Terms: *LYSOSOMES, *LIPOSOMES, *NANOPARTICLES, *NUCLEIC acids, *EXTRACELLULAR vesicles, *SERS spectroscopy

Iridoid glycosides from Morinda officinalis induce lysosomal biogenesis and promote autophagic flux to attenuate oxidative stress.

Authors: Wang, Yin-Yuan^1,2, Ni, Jian-Cheng³, Zhao, Yue-Qin^1,4, Yang, Xu^1,4, Niu, Zhen-Peng^1,5,6, Yang, Xing-Zhi¹, Dong, Xian-Xiang^1,4, Zhao, Yu-Han¹ zhaoyuhan@mail.kib.ac.cn, Hao, Xiao-Jiang^1,5 haoxj@mail.kib.ac.cn, Ding, Xiao^1,5 dingxiao@mail.kib.ac.cn

Source: Journal of Asian Natural Products Research. May2024, Vol. 26 Issue 5, p562-574. 13p.

Subject Terms: *LYSOSOMES, *AUTOPHAGY, *HOMEOSTASIS, *PHOSPHORYLATION, *RESEARCH funding, *TERPENES, *BIOLOGICAL transport, *POLYMERASE chain reaction, *OXIDATIVE stress, *TRANSCRIPTION factors, *PLANT roots, *CULTURE media (Biology), *DESCRIPTIVE statistics, *GENE expression, *CELL lines, *REACTIVE oxygen species, *MEDICINAL plants, *METABOLISM, *ANTIOXIDANTS, *ONE-way analysis of variance, *WESTERN immunoblotting, *DRUG development, *MICROSCOPY, *STAINS & staining (Microscopy), *GENETIC techniques, *DATA analysis software, *CULTURES (Biology)

Optogenetic manipulation of lysosomal physiology and autophagy-dependent clearance of amyloid beta.

Authors: Zeng, Wenping¹ (AUTHOR), Li, Canjun^1,2 (AUTHOR), Wu, Ruikun^3,4 (AUTHOR), Yang, Xingguo¹ (AUTHOR), Wang, Qingyan¹ (AUTHOR), Lin, Bingqian¹ (AUTHOR), Wei, Yanan¹ (AUTHOR), Li, Hao¹ (AUTHOR), Shan, Ge^3,4 (AUTHOR) shange@ustc.edu.cn, Qu, Lili¹ (AUTHOR) shange@ustc.edu.cn, Cang, Chunlei^1,2,4,5 (AUTHOR) shange@ustc.edu.cn

Source: PLoS Biology. 4/23/2024, Vol. 22 Issue 4, p1-26. 26p.

Subject Terms: *LYSOSOMES, *CELL physiology, *LYSOSOMAL storage diseases, *PHYSIOLOGY, *AMYLOID, *ALZHEIMER'S disease, *HOMEOSTASIS

Inflammation and Exosomes in Fabry Disease Pathogenesis.

Authors: Coelho-Ribeiro, Bruna^1,2 (AUTHOR) a84721@alunos.uminho.pt, Silva, Helena G.^1,2 (AUTHOR) helenasgsilva@gmail.com, Sampaio-Marques, Belém^1,2 (AUTHOR) mbmarques@med.uminho.pt, Fraga, Alexandra G.^1,2 (AUTHOR) afraga@med.uminho.pt, Azevedo, Olga³ (AUTHOR) olgazevedo@yahoo.com.br, Pedrosa, Jorge^1,2 (AUTHOR) jpedrosa@med.uminho.pt, Ludovico, Paula^1,2 (AUTHOR) pludovico@med.uminho.pt

Source: Cells (2073-4409). Apr2024, Vol. 13 Issue 8, p654. 18p.

Subject Terms: *ANGIOKERATOMA corporis diffusum, *LYSOSOMES, *X chromosome, *CELL physiology, *EXOSOMES, *EXTRACELLULAR vesicles, *LYSOSOMAL storage diseases

One size does not fit all: Lysosomes exist in biochemically and functionally distinct states.

Authors: Bussi, Claudio¹ (AUTHOR) claudio.bussi@crick.ac.uk, Gutierrez, Maximiliano G.¹ (AUTHOR) claudio.bussi@crick.ac.uk

Source: PLoS Biology. 3/22/2024, Vol. 22 Issue 3, p1-5. 5p.

Subject Terms: *LYSOSOMES, *HETEROGENEITY

Molecular Mechanism of Autophagosome–Lysosome Fusion in Mammalian Cells.

Authors: Ke, Po-Yuan^1,2 (AUTHOR) pyke0324@mail.cgu.edu.tw

Source: Cells (2073-4409). Mar2024, Vol. 13 Issue 6, p500. 34p.

Subject Terms: *CELL fusion, *LYSOSOMES, *AUTOPHAGY, *PROTEOLYTIC enzymes

Defects of mitochondria-lysosomes communication induce secretion of mitochondria-derived vesicles and drive chemoresistance in ovarian cancer cells.

Authors: Gagliardi, Sinforosa¹ (AUTHOR), Mitruccio, Marco¹ (AUTHOR), Di Corato, Riccardo^2,3 (AUTHOR), Romano, Roberta^1,4 (AUTHOR), Aloisi, Alessandra² (AUTHOR), Rinaldi, Rosaria^5,6 (AUTHOR), Alifano, Pietro^1,4 (AUTHOR), Guerra, Flora¹ (AUTHOR), Bucci, Cecilia^1,4 (AUTHOR) cecilia.bucci@unisalento.it

Source: Cell Communication & Signaling. 3/6/2024, Vol. 22 Issue 1, p1-26. 26p.

Subject Terms: *LYSOSOMES, *OVARIAN cancer, *CANCER cells, *SECRETION, *DRUG resistance in cancer cells, *MITOCHONDRIAL DNA, *CHEMORECEPTORS

Comparative study of the steady-state subcellular distribution of lysosome-associated membrane glycoprotein-2 (LAMP-2) isoforms with GYXXΦ-type tyrosine-based motifs that interact differently with four adaptor protein (AP) complexes.

Authors: Yamaguchi, Fumiaki¹ (AUTHOR), Sakane, Hiroshi¹ (AUTHOR), Akasaki, Kenji¹ (AUTHOR) akasaki@fukuyama-u.ac.jp

Source: Journal of Biochemistry. Mar2024, Vol. 175 Issue 3, p275-287. 13p.

Subject Terms: *ADAPTOR proteins, *LYSOSOMES, *CELL fractionation, *MEMBRANE proteins, *CELL membranes, *ORGANELLES